| Entry |
|
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| Name |
Metals to RAS-ERK signaling pathway
|
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| Definition |
Metals -> ROS -> RAS -> RAF -> MEK -> ERK -> AP1 |
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| Expanded |
(C06269,C01413,C19171,C06268,C06696,C00023,C00291) -> C22381 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> (2353,3725) |
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| Class |
|
|---|
| Type |
Env factor
|
|---|
| Pathway |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species |
|
|---|
| Disease |
| H00014 | Non-small cell lung cancer |
| H00048 | Hepatocellular carcinoma |
|
|---|
| Gene |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
| 2353 | FOS; Fos proto-oncogene, AP-1 transcription factor subunit |
| 3725 | JUN; Jun proto-oncogene, AP-1 transcription factor subunit |
|
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| Perturbant |
|
|---|
| Metabolite |
| C22381 | Reactive oxygen species |
|
|---|
| Reference |
|
|---|
| Authors |
Lee JC, Son YO, Pratheeshkumar P, Shi X |
|---|
| Title |
Oxidative stress and metal carcinogenesis. |
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| Journal |
|
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| Reference |
|
|---|
| Authors |
Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M |
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| Title |
Free radicals, metals and antioxidants in oxidative stress-induced cancer. |
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| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Leonard SS, Harris GK, Shi X |
|---|
| Title |
Metal-induced oxidative stress and signal transduction. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Kirtonia A, Sethi G, Garg M |
|---|
| Title |
The multifaceted role of reactive oxygen species in tumorigenesis. |
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| Journal |
|
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