KEGG   PATHWAY: sma00280
Entry
sma00280                    Pathway                                

Name
Valine, leucine and isoleucine degradation - Streptomyces avermitilis
Class
Metabolism; Amino acid metabolism
Pathway map
sma00280  Valine, leucine and isoleucine degradation
sma00280

Module
sma_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:sma00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Streptomyces avermitilis [GN:sma]
Gene
SAVERM_6804  putative D-alanine aminotransferase [KO:K00826] [EC:2.6.1.42]
SAVERM_842  ilvE2; putative branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
SAVERM_2717  ilvE; putative branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
SAVERM_4132  vdh; putative valine dehydrogenase (NADP+) [KO:K00271] [EC:1.4.1.23]
SAVERM_6024  lpdA1; putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAVERM_2154  lpdA2; putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAVERM_6614  fadE17; putative acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
SAVERM_1381  fadE15; putative acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
SAVERM_5280  fadE7; putative acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
SAVERM_5275  fadE4; putative acyl-CoA dehydrogenase [KO:K11410] [EC:1.3.99.12]
SAVERM_1245  echA4; putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SAVERM_717  echA3; putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SAVERM_7216  echA15; putative enoyl-CoA hydratase/isomerase family protein [KO:K01692] [EC:4.2.1.17]
SAVERM_3863  echA12; putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SAVERM_6203  echA13; putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SAVERM_1350  echA5; putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SAVERM_1680  fadB1; putative fatty acid oxidation complex alpha-subunit [KO:K01782] [EC:1.1.1.35 4.2.1.17 5.1.2.3]
SAVERM_5866  ltp1; putative lipid-transfer protein [KO:K00632] [EC:2.3.1.16]
SAVERM_7026  fadA6; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00632] [EC:2.3.1.16]
SAVERM_1604  pcaF1; putative beta-ketoadipyl-CoA thiolase [KO:K00632] [EC:2.3.1.16]
SAVERM_2233  fadA8; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00632] [EC:2.3.1.16]
SAVERM_3866  accA2; putative acetyl/propionyl CoA carboxylase alpha subunit [KO:K01965] [EC:6.4.1.3]
SAVERM_3331  accD4; putative acyl-CoA carboxylase, beta subunit [KO:K01966] [EC:6.4.1.3 2.1.3.15]
SAVERM_3337  accA3; putative acyl-CoA carboxylase, alpha subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
SAVERM_5277  accA1; putative acetyl/propionyl CoA carboxylase alpha subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
SAVERM_2857  hypothetical protein [KO:K05606] [EC:5.1.99.1]
SAVERM_2040  meaA2; putative methylmalonyl-CoA mutase, coenzyme B12-dependent alpha subunit [KO:K01847] [EC:5.4.99.2]
SAVERM_2039  mcmB; putative methylmalonyl-CoA mutase, beta subunit [KO:K01847] [EC:5.4.99.2]
SAVERM_3460  icmB; isobutyryl-CoA mutase, chain B [KO:K01849] [EC:5.4.99.2]
SAVERM_3382  mcmA2; putative methylmalonyl-CoA mutase, alpha subunit [KO:K01848] [EC:5.4.99.2]
SAVERM_2832  icmA; isobutyryl-CoA mutase, chain A [KO:K01848] [EC:5.4.99.2]
SAVERM_1542  putative dehydrogenase [KO:K00020] [EC:1.1.1.31]
SAVERM_5342  iolA; putative methylmalonic acid semialdehyde dehydrogenase [KO:K00140] [EC:1.2.1.18 1.2.1.27]
SAVERM_6595  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SAVERM_4650  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SAVERM_2579  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SAVERM_1187  aldH; putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SAVERM_3347  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SAVERM_5852  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SAVERM_5723  fadD13; putative acyl-CoA synthetase, long-chain fatty-acid:CoA ligase [KO:K18662] [EC:6.2.1.-]
SAVERM_2583  gabT; putative 4-aminobutyrate aminotransferase [KO:K07250] [EC:2.6.1.19 2.6.1.22 2.6.1.48]
SAVERM_5278  accD1; putative acetyl/propionyl CoA carboxylase, beta subunit [KO:K01969] [EC:6.4.1.4]
SAVERM_5276  hmgL; putative hydroxymethylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]
SAVERM_1700  pcaI; putative 3-oxoadipate succinyl-CoA transferase alpha subunit [KO:K01028] [EC:2.8.3.5]
SAVERM_1701  pcaJ; putative 3-oxoadipate succinyl-CoA transferase beta subunit [KO:K01029] [EC:2.8.3.5]
SAVERM_6970  acsA2; putative acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
SAVERM_562  acsA3; putative acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
SAVERM_1384  fadA5; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_2856  fadA1; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_1681  fadA4; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_1242  putative nonspecific lipid-transfer protein [KO:K00626] [EC:2.3.1.9]
SAVERM_5842  fadA7; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_3512  fadA2; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_6199  fadA3; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
sma00020  Citrate cycle (TCA cycle)
sma00240  Pyrimidine metabolism
sma00290  Valine, leucine and isoleucine biosynthesis
sma00522  Biosynthesis of 12-, 14- and 16-membered macrolides
sma00640  Propanoate metabolism
sma00900  Terpenoid backbone biosynthesis
sma01056  Biosynthesis of type II polyketide backbone
KO pathway
ko00280   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (54)   
   KEGG GENES (54)   
All databases (55)   

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