KEGG   Homo sapiens (human): 5914
Entry
5914              CDS       T01001                                 

Symbol
RARA, NR1B1, RAR
Name
(RefSeq) retinoic acid receptor alpha
  KO
K08527  retinoic acid receptor alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04659  Th17 cell differentiation
hsa04915  Estrogen signaling pathway
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05221  Acute myeloid leukemia
Drug target
Acitretin: D02754<US>
Alitretinoin: D02815<US>
Arsenic trioxide: D02106<JP/US>
Etretinate: D00316<JP>
Fenretinide: D04162
Isotretinoin (DG00434): D00348<US> D04636
Retinol (vit A) (DG00123): D00164<JP/US> D01621 D06543<JP> D08477
Tamibarotene: D01418<JP>
Tazarotene: D01132<US>
Tretinoin (DG00433): D00094<JP/US> D00094<JP/US> D01516<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    5914 (RARA)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    5914 (RARA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5914 (RARA)
   05202 Transcriptional misregulation in cancer
    5914 (RARA)
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    5914 (RARA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    5914 (RARA)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    5914 (RARA)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    5914 (RARA)
Nuclear receptors [BR:hsa03310]
 1. Thyroid hormone like
  1B. Retinoic acid receptor (RAR)
   5914 (RARA)
SSDB
Motif
Pfam: zf-C4 Hormone_recep
Other DBs
NCBI-GeneID: 5914
NCBI-ProteinID: NP_000955
OMIM: 180240
HGNC: 9864
Ensembl: ENSG00000131759
Vega: OTTHUMG00000133328
Pharos: P10276(Tclin)
UniProt: P10276 Q6I9R7
Structure
PDB: 

Position
17q21.2
AA seq 462 aa
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
NT seq 1389 nt   +upstreamnt  +downstreamnt
atggccagcaacagcagctcctgcccgacacctgggggcgggcacctcaatgggtacccg
gtgcctccctacgccttcttcttcccccctatgctgggtggactctccccgccaggcgct
ctgaccactctccagcaccagcttccagttagtggatatagcacaccatccccagccacc
attgagacccagagcagcagttctgaagagatagtgcccagccctccctcgccaccccct
ctaccccgcatctacaagccttgctttgtctgtcaggacaagtcctcaggctaccactat
ggggtcagcgcctgtgagggctgcaagggcttcttccgccgcagcatccagaagaacatg
gtgtacacgtgtcaccgggacaagaactgcatcatcaacaaggtgacccggaaccgctgc
cagtactgccgactgcagaagtgctttgaagtgggcatgtccaaggagtctgtgagaaac
gaccgaaacaagaagaagaaggaggtgcccaagcccgagtgctctgagagctacacgctg
acgccggaggtgggggagctcattgagaaggtgcgcaaagcgcaccaggaaaccttccct
gccctctgccagctgggcaaatacactacgaacaacagctcagaacaacgtgtctctctg
gacattgacctctgggacaagttcagtgaactctccaccaagtgcatcattaagactgtg
gagttcgccaagcagctgcccggcttcaccaccctcaccatcgccgaccagatcaccctc
ctcaaggctgcctgcctggacatcctgatcctgcggatctgcacgcggtacacgcccgag
caggacaccatgaccttctcggacgggctgaccctgaaccggacccagatgcacaacgct
ggcttcggccccctcaccgacctggtctttgccttcgccaaccagctgctgcccctggag
atggatgatgcggagacggggctgctcagcgccatctgcctcatctgcggagaccgccag
gacctggagcagccggaccgggtggacatgctgcaggagccgctgctggaggcgctaaag
gtctacgtgcggaagcggaggcccagccgcccccacatgttccccaagatgctaatgaag
attactgacctgcgaagcatcagcgccaagggggctgagcgggtgatcacgctgaagatg
gagatcccgggctccatgccgcctctcatccaggaaatgttggagaactcagagggcctg
gacactctgagcggacagccggggggtggggggcgggacgggggtggcctggcccccccg
ccaggcagctgtagccccagcctcagccccagctccaacagaagcagcccggccacccac
tccccgtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (2)   
   OMIM (2)   
Drug (15)   
   KEGG DRUG (15)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (13)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (59)   
   RefSeq(nuc) (11)   
   GenBank (24)   
   EMBL (24)   
Protein domain (2)   
   Pfam (2)   
All databases (117)   

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KEGG   Homo sapiens (human): 7704
Entry
7704              CDS       T01001                                 

Symbol
ZBTB16, PLZF, ZNF145
Name
(RefSeq) zinc finger and BTB domain containing 16
  KO
K10055  zinc finger and BTB domain-containing protein 16
Organism
hsa  Homo sapiens (human)
Pathway
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05221  Acute myeloid leukemia
Network
nt06240  Transcription
nt06275  Acute myeloid leukemia
  Element
N00110  PLZF-RARA fusion to transcriptional activtion
N00114  PLZF-RARA fusion to transcriptional repression
Disease
H00003  Acute myeloid leukemia
H00969  Skeletal defects, genital hypoplasia, and mental retardation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    7704 (ZBTB16)
   05202 Transcriptional misregulation in cancer
    7704 (ZBTB16)
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    7704 (ZBTB16)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    7704 (ZBTB16)
   04121 Ubiquitin system [BR:hsa04121]
    7704 (ZBTB16)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys2His2 BTB-ZF factors
    7704 (ZBTB16)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul3 complex
    Adoptor and target recognizing subunit (BTB)
     7704 (ZBTB16)
SSDB
Motif
Pfam: zf-H2C2_2 zf-C2H2_4 zf-C2H2 BTB zf-met zf-C2H2_6 zf-C2H2_jaz zf_UBZ zf-C2H2_2 Endonuclease_7
Other DBs
NCBI-GeneID: 7704
NCBI-ProteinID: NP_001018011
OMIM: 176797
HGNC: 12930
Ensembl: ENSG00000109906
Vega: OTTHUMG00000168243
Pharos: Q05516(Tbio)
UniProt: Q05516 A0A024R3C6
Structure
PDB: 
1BUO 1CS3

Position
11q23.2
AA seq 673 aa
MDLTKMGMIQLQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFE
ILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAAEILEIEYLEEQCLK
MLETIQASDDNDTEATMADGGAEEEEDRKARYLKNIFISKHSSEESGYASVAGQSLPGPM
VDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGTLQPPAGPEEPTLAGGGRHPGVAE
VKTEMMQVDEVPSQDSPGAAESSISGGMGDKVEERGKEGPGTPTRSSVITSARELHYGRE
ESAEQVPPPAEAGQAPTGRPEHPAPPPEKHLGIYSVLPNHKADAVLSMPSSVTSGLHVQP
ALAVSMDFSTYGGLLPQGFIQRELFSKLGELAVGMKSESRTIGEQCSVCGVELPDNEAVE
QHRKLHSGMKTYGCELCGKRFLDSLRLRMHLLAHSAGAKAFVCDQCGAQFSKEDALETHR
QTHTGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSH
TGDHPYECEFCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEK
PFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEYCPSLSSMQKHMKGHKPEEIPPD
WRIEKTYLYLCYV
NT seq 2022 nt   +upstreamnt  +downstreamnt
atggatctgacaaaaatgggcatgatccagctgcagaaccctagccaccccacggggcta
ctgtgcaaggccaaccagatgcggctggccgggactttgtgcgatgtggtcatcatggtg
gacagccaggagttccacgcccaccggacggtgctggcctgcaccagcaagatgtttgag
atcctcttccaccgcaatagtcaacactatactttggacttcctctcgccaaagaccttc
cagcagattctggagtatgcatatacagccacgctgcaagccaaggcggaggacctggat
gacctgctgtatgcggccgagatcctggagatcgagtacctggaggaacagtgcctgaag
atgctggagaccatccaggcctcagacgacaatgacacggaggccaccatggccgatggc
ggggccgaggaagaagaggaccgcaaggctcggtacctcaagaacatcttcatctcgaag
cattccagcgaggagagtgggtatgccagtgtggctggacagagcctccctgggcccatg
gtggaccagagcccttcagtctccacttcatttggtctttcagccatgagtcccaccaag
gctgcagtggacagtttgatgaccataggacagtctctcctgcagggaactcttcagcca
cctgcagggcccgaggagccaactctggctgggggtgggcggcaccctggggtggctgag
gtgaagacggagatgatgcaggtggatgaggtgcccagccaggacagccctggggcagcc
gagtccagcatctcaggagggatgggggacaaggttgaggaaagaggcaaagaggggcct
gggaccccgactcgaagcagcgtcatcaccagtgctagggagctacactatgggcgagag
gagagtgccgagcaggtgccacccccagctgaggctggccaggcccccactggccgacct
gagcacccagcacccccgcctgagaagcatctgggcatctactccgtgttgcccaaccac
aaggctgacgctgtattgagcatgccgtcttccgtgacctctggcctccacgtgcagcct
gccctggctgtctccatggacttcagcacctatggggggctgctgccccagggcttcatc
cagagggagctgttcagcaagctgggggagctggctgtgggcatgaagtcagagagccgg
accatcggagagcagtgcagcgtgtgtggggtcgagcttcctgataacgaggctgtggag
cagcacaggaagctgcacagtgggatgaagacgtacgggtgcgagctctgcgggaagcgg
ttcctggatagtttgcggctgagaatgcacttactggctcattcagcgggtgccaaagcc
tttgtctgtgatcagtgcggtgcacagttttcgaaggaggatgccctggagacacacagg
cagacccatactggcactgacatggccgtcttctgtctgctgtgtgggaagcgcttccag
gcgcagagcgcactgcagcagcacatggaggtccacgcgggcgtgcgcagctacatctgc
agtgagtgcaaccgcaccttccccagccacacggctctcaaacgccacctgcgctcacat
acaggcgaccacccctacgagtgtgagttctgtggcagctgcttccgggatgagagcaca
ctcaagagccacaaacgcatccacacgggtgagaaaccctacgagtgcaatggctgtggc
aagaagttcagcctcaagcatcagctggagacgcactatagggtgcacacaggtgagaag
ccctttgagtgtaagctctgccaccagcgctcccgggactactcggccatgatcaagcac
ctgagaacgcacaacggcgcctcgccctaccagtgcaccatctgcacagagtactgcccc
agcctctcctccatgcagaagcacatgaagggccacaagcccgaggagatcccgcccgac
tggaggatagagaagacgtacctctacctgtgctatgtgtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (11)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (27)   
   RefSeq(nuc) (9)   
   GenBank (9)   
   EMBL (9)   
Protein domain (10)   
   Pfam (10)   
All databases (83)   

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