Entry |
|
Name |
Mutation-inactivated APC to Wnt signaling pathway
|
Definition |
(GSK3B+AXIN) // APC* // CTNNB1 -> TCF/LEF => (BIRC5,MYC,CCND1) |
Expanded |
(2932+(8312,8313)) // 324v1 // 1499 -> (6932,83439,6934,51176) => (332,4609,595) |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
|
Gene |
2932 | GSK3B; glycogen synthase kinase 3 beta |
324 | APC; APC, WNT signaling pathway regulator |
1499 | CTNNB1; catenin beta 1 |
6932 | TCF7; transcription factor 7 |
83439 | TCF7L1; transcription factor 7 like 1 |
6934 | TCF7L2; transcription factor 7 like 2 |
51176 | LEF1; lymphoid enhancer binding factor 1 |
332 | BIRC5; baculoviral IAP repeat containing 5 |
4609 | MYC; MYC proto-oncogene, bHLH transcription factor |
|
Variant |
324v1 (APC*) APC mutation
|
Reference |
|
Authors |
Duchartre Y, Kim YM, Kahn M |
Title |
The Wnt signaling pathway in cancer. |
Journal |
|
Reference |
|
Authors |
Takebe N, Harris PJ, Warren RQ, Ivy SP |
Title |
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. |
Journal |
|
Reference |
|
Authors |
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y. |
Title |
Colorectal cancer: genetics of development and metastasis. |
Journal |
|
Reference |
|
Authors |
Polakis P. |
Title |
The adenomatous polyposis coli (APC) tumor suppressor. |
Journal |
|
Reference |
|
Authors |
Behrens J. |
Title |
The role of the Wnt signalling pathway in colorectal tumorigenesis. |
Journal |
|
Reference |
|
Authors |
Giles RH, van Es JH, Clevers H |
Title |
Caught up in a Wnt storm: Wnt signaling in cancer. |
Journal |
|
Reference |
|
Authors |
Li X, Wu WK, Xing R, Wong SH, Liu Y, Fang X, Zhang Y, Wang M, Wang J, Li L, Zhou Y, Tang S, Peng S, Qiu K, Chen L, Chen K, Yang H, Zhang W, Chan MT, Lu Y, Sung JJ, Yu J |
Title |
Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability. |
Journal |
|