KEGG   PATHWAY: dme04150
dme04150                    Pathway                                

mTOR signaling pathway - Drosophila melanogaster (fruit fly)
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Environmental Information Processing; Signal transduction
Pathway map
dme04150  mTOR signaling pathway

Drosophila melanogaster (fruit fly) [GN:dme]
Dmel_CG3297  mnd; minidiscs, isoform A [KO:K13780]
Dmel_CG6070  gb; genderblind, isoform B [KO:K13780]
Dmel_CG12317  JhI-21; juvenile hormone Inducible-21, isoform C [KO:K13780]
Dmel_CG2791  CD98hc; CD98 heavy chain, isoform G [KO:K06519]
Dmel_CG3762  Vha68-2; vacuolar H[+] ATPase 68 kDa subunit 2, isoform D [KO:K02145] [EC:]
Dmel_CG5075  Vha68-3; vacuolar H[+] ATPase 68kD subunit 3 [KO:K02145] [EC:]
Dmel_CG12403  Vha68-1; vacuolar H[+] ATPase 68kD subunit 1, isoform B [KO:K02145] [EC:]
Dmel_CG17369  Vha55; vacuolar H[+]-ATPase 55kD subunit, isoform C [KO:K02147]
Dmel_CG8048  Vha44; vacuolar H[+] ATPase 44kD subunit, isoform F [KO:K02148]
Dmel_CG8310  Vha36-3; vacuolar H[+] ATPase 36kD subunit 3, isoform C [KO:K02149]
Dmel_CG8186  Vha36-1; vacuolar H[+] ATPase 36kD subunit 1 [KO:K02149]
Dmel_CG13167  Vha36-2; vacuolar H[+] ATPase 36kD subunit 2 [KO:K02149]
Dmel_CG1088  Vha26; vacuolar H[+]-ATPase 26kD subunit, isoform C [KO:K02150]
Dmel_CG8210  Vha14-1; vacuolar H[+] ATPase 14kD subunit 1 [KO:K02151]
Dmel_CG1076  Vha14-2; vacuolar H[+] ATPase 14kD subunit 2, isoform A [KO:K02151]
Dmel_CG15719  CG15719; uncharacterized protein, isoform D [KO:K02151]
Dmel_CG6213  Vha13; vacuolar H[+] ATPase 13kD subunit, isoform B [KO:K02152]
Dmel_CG17332  VhaSFD; vacuolar H[+]-ATPase SFD subunit, isoform E [KO:K02144]
Dmel_CG14184  CG14184; uncharacterized protein, isoform B [KO:K20397]
Dmel_CG5189  CG5189; uncharacterized protein, isoform B [KO:K20398]
Dmel_CG5110  CG5110; uncharacterized protein, isoform B [KO:K04370]
Dmel_CG14977  CG14977; uncharacterized protein, isoform A [KO:K20399]
Dmel_CG14812  CG14812; uncharacterized protein, isoform B [KO:K16344]
Dmel_CG8616  BHD; Birt-Hogg-Dube [KO:K09594]
Dmel_CG3764  CG3764; uncharacterized protein, isoform B [KO:K20401]
Dmel_CG11968  RagA-B; Ras-related GTP binding A/B [KO:K16185]
Dmel_CG8707  RagC-D; Ras-related GTP binding C/D [KO:K16186]
Dmel_CG7074  mio; missing oocyte [KO:K20407]
Dmel_CG8722  Nup44A; nucleoporin at 44A, isoform A [KO:K14299]
Dmel_CG7609  Wdr24; WD repeat domain 24, isoform B [KO:K20408]
Dmel_CG4705  Wdr59; WD repeat domain 59, isoform D [KO:K20409]
Dmel_CG6773  Sec13; secretory 13, isoform B [KO:K14004]
Dmel_CG12090  Iml1; increased minichromosome loss 1, isoform A [KO:K20404]
Dmel_CG9104  Nprl2; nitrogen permease regulator-like 2 [KO:K20405]
Dmel_CG8783  Nprl3; nitrogen permease regulator-like 3, isoform C [KO:K20406]
Dmel_CG9772  Skp2; S-phase kinase-associated protein 2, isoform A [KO:K03875]
Dmel_CG4320  raptor; raptor, isoform C [KO:K07204]
Dmel_CG5092  Tor; target of rapamycin, isoform A [KO:K07203] [EC:]
Dmel_CG3004  Lst8; Lst8 [KO:K08266]
Dmel_CG16908  CG16908; uncharacterized protein [KO:K20403]
Dmel_CG5020  CLIP-190; cytoplasmic linker protein 190, isoform A [KO:K10421]
Dmel_CG8709  Lpin; lipin, isoform B [KO:K15728] [EC:]
Dmel_CG10967  Atg1; Autophagy-related 1, isoform B [KO:K08269] [EC:]
Dmel_CG1442  eIF4E6; eukaryotic translation initiation factor 4E6, isoform B [KO:K03259]
Dmel_CG10124  eIF4E4; eukaryotic translation initiation factor 4E4 [KO:K03259]
Dmel_CG4035  eIF4E1; eukaryotic translation initiation factor 4E1, isoform H [KO:K03259]
Dmel_CG33100  eIF4EHP; eukaryotic translation initiation factor 4E homologous protein, isoform B [KO:K03259]
Dmel_CG8023  eIF4E3; eukaryotic translation initiation factor 4E3 [KO:K03259]
Dmel_CG32859  eIF4E7; eukaryotic translation initiation factor 4E7 [KO:K03259]
Dmel_CG8277  eIF4E5; eukaryotic translation initiation factor 4E5 [KO:K03259]
Dmel_CG10539  S6k; ribosomal protein S6 kinase, isoform B [KO:K04688] [EC:]
Dmel_CG10837  eIF4B; eukaryotic translation initiation factor 4B, isoform B [KO:K03258]
Dmel_CG10944  RpS6; ribosomal protein S6, isoform B [KO:K02991]
Dmel_CG40293  Stlk; Ste20-like kinase, isoform A [KO:K08271]
Dmel_CG9374  Lkb1; Lkb1 kinase, isoform J [KO:K07298] [EC:]
Dmel_CG4083  Mo25; Mo25, isoform B [KO:K08272]
Dmel_CG3051  AMPKalpha; AMP-activated protein kinase alpha subunit, isoform A [KO:K07198] [EC:]
Dmel_CG6147  Tsc1; Tsc1 [KO:K07206]
Dmel_CG6975  gig; gigas, isoform B [KO:K07207]
Dmel_CG6182  TBC1d7; TBC1 domain family member 7 [KO:K20396]
Dmel_CG1081  Rheb; Ras homolog enriched in brain, isoform A [KO:K07208]
Dmel_CG4889  wg; wingless [KO:K03209]
Dmel_CG6407  Wnt5; Wnt oncogene analog 5, isoform B [KO:K00444]
Dmel_CG4969  Wnt6; Wnt oncogene analog 6, isoform C [KO:K00445]
Dmel_CG8458  wntD; wnt inhibitor of dorsal [KO:K00714]
Dmel_CG4971  Wnt10; Wnt oncogene analog 10 [KO:K01357]
Dmel_CG17697  fz; frizzled, isoform A [KO:K02432]
Dmel_CG4626  fz4; frizzled 4, isoform A [KO:K02354]
Dmel_CG9739  fz2; frizzled 2, isoform C [KO:K02375]
Dmel_CG16785  fz3; frizzled 3, isoform C [KO:K04690]
Dmel_CG5912  arr; arrow [KO:K03068]
Dmel_CG18361  dsh; dishevelled [KO:K02353]
Dmel_CG2621  sgg; shaggy, isoform B [KO:K03083] [EC:]
Dmel_CG31003  gskt; gasket [KO:K03083] [EC:]
Dmel_CG4201  IKKbeta; I-kappaB kinase beta [KO:K07209] [EC:]
Dmel_CG33273  Ilp5; Insulin-like peptide 5 [KO:K04526]
Dmel_CG8167  Ilp2; Insulin-like peptide 2 [KO:K04526]
Dmel_CG14173  Ilp1; Insulin-like peptide 1 [KO:K04526]
Dmel_CG14167  Ilp3; Insulin-like peptide 3 [KO:K04526]
Dmel_CG6736  Ilp4; Insulin-like peptide 4 [KO:K04526]
Dmel_CG14049  Ilp6; Insulin-like peptide 6, isoform B [KO:K05459]
Dmel_CG18402  InR; Insulin-like receptor, isoform B [KO:K05087] [EC:]
Dmel_CG6033  drk; downstream of receptor kinase, isoform A [KO:K04364]
Dmel_CG7793  Sos; Son of sevenless [KO:K03099]
Dmel_CG9375  Ras85D; Ras oncogene at 85D [KO:K07827]
Dmel_CG2845  Raf; Raf oncogene, isoform E [KO:K04365] [EC:]
Dmel_CG15793  Dsor1; downstream of raf1, isoform A [KO:K04368] [EC:]
Dmel_CG12559  rl; rolled, isoform C [KO:K04371] [EC:]
Dmel_CG17596  S6kII; ribosomal protein S6 kinase II, isoform B [KO:K04373] [EC:]
Dmel_CG5686  chico; chico, isoform B [KO:K16172]
Dmel_CG2699  Pi3K21B; Pi3K21B, isoform C [KO:K02649]
Dmel_CG4141  Pi3K92E; phosphatidylinositol 3-kinase 92E, isoform C [KO:K00922] [EC:]
Dmel_CG5671  Pten; phosphatase and tensin homolog, isoform G [KO:K01110] [EC:]
Dmel_CG1210  Pdk1; Phosphoinositide-dependent kinase 1, isoform J [KO:K06276] [EC:]
Dmel_CG4006  Akt1; Akt1, isoform C [KO:K04456] [EC:]
Dmel_CG10105  Sin1; SAPK-interacting protein 1 [KO:K20410]
Dmel_CG8002  rictor; rapamycin-insensitive companion of Tor, isoform B [KO:K08267]
Dmel_CG8416  Rho1; Rho1, isoform A [KO:K04513]
Dmel_CG6518  inaC; inactivation no afterpotential C [KO:K02677] [EC:]
Dmel_CG6622  Pkc53E; protein C kinase 53E, isoform B [KO:K02677] [EC:]
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Kennedy BK, Lamming DW
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
Cell Metab 23:990-1003 (2016)
Shimobayashi M, Hall MN
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
Nat Rev Mol Cell Biol 15:155-62 (2014)
Huang K, Fingar DC
Growing knowledge of the mTOR signaling network.
Semin Cell Dev Biol 36:79-90 (2014)
Bockaert J, Marin P
mTOR in Brain Physiology and Pathologies.
Physiol Rev 95:1157-87 (2015)
Caron A, Richard D, Laplante M
The Roles of mTOR Complexes in Lipid Metabolism.
Annu Rev Nutr 35:321-48 (2015)
Shimobayashi M, Hall MN
Multiple amino acid sensing inputs to mTORC1.
Cell Res 26:7-20 (2016)
Bar-Peled L, Sabatini DM
Regulation of mTORC1 by amino acids.
Trends Cell Biol 24:400-6 (2014)
Fingar DC
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
Mol Cell 58:713-5 (2015)
Cai H, Dong LQ, Liu F
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
Trends Pharmacol Sci 37:303-17 (2016)
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
Br J Haematol 166:336-51 (2014)
Jewell JL, Guan KL
Nutrient signaling to mTOR and cell growth.
Trends Biochem Sci 38:233-42 (2013)
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
ASN Neuro 5:e00108 (2013)
Kim SG, Buel GR, Blenis J
Nutrient regulation of the mTOR complex 1 signaling pathway.
Mol Cells 35:463-73 (2013)
Laplante M, Sabatini DM
mTOR signaling at a glance.
J Cell Sci 122:3589-94 (2009)
Alessi DR, Sakamoto K, Bayascas JR
LKB1-dependent signaling pathways.
Annu Rev Biochem 75:137-63 (2006)
Dan HC, Antonia RJ, Baldwin AS
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
Oncotarget 7:21064-75 (2016)
Saxton RA, Sabatini DM
mTOR Signaling in Growth, Metabolism, and Disease.
Cell 168:960-976 (2017)
dme00561  Glycerolipid metabolism
dme04140  Autophagy - animal
KO pathway

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