KEGG   PATHWAY: mmu04914
Entry
mmu04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Mus musculus (house mouse)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
mmu04914  Progesterone-mediated oocyte maturation
mmu04914

Other DBs
GO: 0001556
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
104110  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
104111  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
109880  Braf; Braf transforming gene [KO:K04365] [EC:2.7.11.1]
110033  Kif22; kinesin family member 22 [KO:K10403]
110157  Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
110651  Rps6ka3; ribosomal protein S6 kinase polypeptide 3 [KO:K04373] [EC:2.7.11.1]
11512  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
11513  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
11514  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
11515  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
11651  Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
11836  Araf; Araf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
12235  Bub1; BUB1, mitotic checkpoint serine/threonine kinase [KO:K02178] [EC:2.7.11.1]
12427  Ccna1; cyclin A1 [KO:K06627]
12428  Ccna2; cyclin A2 [KO:K06627]
12442  Ccnb2; cyclin B2 [KO:K21770]
12530  Cdc25a; cell division cycle 25A [KO:K06645] [EC:3.1.3.48]
12531  Cdc25b; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
12532  Cdc25c; cell division cycle 25C [KO:K05867] [EC:3.1.3.48]
12534  Cdk1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
12566  Cdk2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
12877  Cpeb1; cytoplasmic polyadenylation element binding protein 1 [KO:K02602]
14677  Gnai1; G protein subunit alpha i1 [KO:K04630]
14678  Gnai2; G protein subunit alpha i2 [KO:K04630]
14679  Gnai3; G protein subunit alpha i3 [KO:K04630]
15516  Hsp90ab1; heat shock protein 90 alpha (cytosolic), class B member 1 [KO:K04079]
15519  Hsp90aa1; heat shock protein 90, alpha (cytosolic), class A member 1 [KO:K04079]
16000  Igf1; insulin-like growth factor 1 [KO:K05459]
16001  Igf1r; insulin-like growth factor I receptor [KO:K05087] [EC:2.7.10.1]
16333  Ins1; insulin I [KO:K04526]
16334  Ins2; insulin II [KO:K04526]
16653  Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
17120  Mad1l1; MAD1 mitotic arrest deficient 1-like 1 [KO:K06679]
17222  Anapc1; anaphase promoting complex subunit 1 [KO:K03348]
17451  Mos; Moloney sarcoma oncogene [KO:K04367] [EC:2.7.11.1]
18576  Pde3b; phosphodiesterase 3B, cGMP-inhibited [KO:K13296] [EC:3.1.4.17]
18667  Pgr; progesterone receptor [KO:K08556]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18747  Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
18817  Plk1; polo like kinase 1 [KO:K06631] [EC:2.7.11.21]
19094  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
20111  Rps6ka1; ribosomal protein S6 kinase polypeptide 1 [KO:K04373] [EC:2.7.11.1]
20112  Rps6ka2; ribosomal protein S6 kinase, polypeptide 2 [KO:K04373] [EC:2.7.11.1]
20868  Stk10; serine/threonine kinase 10 [KO:K08837] [EC:2.7.11.1]
20878  Aurka; aurora kinase A [KO:K11481] [EC:2.7.11.1]
208922  Cpeb3; cytoplasmic polyadenylation element binding protein 3 [KO:K02602]
209091  Ccnb3; cyclin B3 [KO:K21771]
210044  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
217232  Cdc27; cell division cycle 27 [KO:K03350]
224129  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
231207  Cpeb2; cytoplasmic polyadenylation element binding protein 2 [KO:K02602]
23797  Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
241634  Spdye4c; speedy/RINGO cell cycle regulator family, member E4C [KO:K08694]
26395  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26414  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
26415  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
26416  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
26419  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
268697  Ccnb1; cyclin B1 [KO:K05868]
268930  Pkmyt1; protein kinase, membrane associated tyrosine/threonine 1 [KO:K06633] [EC:2.7.11.1]
29857  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
330228  Spdye4b; speedy/RINGO cell cycle regulator family, member E4B [KO:K08694]
432530  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
434175  Ccnb1-ps; cyclin B1, pseudogene [KO:K05868]
52206  Anapc4; anaphase promoting complex subunit 4 [KO:K03351]
52563  Cdc23; CDC23 cell division cycle 23 [KO:K03355]
52717  Anapc16; anaphase promoting complex subunit 16 [KO:K25229]
56150  Mad2l1; MAD2 mitotic arrest deficient-like 1 [KO:K02537]
56317  Anapc7; anaphase promoting complex subunit 7 [KO:K03354]
56371  Fzr1; fizzy and cell division cycle 20 related 1 [KO:K03364]
59008  Anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
66156  Anapc11; anaphase promoting complex subunit 11 [KO:K03358]
66440  Cdc26; cell division cycle 26 [KO:K03359]
67071  Rps6ka6; ribosomal protein S6 kinase polypeptide 6 [KO:K04373] [EC:2.7.11.1]
67579  Cpeb4; cytoplasmic polyadenylation element binding protein 4 [KO:K02602]
68999  Anapc10; anaphase promoting complex subunit 10 [KO:K03357]
69010  Anapc13; anaphase promoting complex subunit 13 [KO:K12456]
69957  Cdc16; CDC16 cell division cycle 16 [KO:K03353]
70891  Spdya; speedy/RINGO cell cycle regulator family, member A [KO:K08694]
71890  Mad2l2; MAD2 mitotic arrest deficient-like 2 [KO:K13728]
74673  Spdye4a; speedy/RINGO cell cycle regulator family, member E4A [KO:K08694]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
75430  Anapc15; anaphase promoting complex C subunit 15 [KO:K25228]
99152  Anapc2; anaphase promoting complex subunit 2 [KO:K03349]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
mmu04010  MAPK signaling pathway
mmu04110  Cell cycle
KO pathway
ko04914   

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