KEGG T01001: 43

Homo sapiens (human): 43

Entry

43                CDS       T01001

Symbol

ACHE, ACEE, ARACHE, N-ACHE, YT

Name

(RefSeq) acetylcholinesterase (Cartwright blood group)

K01049

acetylcholinesterase [EC:3.1.1.7]

Organism

hsa Homo sapiens (human)

Pathway

hsa00564

Glycerophospholipid metabolism

hsa04725

Cholinergic synapse

Drug target

Acotiamide hydrochloride:

D08838<JP>

Ambenonium (DG00990):

D01001<JP>

Buntanetap (DG03220):

D12318 D12319

Demecarium:

D00667

Dimetacrine:

D02565

Distigmine (DG00989):

D01228<JP>

Donepezil (DG00983):

D00670<JP/US> D07869

Ecothiopate (DG01131):

D02193<US>

Edrophonium:

D00994<JP>

Fluostigmine:

D00043

Galantamine (DG00985):

D02173<JP/US> D04292

Gallamine:

D02292

Icopezil maleate:

D03751

Ipidacrine:

D09750

Itopride (DG01395):

D02729<JP> D08094

Ladostigil tartrate:

D03239

Latrepirdine (DG01379):

D09917 D09918

Neostigmine (DG00987):

D00995<JP> D00998<JP/US> D08261

Obidoxime:

D05215

Paraoxon:

D10529

Physostigmine (DG01132):

D00196 D02418 D03826

Pralidoxime (DG01153):

D00469<US> D01572<JP> D05590

Pyridostigmine (DG00988):

D00487<JP/US>

Quilostigmine:

D03823

Rivastigmine (DG00984):

D02558<US> D03822<JP/US>

Suronacrine maleate:

Tacrine (DG00982):

Velnacrine maleate:

Zanapezil fumarate:

Zifrosilone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    43 (ACHE)
09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    43 (ACHE)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
    43 (ACHE)
Enzymes [BR:hsa01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.7  acetylcholinesterase
     43 (ACHE)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
Enzymes
  43 (ACHE)

SSDB

Motif

Pfam:

COesterase AChE_tetra BD-FAE Abhydrolase_3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Pharos:

P22303(Tclin)

UniProt:

P22303

Structure

Position

7:complement(100889994..100896994)

AA seq 614 aa
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL

NT seq 1845 nt +upstreamnt +downstreamnt
atgaggcccccgcagtgtctgctgcacacgccttccctggcttccccactccttctcctc
ctcctctggctcctgggtggaggagtgggggctgagggccgggaggatgcagagctgctg
gtgacggtgcgtgggggccggctgcggggcattcgcctgaagacccccgggggccctgtc
tctgctttcctgggcatcccctttgcggagccacccatgggaccccgtcgctttctgcca
ccggagcccaagcagccttggtcaggggtggtagacgctacaaccttccagagtgtctgc
taccaatatgtggacaccctatacccaggttttgagggcaccgagatgtggaaccccaac
cgtgagctgagcgaggactgcctgtacctcaacgtgtggacaccatacccccggcctaca
tcccccacccctgtcctcgtctggatctatgggggtggcttctacagtggggcctcctcc
ttggacgtgtacgatggccgcttcttggtacaggccgagaggactgtgctggtgtccatg
aactaccgggtgggagcctttggcttcctggccctgccggggagccgagaggccccgggc
aatgtgggtctcctggatcagaggctggccctgcagtgggtgcaggagaacgtggcagcc
ttcgggggtgacccgacatcagtgacgctgtttggggagagcgcgggagccgcctcggtg
ggcatgcacctgctgtccccgcccagccggggcctgttccacagggccgtgctgcagagc
ggtgcccccaatggaccctgggccacggtgggcatgggagaggcccgtcgcagggccacg
cagctggcccaccttgtgggctgtcctccaggcggcactggtgggaatgacacagagctg
gtagcctgccttcggacacgaccagcgcaggtcctggtgaaccacgaatggcacgtgctg
cctcaagaaagcgtcttccggttctccttcgtgcctgtggtagatggagacttcctcagt
gacaccccagaggccctcatcaacgcgggagacttccacggcctgcaggtgctggtgggt
gtggtgaaggatgagggctcgtattttctggtttacggggccccaggcttcagcaaagac
aacgagtctctcatcagccgggccgagttcctggccggggtgcgggtcggggttccccag
gtaagtgacctggcagccgaggctgtggtcctgcattacacagactggctgcatcccgag
gacccggcacgcctgagggaggccctgagcgatgtggtgggcgaccacaatgtcgtgtgc
cccgtggcccagctggctgggcgactggctgcccagggtgcccgggtctacgcctacgtc
tttgaacaccgtgcttccacgctctcctggcccctgtggatgggggtgccccacggctac
gagatcgagttcatctttgggatccccctggacccctctcgaaactacacggcagaggag
aaaatcttcgcccagcgactgatgcgatactgggccaactttgcccgcacaggggatccc
aatgagccccgagaccccaaggccccacaatggcccccgtacacggcgggggctcagcag
tacgttagtctggacctgcggccgctggaggtgcggcgggggctgcgcgcccaggcctgc
gccttctggaaccgcttcctccccaaattgctcagcgccaccgacacgctcgacgaggcg
gagcgccagtggaaggccgagttccaccgctggagctcctacatggtgcactggaagaac
cagttcgaccactacagcaagcaggatcgctgctcagacctgtga

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