KEGG   Homo sapiens (human): 1956Help
Entry
1956              CDS       T01001                                 

Gene name
EGFR, ERBB, ERBB1, HER1, NISBD2, PIG61, mENA
Definition
(RefSeq) epidermal growth factor receptor
  KO
K04361  epidermal growth factor receptor [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04144  Endocytosis
hsa04151  PI3K-Akt signaling pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction
hsa04540  Gap junction
hsa04630  Jak-STAT signaling pathway
hsa04810  Regulation of actin cytoskeleton
hsa04912  GnRH signaling pathway
hsa04915  Estrogen signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04934  Cushing syndrome
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05160  Hepatitis C
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
Network
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00021  EGF-ERBB2-RAS-ERK signaling pathway
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00023  EGF-EGFR-PLCG-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00033  EGF-EGFR-PI3K signaling pathway
N00034  ERBB2-overexpression to PI3K signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00042  EGFR-overexpression to PI3K signaling pathway
N00094  EGF-Jak-STAT signaling pathway
N00095  ERBB2-overexpression to EGF-Jak-STAT signaling pathway
N00096  EGF-EGFR-RAS-RASSF1 signaling pathway
N00103  EGF-EGFR-RAS-RalGDS signaling pathway
N00147  EGF-EGFR-PLCG-calcineurin signaling pathway
N00227  TGFA-EGFR-PLCG-PKC signaling pathway
N00228  TGFA-overexpression to PLCG-PKC signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00230  TGFA-overexpression to RAS-ERK signaling pathway
N00231  TGFA-EGFR-PI3K signaling pathway
N00232  TGFA-overexpression to PI3K signaling pathway
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00253  Amplified ERBB2 to PI3K signaling pathway
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00280  AREG-overexpression to RAS-ERK signaling pathway
N00281  EGF-overexpression to PI3K signaling pathway
N00282  EREG-EGFR-PI3K signaling pathway
N00283  EREG-overexpression to PI3K signaling pathway
N00284  AREG-EGFR-PI3K signaling pathway
N00285  AREG-overexpression to PI3K signaling pathway
N00318  EGFR-ERK-ACTH signaling pathway
N00319  Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway
N00366  HPV E5 to EGFR-PI3K signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00390  EGF-EGFR-PI3K-NFKB signaling pathway
N00391  HCMV gB to EGFR-PI3K-NFKB signaling pathway
N00392  HCMV gB to EGFR-RAS-ERK signaling pathway
N10005  First/second-generation tyrosine kinase inhibitor to EGFR mutation
N10006  Third-generation tyrosine kinase inhibitor to EGFR mutation
 » show all
Disease
H00014  Non-small cell lung cancer
H00016  Oral cancer
H00017  Esophageal cancer
H00022  Bladder cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00031  Breast cancer
H00042  Glioma
H00055  Laryngeal cancer
H01508  Salivary gland cancer
H01559  Oropharyngeal cancer
Drug target
Afatinib (DG00717): D09724 D09733
Canertinib dihydrochloride: D03350
Cetuximab: D03455
Dacomitinib (DG01793): D09883 D10514
Erlotinib (DG00711): D04023 D07907
Gefitinib: D01977
Imgatuzumab: D10439
Lapatinib (DG00715): D04024 D08108
Masoprocol: D04862
Modotuximab: D11125
Naquotinib: D10958
Necitumumab: D10018
Neratinib (DG02303): D08950 D10898
Olmutinib (DG02916): D10859 D11115
Osimertinib: D10766
Panitumumab: D05350
Pelitinib: D05399
Rindopepimut: D09660
Rociletinib: D10858
Vandetanib: D06407
Varlitinib (DG01357): D09689 D09690
Zalutumumab: D10031
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    1956 (EGFR)
   04015 Rap1 signaling pathway
    1956 (EGFR)
   04010 MAPK signaling pathway
    1956 (EGFR)
   04012 ErbB signaling pathway
    1956 (EGFR)
   04630 Jak-STAT signaling pathway
    1956 (EGFR)
   04066 HIF-1 signaling pathway
    1956 (EGFR)
   04068 FoxO signaling pathway
    1956 (EGFR)
   04020 Calcium signaling pathway
    1956 (EGFR)
   04072 Phospholipase D signaling pathway
    1956 (EGFR)
   04151 PI3K-Akt signaling pathway
    1956 (EGFR)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    1956 (EGFR)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    1956 (EGFR)
   04520 Adherens junction
    1956 (EGFR)
   04540 Gap junction
    1956 (EGFR)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1956 (EGFR)
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    1956 (EGFR)
   04915 Estrogen signaling pathway
    1956 (EGFR)
   04921 Oxytocin signaling pathway
    1956 (EGFR)
   04926 Relaxin signaling pathway
    1956 (EGFR)
   04928 Parathyroid hormone synthesis, secretion and action
    1956 (EGFR)
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    1956 (EGFR)
   05230 Central carbon metabolism in cancer
    1956 (EGFR)
   05231 Choline metabolism in cancer
    1956 (EGFR)
   05206 MicroRNAs in cancer
    1956 (EGFR)
   05205 Proteoglycans in cancer
    1956 (EGFR)
  09162 Cancers: Specific types
   05210 Colorectal cancer
    1956 (EGFR)
   05212 Pancreatic cancer
    1956 (EGFR)
   05225 Hepatocellular carcinoma
    1956 (EGFR)
   05226 Gastric cancer
    1956 (EGFR)
   05214 Glioma
    1956 (EGFR)
   05218 Melanoma
    1956 (EGFR)
   05219 Bladder cancer
    1956 (EGFR)
   05215 Prostate cancer
    1956 (EGFR)
   05213 Endometrial cancer
    1956 (EGFR)
   05224 Breast cancer
    1956 (EGFR)
   05223 Non-small cell lung cancer
    1956 (EGFR)
  09167 Endocrine and metabolic diseases
   04934 Cushing syndrome
    1956 (EGFR)
  09171 Infectious diseases: Bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    1956 (EGFR)
  09172 Infectious diseases: Viral
   05160 Hepatitis C
    1956 (EGFR)
   05163 Human cytomegalovirus infection
    1956 (EGFR)
   05165 Human papillomavirus infection
    1956 (EGFR)
  09176 Drug resistance: Antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    1956 (EGFR)
   01522 Endocrine resistance
    1956 (EGFR)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1956 (EGFR)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1956 (EGFR)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     1956 (EGFR)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   1956 (EGFR)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   1956 (EGFR)
  Exosomal proteins of pancreatic cancer cells
   1956 (EGFR)
  Exosomal proteins of bladder cancer cells
   1956 (EGFR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase_Tyr Recep_L_domain GF_recep_IV Pkinase Furin-like APH Kinase-like Haspin_kinase GAPT Kdo
Motif
Other DBs
NCBI-GeneID: 1956
NCBI-ProteinID: NP_005219
OMIM: 131550
HGNC: 3236
Ensembl: ENSG00000146648
Vega: OTTHUMG00000023661
Pharos: P00533(Tclin)
UniProt: P00533 Q504U8 F2YGG7
Structure
PDB: 
5UG9 5HG8 5UG8 3POZ 5HG5 5CNO 5UGC 5U8L 3W33 4I22 5GNK 3W32 4I24 3P0Y 5UGA 5X2A 5HG7 4WKQ 5CNN 4WRG 3W2S 5YU9 4ZSE 2RGP 5X2C 3W2P 3W2R 5CAS 4UV7 5HG9 5X2F 3W2Q 5CAU 3BEL 5D41 3VJN 5XDK 3W2O 5CAP 5C8N 1XKK 5HCY 2ITN 2ITV 5SX5 5J9Z 5CAQ 4RJ8 4LQM 3UG2 2EB2 1MOX 5UGB 6D8E 4RJ7 3B2U 5HIC 5HCX 5EDR 5CZI 5CAO 2GS6 2GS7 1YY9 1M14 1M17 5HCZ 4LI5 3VJO 5FED 5EM5 4KRM 2ITQ 5XDL 5FEE 5CAL 4ZJV 4RJ6 4JR3 3LZB 2ITZ 5CAV 4JQ7 2ITT 2ITP 4HJO 3UG1 3QWQ 5EM6 4RJ4 6B3S 5SX4 5GMP 5J9Y 5EM8 5EDQ 5CZH 5CAN 4ZAU 4JRV 4I23 4G5J 3GOP 2GS2 1NQL 5EM7 4KRP 4JQ8 2EB3 5HIB 4KRL 2ITW 5XWD 5ZWJ 5EDP 5C8M 4R3P 3IKA 2RFE 5WB7 5XGM 5X26 5X27 5X28 4UIP 3GT8 4RIY 2ITX 5WB8 5XGN 5GTZ 5C8K 4R5S 4I1Z 2J5F 4KRO 2JIU 5UWD 5Y25 4RJ5 4RIW 4RIX 2JIT 2J5E 5GTY 4G5P 6ARU 5X2K 4TKS 3C09 5Y9T 4R3R 2ITO 5JEB 4WD5 3NJP 3B2V 1IVO 4I20 4I21 5FEQ 2ITY 2RF9 4LRM 2RFD 4LL0 5LV6 2N5S 2M20 2M0B 2KS1 2JIV 2J6M 2ITU 1Z9I
Thumbnails

Position
7p11.2
AA seq 1210 aa AA seqDB search
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA
NT seq 3633 nt NT seq  +upstreamnt  +downstreamnt
atgcgaccctccgggacggccggggcagcgctcctggcgctgctggctgcgctctgcccg
gcgagtcgggctctggaggaaaagaaagtttgccaaggcacgagtaacaagctcacgcag
ttgggcacttttgaagatcattttctcagcctccagaggatgttcaataactgtgaggtg
gtccttgggaatttggaaattacctatgtgcagaggaattatgatctttccttcttaaag
accatccaggaggtggctggttatgtcctcattgccctcaacacagtggagcgaattcct
ttggaaaacctgcagatcatcagaggaaatatgtactacgaaaattcctatgccttagca
gtcttatctaactatgatgcaaataaaaccggactgaaggagctgcccatgagaaattta
caggaaatcctgcatggcgccgtgcggttcagcaacaaccctgccctgtgcaacgtggag
agcatccagtggcgggacatagtcagcagtgactttctcagcaacatgtcgatggacttc
cagaaccacctgggcagctgccaaaagtgtgatccaagctgtcccaatgggagctgctgg
ggtgcaggagaggagaactgccagaaactgaccaaaatcatctgtgcccagcagtgctcc
gggcgctgccgtggcaagtcccccagtgactgctgccacaaccagtgtgctgcaggctgc
acaggcccccgggagagcgactgcctggtctgccgcaaattccgagacgaagccacgtgc
aaggacacctgccccccactcatgctctacaaccccaccacgtaccagatggatgtgaac
cccgagggcaaatacagctttggtgccacctgcgtgaagaagtgtccccgtaattatgtg
gtgacagatcacggctcgtgcgtccgagcctgtggggccgacagctatgagatggaggaa
gacggcgtccgcaagtgtaagaagtgcgaagggccttgccgcaaagtgtgtaacggaata
ggtattggtgaatttaaagactcactctccataaatgctacgaatattaaacacttcaaa
aactgcacctccatcagtggcgatctccacatcctgccggtggcatttaggggtgactcc
ttcacacatactcctcctctggatccacaggaactggatattctgaaaaccgtaaaggaa
atcacagggtttttgctgattcaggcttggcctgaaaacaggacggacctccatgccttt
gagaacctagaaatcatacgcggcaggaccaagcaacatggtcagttttctcttgcagtc
gtcagcctgaacataacatccttgggattacgctccctcaaggagataagtgatggagat
gtgataatttcaggaaacaaaaatttgtgctatgcaaatacaataaactggaaaaaactg
tttgggacctccggtcagaaaaccaaaattataagcaacagaggtgaaaacagctgcaag
gccacaggccaggtctgccatgccttgtgctcccccgagggctgctggggcccggagccc
agggactgcgtctcttgccggaatgtcagccgaggcagggaatgcgtggacaagtgcaac
cttctggagggtgagccaagggagtttgtggagaactctgagtgcatacagtgccaccca
gagtgcctgcctcaggccatgaacatcacctgcacaggacggggaccagacaactgtatc
cagtgtgcccactacattgacggcccccactgcgtcaagacctgcccggcaggagtcatg
ggagaaaacaacaccctggtctggaagtacgcagacgccggccatgtgtgccacctgtgc
catccaaactgcacctacggatgcactgggccaggtcttgaaggctgtccaacgaatggg
cctaagatcccgtccatcgccactgggatggtgggggccctcctcttgctgctggtggtg
gccctggggatcggcctcttcatgcgaaggcgccacatcgttcggaagcgcacgctgcgg
aggctgctgcaggagagggagcttgtggagcctcttacacccagtggagaagctcccaac
caagctctcttgaggatcttgaaggaaactgaattcaaaaagatcaaagtgctgggctcc
ggtgcgttcggcacggtgtataagggactctggatcccagaaggtgagaaagttaaaatt
cccgtcgctatcaaggaattaagagaagcaacatctccgaaagccaacaaggaaatcctc
gatgaagcctacgtgatggccagcgtggacaacccccacgtgtgccgcctgctgggcatc
tgcctcacctccaccgtgcagctcatcacgcagctcatgcccttcggctgcctcctggac
tatgtccgggaacacaaagacaatattggctcccagtacctgctcaactggtgtgtgcag
atcgcaaagggcatgaactacttggaggaccgtcgcttggtgcaccgcgacctggcagcc
aggaacgtactggtgaaaacaccgcagcatgtcaagatcacagattttgggctggccaaa
ctgctgggtgcggaagagaaagaataccatgcagaaggaggcaaagtgcctatcaagtgg
atggcattggaatcaattttacacagaatctatacccaccagagtgatgtctggagctac
ggggtgactgtttgggagttgatgacctttggatccaagccatatgacggaatccctgcc
agcgagatctcctccatcctggagaaaggagaacgcctccctcagccacccatatgtacc
atcgatgtctacatgatcatggtcaagtgctggatgatagacgcagatagtcgcccaaag
ttccgtgagttgatcatcgaattctccaaaatggcccgagacccccagcgctaccttgtc
attcagggggatgaaagaatgcatttgccaagtcctacagactccaacttctaccgtgcc
ctgatggatgaagaagacatggacgacgtggtggatgccgacgagtacctcatcccacag
cagggcttcttcagcagcccctccacgtcacggactcccctcctgagctctctgagtgca
accagcaacaattccaccgtggcttgcattgatagaaatgggctgcaaagctgtcccatc
aaggaagacagcttcttgcagcgatacagctcagaccccacaggcgccttgactgaggac
agcatagacgacaccttcctcccagtgcctgaatacataaaccagtccgttcccaaaagg
cccgctggctctgtgcagaatcctgtctatcacaatcagcctctgaaccccgcgcccagc
agagacccacactaccaggacccccacagcactgcagtgggcaaccccgagtatctcaac
actgtccagcccacctgtgtcaacagcacattcgacagccctgcccactgggcccagaaa
ggcagccaccaaattagcctggacaaccctgactaccagcaggacttctttcccaaggaa
gccaagccaaatggcatctttaagggctccacagctgaaaatgcagaatacctaagggtc
gcgccacaaagcagtgaatttattggagcatga

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