KEGG   PATHWAY: ehi05146
Entry
ehi05146                    Pathway                                
Name
Amoebiasis - Entamoeba histolytica
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
ehi05146  Amoebiasis
ehi05146

Organism
Entamoeba histolytica [GN:ehi]
Gene
EHI_151440  2.t00055; cysteine proteinase [KO:K08570] [EC:3.4.22.35]
EHI_033710  206.t00005; cysteine proteinase 2 [KO:K08570] [EC:3.4.22.35]
EHI_039610  358.t00002; cysteine proteinase [KO:K08570] [EC:3.4.22.35]
EHI_074180  242.t00001; cysteine proteinase 1 [KO:K08570] [EC:3.4.22.35]
EHI_010850  cysteine proteinase [KO:K08570] [EC:3.4.22.35]
EHI_168240  191.t00018; cysteine proteinase [KO:K08570] [EC:3.4.22.35]
EHI_050570  10.t00046; cysteine proteinase [KO:K08570] [EC:3.4.22.35]
EHI_151400  2.t00042; cysteine proteinase [KO:K08570] [EC:3.4.22.35]
EHI_181230  97.t00014; cysteine protease [KO:K13968]
EHI_181220  97.t00025; adhesin 112 (EhADH112) [KO:K13969]
EHI_012270  16.t00014; Gal/GalNAc lectin heavy subunit [KO:K13970]
EHI_133900  galactose-inhibitable lectin 170 kDa subunit [KO:K13970]
EHI_077500  29.t00015; galactose-specific adhesin 170kD subunit [KO:K13970]
EHI_042370  galactose-specific adhesin 170kD subunit [KO:K13970]
EHI_046650  213.t00006; Gal/GalNAc lectin heavy subunit [KO:K13970]
EHI_035690  17.t00056; galactose-inhibitable lectin 35 kda subunit precursor [KO:K13971]
EHI_049690  galactose-specific adhesin light subunit [KO:K13971]
EHI_058330  168.t00024; galactose-inhibitable lectin [KO:K13971]
EHI_148790  1.t00076; Gal/GalNAc lectin light subunit [KO:K13971]
EHI_159870  galactose-inhibitable lectin small subunit [KO:K13971]
EHI_183400  galactose-inhibitable lectin 35 kDa subunit precursor [KO:K13971]
EHI_027800  galactose binding lectin 35 kDa subunit [KO:K13971]
EHI_006980  53.t00006; hypothetical protein [KO:K13972]
EHI_065330  119.t00005; Gal/GalNAc lectin subunit Igl2 [KO:K13972]
EHI_118270  18.t00027; amoebapore C [KO:K13973]
EHI_159480  88.t00015; pore-forming peptide ameobapore A precursor [KO:K13973]
EHI_194540  pore-forming peptide ameobapore B precursor [KO:K13973]
EHI_169350  22.t00008; nonpathogenic pore-forming peptide precursor [KO:K13973]
EHI_118190  18.t00035; hypothetical protein [KO:K13973]
EHI_120900  56.t00006; calcium-binding protein 1 (EhCBP1) [KO:K13974]
EHI_053040  4.t00093; protein kinase [KO:K04345] [EC:2.7.11.11]
EHI_167650  26.t00031; tyrosine kinase [KO:K13975]
EHI_192810  333.t00002; small GTPase Rab7A [KO:K07897]
EHI_001870  250.t00011; Rab family GTPase [KO:K07897]
EHI_189100  319.t00001; small GTP binding protein Rab7 [KO:K07897]
EHI_189990  122.t00028; Rab family GTPase [KO:K07897]
EHI_081330  7.t00081; Rab family GTPase [KO:K07897]
EHI_082070  141.t00008; Rab family GTPase [KO:K07897]
EHI_059870  101.t00009; hypothetical protein [KO:K19720]
EHI_103610  85.t00005; protein kinase [KO:K13976]
EHI_096420  6.t00038; hypothetical protein [KO:K13977]
EHI_152330  6.t00005; Arginase [KO:K01476] [EC:3.5.3.1]
EHI_150490  124.t00001; alcohol dehydrogenase [KO:K04072] [EC:1.2.1.10 1.1.1.1]
EHI_160940  22.t00022; alcohol dehydrogenase [KO:K04072] [EC:1.2.1.10 1.1.1.1]
EHI_024240  aldehyde-alcohol dehydrogenase 2 [KO:K04072] [EC:1.2.1.10 1.1.1.1]
EHI_095130  269.t00003; phosphatidylinositol 3-kinase [KO:K00922] [EC:2.7.1.153]
EHI_006130  83.t00026; phosphatidylinositol 3-kinase [KO:K00922] [EC:2.7.1.153]
EHI_188970  67.t00015; hypothetical protein [KO:K00922] [EC:2.7.1.153]
EHI_123390  peroxiredoxin [KO:K13279] [EC:1.11.1.24]
EHI_001420  294.t00003; peroxiredoxin [KO:K13279] [EC:1.11.1.24]
EHI_114010  298.t00001; peroxiredoxin [KO:K13279] [EC:1.11.1.24]
EHI_061980  442.t00004; peroxiredoxin [KO:K13279] [EC:1.11.1.24]
EHI_145840  828.t00001; peroxiredoxin [KO:K13279] [EC:1.11.1.24]
EHI_122310  94.t00032; peroxiredoxin [KO:K13279] [EC:1.11.1.24]
EHI_201250  136.t00007; peroxiredoxin [KO:K13279] [EC:1.11.1.24]
EHI_139570  peroxiredoxin [KO:K13279] [EC:1.11.1.24]
EHI_164440  54.t00013; actinin-like protein [KO:K13978]
EHI_164430  467.t00004; actinin-like protein [KO:K13978]
EHI_116360  500.t00001; serine-rich protein [KO:K23601]
EHI_004340  serine-threonine-isoleucine rich protein [KO:K23602]
EHI_012330  16.t00006; serine-threonine-isoleucine rich protein [KO:K23602]
EHI_025700  312.t00002; serine-threonine-isoleucine rich protein [KO:K23602]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
ehi00330  Arginine and proline metabolism
ehi04144  Endocytosis
KO pathway
ko05146   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (62)   
   KEGG GENES (62)   
All databases (63)   

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