KEGG   VARIANT: 1956v1
Entry
1956v1                      Variant                                
Name
EGFR amplification
Gene
EGFR  epidermal growth factor receptor [KO:K04361]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
amplification
ClinVar: 59680 59682
dbVar: nsv532206 nsv532208
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06220  Calcium signaling (cancer)
nt06265  Bladder cancer
nt06273  Glioma
nt06526  MAPK signaling
nt06528  Calcium signaling
nt06530  PI3K signaling
Disease
H00014  Non-small cell lung cancer
H00022  Bladder cancer
H00042  Glioma
Reference
PMID:27809598
  Authors
Miller JJ, Wen PY
  Title
Emerging targeted therapies for glioma.
  Journal
Expert Opin Emerg Drugs 21:441-452 (2016)
DOI:10.1080/14728214.2016.1257609
Reference
PMID:22323597
  Authors
Szerlip NJ, Pedraza A, Chakravarty D, Azim M, McGuire J, Fang Y, Ozawa T, Holland EC, Huse JT, Jhanwar S, Leversha MA, Mikkelsen T, Brennan CW
  Title
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response.
  Journal
Proc Natl Acad Sci U S A 109:3041-6 (2012)
DOI:10.1073/pnas.1114033109
Reference
PMID:17149381
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
PMID:16474624
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318

  All links  
Network (11)   
   KEGG NETWORK (11)   
Disease (3)   
   KEGG DISEASE (3)   
Gene (4)   
   CLINVAR (2)   
   DBVAR (2)   
Literature (4)   
   PubMed (4)   
All databases (22)   

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