KEGG   Homo sapiens (human): 6774
Entry
6774              CDS       T01001                                 

Gene name
STAT3, ADMIO, ADMIO1, APRF, HIES
Definition
(RefSeq) signal transducer and activator of transcription 3
  KO
K04692  signal transducer and activator of transcription 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04217  Necroptosis
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04630  JAK-STAT signaling pathway
hsa04659  Th17 cell differentiation
hsa04917  Prolactin signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04931  Insulin resistance
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04935  Growth hormone synthesis, secretion and action
hsa05145  Toxoplasmosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05169  Epstein-Barr virus infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05212  Pancreatic cancer
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05321  Inflammatory bowel disease
Network
nt06119  JAK-STAT signaling (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06167  Human cytomegalovirus (HCMV)
nt06219  JAK-STAT signaling
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N00094  EGF-Jak-STAT signaling pathway
N00095  ERBB2-overexpression to EGF-Jak-STAT signaling pathway
N00105  EML4-ALK fusion kinase to Jak-STAT signaling pathway
N00181  KSHV vIL-6 to Jak-STAT signaling pathway
N00415  IL10-Jak-STAT signaling pathway
N00416  HCMV vIL10 to IL10-JAK-STAT signaling pathway
N00486  EBV LMP1 to Jak-STAT signaling pathway
N00548  HBV HBx to Jak-STAT signaling pathway
Disease
H00016  Oral cancer
H00107  Other well-defined immunodeficiency syndromes
H01968  Hyper-IgE syndrome
Drug target
Napabucasin: D10717
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    6774 (STAT3)
   04066 HIF-1 signaling pathway
    6774 (STAT3)
   04068 FoxO signaling pathway
    6774 (STAT3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    6774 (STAT3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    6774 (STAT3)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    6774 (STAT3)
   04062 Chemokine signaling pathway
    6774 (STAT3)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    6774 (STAT3)
   04917 Prolactin signaling pathway
    6774 (STAT3)
   04935 Growth hormone synthesis, secretion and action
    6774 (STAT3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6774 (STAT3)
   05206 MicroRNAs in cancer
    6774 (STAT3)
   05205 Proteoglycans in cancer
    6774 (STAT3)
   05203 Viral carcinogenesis
    6774 (STAT3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    6774 (STAT3)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    6774 (STAT3)
   05221 Acute myeloid leukemia
    6774 (STAT3)
   05223 Non-small cell lung cancer
    6774 (STAT3)
  09172 Infectious disease: viral
   05161 Hepatitis B
    6774 (STAT3)
   05160 Hepatitis C
    6774 (STAT3)
   05171 Coronavirus disease - COVID-19
    6774 (STAT3)
   05162 Measles
    6774 (STAT3)
   05163 Human cytomegalovirus infection
    6774 (STAT3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    6774 (STAT3)
   05169 Epstein-Barr virus infection
    6774 (STAT3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    6774 (STAT3)
  09163 Immune disease
   05321 Inflammatory bowel disease
    6774 (STAT3)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    6774 (STAT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    6774 (STAT3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    6774 (STAT3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    6774 (STAT3)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   STAT
    6774 (STAT3)
SSDB
Motif
Pfam: STAT_alpha STAT_bind STAT_int SH2 E2R135 DUF4795 Syntaxin-6_N AP1AR Fib_alpha
Other DBs
NCBI-GeneID: 6774
NCBI-ProteinID: NP_644805
OMIM: 102582
HGNC: 11364
Ensembl: ENSG00000168610
Vega: OTTHUMG00000150645
Pharos: P40763(Tchem)
UniProt: P40763
Structure
PDB: 
6QHD

Position
17q21.2
AA seq 770 aa
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
NT seq 2313 nt   +upstreamnt  +downstreamnt
atggcccaatggaatcagctacagcagcttgacacacggtacctggagcagctccatcag
ctctacagtgacagcttcccaatggagctgcggcagtttctggccccttggattgagagt
caagattgggcatatgcggccagcaaagaatcacatgccactttggtgtttcataatctc
ctgggagagattgaccagcagtatagccgcttcctgcaagagtcgaatgttctctatcag
cacaatctacgaagaatcaagcagtttcttcagagcaggtatcttgagaagccaatggag
attgcccggattgtggcccggtgcctgtgggaagaatcacgccttctacagactgcagcc
actgcggcccagcaagggggccaggccaaccaccccacagcagccgtggtgacggagaag
cagcagatgctggagcagcaccttcaggatgtccggaagagagtgcaggatctagaacag
aaaatgaaagtggtagagaatctccaggatgactttgatttcaactataaaaccctcaag
agtcaaggagacatgcaagatctgaatggaaacaaccagtcagtgaccaggcagaagatg
cagcagctggaacagatgctcactgcgctggaccagatgcggagaagcatcgtgagtgag
ctggcggggcttttgtcagcgatggagtacgtgcagaaaactctcacggacgaggagctg
gctgactggaagaggcggcaacagattgcctgcattggaggcccgcccaacatctgccta
gatcggctagaaaactggataacgtcattagcagaatctcaacttcagacccgtcaacaa
attaagaaactggaggagttgcagcaaaaagtttcctacaaaggggaccccattgtacag
caccggccgatgctggaggagagaatcgtggagctgtttagaaacttaatgaaaagtgcc
tttgtggtggagcggcagccctgcatgcccatgcatcctgaccggcccctcgtcatcaag
accggcgtccagttcactactaaagtcaggttgctggtcaaattccctgagttgaattat
cagcttaaaattaaagtgtgcattgacaaagactctggggacgttgcagctctcagagga
tcccggaaatttaacattctgggcacaaacacaaaagtgatgaacatggaagaatccaac
aacggcagcctctctgcagaattcaaacacttgaccctgagggagcagagatgtgggaat
gggggccgagccaattgtgatgcttccctgattgtgactgaggagctgcacctgatcacc
tttgagaccgaggtgtatcaccaaggcctcaagattgacctagagacccactccttgcca
gttgtggtgatctccaacatctgtcagatgccaaatgcctgggcgtccatcctgtggtac
aacatgctgaccaacaatcccaagaatgtaaacttttttaccaagcccccaattggaacc
tgggatcaagtggccgaggtcctgagctggcagttctcctccaccaccaagcgaggactg
agcatcgagcagctgactacactggcagagaaactcttgggacctggtgtgaattattca
gggtgtcagatcacatgggctaaattttgcaaagaaaacatggctggcaagggcttctcc
ttctgggtctggctggacaatatcattgaccttgtgaaaaagtacatcctggccctttgg
aacgaagggtacatcatgggctttatcagtaaggagcgggagcgggccatcttgagcact
aagcctccaggcaccttcctgctaagattcagtgaaagcagcaaagaaggaggcgtcact
ttcacttgggtggagaaggacatcagcggtaagacccagatccagtccgtggaaccatac
acaaagcagcagctgaacaacatgtcatttgctgaaatcatcatgggctataagatcatg
gatgctaccaatatcctggtgtctccactggtctatctctatcctgacattcccaaggag
gaggcattcggaaagtattgtcggccagagagccaggagcatcctgaagctgacccaggt
agcgctgccccatacctgaagaccaagtttatctgtgtgacaccaacgacctgcagcaat
accattgacctgccgatgtccccccgcactttagattcattgatgcagtttggaaataat
ggtgaaggtgctgaaccctcagcaggagggcagtttgagtccctcacctttgacatggag
ttgacctcggagtgcgctacctcccccatgtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (30)   
   KEGG PATHWAY (30)   
Network (9)   
   KEGG NETWORK (9)   
Disease (6)   
   KEGG DISEASE (3)   
   OMIM (3)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (25)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (23)   
DNA sequence (65)   
   RefSeq(nuc) (23)   
   GenBank (21)   
   EMBL (21)   
Protein domain (9)   
   Pfam (9)   
All databases (171)   

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