KEGG   PATHWAY: bna00908
Entry
bna00908                    Pathway                                
Name
Zeatin biosynthesis - Brassica napus (rape)
Description
Zeatin is a member of the cytokinin family, a class of phytohormones involved in various processes of growth and development in plants. Most abundant cytokinins are adenine-type, where the N6 position of adenine is substituted with an isoprenoid, such as in zeatin, or an aromatic side chain, such as in kinetin. Zeatin can be synthesized in two different pathways: the tRNA pathway and the AMP pathway. In the tRNA pathway zeatin is a recycled product of isopentenylated tRNAs. In the AMP pathway zeatin is synthesized from an isopentenyl donor, dimethylallyl diphosphate (DMAPP), and AMP, ADP, or ATP by isopentenyltransferases. After synthesis cytokinins can be glucosylated.
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
bna00908  Zeatin biosynthesis
bna00908

Other DBs
GO: 0009691
Organism
Brassica napus (rape) [GN:bna]
Gene
106379815  adenylate isopentenyltransferase 8, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106374850  adenylate isopentenyltransferase 7, mitochondrial-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106357101  adenylate isopentenyltransferase 1, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106355091  adenylate isopentenyltransferase 7, mitochondrial-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106356241  adenylate isopentenyltransferase 7, mitochondrial [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106356242  adenylate isopentenyltransferase 7, mitochondrial [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106365430  adenylate isopentenyltransferase 3, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106370918  adenylate isopentenyltransferase 8, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106377813  adenylate isopentenyltransferase 8, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106374178  adenylate isopentenyltransferase 3, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106385904  adenylate isopentenyltransferase 5, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106385487  adenylate isopentenyltransferase 5, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106395095  adenylate isopentenyltransferase 1, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106444096  adenylate isopentenyltransferase 8, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106431451  adenylate isopentenyltransferase 5, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106420240  adenylate isopentenyltransferase 1, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106444949  adenylate isopentenyltransferase 3, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106370472  adenylate isopentenyltransferase 5, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106409499  adenylate isopentenyltransferase 1, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106413713  adenylate isopentenyltransferase 3, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
106379345  cytokinin hydroxylase [KO:K10717]
106391900  cytokinin hydroxylase-like isoform X1 [KO:K10717]
106429444  cytokinin hydroxylase [KO:K10717]
125585523  cytokinin hydroxylase-like [KO:K10717]
106437984  cytokinin dehydrogenase 1-like precursor [KO:K00279] [EC:1.5.99.12]
106450132  cytokinin dehydrogenase 2-like precursor [KO:K00279] [EC:1.5.99.12]
106354495  cytokinin dehydrogenase 5 [KO:K00279] [EC:1.5.99.12]
106415860  cytokinin dehydrogenase 6 [KO:K00279] [EC:1.5.99.12]
106370330  cytokinin dehydrogenase 3 isoform X1 [KO:K00279] [EC:1.5.99.12]
106450662  cytokinin dehydrogenase 1-like [KO:K00279] [EC:1.5.99.12]
106450297  LOW QUALITY PROTEIN: cytokinin dehydrogenase 1 [KO:K00279] [EC:1.5.99.12]
106356750  cytokinin dehydrogenase 2 [KO:K00279] [EC:1.5.99.12]
106396215  cytokinin dehydrogenase 1-like [KO:K00279] [EC:1.5.99.12]
106371682  cytokinin dehydrogenase 7 isoform X1 [KO:K00279] [EC:1.5.99.12]
106374136  cytokinin dehydrogenase 3 [KO:K00279] [EC:1.5.99.12]
106384861  cytokinin dehydrogenase 7 [KO:K00279] [EC:1.5.99.12]
106395144  cytokinin dehydrogenase 1 [KO:K00279] [EC:1.5.99.12]
106405957  cytokinin dehydrogenase 5 [KO:K00279] [EC:1.5.99.12]
106406332  cytokinin dehydrogenase 6 [KO:K00279] [EC:1.5.99.12]
106417645  cytokinin dehydrogenase 3 [KO:K00279] [EC:1.5.99.12]
106409476  cytokinin dehydrogenase 2 [KO:K00279] [EC:1.5.99.12]
106409493  cytokinin dehydrogenase 4 [KO:K00279] [EC:1.5.99.12]
106417025  cytokinin dehydrogenase 4 [KO:K00279] [EC:1.5.99.12]
106421388  cytokinin dehydrogenase 7 [KO:K00279] [EC:1.5.99.12]
106389384  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
106432180  UDP-glycosyltransferase 76C2 [KO:K13493] [EC:2.4.1.-]
106432224  UDP-glycosyltransferase 76C1 isoform X1 [KO:K13493] [EC:2.4.1.-]
106419086  UDP-glycosyltransferase 76C2 [KO:K13493] [EC:2.4.1.-]
106380042  UDP-glycosyltransferase 73C7-like [KO:K13496] [EC:2.4.1.-]
106451092  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
106391489  UDP-glycosyltransferase 73C1-like [KO:K13496] [EC:2.4.1.-]
106367791  UDP-glycosyltransferase 73C7 [KO:K13496] [EC:2.4.1.-]
106392273  UDP-glycosyltransferase 73C2-like [KO:K13496] [EC:2.4.1.-]
106437892  UDP-glycosyltransferase 73C4-like [KO:K13496] [EC:2.4.1.-]
106364204  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
106375825  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
106375826  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
106375829  UDP-glycosyltransferase 73C12-like [KO:K13496] [EC:2.4.1.-]
106451088  UDP-glycosyltransferase 73C12-like [KO:K13496] [EC:2.4.1.-]
106451089  UDP-glycosyltransferase 73C12-like [KO:K13496] [EC:2.4.1.-]
106451093  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
106451096  UDP-glycosyltransferase 73C1-like [KO:K13496] [EC:2.4.1.-]
106437891  UDP-glycosyltransferase 73C5 [KO:K13496] [EC:2.4.1.-]
106443521  UDP-glycosyltransferase 73C12-like [KO:K13496] [EC:2.4.1.-]
106375828  UDP-glycosyltransferase 73C12-like [KO:K13496] [EC:2.4.1.-]
125585636  UDP-glycosyltransferase 73C1-like [KO:K13496] [EC:2.4.1.-]
125585638  UDP-glycosyltransferase 73C2-like [KO:K13496] [EC:2.4.1.-]
125585646  UDP-glycosyltransferase 73C1-like [KO:K13496] [EC:2.4.1.-]
125585647  UDP-glycosyltransferase 73C2-like [KO:K13496] [EC:2.4.1.-]
125598297  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
125609303  UDP-glycosyltransferase 73C12 [KO:K13496] [EC:2.4.1.-]
125609304  UDP-glycosyltransferase 73C12-like [KO:K13496] [EC:2.4.1.-]
106435475  LOW QUALITY PROTEIN: UDP-glycosyltransferase 85A1 [KO:K23452] [EC:2.4.1.-]
106358180  UDP-glycosyltransferase 85A3 [KO:K23452] [EC:2.4.1.-]
106397855  UDP-glycosyltransferase 85A4-like [KO:K23452] [EC:2.4.1.-]
106434206  UDP-glycosyltransferase 85A5-like [KO:K23452] [EC:2.4.1.-]
106451243  UDP-glycosyltransferase 85A5 [KO:K23452] [EC:2.4.1.-]
106358178  UDP-glycosyltransferase 85A1 [KO:K23452] [EC:2.4.1.-]
106451242  UDP-glycosyltransferase 85A2 isoform X2 [KO:K23452] [EC:2.4.1.-]
106425979  UDP-glycosyltransferase 85A5-like [KO:K23452] [EC:2.4.1.-]
106358176  UDP-glycosyltransferase 85A1-like [KO:K23452] [EC:2.4.1.-]
106435467  LOW QUALITY PROTEIN: UDP-glycosyltransferase 85A1 [KO:K23452] [EC:2.4.1.-]
106397643  UDP-glycosyltransferase 85A2 isoform X2 [KO:K23452] [EC:2.4.1.-]
106416530  UDP-glycosyltransferase 85A4 [KO:K23452] [EC:2.4.1.-]
106386723  tRNA dimethylallyltransferase 9-like [KO:K00791] [EC:2.5.1.75]
106424236  tRNA dimethylallyltransferase 2-like [KO:K00791] [EC:2.5.1.75]
106446741  tRNA dimethylallyltransferase 2-like [KO:K00791] [EC:2.5.1.75]
106434529  tRNA dimethylallyltransferase 9-like [KO:K00791] [EC:2.5.1.75]
106425705  tRNA dimethylallyltransferase 9-like [KO:K00791] [EC:2.5.1.75]
106380719  tRNA dimethylallyltransferase 9 [KO:K00791] [EC:2.5.1.75]
Compound
C00002  ATP
C00008  ADP
C00015  UDP
C00019  S-Adenosyl-L-methionine
C00020  AMP
C00029  UDP-glucose
C00033  Acetate
C00147  Adenine
C00170  5'-Methylthioadenosine
C00190  UDP-D-xylose
C00235  Dimethylallyl diphosphate
C00371  Zeatin
C00979  O-Acetyl-L-serine
C01513  Lupinate
C01804  Discadenine
C02029  Dihydrozeatin
C03300  O-beta-D-Xylosylzeatin
C03423  O-beta-D-Glucosylzeatin
C04083  N6-(Delta2-Isopentenyl)-adenine
C04432  tRNA containing 6-isopentenyladenosine
C04713  N6-(delta2-Isopentenyl)-adenosine 5'-monophosphate
C07330  3-Methyl-2-butenal
C15545  cis-Zeatin
C15546  O-beta-D-Glucopyranosyl-cis-zeatin
C16424  Isopentenyladenosine-5'-triphosphate
C16426  Isopentenyladenosine-5'-diphosphate
C16427  Isopentenyl adenosine
C16428  trans-Zeatin riboside triphosphate
C16429  trans-Zeatin riboside diphosphate
C16430  trans-Zeatin riboside monophosphate
C16431  trans-Zeatin riboside
C16441  cis-Zeatin riboside monophosphate
C16443  trans-Zeatin-7-beta-D-glucoside
C16445  Dihydrozeatin riboside monophosphate
C16447  Dihydrozeatin riboside
C16448  Dihydrozeatin-O-glucoside
C16449  cis-Zeatin riboside
C16467  cis-Prenyl-tRNA
C17324  tRNA adenine
Reference
PMID:14726522
  Authors
Kasahara H, Takei K, Ueda N, Hishiyama S, Yamaya T, Kamiya Y, Yamaguchi S, Sakakibara H.
  Title
Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis.
  Journal
J Biol Chem 279:14049-54 (2004)
DOI:10.1074/jbc.M314195200
Reference
PMID:11313355
  Authors
Takei K, Sakakibara H, Sugiyama T.
  Title
Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.
  Journal
J Biol Chem 276:26405-10 (2001)
DOI:10.1074/jbc.M102130200
Reference
PMID:11479373
  Authors
Kakimoto T.
  Title
Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.
  Journal
Plant Cell Physiol 42:677-85 (2001)
DOI:10.1093/pcp/pce112
Reference
PMID:15280363
  Authors
Takei K, Yamaya T, Sakakibara H.
  Title
Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin.
  Journal
J Biol Chem 279:41866-72 (2004)
DOI:10.1074/jbc.M406337200
Reference
PMID:15342621
  Authors
Hou B, Lim EK, Higgins GS, Bowles DJ.
  Title
N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana.
  Journal
J Biol Chem 279:47822-32 (2004)
DOI:10.1074/jbc.M409569200
Reference
PMID:9874810
  Authors
Martin RC, Mok MC, Mok DW
  Title
Isolation of a cytokinin gene, ZOG1, encoding zeatin O-glucosyltransferase from Phaseolus lunatus.
  Journal
Proc Natl Acad Sci U S A 96:284-9 (1999)
DOI:10.1073/pnas.96.1.284
Reference
PMID:10364407
  Authors
Martin RC, Mok MC, Mok DW
  Title
A gene encoding the cytokinin enzyme zeatin O-xylosyltransferase of Phaseolus vulgaris.
  Journal
Plant Physiol 120:553-8 (1999)
DOI:10.1104/pp.120.2.553
Reference
PMID:12644686
  Authors
Veach YK, Martin RC, Mok DW, Malbeck J, Vankova R, Mok MC
  Title
O-glucosylation of cis-zeatin in maize. Characterization of genes, enzymes, and endogenous cytokinins.
  Journal
Plant Physiol 131:1374-80 (2003)
DOI:10.1104/pp.017210
Reference
PMID:14555694
  Authors
Werner T, Motyka V, Laucou V, Smets R, Van Onckelen H, Schmulling T
  Title
Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity.
  Journal
Plant Cell 15:2532-50 (2003)
DOI:10.1105/tpc.014928
Reference
PMID:17062755
  Authors
Miyawaki K, Tarkowski P, Matsumoto-Kitano M, Kato T, Sato S, Tarkowska D, Tabata S, Sandberg G, Kakimoto T
  Title
Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 103:16598-603 (2006)
DOI:10.1073/pnas.0603522103
Related
pathway
bna00900  Terpenoid backbone biosynthesis
KO pathway
ko00908   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (90)   
   KEGG GENES (90)   
All databases (91)   

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