KEGG   Homo sapiens (human): 43
Entry
43                CDS       T01001                                 

Gene name
ACHE, ACEE, ARACHE, N-ACHE, YT
Definition
(RefSeq) acetylcholinesterase (Cartwright blood group)
  KO
K01049  acetylcholinesterase [EC:3.1.1.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse
Drug target
Acotiamide hydrochloride: D08838
Ambenonium (DG00990): D01001
Demecarium: D00667
Dimetacrine: D02565
Distigmine (DG00989): D01228
Donepezil (DG00983): D00670 D07869
Ecothiopate (DG01131): D02193
Edrophonium: D00994
Fluostigmine: D00043
Galantamine (DG00985): D02173 D04292
Gallamine: D02292
Icopezil maleate: D03751
Ipidacrine: D09750
Itopride (DG01395): D02729 D08094
Ladostigil tartrate: D03239
Latrepirdine (DG01379): D09917 D09918
Neostigmine (DG00987): D00995 D00998 D08261
Obidoxime: D05215
Paraoxon: D10529
Physostigmine (DG01132): D00196 D02418 D03826
Pralidoxime (DG01153): D00469 D01572 D05590
Pyridostigmine (DG00988): D00487
Quilostigmine: D03823
Rivastigmine (DG00984): D02558 D03822
Suronacrine maleate: D05981
Tacrine (DG00982): D02068 D08555
Velnacrine maleate: D06288
Zanapezil fumarate: D09835
Zifrosilone: D06365
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    43 (ACHE)
 09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    43 (ACHE)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
    43 (ACHE)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.7  acetylcholinesterase
     43 (ACHE)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
 Enzymes
  43 (ACHE)
SSDB
Motif
Pfam: COesterase AChE_tetra Abhydrolase_3
Other DBs
NCBI-GeneID: 43
NCBI-ProteinID: NP_000656
OMIM: 100740
HGNC: 108
Ensembl: ENSG00000087085
Vega: OTTHUMG00000157033
Pharos: P22303(Tclin)
UniProt: P22303
Structure
PDB: 

Position
7q22.1
AA seq 614 aa
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
NT seq 1845 nt   +upstreamnt  +downstreamnt
atgaggcccccgcagtgtctgctgcacacgccttccctggcttccccactccttctcctc
ctcctctggctcctgggtggaggagtgggggctgagggccgggaggatgcagagctgctg
gtgacggtgcgtgggggccggctgcggggcattcgcctgaagacccccgggggccctgtc
tctgctttcctgggcatcccctttgcggagccacccatgggaccccgtcgctttctgcca
ccggagcccaagcagccttggtcaggggtggtagacgctacaaccttccagagtgtctgc
taccaatatgtggacaccctatacccaggttttgagggcaccgagatgtggaaccccaac
cgtgagctgagcgaggactgcctgtacctcaacgtgtggacaccatacccccggcctaca
tcccccacccctgtcctcgtctggatctatgggggtggcttctacagtggggcctcctcc
ttggacgtgtacgatggccgcttcttggtacaggccgagaggactgtgctggtgtccatg
aactaccgggtgggagcctttggcttcctggccctgccggggagccgagaggccccgggc
aatgtgggtctcctggatcagaggctggccctgcagtgggtgcaggagaacgtggcagcc
ttcgggggtgacccgacatcagtgacgctgtttggggagagcgcgggagccgcctcggtg
ggcatgcacctgctgtccccgcccagccggggcctgttccacagggccgtgctgcagagc
ggtgcccccaatggaccctgggccacggtgggcatgggagaggcccgtcgcagggccacg
cagctggcccaccttgtgggctgtcctccaggcggcactggtgggaatgacacagagctg
gtagcctgccttcggacacgaccagcgcaggtcctggtgaaccacgaatggcacgtgctg
cctcaagaaagcgtcttccggttctccttcgtgcctgtggtagatggagacttcctcagt
gacaccccagaggccctcatcaacgcgggagacttccacggcctgcaggtgctggtgggt
gtggtgaaggatgagggctcgtattttctggtttacggggccccaggcttcagcaaagac
aacgagtctctcatcagccgggccgagttcctggccggggtgcgggtcggggttccccag
gtaagtgacctggcagccgaggctgtggtcctgcattacacagactggctgcatcccgag
gacccggcacgcctgagggaggccctgagcgatgtggtgggcgaccacaatgtcgtgtgc
cccgtggcccagctggctgggcgactggctgcccagggtgcccgggtctacgcctacgtc
tttgaacaccgtgcttccacgctctcctggcccctgtggatgggggtgccccacggctac
gagatcgagttcatctttgggatccccctggacccctctcgaaactacacggcagaggag
aaaatcttcgcccagcgactgatgcgatactgggccaactttgcccgcacaggggatccc
aatgagccccgagaccccaaggccccacaatggcccccgtacacggcgggggctcagcag
tacgttagtctggacctgcggccgctggaggtgcggcgggggctgcgcgcccaggcctgc
gccttctggaaccgcttcctccccaaattgctcagcgccaccgacacgctcgacgaggcg
gagcgccagtggaaggccgagttccaccgctggagctcctacatggtgcactggaagaac
cagttcgaccactacagcaagcaggatcgctgctcagacctgtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (2)   
   OMIM (2)   
Drug (41)   
   KEGG DRUG (41)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (41)   
   RefSeq(nuc) (11)   
   GenBank (15)   
   EMBL (15)   
Protein domain (3)   
   Pfam (3)   
All databases (131)   

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