Entry |
|
Name |
|
Gene |
|
Organism |
hsa_var Human gene variants (Homo sapiens)
|
Variation |
overexpression |
Network |
|
Element |
N00022 | ERBB2-overexpression to RAS-ERK signaling pathway |
N00034 | ERBB2-overexpression to PI3K signaling pathway |
N00095 | ERBB2-overexpression to EGF-Jak-STAT signaling pathway |
N10009 | Tyrosine kinase inhibitor to HER2 overexpression/amplification |
|
Drug target |
Trastuzumab deruxtecan: | D11529<JP/US> |
Trastuzumab emtansine: | D09980<JP/US> |
|
Reference |
|
Authors |
Sugano K, Kakizoe T. |
Title |
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging. |
Journal |
|
Reference |
|
Authors |
Ingvarsson S. |
Title |
Molecular genetics of breast cancer progression. |
Journal |
|
Reference |
|
Authors |
Kenemans P, Verstraeten RA, Verheijen RH. |
Title |
Oncogenic pathways in hereditary and sporadic breast cancer. |
Journal |
|
Reference |
|
Authors |
Bardeesy N, DePinho RA. |
Title |
Pancreatic cancer biology and genetics. |
Journal |
|
Reference |
|
Authors |
Panani AD, Roussos C. |
Title |
Cytogenetic and molecular aspects of lung cancer. |
Journal |
|