Entry
Name
Progesterone-mediated oocyte maturation - Mus musculus (house mouse)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
mmu04914 Progesterone-mediated oocyte maturation
Other DBs
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
12877 Cpeb1; cytoplasmic polyadenylation element binding protein 1 [KO:K02602 ]
15516 Hsp90ab1; heat shock protein 90 alpha (cytosolic), class B member 1 [KO:K04079 ]
15519 Hsp90aa1; heat shock protein 90, alpha (cytosolic), class A member 1 [KO:K04079 ]
16653 Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827 ]
17120 Mad1l1; MAD1 mitotic arrest deficient 1-like 1 [KO:K06679 ]
17222 Anapc1; anaphase promoting complex subunit 1 [KO:K03348 ]
18706 Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922 ] [EC:2.7.1.153 ]
18707 Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922 ] [EC:2.7.1.153 ]
18708 Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
18709 Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
18710 Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
208922 Cpeb3; cytoplasmic polyadenylation element binding protein 3 [KO:K02602 ]
231207 Cpeb2; cytoplasmic polyadenylation element binding protein 2 [KO:K02602 ]
241634 Spdye4c; speedy/RINGO cell cycle regulator family, member E4C [KO:K08694 ]
330228 Spdye4b; speedy/RINGO cell cycle regulator family, member E4B [KO:K08694 ]
52206 Anapc4; anaphase promoting complex subunit 4 [KO:K03351 ]
52717 Anapc16; anaphase promoting complex subunit 16 [KO:K25229 ]
56150 Mad2l1; MAD2 mitotic arrest deficient-like 1 [KO:K02537 ]
56317 Anapc7; anaphase promoting complex subunit 7 [KO:K03354 ]
56371 Fzr1; fizzy and cell division cycle 20 related 1 [KO:K03364 ]
59008 Anapc5; anaphase-promoting complex subunit 5 [KO:K03352 ]
66156 Anapc11; anaphase promoting complex subunit 11 [KO:K03358 ]
67579 Cpeb4; cytoplasmic polyadenylation element binding protein 4 [KO:K02602 ]
68999 Anapc10; anaphase promoting complex subunit 10 [KO:K03357 ]
69010 Anapc13; anaphase promoting complex subunit 13 [KO:K12456 ]
70891 Spdya; speedy/RINGO cell cycle regulator family, member A [KO:K08694 ]
71890 Mad2l2; MAD2 mitotic arrest deficient-like 2 [KO:K13728 ]
74673 Spdye4a; speedy/RINGO cell cycle regulator family, member E4A [KO:K08694 ]
74769 Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922 ] [EC:2.7.1.153 ]
75430 Anapc15; anaphase promoting complex C subunit 15 [KO:K25228 ]
99152 Anapc2; anaphase promoting complex subunit 2 [KO:K03349 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Schmitt A, Nebreda AR.
Title
Signalling pathways in oocyte meiotic maturation.
Journal
J Cell Sci 115:2457-9 (2002)
Reference
Authors
Cato AC, Nestl A, Mink S.
Title
Rapid actions of steroid receptors in cellular signaling pathways.
Journal
Reference
Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
Journal
Reference
Authors
Nebreda AR, Ferby I.
Title
Regulation of the meiotic cell cycle in oocytes.
Journal
Reference
Authors
Ferrell JE Jr.
Title
Xenopus oocyte maturation: new lessons from a good egg.
Journal
Reference
Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
Journal
Reference
Authors
Duckworth BC, Weaver JS, Ruderman JV.
Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
Journal
Reference
Authors
Abrieu A, Doree M, Fisher D.
Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
Journal
J Cell Sci 114:257-67 (2001)
Related pathway
KO pathway