KEGG   Homo sapiens (human): 673Help
Entry
673               CDS       T01001                                 

Gene name
BRAF, B-RAF1, B-raf, BRAF1, NS7, RAFB1
Definition
(RefSeq) B-Raf proto-oncogene, serine/threonine kinase
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04068  FoxO signaling pathway
hsa04150  mTOR signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04510  Focal adhesion
hsa04650  Natural killer cell mediated cytotoxicity
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04726  Serotonergic synapse
hsa04730  Long-term depression
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04934  Cushing syndrome
hsa05034  Alcoholism
hsa05160  Hepatitis C
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05216  Thyroid cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Module
hsa_M00687  MAPK (ERK1/2) signaling
Network
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  Mutation-activated KIT to RAS-ERK signaling pathway
N00004  Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway
N00005  Mutation-activated MET to RAS-ERK signaling pathway
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00007  EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  TRK fusion kinase to RAS-ERK signaling pathway
N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00013  Mutation-activated BRAF to ERK signaling pathway
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  PDGF-PDGFR-RAS-ERK signaling pathway
N00016  PDGF-overexpression to RAS-ERK signaling pathway
N00018  Amplified PDGFR to RAS-ERK signaling pathway
N00019  FGF-FGFR-RAS-ERK signaling pathway
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00021  EGF-ERBB2-RAS-ERK signaling pathway
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00023  EGF-EGFR-PLCG-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00077  HRAS-overexpression to RAS-ERK signaling pathway
N00078  Mutation-activated HRAS to RAS-ERK signaling pathway
N00160  KSHV K1 to RAS-ERK signaling pathway
N00215  KITLG-KIT-RAS-ERK signaling pathway
N00216  HGF-MET-RAS-ERK signaling pathway
N00217  FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00230  TGFA-overexpression to RAS-ERK signaling pathway
N00233  IGF2-IGF1R-RAS-ERK signaling pathway
N00235  IGF2-overexpression to RAS-ERK signaling pathway
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00246  HGF-overexpression to RAS-ERK signaling pathway
N00248  MET-overexpression to RAS-ERK signaling pathway
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00259  Amplified MET to RAS-ERK signaling pathway
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00280  AREG-overexpression to RAS-ERK signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00369  HPV E5 to PDGFR-RAS-ERK signaling pathway
N00386  HCMV gB to PDGFR-RAS-ERK signaling pathway
N00392  HCMV gB to EGFR-RAS-ERK signaling pathway
N00513  Mutation-activated EGFR to RAS-ERK signaling pathway
N10007  Kinase inhibitor to BRAF mutation
 » show all
Disease
H00032  Thyroid cancer
H00038  Melanoma
H00523  Noonan syndrome and related disorders
H01512  Langerhans cell histiocytosis
H01738  Noonan syndrome
H01745  Cardiofaciocutaneous syndrome
H01984  Leopard syndrome
Drug target
Dabrafenib (DG00721): D10064 D10104
Encorafenib: D11053
Regorafenib (DG00720): D10137 D10138
Sorafenib (DG00713): D06272 D08524
Vemurafenib: D09996
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    673 (BRAF)
   04010 MAPK signaling pathway
    673 (BRAF)
   04012 ErbB signaling pathway
    673 (BRAF)
   04068 FoxO signaling pathway
    673 (BRAF)
   04024 cAMP signaling pathway
    673 (BRAF)
   04150 mTOR signaling pathway
    673 (BRAF)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    673 (BRAF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    673 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    673 (BRAF)
   04062 Chemokine signaling pathway
    673 (BRAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    673 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    673 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    673 (BRAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    673 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    673 (BRAF)
   04720 Long-term potentiation
    673 (BRAF)
   04730 Long-term depression
    673 (BRAF)
   04722 Neurotrophin signaling pathway
    673 (BRAF)
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    673 (BRAF)
   05205 Proteoglycans in cancer
    673 (BRAF)
  09162 Cancers: Specific types
   05210 Colorectal cancer
    673 (BRAF)
   05212 Pancreatic cancer
    673 (BRAF)
   05225 Hepatocellular carcinoma
    673 (BRAF)
   05226 Gastric cancer
    673 (BRAF)
   05214 Glioma
    673 (BRAF)
   05216 Thyroid cancer
    673 (BRAF)
   05221 Acute myeloid leukemia
    673 (BRAF)
   05220 Chronic myeloid leukemia
    673 (BRAF)
   05218 Melanoma
    673 (BRAF)
   05211 Renal cell carcinoma
    673 (BRAF)
   05219 Bladder cancer
    673 (BRAF)
   05215 Prostate cancer
    673 (BRAF)
   05213 Endometrial cancer
    673 (BRAF)
   05224 Breast cancer
    673 (BRAF)
   05223 Non-small cell lung cancer
    673 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    673 (BRAF)
  09167 Endocrine and metabolic diseases
   04934 Cushing syndrome
    673 (BRAF)
  09172 Infectious diseases: Viral
   05160 Hepatitis C
    673 (BRAF)
  09176 Drug resistance: Antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    673 (BRAF)
   01522 Endocrine resistance
    673 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    673 (BRAF)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     673 (BRAF)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   673 (BRAF)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase_Tyr Pkinase RBD C1_1 Kinase-like zf-RING-like C1_2 Pkinase_fungal APH Kdo Rtt106_N
Motif
Other DBs
NCBI-GeneID: 673
NCBI-ProteinID: NP_004324
OMIM: 164757
HGNC: 1097
Ensembl: ENSG00000157764
Vega: OTTHUMG00000157457
Pharos: P15056(Tclin)
UniProt: P15056
Structure
PDB: 

Position
7q34
AA seq 766 aa AA seqDB search
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
NT seq 2301 nt NT seq  +upstreamnt  +downstreamnt
atggcggcgctgagcggtggcggtggtggcggcgcggagccgggccaggctctgttcaac
ggggacatggagcccgaggccggcgccggcgccggcgccgcggcctcttcggctgcggac
cctgccattccggaggaggtgtggaatatcaaacaaatgattaagttgacacaggaacat
atagaggccctattggacaaatttggtggggagcataatccaccatcaatatatctggag
gcctatgaagaatacaccagcaagctagatgcactccaacaaagagaacaacagttattg
gaatctctggggaacggaactgatttttctgtttctagctctgcatcaatggataccgtt
acatcttcttcctcttctagcctttcagtgctaccttcatctctttcagtttttcaaaat
cccacagatgtggcacggagcaaccccaagtcaccacaaaaacctatcgttagagtcttc
ctgcccaacaaacagaggacagtggtacctgcaaggtgtggagttacagtccgagacagt
ctaaagaaagcactgatgatgagaggtctaatcccagagtgctgtgctgtttacagaatt
caggatggagagaagaaaccaattggttgggacactgatatttcctggcttactggagaa
gaattgcatgtggaagtgttggagaatgttccacttacaacacacaactttgtacgaaaa
acgtttttcaccttagcattttgtgacttttgtcgaaagctgcttttccagggtttccgc
tgtcaaacatgtggttataaatttcaccagcgttgtagtacagaagttccactgatgtgt
gttaattatgaccaacttgatttgctgtttgtctccaagttctttgaacaccacccaata
ccacaggaagaggcgtccttagcagagactgccctaacatctggatcatccccttccgca
cccgcctcggactctattgggccccaaattctcaccagtccgtctccttcaaaatccatt
ccaattccacagcccttccgaccagcagatgaagatcatcgaaatcaatttgggcaacga
gaccgatcctcatcagctcccaatgtgcatataaacacaatagaacctgtcaatattgat
gacttgattagagaccaaggatttcgtggtgatggaggatcaaccacaggtttgtctgct
accccccctgcctcattacctggctcactaactaacgtgaaagccttacagaaatctcca
ggacctcagcgagaaaggaagtcatcttcatcctcagaagacaggaatcgaatgaaaaca
cttggtagacgggactcgagtgatgattgggagattcctgatgggcagattacagtggga
caaagaattggatctggatcatttggaacagtctacaagggaaagtggcatggtgatgtg
gcagtgaaaatgttgaatgtgacagcacctacacctcagcagttacaagccttcaaaaat
gaagtaggagtactcaggaaaacacgacatgtgaatatcctactcttcatgggctattcc
acaaagccacaactggctattgttacccagtggtgtgagggctccagcttgtatcaccat
ctccatatcattgagaccaaatttgagatgatcaaacttatagatattgcacgacagact
gcacagggcatggattacttacacgccaagtcaatcatccacagagacctcaagagtaat
aatatatttcttcatgaagacctcacagtaaaaataggtgattttggtctagctacagtg
aaatctcgatggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatg
gcaccagaagtcatcagaatgcaagataaaaatccatacagctttcagtcagatgtatat
gcatttggaattgttctgtatgaattgatgactggacagttaccttattcaaacatcaac
aacagggaccagataatttttatggtgggacgaggatacctgtctccagatctcagtaag
gtacggagtaactgtccaaaagccatgaagagattaatggcagagtgcctcaaaaagaaa
agagatgagagaccactctttccccaaattctcgcctctattgagctgctggcccgctca
ttgccaaaaattcaccgcagtgcatcagaaccctccttgaatcgggctggtttccaaaca
gaggattttagtctatatgcttgtgcttctccaaaaacacccatccaggcagggggatat
ggtgcgtttcctgtccactga

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