KEGG   PATHWAY: hsa00232
Entry
hsa00232                    Pathway                                

Name
Caffeine metabolism - Homo sapiens (human)
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
hsa00232  Caffeine metabolism
hsa00232

Drug
D09786  Topiroxostat (JAN/INN)
Other DBs
UMBBD: caf caf2
Organism
Homo sapiens (human) [GN:hsa]
Gene
1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
10  NAT2; N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
9  NAT1; N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
1548  CYP2A6; cytochrome P450 family 2 subfamily A member 6 [KO:K17683] [EC:1.14.14.-]
1549  CYP2A7; cytochrome P450 family 2 subfamily A member 7 [KO:K17683] [EC:1.14.14.-]
7498  XDH; xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Compound
C00048  Glyoxylate
C00385  Xanthine
C01762  Xanthosine
C07130  Theophylline
C07480  Theobromine
C07481  Caffeine
C13747  1,7-Dimethylxanthine
C16352  7-Methylxanthosine
C16353  7-Methylxanthine
C16355  7-Methyluric acid
C16356  1,7-Dimethyluric acid
C16357  3-Methylxanthine
C16358  1-Methylxanthine
C16359  1-Methyluric acid
C16360  3,7-Dimethyluric acid
C16361  1,3,7-Trimethyluric acid
C16362  3,6,8-Trimethylallantoin
C16363  N-Methylurea
C16364  N,N'-Dimethylurea
C16365  5-Acetylamino-6-formylamino-3-methyluracil
C16366  5-Acetylamino-6-amino-3-methyluracil
C21144  1,3,7-Trimethyl-5-hydroxyisourate
Reference
PMID:9705852
  Authors
Madyastha KM, Sridhar GR.
  Title
A novel pathway for the metabolism of caffeine by a mixed culture consortium.
  Journal
Biochem Biophys Res Commun 249:178-81 (1998)
DOI:10.1006/bbrc.1998.9102
Reference
  Authors
Mazzafera P.
  Title
Catabolism of caffeine in plants and microorganisms.
  Journal
Front Biosci 9:1348-59 (2004)
DOI:10.2741/1339
Reference
  Authors
Nyeki A, Biollaz J, Kesselring UW, Decosterd LA.
  Title
Extractionless method for the simultaneous high-performance liquid chromatographic determination of urinary caffeine metabolites for N-acetyltransferase 2, cytochrome P450 1A2 and xanthine oxidase activity assessment.
  Journal
J Chromatogr B Biomed Sci Appl 755:73-84 (2001)
DOI:10.1016/S0378-4347(00)00616-2
Reference
  Authors
Ashihara H, Crozier A.
  Title
Caffeine: a well known but little mentioned compound in plant science.
  Journal
Trends Plant Sci 6:407-13 (2001)
DOI:10.1016/S1360-1385(01)02055-6
Reference
  Authors
Yoneyama N, Morimoto H, Ye CX, Ashihara H, Mizuno K, Kato M.
  Title
Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme.
  Journal
Mol Genet Genomics 275:125-35 (2006)
DOI:10.1007/s00438-005-0070-z
Related
pathway
hsa00230  Purine metabolism
hsa00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00232   

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