Entry |
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Name |
Progesterone-mediated oocyte maturation - Mus musculus (mouse)
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Description |
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
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Class |
Organismal Systems; Endocrine system
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Pathway map |
mmu04914 | Progesterone-mediated oocyte maturation |

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Other DBs |
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Organism |
Mus musculus (mouse) [GN: mmu]
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Gene |
18709 | Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649] |
18708 | Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649] |
18710 | Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649] |
18706 | Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153] |
18707 | Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153] |
74769 | Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153] |
14677 | Gnai1; guanine nucleotide binding protein (G protein), alpha inhibiting 1 [KO:K04630] |
14679 | Gnai3; guanine nucleotide binding protein (G protein), alpha inhibiting 3 [KO:K04630] |
14678 | Gnai2; guanine nucleotide binding protein (G protein), alpha inhibiting 2 [KO:K04630] |
12877 | Cpeb1; cytoplasmic polyadenylation element binding protein 1 [KO:K02602] |
208922 | Cpeb3; cytoplasmic polyadenylation element binding protein 3 [KO:K02602] |
231207 | Cpeb2; cytoplasmic polyadenylation element binding protein 2 [KO:K02602] |
67579 | Cpeb4; cytoplasmic polyadenylation element binding protein 4 [KO:K02602] |
70891 | Spdya; speedy/RINGO cell cycle regulator family, member A [KO:K08694] |
74673 | Spdye4a; speedy/RINGO cell cycle regulator family, member E4A [KO:K08694] |
241634 | Spdye4c; speedy/RINGO cell cycle regulator family, member E4C [KO:K08694] |
330228 | Spdye4b; speedy/RINGO cell cycle regulator family, member E4B [KO:K08694] |
15519 | Hsp90aa1; heat shock protein 90, alpha (cytosolic), class A member 1 [KO:K04079] |
15516 | Hsp90ab1; heat shock protein 90 alpha (cytosolic), class B member 1 [KO:K04079] |
16653 | Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827] |
17120 | Mad1l1; MAD1 mitotic arrest deficient 1-like 1 [KO:K06679] |
56150 | Mad2l1; MAD2 mitotic arrest deficient-like 1 [KO:K02537] |
71890 | Mad2l2; MAD2 mitotic arrest deficient-like 2 [KO:K13728] |
56371 | Fzr1; fizzy and cell division cycle 20 related 1 [KO:K03364] |
17222 | Anapc1; anaphase promoting complex subunit 1 [KO:K03348] |
99152 | Anapc2; anaphase promoting complex subunit 2 [KO:K03349] |
52206 | Anapc4; anaphase promoting complex subunit 4 [KO:K03351] |
59008 | Anapc5; anaphase-promoting complex subunit 5 [KO:K03352] |
56317 | Anapc7; anaphase promoting complex subunit 7 [KO:K03354] |
68999 | Anapc10; anaphase promoting complex subunit 10 [KO:K03357] |
66156 | Anapc11; anaphase promoting complex subunit 11 [KO:K03358] |
69010 | Anapc13; anaphase promoting complex subunit 13 [KO:K12456] |
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Compound |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
C11554 | 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate |
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Reference |
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Authors |
Schmitt A, Nebreda AR. |
Title |
Signalling pathways in oocyte meiotic maturation. |
Journal |
J Cell Sci 115:2457-9 (2002) |
Reference |
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Authors |
Cato AC, Nestl A, Mink S. |
Title |
Rapid actions of steroid receptors in cellular signaling pathways. |
Journal |
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Reference |
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Authors |
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ. |
Title |
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes. |
Journal |
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Reference |
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Authors |
Nebreda AR, Ferby I. |
Title |
Regulation of the meiotic cell cycle in oocytes. |
Journal |
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Reference |
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Authors |
Ferrell JE Jr. |
Title |
Xenopus oocyte maturation: new lessons from a good egg. |
Journal |
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Reference |
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Authors |
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA. |
Title |
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes. |
Journal |
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Reference |
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Authors |
Duckworth BC, Weaver JS, Ruderman JV. |
Title |
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A. |
Journal |
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Reference |
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Authors |
Abrieu A, Doree M, Fisher D. |
Title |
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes. |
Journal |
J Cell Sci 114:257-67 (2001) |
Related pathway |
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KO pathway |
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