KEGG   Homo sapiens (human): 596
Entry
596               CDS       T01001                                 

Gene name
BCL2, Bcl-2, PPP1R50
Definition
(RefSeq) BCL2 apoptosis regulator
  KO
K02161  apoptosis regulator Bcl-2
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04064  NF-kappa B signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04115  p53 signaling pathway
hsa04140  Autophagy - animal
hsa04141  Protein processing in endoplasmic reticulum
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04340  Hedgehog signaling pathway
hsa04510  Focal adhesion
hsa04621  NOD-like receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04915  Estrogen signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05162  Measles
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05215  Prostate cancer
hsa05222  Small cell lung cancer
hsa05226  Gastric cancer
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06131  Apoptosis (viruses and bacteria)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06227  Nuclear receptor signaling
nt06231  Apoptosis
nt06260  Colorectal cancer
nt06267  Small cell lung cancer
nt06270  Breast cancer
nt06323  KISS1-GnRH-LH/FSH-E2 signaling
nt06414  Apoptosis
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
  Element
N00098  Intrinsic apoptotic pathway
N00100  BCL2-overexpression to intrinsic apoptotic pathway
N00286  Nuclear-initiated estrogen signaling pathway
N00451  HIV Tat to intrinsic apoptotic pathway
N00453  HIV Vpr to intrinsic apoptotic pathway
N00475  EBV BHRF1 to intrinsic apoptotic pathway
N00478  EBV BARF1 to intrinsic apoptotic pathway
N01135  Mutation-caused aberrant SOD1 to intrinsic apoptotic pathway
Disease
H00005  Chronic lymphocytic leukemia
H00013  Small cell lung cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00041  Kaposi sarcoma
H00054  Nasopharyngeal cancer
H01613  Follicular lymphoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Drug target
Obatoclax mesylate: D08954
Oblimersen (DG00728): D05216 D08290
Venetoclax: D10679<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    596 (BCL2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    596 (BCL2)
   04630 JAK-STAT signaling pathway
    596 (BCL2)
   04064 NF-kappa B signaling pathway
    596 (BCL2)
   04066 HIF-1 signaling pathway
    596 (BCL2)
   04071 Sphingolipid signaling pathway
    596 (BCL2)
   04151 PI3K-Akt signaling pathway
    596 (BCL2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    596 (BCL2)
  09143 Cell growth and death
   04210 Apoptosis
    596 (BCL2)
   04215 Apoptosis - multiple species
    596 (BCL2)
   04217 Necroptosis
    596 (BCL2)
   04115 p53 signaling pathway
    596 (BCL2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    596 (BCL2)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    596 (BCL2)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    596 (BCL2)
   04928 Parathyroid hormone synthesis, secretion and action
    596 (BCL2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    596 (BCL2)
  09156 Nervous system
   04725 Cholinergic synapse
    596 (BCL2)
   04722 Neurotrophin signaling pathway
    596 (BCL2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    596 (BCL2)
   05206 MicroRNAs in cancer
    596 (BCL2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    596 (BCL2)
   05226 Gastric cancer
    596 (BCL2)
   05215 Prostate cancer
    596 (BCL2)
   05222 Small cell lung cancer
    596 (BCL2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    596 (BCL2)
   05161 Hepatitis B
    596 (BCL2)
   05162 Measles
    596 (BCL2)
   05168 Herpes simplex virus 1 infection
    596 (BCL2)
   05169 Epstein-Barr virus infection
    596 (BCL2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    596 (BCL2)
   05131 Shigellosis
    596 (BCL2)
   05152 Tuberculosis
    596 (BCL2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    596 (BCL2)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    596 (BCL2)
   05022 Pathways of neurodegeneration - multiple diseases
    596 (BCL2)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    596 (BCL2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    596 (BCL2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    596 (BCL2)
   01524 Platinum drug resistance
    596 (BCL2)
   01522 Endocrine resistance
    596 (BCL2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    596 (BCL2)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     596 (BCL2)
SSDB
Motif
Pfam: Bcl-2 BH4 Bcl-2_3
Other DBs
NCBI-GeneID: 596
NCBI-ProteinID: NP_000624
OMIM: 151430
HGNC: 990
Ensembl: ENSG00000171791
Vega: OTTHUMG00000132791
Pharos: P10415(Tclin)
UniProt: P10415 A0A024R2B3
Structure
PDB: 

Position
18q21.33
AA seq 239 aa
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
NT seq 720 nt   +upstreamnt  +downstreamnt
atggcgcacgctgggagaacagggtacgataaccgggagatagtgatgaagtacatccat
tataagctgtcgcagaggggctacgagtgggatgcgggagatgtgggcgccgcgcccccg
ggggccgcccccgcaccgggcatcttctcctcccagcccgggcacacgccccatccagcc
gcatcccgggacccggtcgccaggacctcgccgctgcagaccccggctgcccccggcgcc
gccgcggggcctgcgctcagcccggtgccacctgtggtccacctgaccctccgccaggcc
ggcgacgacttctcccgccgctaccgccgcgacttcgccgagatgtccagccagctgcac
ctgacgcccttcaccgcgcggggacgctttgccacggtggtggaggagctcttcagggac
ggggtgaactgggggaggattgtggccttctttgagttcggtggggtcatgtgtgtggag
agcgtcaaccgggagatgtcgcccctggtggacaacatcgccctgtggatgactgagtac
ctgaaccggcacctgcacacctggatccaggataacggaggctgggatgcctttgtggaa
ctgtacggccccagcatgcggcctctgtttgatttctcctggctgtctctgaagactctg
ctcagtttggccctggtgggagcttgcatcaccctgggtgcctatctgggccacaagtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (41)   
   KEGG PATHWAY (41)   
Network (8)   
   KEGG NETWORK (8)   
Disease (9)   
   KEGG DISEASE (8)   
   OMIM (1)   
Drug (4)   
   KEGG DRUG (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (21)   
   RefSeq(nuc) (5)   
   GenBank (8)   
   EMBL (8)   
Protein domain (3)   
   Pfam (3)   
All databases (112)   

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KEGG   Homo sapiens (human): 598
Entry
598               CDS       T01001                                 

Gene name
BCL2L1, BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52
Definition
(RefSeq) BCL2 like 1
  KO
K04570  Bcl-2-like 1 (apoptosis regulator Bcl-X)
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01524  Platinum drug resistance
hsa04014  Ras signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04115  p53 signaling pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04621  NOD-like receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05145  Toxoplasmosis
hsa05162  Measles
hsa05166  Human T-cell leukemia virus 1 infection
hsa05168  Herpes simplex virus 1 infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05212  Pancreatic cancer
hsa05220  Chronic myeloid leukemia
hsa05222  Small cell lung cancer
hsa05225  Hepatocellular carcinoma
Network
nt06131  Apoptosis (viruses and bacteria)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06219  JAK-STAT signaling
nt06231  Apoptosis
nt06240  Transcription
nt06260  Colorectal cancer
nt06267  Small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06414  Apoptosis
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
  Element
N00055  BCR-ABL fusion kinase to Jak-STAT signaling pathway
N00098  Intrinsic apoptotic pathway
N00123  Amplified REL to transcription
N00451  HIV Tat to intrinsic apoptotic pathway
N01051  Mutation-inactivated DJ1 to intrinsic apoptotic pathway
Drug target
Navitoclax: D09935
Navitoclax dihydrochloride: D09936
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    598 (BCL2L1)
   04630 JAK-STAT signaling pathway
    598 (BCL2L1)
   04064 NF-kappa B signaling pathway
    598 (BCL2L1)
   04151 PI3K-Akt signaling pathway
    598 (BCL2L1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    598 (BCL2L1)
   04137 Mitophagy - animal
    598 (BCL2L1)
  09143 Cell growth and death
   04210 Apoptosis
    598 (BCL2L1)
   04215 Apoptosis - multiple species
    598 (BCL2L1)
   04115 p53 signaling pathway
    598 (BCL2L1)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    598 (BCL2L1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    598 (BCL2L1)
   05202 Transcriptional misregulation in cancer
    598 (BCL2L1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    598 (BCL2L1)
   05225 Hepatocellular carcinoma
    598 (BCL2L1)
   05220 Chronic myeloid leukemia
    598 (BCL2L1)
   05222 Small cell lung cancer
    598 (BCL2L1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    598 (BCL2L1)
   05170 Human immunodeficiency virus 1 infection
    598 (BCL2L1)
   05162 Measles
    598 (BCL2L1)
   05168 Herpes simplex virus 1 infection
    598 (BCL2L1)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    598 (BCL2L1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    598 (BCL2L1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    598 (BCL2L1)
   05014 Amyotrophic lateral sclerosis
    598 (BCL2L1)
   05022 Pathways of neurodegeneration - multiple diseases
    598 (BCL2L1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    598 (BCL2L1)
   01524 Platinum drug resistance
    598 (BCL2L1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    598 (BCL2L1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    598 (BCL2L1)
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    598 (BCL2L1)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     598 (BCL2L1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Other centriole associated proteins
    598 (BCL2L1)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   598 (BCL2L1)
SSDB
Motif
Pfam: Bcl-2 BH4 Bcl-2_3
Other DBs
NCBI-GeneID: 598
NCBI-ProteinID: NP_001304848
OMIM: 600039
HGNC: 992
Ensembl: ENSG00000171552
Vega: OTTHUMG00000032192
Pharos: Q07817(Tchem)
UniProt: Q07817 A0A0S2Z3C5
Structure
PDB: 

Position
20q11.21
AA seq 233 aa
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
NT seq 702 nt   +upstreamnt  +downstreamnt
atgtctcagagcaaccgggagctggtggttgactttctctcctacaagctttcccagaaa
ggatacagctggagtcagtttagtgatgtggaagagaacaggactgaggccccagaaggg
actgaatcggagatggagacccccagtgccatcaatggcaacccatcctggcacctggca
gacagccccgcggtgaatggagccactggccacagcagcagtttggatgcccgggaggtg
atccccatggcagcagtaaagcaagcgctgagggaggcaggcgacgagtttgaactgcgg
taccggcgggcattcagtgacctgacatcccagctccacatcaccccagggacagcatat
cagagctttgaacaggtagtgaatgaactcttccgggatggggtaaactggggtcgcatt
gtggcctttttctccttcggcggggcactgtgcgtggaaagcgtagacaaggagatgcag
gtattggtgagtcggatcgcagcttggatggccacttacctgaatgaccacctagagcct
tggatccaggagaacggcggctgggatacttttgtggaactctatgggaacaatgcagca
gccgagagccgaaagggccaggaacgcttcaaccgctggttcctgacgggcatgactgtg
gccggcgtggttctgctgggctcactcttcagtcggaaatga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (27)   
   KEGG PATHWAY (27)   
Network (5)   
   KEGG NETWORK (5)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (15)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (13)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (55)   
   RefSeq(nuc) (13)   
   GenBank (21)   
   EMBL (21)   
Protein domain (3)   
   Pfam (3)   
All databases (135)   

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