KEGG ORTHOLOGY: K05032

ORTHOLOGY: K05032

Entry

K05032                      KO

Symbol

ABCC8, SUR1

Name

ATP-binding cassette subfamily C (CFTR/MRP) member 8

Pathway

map02010

ABC transporters

map04911

Insulin secretion

map04930

Type II diabetes mellitus

Disease

H00512

Permanent neonatal diabetes mellitus

H00513

Transient neonatal diabetes mellitus

H01267

Familial hyperinsulinemic hypoglycemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09131 Membrane transport
   02010 ABC transporters
    K05032  ABCC8, SUR1; ATP-binding cassette subfamily C (CFTR/MRP) member 8
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K05032  ABCC8, SUR1; ATP-binding cassette subfamily C (CFTR/MRP) member 8
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K05032  ABCC8, SUR1; ATP-binding cassette subfamily C (CFTR/MRP) member 8
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K05032  ABCC8, SUR1; ATP-binding cassette subfamily C (CFTR/MRP) member 8
Transporters [BR:ko02000]
ABC transporters, eukaryotic type
  ABCC (CFTR/MRP) subfamily
   ABCC8, 9 subgroups
    K05032  ABCC8, SUR1; ATP-binding cassette subfamily C (CFTR/MRP) member 8

Other DBs

TC:	3.A.1.208.4

Genes

HSA:	6833(ABCC8)

PTR:	451056(ABCC8)

PPS:	100980650(ABCC8)

GGO:	101128886(ABCC8)

PON:	100433186(ABCC8)

NLE:	100603002(ABCC8)

HMH:	116476468(ABCC8)

MCC:	654490(ABCC8)

MCF:	102118880(ABCC8)

MTHB:

126934629

MNI:	105486959(ABCC8)

CSAB:

103239480(ABCC8)

CATY:

105598894(ABCC8)

PANU:

101010659(ABCC8)

TGE:	112606507(ABCC8)

MLEU:

105548762(ABCC8)

RRO:	104667632(ABCC8)

RBB:	108528235(ABCC8)

TFN:	117081714(ABCC8)

PTEH:

111555065(ABCC8)

CANG:

105508627(ABCC8)

CJC:	100386093(ABCC8)

SBQ:	101041998(ABCC8)

CIMI:

108302262(ABCC8)

CSYR:

103274377(ABCC8)

MMUR:

105879980(ABCC8)

LCAT:

123642490(ABCC8)

PCOQ:

105818231(ABCC8)

OGA:	100940864(ABCC8)

MMU:	20927(Abcc8)

MCAL:

110297901(Abcc8)

MPAH:

110321515(Abcc8)

RNO:	25559(Abcc8)

MCOC:

116102244(Abcc8)

ANU:	117718725(Abcc8)

MUN:	110550473(Abcc8)

CGE:	100764394(Abcc8)

MAUA:

101835030(Abcc8)

PROB:

127213846(Abcc8)

PLEU:

114700534(Abcc8)

MORG:

121435231(Abcc8)

MFOT:

126493312

AAMP:

119802563(Abcc8)

NGI:	103734450(Abcc8)

HGL:	101705546(Abcc8)

CPOC:

100722700(Abcc8)

CCAN:

109695032(Abcc8)

DORD:

105999175(Abcc8)

DSP:	122117689(Abcc8)

PLOP:

125361636(Abcc8)

NCAR:

124960270

MMMA:

107135681(Abcc8)

OCU:

100341472

OPI:	101518410(ABCC8)

TUP:	102490959(ABCC8)

GVR:	103596135(ABCC8)

CFA:	485402(ABCC8)

CLUD:

112667698(ABCC8)

VVP:	112927030(ABCC8)

VLG:	121476634(ABCC8)

NPO:	129505154(ABCC8)

AML:	100480112(ABCC8)

UMR:	103679402(ABCC8)

UAH:	113246622(ABCC8)

UAR:	123791679(ABCC8)

ELK:

111149755

LLV:

125078210

MPUF:

101681504(ABCC8)

MNP:	132022294(ABCC8)

MLK:	131809980(ABCC8)

NVS:	122912758(ABCC8)

ORO:	101366537(ABCC8)

EJU:	114219319(ABCC8)

ZCA:	113914386(ABCC8)

MLX:	118003947(ABCC8)

NSU:	110576612(ABCC8)

FCA:	101096101(ABCC8)

PYU:	121043704(ABCC8)

PCOO:

112865636(ABCC8)

PBG:	122484402(ABCC8)

PVIV:

125176625(ABCC8)

LRUF:

124505376

PTG:	102967889(ABCC8)

PPAD:

109271201(ABCC8)

PUC:

125913358

AJU:

106977473

HHV:	120234808(ABCC8)

BTA:	538996(ABCC8)

BOM:	102274573(ABCC8)

BIU:	109569744(ABCC8)

BBUB:

102404986(ABCC8)

BBIS:

104981430(ABCC8)

CHX:	102185675(ABCC8)

OAS:	101120522(ABCC8)

BTAX:

128060025(ABCC8)

ODA:	120876401(ABCC8)

CCAD:

122450186(ABCC8)

MBEZ:

129554470(ABCC8)

SSC:	100158245(ABCC8)

CFR:	102523396(ABCC8)

CBAI:

105076592(ABCC8)

CDK:	105086704(ABCC8)

VPC:	102534857(ABCC8)

BACU:

102999613(ABCC8)

BMUS:

118900238(ABCC8)

LVE:	103081595(ABCC8)

OOR:	101271740(ABCC8)

DLE:	111165221(ABCC8)

PCAD:

102975396(ABCC8)

PSIU:

116758486(ABCC8)

NASI:

112390599(ABCC8)

ECB:	100071788(ABCC8)

EAI:	106835490(ABCC8)

MYB:	102251988(ABCC8)

MYD:

102759330

MMYO:

118664886(ABCC8)

MLF:	102433282(ABCC8)

PKL:	118713153(ABCC8)

EFUS:

103292741(ABCC8)

MNA:	107546729(ABCC8)

DRO:	112303290(ABCC8)

SHON:

118989712(ABCC8)

AJM:	119053086(ABCC8)

PDIC:

114499434(ABCC8)

PHAS:

123810127(ABCC8)

MMF:	118627689(ABCC8)

PPAM:

129080528(ABCC8)

HAI:	109388106(ABCC8)

RFQ:	117031244(ABCC8)

PALE:

102883696(ABCC8)

PGIG:

120593603(ABCC8)

PVP:	105304230(ABCC8)

RAY:	107508030(ABCC8)

MJV:	108404861(ABCC8)

TOD:	119255508(ABCC8)

SARA:

101548091(ABCC8)

SETR:

126018997(ABCC8)

LAV:	100660003(ABCC8)

TMU:

101359595

ETF:	101655157(ABCC8)

DNM:

101437876

MDO:	100020181(ABCC8)

GAS:	123252514(ABCC8)

SHR:	100915705(ABCC8)

AFZ:

127542074

PCW:	110220976(ABCC8)

OAA:	100078637(ABCC8)

GGA:	423072(ABCC8)

PCOC:

116242874(ABCC8)

MGP:	100548594(ABCC8)

CJO:	107314654(ABCC8)

TPAI:

128085637(ABCC8)

LMUT:

125694531(ABCC8)

NMEL:

110401613(ABCC8)

APLA:

101804688(ABCC8)

ACYG:

106033850(ABCC8)

CATA:

118249879(ABCC8)

AFUL:

116490265(ABCC8)

TGU:	100223853(ABCC8)

LSR:	110468059(ABCC8)

SCAN:

103827026(ABCC8)

PMOA:

120501316(ABCC8)

OTC:	121341472(ABCC8)

PRUF:

121360941(ABCC8)

GFR:	102036551(ABCC8)

FAB:	101812634(ABCC8)

OMA:	130254214(ABCC8)

PHI:	102105363(ABCC8)

PMAJ:

107206079(ABCC8)

CCAE:

111930701(ABCC8)

CCW:	104687870(ABCC8)

CBRC:

103624946(ABCC8)

ETL:	114068369(ABCC8)

ZAB:	102064576(ABCC8)

ACHL:

103803549(ABCC8)

SVG:	106853227(ABCC8)

MMEA:

130575407(ABCC8)

HRT:	120754050(ABCC8)

FPG:	101920296(ABCC8)

FCH:	102047812(ABCC8)

CLV:	102097135(ABCC8)

EGZ:	104123163(ABCC8)

NNI:	104010907(ABCC8)

PLET:

104622298(ABCC8)

EHS:

104513575

PCAO:

104052950(ABCC8)

ACUN:

113480965(ABCC8)

TALA:

104363920(ABCC8)

PADL:

103920770(ABCC8)

AFOR:

103906739(ABCC8)

ACHC:

115351751(ABCC8)

HALD:

104319647(ABCC8)

HLE:	104829535(ABCC8)

AGEN:

126047411

GCL:

127017228

CCRI:

104166418(ABCC8)

CSTI:

104553480(ABCC8)

MUI:

104547326

BREG:

104639314(ABCC8)

FGA:

104076374

GSTE:

104265069(ABCC8)

LDI:	104340437(ABCC8)

MNB:	103767878(ABCC8)

OHA:	104330144(ABCC8)

SHAB:

115607050(ABCC8)

DPUB:

104304433(ABCC8)

PGUU:

104465852(ABCC8)

ACAR:

104525205

CPEA:

104386756(ABCC8)

AVIT:

104267757(ABCC8)

CVF:	104292638(ABCC8)

RTD:	128909097(ABCC8)

CUCA:

104068954(ABCC8)

TEO:

104383690

BRHI:

104500601

AAM:	106497135(ABCC8)

AROW:

112972383(ABCC8)

NPD:	112948837(ABCC8)

TGT:	104580441(ABCC8)

DNE:	112985704(ABCC8)

SCAM:

104140425(ABCC8)

ASN:	102368362(ABCC8)

AMJ:	106736701(ABCC8)

CPOO:

109321393(ABCC8)

GGN:	109299129(ABCC8)

PSS:	102455761(ABCC8)

CMY:	102936267(ABCC8)

DCC:	119857468(ABCC8)

CPIC:

101949000(ABCC8)

TST:	117877251(ABCC8)

CABI:

116835930(ABCC8)

MRV:	120404189(ABCC8)

ACS:	100562467(abcc8)

ASAO:

132770679(ABCC8)

PVT:	110083986(ABCC8)

SUND:

121919682(ABCC8)

PBI:	103057429(ABCC8)

PMUR:

107299624(ABCC8)

CTIG:

120308497(ABCC8)

TSR:	106545199(ABCC8)

PGUT:

117666150(ABCC8)

APRI:

131185761(ABCC8)

PTEX:

113440277(ABCC8)

NSS:	113412574(ABCC8)

VKO:	123021194(ABCC8)

PMUA:

114598697(ABCC8)

PRAF:

128415910(ABCC8)

ZVI:	118087500(ABCC8)

HCG:	128339366(ABCC8)

GJA:	107120528(ABCC8)

STOW:

125426709(ABCC8)

EMC:	129324773(ABCC8)

XLA:	108713435 108714951

XTR:	101730668(abcc8)

RTEM:

120921981(ABCC8)

BBUF:

120980687(ABCC8)

BGAR:

122920717 122921146(ABCC8)

MUO:	115468922(ABCC8)

GSH:	117352154(ABCC8)

DRE:	100329706(abcc8b) 553281(abcc8)

SRX:	107740359 107744191 107758750(abcc8)

SANH:

107675245 107675473

SGH:	107549258 107569903

CAUA:

113043572 113067090 113087741 113118620

CGIB:

127947493 127977920 128014210

PTET:

122331105 122362581(abcc8b)

LROH:

127156710(abcc8) 127180699(abcc8b)

OMC:	131524287(abcc8b) 131534611(abcc8)

PPRM:

120459923 120473380(abcc8)

RKG:	130075671(abcc8b) 130086027(abcc8)

MAMB:

125247757(abcc8) 125254541(abcc8b)

CIDE:

127499386 127506740

MASI:

127417192 127436184 127437715 127455686

TROS:

130552301(abcc8) 130562542(abcc8b)

TDW:	130414479(abcc8) 130435984(abcc8b)

MANU:

129418733(abcc8b) 129433821(abcc8)

IPU:	108264060 108274972

IFU:	128606483(abcc8b) 128618598(abcc8)

PHYP:

113526366 113529828(abcc8)

SMEO:

124392507(abcc8) 124395459(abcc8b)

TFD:	113660185(abcc8) 113662125(abcc8b)

TVC:	132851584(abcc8b) 132857427(abcc8)

AMEX:

103030655(abcc8) 103043789

CMAO:

118811550(abcc8) 118817965

EEE:	113580554(abcc8)

CHAR:

105904752(abcc8) 105906456

TRU:	101077334 115251137

TFS:	130536500(abcc8)

TNG:	GSTEN00012676G001

LCO:	104936259(abcc8)

TBEN:

117491265(abcc8)

CGOB:

115009613(abcc8)

PGEO:

117448217(abcc8)

GACU:

117545884(abcc8)

EMAC:

134859792(abcc8)

ELY:	117261702(abcc8)

EFO:	125888149(abcc8)

PLEP:

121949949(abcc8)

SLUC:

116038378(abcc8)

ECRA:

117949295(abcc8)

ESP:

116693530

PFLV:

114559780(abcc8)

GAT:	120808796 120812315

PPUG:

119195781(abcc8)

AFB:	129107901(abcc8)

CLUM:

117732266(abcc8)

PSWI:

130195562(abcc8)

MSAM:

119894090(abcc8)

SCHU:

122874267(abcc8)

CUD:	121514983(abcc8)

ALAT:

119024008(abcc8)

MZE:	101476511(abcc8)

ONL:	100705598(abcc8)

OAU:	116327611(abcc8)

OLA:	101167867(abcc8)

OML:	112152062(abcc8)

CSAI:

133444019(abcc8)

XMA:	102224164(abcc8)

XCO:	114156649(abcc8)

XHE:

116734241

PRET:

103466172(abcc8)

PFOR:

103144417(abcc8)

PLAI:

106948429(abcc8)

PMEI:

106916767(abcc8)

GAF:	122835889(abcc8)

PPRL:

129356036(abcc8)

CVG:	107089489(abcc8)

CTUL:

119796775(abcc8)

GMU:	124884253(abcc8)

NFU:	107389030(abcc8)

KMR:	108237504(abcc8)

ALIM:

106515675(abcc8)

NWH:	119416013(abcc8)

AOCE:

111563344(abcc8)

MCEP:

125014849(abcc8)

CSEM:

103398783(abcc8)

POV:	109638969(abcc8)

SSEN:

122775912(abcc8)

HHIP:

117763773(abcc8)

HSP:	118109292(abcc8)

SMAU:

118314890(abcc8)

LCF:

108875227

SDU:	111228432(abcc8)

SLAL:

111661756(abcc8)

XGL:	120793668(abcc8)

HCQ:	109530389(abcc8)

SSCV:

125971165

SBIA:

133502054(abcc8)

PEE:	133402697(abcc8)

PTAO:

133477592(abcc8)

BPEC:

110165898(abcc8)

MALB:

109967883(abcc8)

BSPL:

114857693(abcc8)

SJO:	128359295(abcc8)

SASA:

106561050 106584588

STRU:

115192777 115197051

OTW:	112218237 112259407

OMY:	110492500 110522733

OGO:	124037570 124044709

ONE:	115134487(abcc8) 115144802

OKI:	109867182 109898452

OKE:	118358785 118396446

SALP:

111962152 111971785

SNH:	120052367 120066623(abcc8)

CCLU:

121532059 121540705(abcc8)

ELS:	105030992(abcc8)

SFM:	108942292(abcc8)

PKI:	111859508(abcc8)

AANG:

118215344(abcc8)

LOC:	102684969(abcc8)

PSPA:

121294880 121330387

ARUT:

117432376 117434723

PSEX:

120516667(abcc8)

LCM:	102365463(ABCC8)

CMK:	103174891(abcc8)

CPLA:

122557842(abcc8)

HOC:	132811042 132824420(abcc8)

LERI:

129705734(abcc8)

PMRN:

116940098 116945488

LRJ:	133350306 133351506

BBEL:

SPU:

APLC:

SKO:

LSM:

RMP:

DFR:

BGT:

OSN:

Reference

PMID:18990670

Authors

Aittoniemi J, Fotinou C, Craig TJ, de Wet H, Proks P, Ashcroft FM

Title

Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.

Journal

Philos Trans R Soc Lond B Biol Sci 364:257-67 (2009)
DOI:10.1098/rstb.2008.0142

Reference

PMID:7716547

Authors

Aguilar-Bryan L, Nichols CG, Wechsler SW, Clement JP 4th, Boyd AE 3rd, Gonzalez G, Herrera-Sosa H, Nguy K, Bryan J, Nelson DA

Title

Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.

Journal

Science 268:423-6 (1995)
DOI:10.1126/science.7716547

Sequence

[hsa:6833]

All links

Ontology (3)   
   KEGG BRITE (2)   
   TC (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (3)   
   KEGG DISEASE (3)   
Drug (27)   
   KEGG DRUG (27)   
Gene (1308)   
   KEGG GENES (442)   
   KEGG MGENES (467)   
   RefGene (393)   
   OC (6)   
Literature (2)   
   PubMed (2)   
All databases (1349)   

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