KEGG   PATHWAY: sma00280
Entry
sma00280                    Pathway                                
Name
Valine, leucine and isoleucine degradation - Streptomyces avermitilis
Class
Metabolism; Amino acid metabolism
Pathway map
sma00280  Valine, leucine and isoleucine degradation
sma00280

Module
sma_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:sma00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Streptomyces avermitilis [GN:sma]
Gene
SAVERM_1187  aldH; putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SAVERM_1242  [KO:K00626] [EC:2.3.1.9]
SAVERM_1381  fadE15; putative acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
SAVERM_1384  fadA5; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00632] [EC:2.3.1.16]
SAVERM_1542  [KO:K00020] [EC:1.1.1.31]
SAVERM_1680  fadB1; putative fatty acid oxidation complex alpha-subunit [KO:K01782] [EC:1.1.1.35 4.2.1.17 5.1.2.3]
SAVERM_1681  fadA4; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_1700  pcaI; putative 3-oxoadipate succinyl-CoA transferase alpha subunit [KO:K01028] [EC:2.8.3.5]
SAVERM_1701  pcaJ; putative 3-oxoadipate succinyl-CoA transferase beta subunit [KO:K01029] [EC:2.8.3.5]
SAVERM_2039  mcmB; putative methylmalonyl-CoA mutase, beta subunit [KO:K01847] [EC:5.4.99.2]
SAVERM_2040  meaA2; putative methylmalonyl-CoA mutase, coenzyme B12-dependent alpha subunit [KO:K01847] [EC:5.4.99.2]
SAVERM_2154  lpdA2; putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAVERM_2233  fadA8; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00632] [EC:2.3.1.16]
SAVERM_2306  fadE10; putative acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
SAVERM_2583  gabT; putative 4-aminobutyrate aminotransferase [KO:K07250] [EC:2.6.1.19 2.6.1.22 2.6.1.48]
SAVERM_2717  ilvE; putative branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
SAVERM_2786  echA8; putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SAVERM_2856  fadA1; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_2857  [KO:K05606] [EC:5.1.99.1]
SAVERM_3331  accD4; putative acyl-CoA carboxylase, beta subunit [KO:K27094]
SAVERM_3332  [KO:K27095]
SAVERM_3337  accA3; putative acyl-CoA carboxylase, alpha subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
SAVERM_3347  [KO:K00128] [EC:1.2.1.3]
SAVERM_3382  mcmA2; putative methylmalonyl-CoA mutase, alpha subunit [KO:K01848] [EC:5.4.99.2]
SAVERM_3512  fadA2; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_4132  vdh; putative valine dehydrogenase (NADP+) [KO:K00271] [EC:1.4.1.23]
SAVERM_4362  bkdA; putative 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) (EC 1.2.4.4) E1-alpha chain [KO:K00166] [EC:1.2.4.4]
SAVERM_4363  bkdB; putative 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) (EC 1.2.4.4) E1-beta chain [KO:K00167] [EC:1.2.4.4]
SAVERM_4364  bkdC; putative dihydrolipoamide acyltransferase [KO:K09699] [EC:2.3.1.168]
SAVERM_4376  bkdF; putative branched-chain alpha keto acid dehydrogenase E1 alpha subunit [KO:K00166] [EC:1.2.4.4]
SAVERM_4377  bkdG; putative branched-chain alpha keto acid dehydrogenase E1 beta subunit [KO:K00167] [EC:1.2.4.4]
SAVERM_4378  bkdH; putative dihydrolipoamide acyltransferase component [KO:K09699] [EC:2.3.1.168]
SAVERM_4650  [KO:K00128] [EC:1.2.1.3]
SAVERM_5275  fadE4; putative acyl-CoA dehydrogenase [KO:K11410] [EC:1.3.8.5]
SAVERM_5276  hmgL; putative hydroxymethylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]
SAVERM_5277  accA1; putative acetyl/propionyl CoA carboxylase alpha subunit [KO:K01968] [EC:6.4.1.4]
SAVERM_5278  accD1; putative acetyl/propionyl CoA carboxylase, beta subunit [KO:K01969] [EC:6.4.1.4]
SAVERM_5342  iolA; putative methylmalonic acid semialdehyde dehydrogenase [KO:K00140] [EC:1.2.1.18 1.2.1.27]
SAVERM_562  acsA3; putative acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
SAVERM_5723  fadD13; putative acyl-CoA synthetase, long-chain fatty-acid:CoA ligase [KO:K18661] [EC:6.2.1.76 6.2.1.-]
SAVERM_5842  fadA7; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00632] [EC:2.3.1.16]
SAVERM_5852  [KO:K00128] [EC:1.2.1.3]
SAVERM_5866  ltp1; putative lipid-transfer protein [KO:K00632] [EC:2.3.1.16]
SAVERM_6024  lpdA1; putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAVERM_6199  fadA3; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00632] [EC:2.3.1.16]
SAVERM_6595  [KO:K00128] [EC:1.2.1.3]
SAVERM_6614  fadE17; putative acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
SAVERM_6804  [KO:K00826] [EC:2.6.1.42]
SAVERM_6970  acsA2; putative acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
SAVERM_7026  fadA6; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00632] [EC:2.3.1.16]
SAVERM_842  ilvE2; putative branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
sma00020  Citrate cycle (TCA cycle)
sma00240  Pyrimidine metabolism
sma00290  Valine, leucine and isoleucine biosynthesis
sma00522  Biosynthesis of 12-, 14- and 16-membered macrolides
sma00640  Propanoate metabolism
sma00900  Terpenoid backbone biosynthesis
sma01056  Biosynthesis of type II polyketide backbone
KO pathway
ko00280   

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