KEGG   PATHWAY: mmu04914
mmu04914                    Pathway                                

Progesterone-mediated oocyte maturation - Mus musculus (mouse)
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Organismal Systems; Endocrine system
Pathway map
mmu04914  Progesterone-mediated oocyte maturation

Other DBs
GO: 0001556
Mus musculus (mouse) [GN:mmu]
18667  Pgr; progesterone receptor [KO:K08556]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:]
26419  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:]
26420  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:]
26414  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:]
26416  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:]
19094  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:]
29857  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:]
26415  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:]
14677  Gnai1; guanine nucleotide binding protein (G protein), alpha inhibiting 1 [KO:K04630]
14679  Gnai3; guanine nucleotide binding protein (G protein), alpha inhibiting 3 [KO:K04630]
14678  Gnai2; guanine nucleotide binding protein (G protein), alpha inhibiting 2 [KO:K04630]
432530  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:]
210044  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:]
104111  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:]
104110  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:]
224129  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:]
11512  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:]
11513  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:]
11514  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:]
11515  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:]
18747  Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:]
18749  Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:]
20878  Aurka; aurora kinase A [KO:K11481] [EC:]
12877  Cpeb1; cytoplasmic polyadenylation element binding protein 1 [KO:K02602]
208922  Cpeb3; cytoplasmic polyadenylation element binding protein 3 [KO:K02602]
231207  Cpeb2; cytoplasmic polyadenylation element binding protein 2 [KO:K02602]
67579  Cpeb4; cytoplasmic polyadenylation element binding protein 4 [KO:K02602]
70891  Spdya; speedy/RINGO cell cycle regulator family, member A [KO:K08694]
74673  Spdye4a; speedy/RINGO cell cycle regulator family, member E4A [KO:K08694]
241634  Spdye4c; speedy/RINGO cell cycle regulator family, member E4C [KO:K08694]
330228  Spdye4b; speedy/RINGO cell cycle regulator family, member E4B [KO:K08694]
12566  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:]
12534  Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:]
12428  Ccna2; cyclin A2 [KO:K06627]
12427  Ccna1; cyclin A1 [KO:K06627]
17451  Mos; Moloney sarcoma oncogene [KO:K04367] [EC:]
15519  Hsp90aa1; heat shock protein 90, alpha (cytosolic), class A member 1 [KO:K04079]
15516  Hsp90ab1; heat shock protein 90 alpha (cytosolic), class B member 1 [KO:K04079]
26395  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:]
110651  Rps6ka3; ribosomal protein S6 kinase polypeptide 3 [KO:K04373] [EC:]
20111  Rps6ka1; ribosomal protein S6 kinase polypeptide 1 [KO:K04373] [EC:]
20112  Rps6ka2; ribosomal protein S6 kinase, polypeptide 2 [KO:K04373] [EC:]
67071  Rps6ka6; ribosomal protein S6 kinase polypeptide 6 [KO:K04373] [EC:]
268930  Pkmyt1; protein kinase, membrane associated tyrosine/threonine 1 [KO:K06633] [EC:]
268697  Ccnb1; cyclin B1 [KO:K05868]
12442  Ccnb2; cyclin B2 [KO:K21770]
209091  Ccnb3; cyclin B3 [KO:K21771]
20868  Stk10; serine/threonine kinase 10 [KO:K08837] [EC:]
18817  Plk1; polo like kinase 1 [KO:K06631] [EC:]
12530  Cdc25a; cell division cycle 25A [KO:K06645] [EC:]
12531  Cdc25b; cell division cycle 25B [KO:K05866] [EC:]
12532  Cdc25c; cell division cycle 25C [KO:K05867] [EC:]
16334  Ins2; insulin II [KO:K04526]
16333  Ins1; insulin I [KO:K04526]
16000  Igf1; insulin-like growth factor 1 [KO:K05459]
16001  Igf1r; insulin-like growth factor I receptor [KO:K05087] [EC:]
11651  Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:]
11652  Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:]
23797  Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:]
18576  Pde3b; phosphodiesterase 3B, cGMP-inhibited [KO:K13296] [EC:]
16653  Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
11836  Araf; Araf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:]
109880  Braf; Braf transforming gene [KO:K04365] [EC:]
110157  Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:]
12235  Bub1; BUB1, mitotic checkpoint serine/threonine kinase [KO:K02178] [EC:]
17120  Mad1l1; MAD1 mitotic arrest deficient 1-like 1 [KO:K06679]
56150  Mad2l1; MAD2 mitotic arrest deficient-like 1 [KO:K02537]
71890  Mad2l2; MAD2 mitotic arrest deficient-like 2 [KO:K13728]
56371  Fzr1; fizzy and cell division cycle 20 related 1 [KO:K03364]
17222  Anapc1; anaphase promoting complex subunit 1 [KO:K03348]
99152  Anapc2; anaphase promoting complex subunit 2 [KO:K03349]
217232  Cdc27; cell division cycle 27 [KO:K03350]
52206  Anapc4; anaphase promoting complex subunit 4 [KO:K03351]
59008  Anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
69957  Cdc16; CDC16 cell division cycle 16 [KO:K03353]
56317  Anapc7; anaphase promoting complex subunit 7 [KO:K03354]
52563  Cdc23; CDC23 cell division cycle 23 [KO:K03355]
68999  Anapc10; anaphase promoting complex subunit 10 [KO:K03357]
66156  Anapc11; anaphase promoting complex subunit 11 [KO:K03358]
66440  Cdc26; cell division cycle 26 [KO:K03359]
69010  Anapc13; anaphase promoting complex subunit 13 [KO:K12456]
110033  Kif22; kinesin family member 22 [KO:K10403]
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Schmitt A, Nebreda AR.
Signalling pathways in oocyte meiotic maturation.
J Cell Sci 115:2457-9 (2002)
Cato AC, Nestl A, Mink S.
Rapid actions of steroid receptors in cellular signaling pathways.
Sci STKE 2002:RE9 (2002)
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
Biol Cell 93:27-33 (2001)
Nebreda AR, Ferby I.
Regulation of the meiotic cell cycle in oocytes.
Curr Opin Cell Biol 12:666-75 (2000)
Ferrell JE Jr.
Xenopus oocyte maturation: new lessons from a good egg.
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
Biochem J 369:227-38 (2003)
Duckworth BC, Weaver JS, Ruderman JV.
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
Proc Natl Acad Sci U S A 99:16794-9 (2002)
Abrieu A, Doree M, Fisher D.
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
J Cell Sci 114:257-67 (2001)
mmu04010  MAPK signaling pathway
mmu04110  Cell cycle
KO pathway

DBGET integrated database retrieval system