KEGG   PATHWAY: dse04013
dse04013                    Pathway                                

MAPK signaling pathway - fly - Drosophila sechellia
The mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role in mitosis, apoptosis, motility and metabolism. In fruit fly, three major classes of MAPK pathways have been distinguished with little or no redundancy, including extracellular signal-regulated kinase (ERK) / Rolled, c-Jun N-terminal kinase (JNK) / Bsk, and p38 kinase. Signals from growth factors or mitogens are dominantly transduced by the ERK pathway, whereas the JNK and p38 pathways are activated mostly by environmental stresses. The MAPK signaling cascades are typically linked to regulation of gene expression, because transcription factors are often the targets of regulatory phosphorylation events.
Environmental Information Processing; Signal transduction
Pathway map
dse04013  MAPK signaling pathway - fly

Other DBs
GO: 0000165
Drosophila sechellia [GN:dse]
6607334  torso-like protein [KO:K12377]
116800232  protein trunk [KO:K20226]
6612328  uncharacterized protein LOC6612328 [KO:K20227]
6605965  protein giant-lens [KO:K02104]
6610925  protein vein isoform X2 [KO:K16690]
6614716  protein spitz [KO:K20229]
6611692  protein gurken [KO:K02447]
6606113  protein spitz [KO:K16691]
6615396  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:]
6617775  uncharacterized protein LOC6617775 [KO:K20230]
116801596  protein bride of sevenless [KO:K04623]
6605028  SHC-transforming protein 4 [KO:K06279]
6610496  protein daughter of sevenless [KO:K20231]
6616088  tyrosine-protein phosphatase corkscrew isoform X2 [KO:K07293] [EC:]
6611201  protein son of sevenless [KO:K03099]
6610636  protein sprouty [KO:K17383]
6620727  ras GTPase-activating protein 1 [KO:K04352]
6605110  GTPase-activating protein isoform X2 [KO:K12380]
6616144  raf homolog serine/threonine-protein kinase Raf [KO:K04365] [EC:]
6608463  14-3-3 protein zeta isoform X3 [KO:K16197]
6611581  serine/threonine-protein phosphatase PP2A isoform X1 [KO:K04382] [EC:]
6613953  kinase suppressor of Ras 1 [KO:K18529] [EC:]
6620447  dual specificity mitogen-activated protein kinase kinase dSOR1 isoform X1 [KO:K04368] [EC:]
6620522  mitogen-activated protein kinase ERK-A isoform X1 [KO:K04371] [EC:]
6615405  uncharacterized protein LOC6615405 [KO:K20220] [EC:]
6604817  importin-7 [KO:K20223]
6612916  protein tailless [KO:K08545]
6617015  protein groucho isoform X1 [KO:K04497]
6613814  Krueppel-like factor 16 [KO:K12379]
6607563  ETS-like protein pointed isoform X2 [KO:K02678]
6620617  ets DNA-binding protein pokkuri [KO:K03211]
6609835  uncharacterized protein LOC6609835 [KO:K20232]
6611688  exportin-1 [KO:K14290]
6609148  protein phyllopod [KO:K20233]
6606021  E3 ubiquitin-protein ligase sina [KO:K04506] [EC:]
6606022  probable E3 ubiquitin-protein ligase sinah [KO:K04506] [EC:]
6617249  F-box-like/WD repeat-containing protein ebi [KO:K04508]
6606359  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:]
6620460  protein lozenge isoform X1 [KO:K20214]
6606834  homeobox protein prospero isoform X1 [KO:K20211]
6608456  protein eiger isoform X1 [KO:K16678]
6614887  tumor necrosis factor receptor superfamily member wengen [KO:K16679]
6618976  uncharacterized protein LOC6618976 [KO:K20234]
6619143  tyrosine-protein kinase Src42A isoform X3 [KO:K08892] [EC:]
6610805  tyrosine-protein kinase Src64B [KO:K05704] [EC:]
6611649  tyrosine-protein kinase Btk29A isoform X1 [KO:K07364] [EC:]
6609395  tyrosine-protein kinase Shark [KO:K17512] [EC:]
6610494  mitogen-activated protein kinase kinase kinase kinase 4 isoform X2 [KO:K08840] [EC:]
6610295  ras-related protein Rac1 [KO:K04392]
6611146  ras-related protein Rac2 [KO:K04392]
6621686  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
6607106  LOW QUALITY PROTEIN: ras-like GTP-binding protein RhoL [KO:K04392]
6620179  TNF receptor-associated factor 6 [KO:K03175] [EC:]
6611953  ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:]
6609916  putative mediator of RNA polymerase II transcription subunit 12 isoform X1 [KO:K04404]
6620185  mitogen-activated protein kinase kinase kinase isoform X1 [KO:K04417] [EC:]
6615141  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:]
6619218  putative mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:]
6617041  protein phosphatase 1A [KO:K04461] [EC:]
6621278  protein phosphatase 1B isoform X1 [KO:K04461] [EC:]
6618620  dual specificity mitogen-activated protein kinase kinase hemipterous isoform X1 [KO:K04431] [EC:]
6607241  dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:]
6611938  stress-activated protein kinase JNK [KO:K04440] [EC:]
6611606  striatin-4 isoform X1 [KO:K17608]
6608460  LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
6612743  transcription factor kayak isoform X4 [KO:K09031]
6612491  zinc finger protein 236 [KO:K20210]
6611740  uncharacterized protein LOC6611740 isoform X1 [KO:K20235]
6613103  protein decapentaplegic isoform X1 [KO:K04662]
6613554  profilin [KO:K05759]
6607318  tyrosine-protein phosphatase vhp-1 [KO:K20216] [EC:]
6613461  bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:]
6613723  mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:]
6619027  mitogen-activated protein kinase kinase kinase 15 [KO:K04426] [EC:]
6618621  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04432] [EC:]
6611191  mitogen-activated protein kinase p38b [KO:K04441] [EC:]
6607690  putative mitogen-activated protein kinase 14C [KO:K04441] [EC:]
6607691  mitogen-activated protein kinase p38a [KO:K04441] [EC:]
6618893  cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
6613156  dual oxidase isoform X1 [KO:K13411] [EC: 1.11.1.-]
6612505  optomotor-blind protein isoform X1 [KO:K10176]
6608433  myocyte-specific enhancer factor 2 isoform X1 [KO:K09260]
6609491  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:]
Sopko R, Perrimon N
Receptor tyrosine kinases in Drosophila development.
Cold Spring Harb Perspect Biol 5:a009050 (2013)
Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.
Dev Dyn 232:656-72 (2005)
Shilo BZ
Signaling by the Drosophila epidermal growth factor receptor pathway during development.
Exp Cell Res 284:140-9 (2003)
Raabe T
The sevenless signaling pathway: variations of a common theme.
Biochim Biophys Acta 1496:151-63 (2000)
Rios-Barrera LD, Riesgo-Escovar JR
Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway.
Genesis 51:147-62 (2013)
Igaki T, Miura M
The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.
Semin Immunol 26:267-74 (2014)
Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX
Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli.
Cell Signal 18:441-8 (2006)
Stronach BE, Perrimon N
Stress signaling in Drosophila.
Oncogene 18:6172-82 (1999)
dse04214  Apoptosis - fly
KO pathway

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