KEGG   PATHWAY: cjc04145
Entry
cjc04145                    Pathway                                
Name
Phagosome - Callithrix jacchus (white-tufted-ear marmoset)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
cjc04145  Phagosome
cjc04145

Other DBs
GO: 0045335
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100394146  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
100392943  STX12; syntaxin-12 isoform X1 [KO:K13813]
100413538  STX7; syntaxin-7 [KO:K08488]
100398645  actin, cytoplasmic 2-like [KO:K05692]
100404409  actin, cytoplasmic 1-like [KO:K05692]
100406907  actin, cytoplasmic 2-like [KO:K05692]
100410882  actin, cytoplasmic 2-like [KO:K05692]
100412618  actin, cytoplasmic 1 [KO:K05692]
100409006  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100388094  actin, cytoplasmic 2 [KO:K05692]
100406296  ACTB; actin, cytoplasmic 1 [KO:K05692]
100401391  actin, cytoplasmic 2-like [KO:K05692]
118150586  actin, cytoplasmic 2-like [KO:K05692]
100392238  CORO1A; coronin-1A [KO:K13882]
100411497  STX18; syntaxin-18 isoform X1 [KO:K08492]
100389503  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
100406240  saoe class I histocompatibility antigen, A alpha chain isoform X1 [KO:K06751]
100398361  patr class I histocompatibility antigen, CH28 alpha chain isoform X3 [KO:K06751]
100405128  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
100399078  patr class I histocompatibility antigen, A-126 alpha chain isoform X3 [KO:K06751]
100411069  patr class I histocompatibility antigen, A-126 alpha chain isoform X6 [KO:K06751]
100388209  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
100387811  CAJA-E; patr class I histocompatibility antigen, alpha chain E precursor [KO:K06751]
118151094  saoe class I histocompatibility antigen, A alpha chain [KO:K06751]
100386155  CAJA-DRB1; HLA class II histocompatibility antigen, DRB1-13 beta chain-like precursor [KO:K06752]
100397732  HLA class II histocompatibility antigen, DR beta 5 chain [KO:K06752]
100386865  HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752]
100387227  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
100405222  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752]
100411388  HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752]
100412691  CAJA-DMB; HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
100408132  CAJA-DOA; HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100408503  CAJA-DPB1; HLA class II histocompatibility antigen, DP beta 1 chain isoform X3 [KO:K06752]
100407771  CAJA-DMA; HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
100413648  CAJA-DPA1; HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
100385427  CAJA-DRA; HLA class II histocompatibility antigen, DR alpha chain precursor [KO:K06752]
128931734  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
100389972  RAB5A; ras-related protein Rab-5A [KO:K07887]
100894569  ras-related protein Rab-5A-like [KO:K07887]
100408426  RAB5B; ras-related protein Rab-5B [KO:K07888]
100410452  RAB5C; ras-related protein Rab-5C [KO:K07889]
100402865  EEA1; early endosome antigen 1 isoform X3 [KO:K12478]
100414570  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
100407510  TFRC; transferrin receptor protein 1 [KO:K06503]
100391698  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
100411357  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100400819  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
100405540  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100402895  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X10 [KO:K02148]
100395645  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
100399709  ATP6V1D; V-type proton ATPase subunit D isoform X4 [KO:K02149]
100402779  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
100396342  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
100397160  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
100415557  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
100396510  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X2 [KO:K02152]
103795015  V-type proton ATPase subunit G 1-like [KO:K02152]
100393000  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
100407218  V-type proton ATPase subunit e 2 [KO:K02153]
100405532  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 isoform X1 [KO:K02154]
100412131  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X5 [KO:K02154]
100406490  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 isoform X1 [KO:K02154]
100896337  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
100400110  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
100385552  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
100408708  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
100397181  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
100414397  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X3 [KO:K03661]
100386892  ATP6AP1; V-type proton ATPase subunit S1 isoform X1 [KO:K03662]
100398786  RAB7A; ras-related protein Rab-7a [KO:K07897]
100406718  RAB7B; ras-related protein Rab-7b isoform X3 [KO:K07898]
100404635  RILP; rab-interacting lysosomal protein isoform X1 [KO:K13883]
100415628  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
100414677  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
100406953  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X7 [KO:K10415]
100402490  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X2 [KO:K10415]
100405807  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
100408371  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
100404055  tubulin alpha-3 chain [KO:K07374]
100403861  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
100410702  tubulin alpha-4A chain-like [KO:K07374]
100400294  TUBA4A; tubulin alpha-4A chain isoform X3 [KO:K07374]
100410466  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
100392817  tubulin alpha-1A chain [KO:K07374]
100409161  TUBA1C; tubulin alpha-1C chain isoform X1 [KO:K07374]
100392213  tubulin alpha-1B chain [KO:K07374]
100390144  LOW QUALITY PROTEIN: tubulin alpha-3 chain [KO:K07374]
118147191  tubulin alpha-3 chain [KO:K07374]
100395528  TUBB4B; tubulin beta-4B chain [KO:K07375]
100403851  tubulin beta-8 chain [KO:K07375]
100389230  tubulin beta-8 chain [KO:K07375]
100409299  TUBB6; tubulin beta-6 chain isoform X2 [KO:K07375]
100386618  LOW QUALITY PROTEIN: tubulin beta-3 chain-like [KO:K07375]
100386505  TUBB2B; tubulin beta-2B chain [KO:K07375]
100409603  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
100415692  TUBB4A; tubulin beta-4A chain [KO:K07375]
100394345  LOW QUALITY PROTEIN: tubulin beta-3 chain-like [KO:K07375]
100400472  LOW QUALITY PROTEIN: tubulin beta chain [KO:K07375]
103792349  TUBB; tubulin beta chain [KO:K07375]
118152807  TUBB2A; tubulin beta-2A chain [KO:K07375]
100411833  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
100398116  LAMP2; LOW QUALITY PROTEIN: lysosome-associated membrane glycoprotein 2 [KO:K06528]
100415724  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X6 [KO:K00921] [EC:2.7.1.150]
100409522  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
100895717  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
100408045  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
100412536  CTSL; procathepsin L isoform X2 [KO:K01365] [EC:3.4.22.15]
100410974  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
100409214  CTSS; cathepsin S isoform X2 [KO:K01368] [EC:3.4.22.27]
100415365  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
100413259  SEC61A1; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
100413011  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
108590794  protein transport protein Sec61 subunit beta-like [KO:K09481]
100411550  SEC61G; protein transport protein Sec61 subunit gamma isoform X2 [KO:K07342]
100407051  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100406316  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
100401971  CALR; calreticulin [KO:K08057]
100384924  CANX; calnexin [KO:K08054]
100393738  FCGR1A; high affinity immunoglobulin gamma Fc receptor I isoform X2 [KO:K06498]
100387574  FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a isoform X2 [KO:K06472]
100412558  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X3 [KO:K12560]
100387926  low affinity immunoglobulin gamma Fc region receptor III-A-like isoform X1 [KO:K06463]
103793556  immunoglobulin heavy variable 1-18 [KO:K06856]
100386784  C1R; complement C1r subcomponent isoform X1 [KO:K01330] [EC:3.4.21.41]
100389341  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
100402685  ITGB2; integrin beta-2 isoform X2 [KO:K06464]
100400501  C3; complement C3 [KO:K03990]
100413014  COLEC11; collectin-11 isoform X1 [KO:K10066]
100392117  COLEC12; collectin-12 isoform X1 [KO:K10062]
100387292  MBL2; mannose-binding protein C isoform X1 [KO:K03991]
100395728  mannose-binding protein A-like isoform X2 [KO:K03991]
100397554  mannose-binding protein A-like [KO:K03991]
100397920  SFTPA2; pulmonary surfactant-associated protein A1 isoform X1 [KO:K10067]
118146273  pulmonary surfactant-associated protein A1-like [KO:K10067]
100415006  SFTPD; pulmonary surfactant-associated protein D [KO:K10068]
100391820  LOW QUALITY PROTEIN: pulmonary surfactant-associated protein D [KO:K10068]
100389906  ITGAV; integrin alpha-V [KO:K06487]
100403636  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
100386674  ITGA5; integrin alpha-5 [KO:K06484]
100394145  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100386042  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100395279  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
100390178  THBS1; thrombospondin-1 [KO:K16857]
100397101  THBS3; thrombospondin-3 isoform X3 [KO:K04659]
100391690  COMP; cartilage oligomeric matrix protein [KO:K04659]
100391538  THBS4; thrombospondin-4 [KO:K04659]
100401976  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
100404611  TLR2; toll-like receptor 2 [KO:K10159]
100390591  TLR6; toll-like receptor 6 [KO:K10169]
100399012  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
100895453  CD14; monocyte differentiation antigen CD14 [KO:K04391]
100406333  MRC2; C-type mannose receptor 2 isoform X2 [KO:K06560]
100401998  PLA2R1; secretory phospholipase A2 receptor isoform X2 [KO:K06560]
100399087  MRC1; macrophage mannose receptor 1 [KO:K06560]
100410070  CD209; CD209 antigen [KO:K06563]
100386005  CD209 antigen-like protein 2-like [KO:K06563]
100400667  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
100386222  MSR1; macrophage scavenger receptor types I and II isoform X1 [KO:K06558]
100405369  MARCO; macrophage receptor MARCO [KO:K13884]
100400307  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
128931136  LOW QUALITY PROTEIN: oxidized low-density lipoprotein receptor 1-like [KO:K08763]
100389325  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
100387385  CD36; platelet glycoprotein 4 [KO:K06259]
100414967  CYBA; cytochrome b-245 light chain isoform X2 [KO:K08009]
100415466  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100404109  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100895294  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
100402613  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
100390952  NCF2; neutrophil cytosol factor 2 isoform X2 [KO:K08010]
100393114  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
cjc04142  Lysosome
cjc04144  Endocytosis
cjc04610  Complement and coagulation cascades
cjc04612  Antigen processing and presentation
cjc04620  Toll-like receptor signaling pathway
cjc04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   

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Genome (1)   
   KEGG GENOME (1)   
Gene (170)   
   KEGG GENES (170)   
All databases (171)   

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