KEGG   PATHWAY: hsa00740Help
Entry
hsa00740                    Pathway                                

Name
Riboflavin metabolism - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
hsa00740  Riboflavin metabolism
hsa00740

Ortholog table
Disease
H01002  Generalized arterial calcification of infancy
H01113  Acid phosphatase deficiency
H01394  Cole disease
Other DBs
BSID: 83012
GO: 0006771
Organism
Homo sapiens (human) [GN:hsa]
Gene
55312  RFK; riboflavin kinase [KO:K00861] [EC:2.7.1.26]
54  ACP5; acid phosphatase 5, tartrate resistant [KO:K14379] [EC:3.1.3.2]
52  ACP1; acid phosphatase 1 [KO:K14394] [EC:3.1.3.48 3.1.3.2]
53  ACP2; acid phosphatase 2, lysosomal [KO:K14410] [EC:3.1.3.2]
80308  FLAD1; flavin adenine dinucleotide synthetase 1 [KO:K00953] [EC:2.7.7.2]
5167  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.6.1.9 3.1.4.1]
5169  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.6.1.9 3.1.4.1]
645  BLVRB; biliverdin reductase B [KO:K05901] [EC:1.5.1.30 1.3.1.24]
Compound
C00016  FAD
C00044  GTP
C00061  FMN
C00199  D-Ribulose 5-phosphate
C00255  Riboflavin
C00474  Ribitol
C01007  Reduced riboflavin
C01268  5-Amino-6-(5'-phosphoribosylamino)uracil
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C01352  FADH2
C01727  Lumichrome
C01847  Reduced FMN
C03114  Dimethylbenzimidazole
C04332  6,7-Dimethyl-8-(D-ribityl)lumazine
C04454  5-Amino-6-(5'-phospho-D-ribitylamino)uracil
C04732  5-Amino-6-(1-D-ribitylamino)uracil
C05995  7-Hydroxy-6-methyl-8-ribityllumazine
C15556  L-3,4-Dihydroxybutan-2-one 4-phosphate
C15563  2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C18910  2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one
Reference
  Authors
Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS.
  Title
Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.
  Journal
Nucleic Acids Res 30:3141-51 (2002)
DOI:10.1093/nar/30.14.3141
Reference
  Authors
Fischer M, Haase I, Feicht R, Richter G, Gerhardt S, Changeux JP, Huber R, Bacher A.
  Title
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
  Journal
Eur J Biochem 269:519-26 (2002)
DOI:10.1046/j.0014-2956.2001.02674.x
Reference
  Authors
Haase I, Fischer M, Bacher A, Schramek N.
  Title
Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
  Journal
J Biol Chem 278:37909-15 (2003)
DOI:10.1074/jbc.M303090200
Reference
  Authors
Fischer M, Romisch W, Illarionov B, Eisenreich W, Bacher A.
  Title
Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.
  Journal
Biochem Soc Trans 33:780-4 (2005)
DOI:10.1042/BST0330780
KO pathway
ko00740   

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