KEGG   Homo sapiens (human): 8826
Entry
8826              CDS       T01001                                 
Symbol
IQGAP1, HUMORFA01, SAR1, p195
Name
(RefSeq) IQ motif containing GTPase activating protein 1
  KO
K16848  Ras GTPase-activating-like protein IQGAP1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04520  Adherens junction
hsa04810  Regulation of actin cytoskeleton
hsa05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    8826 (IQGAP1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    8826 (IQGAP1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    8826 (IQGAP1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    8826 (IQGAP1)
   04147 Exosome [BR:hsa04147]
    8826 (IQGAP1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Others
     8826 (IQGAP1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   8826 (IQGAP1)
  Exosomal proteins of breast milk
   8826 (IQGAP1)
  Exosomal proteins of other body fluids (saliva and urine)
   8826 (IQGAP1)
  Exosomal proteins of colorectal cancer cells
   8826 (IQGAP1)
SSDB
Motif
Pfam: RasGAP RasGAP_C IQ CH WW CAMSAP_CH bZIP_1 DUF5390
Other DBs
NCBI-GeneID: 8826
NCBI-ProteinID: NP_003861
OMIM: 603379
HGNC: 6110
Ensembl: ENSG00000140575
UniProt: P46940
Structure
Position
15:90388242..90502239
AA seq 1657 aa
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGE
DLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWL
NAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEE
EINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAAL
KNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNI
NKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS
GQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQ
VYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLS
SSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERIL
AIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAV
LWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPEC
GETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQL
SREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAIT
CIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDII
KIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLI
RSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKA
LSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEY
LLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIM
DDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRA
VTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAI
VAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQ
KFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEH
NDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMD
ARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKK
SKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRK
AELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKIS
LKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQ
DLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK
NT seq 4974 nt   +upstreamnt  +downstreamnt
atgtccgccgcagacgaggttgacgggctgggcgtggcccggccgcactatggctctgtc
ctggataatgaaagacttactgcagaggagatggatgaaaggagacgtcagaacgtggct
tatgagtacctttgtcatttggaagaagcgaagaggtggatggaagcatgcctaggggaa
gatctgcctcccaccacagaactggaggaggggcttaggaatggggtctaccttgccaaa
ctggggaacttcttctctcccaaagtagtgtccctgaaaaaaatctatgatcgagaacag
accagatacaaggcgactggcctccactttagacacactgataatgtgattcagtggttg
aatgccatggatgagattggattgcctaagattttttacccagaaactacagatatctat
gatcgaaagaacatgccaagatgtatctactgtatccatgcactcagtttgtacctgttc
aagctaggcctggcccctcagattcaagacctatatggaaaggttgacttcacagaagaa
gaaatcaacaacatgaagactgagttggagaagtatggcatccagatgcctgcctttagc
aagattgggggcatcttggctaatgaactgtcagtggatgaagccgcattacatgctgct
gttattgctattaatgaagctattgaccgtagaattccagccgacacatttgcagctttg
aaaaatccgaatgccatgcttgtaaatcttgaagagcccttggcatccacttaccaggat
atactttaccaggctaagcaggacaaaatgacaaatgctaaaaacaggacagaaaactca
gagagagaaagagatgtttatgaggagctgctcacgcaagctgaaattcaaggcaatata
aacaaagtcaatacattttctgcattagcaaatatcgacctggctttagaacaaggagat
gcactggccttgttcagggctctgcagtcaccagccctggggcttcgaggactgcagcaa
cagaatagcgactggtacttgaagcagctcctgagtgataaacagcagaagagacagagt
ggtcagactgaccccctgcagaaggaggagctgcagtctggagtggatgctgcaaacagt
gctgcccagcaatatcagagaagattggcagcagtagcactgattaatgctgcaatccag
aagggtgttgctgagaagactgttttggaactgatgaatcccgaagcccagctgccccag
gtgtatccatttgccgccgatctctatcagaaggagctggctaccctgcagcgacaaagt
cctgaacataatctcacccacccagagctctctgtcgcagtggagatgttgtcatcggtg
gccctgatcaacagggcattggaatcaggagatgtgaatacagtgtggaagcaattgagc
agttcagttactggtcttaccaatattgaggaagaaaactgtcagaggtatctcgatgag
ttgatgaaactgaaggctcaggcacatgcagagaataatgaattcattacatggaatgat
atccaagcttgcgtggaccatgtgaacctggtggtgcaagaggaacatgagaggatttta
gccattggtttaattaatgaagccctggatgaaggtgatgcccaaaagactctgcaggcc
ctacagattcctgcagctaaacttgagggagtccttgcagaagtggcccagcattaccaa
gacacgctgattagagcgaagagagagaaagcccaggaaatccaggatgagtcagctgtg
ttatggttggatgaaattcaaggtggaatctggcagtccaacaaagacacccaagaagca
cagaagtttgccttaggaatctttgccattaatgaggcagtagaaagtggtgatgttggc
aaaacactgagtgcccttcgctcccctgatgttggcttgtatggagtcatccctgagtgt
ggtgaaacttaccacagtgatcttgctgaagccaagaagaaaaaactggcagtaggagat
aataacagcaagtgggtgaagcactgggtaaaaggtggatattattattaccacaatctg
gagacccaggaaggaggatgggatgaacctccaaattttgtgcaaaattctatgcagctt
tctcgggaggagatccagagttctatctctggggtgactgccgcatataaccgagaacag
ctgtggctggccaatgaaggcctgatcaccaggctgcaggctcgctgccgtggatactta
gttcgacaggaattccgatccaggatgaatttcctgaagaaacaaatccctgccatcacc
tgcattcagtcacagtggagaggatacaagcagaagaaggcatatcaagatcggttagct
tacctgcgctcccacaaagatgaagttgtaaagattcagtccctggcaaggatgcaccaa
gctcgaaagcgctatcgagatcgcctgcagtacttccgggaccatataaatgacattatc
aaaatccaggcttttattcgggcaaacaaagctcgggatgactacaagactctcatcaat
gctgaggatcctcctatggttgtggtccgaaaatttgtccacctgctggaccaaagtgac
caggattttcaggaggagcttgaccttatgaagatgcgggaagaggttatcaccctcatt
cgttctaaccagcagctggagaatgacctcaatctcatggatatcaaaattggactgcta
gtgaaaaataagattacgttgcaggatgtggtttcccacagtaaaaaacttaccaaaaaa
aataaggaacagttgtctgatatgatgatgataaataaacagaagggaggtctcaaggct
ttgagcaaggagaagagagagaagttggaagcttaccagcacctgttttatttattgcaa
accaatcccacctatctggccaagctcatttttcagatgccccagaacaagtccaccaag
ttcatggactctgtaatcttcacactctacaactacgcgtccaaccagcgagaggagtac
ctgctcctgcggctctttaagacagcactccaagaggaaatcaagtcgaaggtagatcag
attcaagagattgtgacaggaaatcctacggttattaaaatggttgtaagtttcaaccgt
ggtgcccgtggccagaatgccctgagacagatcttggccccagtcgtgaaggaaattatg
gatgacaaatctctcaacatcaaaactgaccctgtggatatttacaaatcttgggttaat
cagatggagtctcagacaggagaggcaagcaaactgccctatgatgtgacccctgagcag
gcgctagctcatgaagaagtgaagacacggctagacagctccatcaggaacatgcgggct
gtgacagacaagtttctctcagccattgtcagctctgtggacaaaatcccttatgggatg
cgcttcattgccaaagtgctgaaggactcgttgcatgagaagttccctgatgctggtgag
gatgagctgctgaagattattggtaacttgctttattatcgatacatgaatccagccatt
gttgctcctgatgcctttgacatcattgacctgtcagcaggaggccagcttaccacagac
caacgccgaaatctgggctccattgcaaaaatgcttcagcatgctgcttccaataagatg
tttctgggagataatgcccacttaagcatcattaatgaatatctttcccagtcctaccag
aaattcagacggtttttccaaactgcttgtgatgtcccagagcttcaggataaatttaat
gtggatgagtactctgatttagtaaccctcaccaaaccagtaatctacatttccattggt
gaaatcatcaacacccacactctcctgttggatcaccaggatgccattgctccggagcac
aatgatccaatccacgaactgctggacgacctcggcgaggtgcccaccatcgagtccctg
ataggggaaagctctggcaatttaaatgacccaaataaggaggcactggctaagacggaa
gtgtctctcaccctgaccaacaagttcgacgtgcctggagatgagaatgcagaaatggat
gctcgaaccatcttactgaatacaaaacgtttaattgtggatgtcatccggttccagcca
ggagagaccttgactgaaatcctagaaacaccagccaccagtgaacaggaagcagaacat
cagagagccatgcagagacgtgctatccgtgatgccaaaacacctgacaagatgaaaaag
tcaaaatctgtaaaggaagacagcaacctcactcttcaagagaagaaagagaagatccag
acaggtttaaagaagctaacagagcttggaaccgtggacccaaagaacaaataccaggaa
ctgatcaacgacattgccagggatattcggaatcagcggaggtaccgacagaggagaaag
gccgaactagtgaaactgcaacagacatacgctgctctgaactctaaggccaccttttat
ggggagcaggtggattactataaaagctatatcaaaacctgcttggataacttagccagc
aagggcaaagtctccaaaaagcctagggaaatgaaaggaaagaaaagcaaaaagatttct
ctgaaatatacagcagcaagactacatgaaaaaggagttcttctggaaattgaggacctg
caagtgaatcagtttaaaaatgttatatttgaaatcagtccaacagaagaagttggagac
ttcgaagtgaaagccaaattcatgggagttcaaatggagacttttatgttacattatcag
gacctgctgcagctacagtatgaaggagttgcagtcatgaaattatttgatagagctaaa
gtaaatgtcaacctcctgatcttccttctcaacaaaaagttctacgggaagtaa

  All links  
Disease (1)   
   OMIM (1)   
Gene (26)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (39)   
   RefSeq(nuc) (3)   
   GenBank (18)   
   EMBL (18)   
3D Structure (5)   
   PDB (5)   
Protein domain (8)   
   Pfam (8)   
All databases (84)   

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