KEGG   PATHWAY: hsa00630
Entry
hsa00630                    Pathway                                

Name
Glyoxylate and dicarboxylate metabolism - Homo sapiens (human)
Class
Metabolism; Carbohydrate metabolism
Pathway map
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa00630

Module
hsa_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:hsa00630]
Drug
D11925  Lumasiran (USAN/INN)
D11926  Lumasiran sodium
Organism
Homo sapiens (human) [GN:hsa]
Gene
84532  ACSS1; acyl-CoA synthetase short chain family member 1 [KO:K01895] [EC:6.2.1.1]
55902  ACSS2; acyl-CoA synthetase short chain family member 2 [KO:K01895] [EC:6.2.1.1]
4190  MDH1; malate dehydrogenase 1 [KO:K00025] [EC:1.1.1.37]
4191  MDH2; malate dehydrogenase 2 [KO:K00026] [EC:1.1.1.37]
1431  CS; citrate synthase [KO:K01647] [EC:2.3.3.1]
50  ACO2; aconitase 2 [KO:K01681] [EC:4.2.1.3]
48  ACO1; aconitase 1 [KO:K01681] [EC:4.2.1.3]
39  ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
38  ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
84693  MCEE; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
5095  PCCA; propionyl-CoA carboxylase subunit alpha [KO:K01965] [EC:6.4.1.3]
5096  PCCB; propionyl-CoA carboxylase subunit beta [KO:K01966] [EC:6.4.1.3 2.1.3.15]
4594  MMUT; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
51179  HAO2; hydroxyacid oxidase 2 [KO:K11517] [EC:1.1.3.15]
54363  HAO1; hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
847  CAT; catalase [KO:K03781] [EC:1.11.1.6]
9380  GRHPR; glyoxylate and hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
283871  PGP; phosphoglycolate phosphatase [KO:K19269] [EC:3.1.3.18 3.1.3.48]
189  AGXT; alanine--glyoxylate and serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
2752  GLUL; glutamate-ammonia ligase [KO:K01915] [EC:6.3.1.2]
6472  SHMT2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
6470  SHMT1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
2731  GLDC; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]
275  AMT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
1738  DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
2653  GCSH; glycine cleavage system protein H [KO:K02437]
81888  HYI; hydroxypyruvate isomerase (putative) [KO:K01816] [EC:5.3.1.22]
132158  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
112817  HOGA1; 4-hydroxy-2-oxoglutarate aldolase 1 [KO:K18123] [EC:4.1.3.16]
125061  AFMID; arylformamidase [KO:K01432] [EC:3.5.1.9]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
Reference
PMID:10978349 (EC5.3.1.22)
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta -hydroxyacid dehydrogenases in Escherichia coli and Haemophilusinfluenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00020  Citrate cycle (TCA cycle)
hsa00053  Ascorbate and aldarate metabolism
hsa00071  Fatty acid degradation
hsa00230  Purine metabolism
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00260  Glycine, serine and threonine metabolism
hsa00620  Pyruvate metabolism
hsa00750  Vitamin B6 metabolism
hsa00910  Nitrogen metabolism
KO pathway
ko00630   

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