KEGG   Homo sapiens (human): 1763
Entry
1763              CDS       T01001                                 
Symbol
DNA2, DNA2L, RTS4, hDNA2
Name
(RefSeq) DNA replication helicase/nuclease 2
  KO
K10742  DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
Network
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01446  DNA end resection and RPA loading
N01472  Okazaki fragment maturation
Disease
H00992  Seckel syndrome
H01118  Progressive external ophthalmoplegia
H01734  Rothmund-Thomson syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    1763 (DNA2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    1763 (DNA2)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.3  DNA 5'-3' helicase
     1763 (DNA2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   Other elongation factors
    1763 (DNA2)
 Prokaryotic type
   Elongation factors (archaeal)
    Other elongation factors
     1763 (DNA2)
SSDB
Motif
Pfam: Dna2 AAA_12 Dna2_Rift AAA_11 AAA_30 AAA_19 nSTAND3 UvrD-helicase SRP54 bpMoxR DEAD Cas_Cas4 ResIII AAA_25 CbiA SLFN-g3_helicase UvrD_C_2 MobB AAA_22 AAA_7 PhoH AAA
Other DBs
NCBI-GeneID: 1763
NCBI-ProteinID: NP_001073918
OMIM: 601810
HGNC: 2939
Ensembl: ENSG00000138346
UniProt: P51530
Structure
Position
10:complement(68414064..68472521)
AA seq 1060 aa
MEQLNELELLMEKSFWEEAELPAELFQKKVVASFPRTVLSTGMDNRYLVLAVNTVQNKEG
NCEKRLVITASQSLENKELCILRNDWCSVPVEPGDIIHLEGDCTSDTWIIDKDFGYLILY
PDMLISGTSIASSIRCMRRAVLSETFRSSDPATRQMLIGTVLHEVFQKAINNSFAPEKLQ
ELAFQTIQEIRHLKEMYRLNLSQDEIKQEVEDYLPSFCKWAGDFMHKNTSTDFPQMQLSL
PSDNSKDNSTCNIEVVKPMDIEESIWSPRFGLKGKIDVTVGVKIHRGYKTKYKIMPLELK
TGKESNSIEHRSQVVLYTLLSQERRADPEAGLLLYLKTGQMYPVPANHLDKRELLKLRNQ
MAFSLFHRISKSATRQKTQLASLPQIIEEEKTCKYCSQIGNCALYSRAVEQQMDCSSVPI
VMLPKIEEETQHLKQTHLEYFSLWCLMLTLESQSKDNKKNHQNIWLMPASEMEKSGSCIG
NLIRMEHVKIVCDGQYLHNFQCKHGAIPVTNLMAGDRVIVSGEERSLFALSRGYVKEINM
TTVTCLLDRNLSVLPESTLFRLDQEEKNCDIDTPLGNLSKLMENTFVSKKLRDLIIDFRE
PQFISYLSSVLPHDAKDTVACILKGLNKPQRQAMKKVLLSKDYTLIVGMPGTGKTTTICT
LVRILYACGFSVLLTSYTHSAVDNILLKLAKFKIGFLRLGQIQKVHPAIQQFTEQEICRS
KSIKSLALLEELYNSQLIVATTCMGINHPIFSRKIFDFCIVDEASQISQPICLGPLFFSR
RFVLVGDHQQLPPLVLNREARALGMSESLFKRLEQNKSAVVQLTVQYRMNSKIMSLSNKL
TYEGKLECGSDKVANAVINLRHFKDVKLELEFYADYSDNPWLMGVFEPNNPVCFLNTDKV
PAPEQVEKGGVSNVTEAKLIVFLTSIFVKAGCSPSDIGIIAPYRQQLKIINDLLARSIGM
VEVNTVDKYQGRDKSIVLVSFVRSNKDGTVGELLKDWRRLNVAITRAKHKLILLGCVPSL
NCYPPLEKLLNHLNSEKLIIDLPSREHESLCHILGDFQRE
NT seq 3183 nt   +upstreamnt  +downstreamnt
atggagcagctgaacgaactggagctgctgatggagaagagtttttgggaggaggcggag
ctgccggcggagctatttcagaagaaagtggtagcttcctttccaagaacagttctgagc
acaggaatggataaccggtacctggtgttggcagtcaatactgtacagaacaaagaggga
aactgtgaaaagcgcctggtcatcactgcttcacagtcactagaaaataaagaactatgc
atccttaggaatgactggtgttctgttccagtagagccaggagatatcattcatttggag
ggagactgcacatctgacacttggataatagataaagattttggatatttgattctgtat
ccagacatgctgatttctggcaccagcatagccagtagtattcgatgtatgagaagagct
gtcctgagtgaaacttttaggagctctgatccagccacacgccaaatgctaattggtacg
gttctccatgaggtgtttcaaaaagccataaataatagctttgccccagaaaagctacaa
gaacttgcttttcaaacaattcaagaaataagacatttgaaggaaatgtaccgcttaaat
ctaagtcaagatgaaataaaacaagaagtagaggactatcttccttcgttttgtaaatgg
gcaggagatttcatgcataaaaacacttcgactgacttccctcagatgcagctctctctg
ccaagtgataatagtaaggataattcaacatgtaacattgaagtcgtgaaaccaatggat
attgaagaaagcatttggtcccctaggtttggattgaaaggcaaaatagatgttacagtt
ggtgtgaaaatacatcgagggtataaaacaaaatacaagataatgccgctggaacttaaa
actggcaaagaatcaaattctattgaacaccgtagtcaggttgttctgtacactctacta
agccaagagagaagagctgatccagaggctggcttgcttctctacctcaagactggtcag
atgtaccctgtgcctgccaaccatctagataaaagagaattattaaagctaagaaaccag
atggcattctcattgtttcaccgtattagcaaatctgctactagacagaagacacagctt
gcttctttgccacaaataattgaggaagagaaaacttgtaaatattgttcacaaattggc
aattgtgctctttatagcagagcagttgaacaacagatggattgtagttcagtcccaatt
gtgatgctgcccaaaatagaagaagaaacccagcatctgaagcaaacacacttagaatat
ttcagcctttggtgtctaatgttaaccctggagtcacaatcgaaggataataaaaagaat
caccaaaatatctggctaatgcctgcttcggaaatggagaagagtggcagttgcattgga
aacctgattagaatggaacatgtaaagatagtttgtgatgggcaatatttacataatttc
caatgtaaacatggtgccatacctgtcacaaatctaatggcaggtgacagagttattgta
agtggagaagaaaggtcactgtttgctttgtctagaggatatgtgaaggagattaacatg
acaacagtaacttgtttattagacagaaacttgtcggtccttccagaatcaactttgttc
agattagaccaagaagaaaaaaattgtgatatagataccccattaggaaatctttccaaa
ttgatggaaaacacgtttgtcagcaaaaaacttcgagatttaattattgactttcgtgaa
cctcagtttatatcctaccttagttctgttcttccacatgatgcaaaggatacagttgcc
tgcattctaaagggtttgaataagcctcagaggcaagcgatgaaaaaggtacttctttca
aaagactacacactcatcgtgggtatgcctgggacaggaaaaacaactacgatatgtact
ctcgtaagaattctctacgcctgtggttttagcgttttgttgaccagctatacacactct
gctgttgacaatattcttttgaagttagccaagtttaaaataggatttttgcgtttgggt
cagattcagaaggttcatccagctatccagcaatttacagagcaagaaatttgcagatca
aagtccattaaatccttagctcttctagaagaactctacaatagtcaacttatagttgca
acaacatgtatgggaataaaccatccaatattttcccgtaaaatttttgatttttgtatt
gtggatgaagcctctcaaattagccaaccaatttgtctgggccccctttttttttcacgg
agatttgtgttagtgggggaccatcagcagcttcctcccctggtgctaaaccgtgaagca
agagctcttggcatgagtgaaagcttattcaagaggctggagcagaataagagtgctgtt
gtacagttaaccgtgcagtacagaatgaacagtaaaattatgtccttaagtaataagctg
acctatgagggcaagctggagtgtggatcagacaaagtggccaatgcagtgataaaccta
cgtcactttaaagatgtgaagctggaactggaattttatgctgactattctgataatcct
tggttgatgggagtatttgaacccaacaatcctgtttgtttccttaatacagacaaggtt
ccagcgccagaacaagttgaaaaaggtggtgtgagcaatgtaacagaagccaaactcata
gttttcctaacctccatttttgttaaggctggatgcagtccctctgatattggtattatt
gcaccgtacaggcagcaattaaagatcatcaatgatttattggcacgttctattgggatg
gtcgaagttaatacagtagacaaataccaaggaagggacaaaagtattgtcctagtatct
tttgttagaagtaataaggatggaactgttggtgaactcttgaaagattggcgacgtctt
aatgttgctataaccagagccaaacataaactgattcttctggggtgtgtgccctcacta
aattgctatcctcctttggagaagctgcttaatcatttaaactcagaaaaattaatcatt
gatcttccatcaagagaacatgaaagtctttgccacatattgggtgactttcaaagagaa
taa

  All links  
Disease (4)   
   OMIM (4)   
Gene (23)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (32)   
   RefSeq(nuc) (8)   
   GenBank (12)   
   EMBL (12)   
3D Structure (1)   
   PDB (1)   
Protein domain (22)   
   Pfam (22)   
All databases (91)   

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