KEGG   Homo sapiens (human): 7157Help
Entry
7157              CDS       T01001                                 

Gene name
TP53, BCC7, LFS1, P53, TRP53
Definition
(RefSeq) tumor protein p53
  KO
K04451  tumor protein p53
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04010  MAPK signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04110  Cell cycle
hsa04115  p53 signaling pathway
hsa04137  Mitophagy - animal
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04216  Ferroptosis
hsa04218  Cellular senescence
hsa04310  Wnt signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa05014  Amyotrophic lateral sclerosis (ALS)
hsa05016  Huntington disease
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  HTLV-I infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05216  Thyroid cancer
hsa05217  Basal cell carcinoma
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05418  Fluid shear stress and atherosclerosis
Network
N00066  MDM2-p21-Cell cycle G1/S
N00067  Deleted p14(ARF) to p21-cell cycle G1/S
N00068  Amplified MDM2 to p21-cell cycle G1/S
N00076  Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
N00115  Mutation-inactivated TP53 to transcription
N00131  Amplified MYCN to transcriptional activation
N00167  KSHV vIRF1/3 to p21-cell cycle G1/S
N00169  KSHV LANA to p21-cell cycle G1/S
N00193  HPV E6 to host-cell-protein inhibition
N00196  KSHV vIRF1/2/3 to host-cell-protein inhibition
N00205  KSHV LANA to host-cell-protein inhibition
N00222  HTLV-I Tax to host-cell-protein inhibition
N00223  EBV EBNA1 to host-cell-protein inhibition
N00262  EBV EBNA3C to host-cell-protein inhibition
N00268  HBV HBx to host-cell-protein inhibition
N00273  HCV NS5A to host-cell-protein inhibition
N00347  p300-p21-Cell cycle G1/S
N00348  HPV E6 to p300-p21-Cell cycle G1/S
N00349  HPV E6 to p300-p21-Cell cycle G1/S
N00358  HPV E6 to p21-cell cycle G1/S
N00420  HCMV IE2-86 to p21-cell cycle G1/S
Disease
H00004  Chronic myeloid leukemia (CML)
H00005  Chronic lymphocytic leukemia (CLL)
H00006  Hairy-cell leukemia
H00008  Burkitt lymphoma
H00009  Adult T-cell leukemia
H00010  Multiple myeloma
H00013  Small cell lung cancer
H00014  Non-small cell lung cancer
H00015  Malignant pleural mesothelioma
H00016  Oral cancer
H00017  Esophageal cancer
H00018  Gastric cancer
H00019  Pancreatic cancer
H00020  Colorectal cancer
H00022  Bladder cancer
H00025  Penile cancer
H00026  Endometrial cancer
H00027  Ovarian cancer
H00028  Choriocarcinoma
H00029  Vulvar cancer
H00031  Breast cancer
H00032  Thyroid cancer
H00033  Adrenal carcinoma
H00036  Osteosarcoma
H00038  Melanoma
H00039  Basal cell carcinoma
H00040  Squamous cell carcinoma
H00041  Kaposi sarcoma
H00042  Glioma
H00044  Cancer of the anal canal
H00046  Cholangiocarcinoma
H00047  Gallbladder cancer
H00048  Hepatocellular carcinoma
H00055  Laryngeal cancer
H00881  Li-Fraumeni syndrome
H01007  Choroid plexus papilloma
H01463  Mycosis fungoides
H01464  Mantle cell lymphoma
H01470  Giant cell tumor of bone
H01481  Myelodysplastic syndrome (MDS)
H01554  Fallopian tube cancer
H01555  Merkel cell carcinoma
H01557  Hepatic angiosarcoma
H01559  Oropharyngeal cancer
H01667  Medulloblastoma
Drug target
Cenersen sodium: D08887
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    7157 (TP53)
   04310 Wnt signaling pathway
    7157 (TP53)
   04071 Sphingolipid signaling pathway
    7157 (TP53)
   04151 PI3K-Akt signaling pathway
    7157 (TP53)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    7157 (TP53)
  09143 Cell growth and death
   04110 Cell cycle
    7157 (TP53)
   04210 Apoptosis
    7157 (TP53)
   04216 Ferroptosis
    7157 (TP53)
   04115 p53 signaling pathway
    7157 (TP53)
   04218 Cellular senescence
    7157 (TP53)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    7157 (TP53)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    7157 (TP53)
  09149 Aging
   04211 Longevity regulating pathway - mammal
    7157 (TP53)
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    7157 (TP53)
   05230 Central carbon metabolism in cancer
    7157 (TP53)
   05202 Transcriptional misregulation in cancers
    7157 (TP53)
   05206 MicroRNAs in cancer
    7157 (TP53)
   05205 Proteoglycans in cancer
    7157 (TP53)
   05203 Viral carcinogenesis
    7157 (TP53)
   05210 Colorectal cancer
    7157 (TP53)
   05212 Pancreatic cancer
    7157 (TP53)
   05225 Hepatocellular carcinoma
    7157 (TP53)
   05226 Gastric cancer
    7157 (TP53)
   05214 Glioma
    7157 (TP53)
   05216 Thyroid cancer
    7157 (TP53)
   05220 Chronic myeloid leukemia
    7157 (TP53)
   05217 Basal cell carcinoma
    7157 (TP53)
   05218 Melanoma
    7157 (TP53)
   05219 Bladder cancer
    7157 (TP53)
   05215 Prostate cancer
    7157 (TP53)
   05213 Endometrial cancer
    7157 (TP53)
   05224 Breast cancer
    7157 (TP53)
   05222 Small cell lung cancer
    7157 (TP53)
   05223 Non-small cell lung cancer
    7157 (TP53)
  09163 Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    7157 (TP53)
   05016 Huntington disease
    7157 (TP53)
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    7157 (TP53)
  09167 Infectious diseases
   05166 HTLV-I infection
    7157 (TP53)
   05162 Measles
    7157 (TP53)
   05161 Hepatitis B
    7157 (TP53)
   05160 Hepatitis C
    7157 (TP53)
   05168 Herpes simplex infection
    7157 (TP53)
   05163 Human cytomegalovirus infection
    7157 (TP53)
   05167 Kaposi sarcoma-associated herpesvirus infection
    7157 (TP53)
   05169 Epstein-Barr virus infection
    7157 (TP53)
   05165 Human papillomavirus infection
    7157 (TP53)
  09168 Drug resistance
   01524 Platinum drug resistance
    7157 (TP53)
   01522 Endocrine resistance
    7157 (TP53)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    7157 (TP53)
   03036 Chromosome and associated proteins [BR:hsa03036]
    7157 (TP53)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    7157 (TP53)
Transcription factors [BR:hsa03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   p53
    7157 (TP53)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic Type
  Sister chromatid separation proteins
   Aurora kinases
    Regulators of Aurora kinases
     7157 (TP53)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic Type
  Check point factors
   Other check point factors
    7157 (TP53)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: P53 P53_tetramer P53_TAD
Motif
Other DBs
NCBI-GeneID: 7157
NCBI-ProteinID: NP_000537
OMIM: 191170
HGNC: 11998
Ensembl: ENSG00000141510
Vega: OTTHUMG00000162125
Pharos: P04637(Tchem)
UniProt: P04637 K7PPA8 Q53GA5
Structure
PDB: 

Position
17p13.1
AA seq 393 aa AA seqDB search
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
NT seq 1182 nt NT seq  +upstreamnt  +downstreamnt
atggaggagccgcagtcagatcctagcgtcgagccccctctgagtcaggaaacattttca
gacctatggaaactacttcctgaaaacaacgttctgtcccccttgccgtcccaagcaatg
gatgatttgatgctgtccccggacgatattgaacaatggttcactgaagacccaggtcca
gatgaagctcccagaatgccagaggctgctccccccgtggcccctgcaccagcagctcct
acaccggcggcccctgcaccagccccctcctggcccctgtcatcttctgtcccttcccag
aaaacctaccagggcagctacggtttccgtctgggcttcttgcattctgggacagccaag
tctgtgacttgcacgtactcccctgccctcaacaagatgttttgccaactggccaagacc
tgccctgtgcagctgtgggttgattccacacccccgcccggcacccgcgtccgcgccatg
gccatctacaagcagtcacagcacatgacggaggttgtgaggcgctgcccccaccatgag
cgctgctcagatagcgatggtctggcccctcctcagcatcttatccgagtggaaggaaat
ttgcgtgtggagtatttggatgacagaaacacttttcgacatagtgtggtggtgccctat
gagccgcctgaggttggctctgactgtaccaccatccactacaactacatgtgtaacagt
tcctgcatgggcggcatgaaccggaggcccatcctcaccatcatcacactggaagactcc
agtggtaatctactgggacggaacagctttgaggtgcgtgtttgtgcctgtcctgggaga
gaccggcgcacagaggaagagaatctccgcaagaaaggggagcctcaccacgagctgccc
ccagggagcactaagcgagcactgcccaacaacaccagctcctctccccagccaaagaag
aaaccactggatggagaatatttcacccttcagatccgtgggcgtgagcgcttcgagatg
ttccgagagctgaatgaggccttggaactcaaggatgcccaggctgggaaggagccaggg
gggagcagggctcactccagccacctgaagtccaaaaagggtcagtctacctcccgccat
aaaaaactcatgttcaagacagaagggcctgactcagactga

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