KEGG   PATHWAY: egr03015
Entry
egr03015                    Pathway                                
Name
mRNA surveillance pathway - Eucalyptus grandis (rose gum)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
egr03015  mRNA surveillance pathway
egr03015

Other DBs
GO: 0071028
Organism
Eucalyptus grandis (rose gum) [GN:egr]
Gene
104433862  nuclear cap-binding protein subunit 1 [KO:K12882]
104424939  nuclear cap-binding protein subunit 2 [KO:K12883]
104420011  regulator of nonsense transcripts UPF3 [KO:K14328]
104421496  RNA-binding protein Y14 [KO:K12876]
104441364  protein mago nashi homolog [KO:K12877]
104421593  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
104444203  LOW QUALITY PROTEIN: eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
104444206  LOW QUALITY PROTEIN: eukaryotic initiation factor 4A-III homolog B [KO:K13025] [EC:5.6.2.7]
108954036  eukaryotic initiation factor 4A-3-like [KO:K13025] [EC:5.6.2.7]
120293422  eukaryotic initiation factor 4A-3-like isoform X1 [KO:K13025] [EC:5.6.2.7]
104444296  histone deacetylase complex subunit SAP18 [KO:K14324]
104452737  pinin [KO:K13114]
104418232  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
104450015  serine/arginine-rich splicing factor SR45 isoform X2 [KO:K14325]
104432755  THO complex subunit 4A [KO:K12881]
104455868  THO complex subunit 4B [KO:K12881]
104422162  THO complex subunit 4D isoform X1 [KO:K12881]
104425932  DEAD-box ATP-dependent RNA helicase 38 [KO:K18655] [EC:5.6.2.7]
104433474  protein GLE1 [KO:K18723]
104437679  DEAD-box ATP-dependent RNA helicase 15 [KO:K12812] [EC:5.6.2.7]
104437040  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:5.6.2.7]
104419949  partner of Y14 and mago [KO:K14294]
104432692  serine/arginine repetitive matrix protein 1 [KO:K13171]
104426395  mRNA-capping enzyme-like [KO:K13917] [EC:2.7.7.50 3.6.1.74]
120285921  LOW QUALITY PROTEIN: mRNA-capping enzyme-like [KO:K13917] [EC:2.7.7.50 3.6.1.74]
104450185  mRNA cap guanine-N7 methyltransferase 1 [KO:K00565] [EC:2.1.1.56]
104454121  mRNA cap guanine-N7 methyltransferase 2 isoform X1 [KO:K00565] [EC:2.1.1.56]
104432617  transcription initiation factor TFIID subunit 15b isoform X1 [KO:K13098]
104450087  polyadenylate-binding protein 1 isoform X1 [KO:K14396]
104419895  polyadenylate-binding protein 2 [KO:K14396]
104418311  polyadenylate-binding protein 2 isoform X1 [KO:K14396]
104448901  pre-mRNA cleavage factor Im 25 kDa subunit 2 [KO:K14397]
104438066  pre-mRNA cleavage factor Im 25 kDa subunit 1 [KO:K14397]
104443464  pre-mRNA cleavage factor Im 25 kDa subunit 2 isoform X1 [KO:K14397]
104450422  LOW QUALITY PROTEIN: uncharacterized PE-PGRS family protein PE_PGRS54 [KO:K14398]
104423071  nuclear poly(A) polymerase 4 [KO:K14376] [EC:2.7.7.19]
104425805  nuclear poly(A) polymerase 1 [KO:K14376] [EC:2.7.7.19]
104419345  protein CLP1 homolog [KO:K14399] [EC:2.7.1.78]
104438418  polyadenylation and cleavage factor homolog 4 [KO:K14400]
104441387  polyadenylation and cleavage factor homolog 4 [KO:K14400]
104424329  LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
104424427  cleavage and polyadenylation specificity factor subunit 2 isoform X1 [KO:K14402]
104452616  cleavage and polyadenylation specificity factor subunit 3-I [KO:K14403] [EC:3.1.27.-]
104452614  cleavage and polyadenylation specificity factor subunit 3-I [KO:K14403] [EC:3.1.27.-]
104452615  cleavage and polyadenylation specificity factor subunit 3-I [KO:K14403] [EC:3.1.27.-]
104421172  uncharacterized protein LOC104421172 isoform X1 [KO:K14404]
104444897  LOW QUALITY PROTEIN: 30-kDa cleavage and polyadenylation specificity factor 30 [KO:K14404]
104454545  LOW QUALITY PROTEIN: flowering time control protein FY [KO:K15542]
104420791  protein ANTHESIS POMOTING FACTOR 1 [KO:K14962]
104422631  protein ANTHESIS POMOTING FACTOR 1 [KO:K14962]
104433366  serine/threonine-protein phosphatase PP1 isoform X1 [KO:K06269] [EC:3.1.3.16]
104432280  serine/threonine-protein phosphatase PP1 isozyme 9 [KO:K06269] [EC:3.1.3.16]
104432529  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1 [KO:K06269] [EC:3.1.3.16]
104432687  serine/threonine-protein phosphatase PP1 isozyme 2 [KO:K06269] [EC:3.1.3.16]
104414514  serine/threonine-protein phosphatase PP1 isozyme 3 isoform X1 [KO:K06269] [EC:3.1.3.16]
104422547  serine/threonine-protein phosphatase PP1 isozyme 3 [KO:K06269] [EC:3.1.3.16]
104416909  serine/threonine-protein phosphatase PP1 isozyme 3 [KO:K06269] [EC:3.1.3.16]
104415613  serine/threonine-protein phosphatase PP1 [KO:K06269] [EC:3.1.3.16]
120290871  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
104421960  RNA polymerase II subunit A C-terminal domain phosphatase SSU72 isoform X2 [KO:K15544] [EC:3.1.3.16]
120286630  LOW QUALITY PROTEIN: RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like [KO:K15544] [EC:3.1.3.16]
104426027  cleavage stimulation factor subunit 50 isoform X1 [KO:K14406]
104451957  cleavage stimulating factor 64 [KO:K14407]
104426832  cleavage stimulation factor subunit 77 [KO:K14408]
104433139  symplekin [KO:K06100]
104449207  uncharacterized protein LOC104449207 isoform X1 [KO:K06100]
104445614  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
104457106  heterogeneous nuclear ribonucleoprotein A1-like 2 [KO:K14411]
104424662  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
104449238  RNA-binding protein 1 [KO:K14411]
104448159  heterogeneous nuclear ribonucleoprotein 1 isoform X1 [KO:K14411]
104420429  LOW QUALITY PROTEIN: RNA-binding protein Musashi homolog 1 [KO:K14411]
104423590  30S ribosomal protein 2, chloroplastic [KO:K13126]
104418709  polyadenylate-binding protein 2 [KO:K13126]
104447874  polyadenylate-binding protein 2 [KO:K13126]
104438776  polyadenylate-binding protein 7 [KO:K13126]
104449933  polyadenylate-binding protein 6 [KO:K13126]
104422231  eukaryotic peptide chain release factor subunit 1-3 [KO:K03265]
104419069  eukaryotic peptide chain release factor subunit 1-3 [KO:K03265]
104422000  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
104425818  LOW QUALITY PROTEIN: eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267]
104443591  regulator of nonsense transcripts 1 homolog [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104454177  regulator of nonsense transcripts UPF2 [KO:K14327]
104420534  uncharacterized protein LOC104420534 [KO:K08873] [EC:2.7.11.1]
104438482  protein SMG7-like [KO:K14409]
104438483  protein SMG7 isoform X1 [KO:K14409]
104432941  serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
104433580  serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
104433787  serine/threonine-protein phosphatase PP2A-2 catalytic subunit [KO:K04382] [EC:3.1.3.16]
104422309  serine/threonine-protein phosphatase PP2A-2 catalytic subunit [KO:K04382] [EC:3.1.3.16]
104425519  serine/threonine-protein phosphatase PP2A-4 catalytic subunit [KO:K04382] [EC:3.1.3.16]
104433288  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
104425779  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
104417952  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
104436290  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
104449952  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
104432544  serine/threonine protein phosphatase 2A regulatory subunit B''beta isoform X1 [KO:K11583]
104415362  serine/threonine protein phosphatase 2A regulatory subunit B''beta [KO:K11583]
104415099  probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2 [KO:K11583]
104437079  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform [KO:K11584]
104438475  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform [KO:K11584]
104433636  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform [KO:K11584]
104453442  serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform [KO:K11584]
104415719  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform [KO:K11584]
104419175  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform [KO:K11584]
104425950  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform [KO:K11584]
104438375  LOW QUALITY PROTEIN: HBS1-like protein [KO:K14416]
120286344  LOW QUALITY PROTEIN: HBS1-like protein [KO:K14416]
104426679  protein PELOTA 1 isoform X1 [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
egr03013  Nucleocytoplasmic transport
egr03018  RNA degradation
egr03040  Spliceosome
KO pathway
ko03015   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (109)   
   KEGG GENES (109)   
All databases (110)   

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