KEGG   PATHWAY: loa03420
Entry
loa03420                    Pathway                                
Name
Nucleotide excision repair - Loa loa (eye worm)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
loa03420  Nucleotide excision repair
loa03420

Other DBs
GO: 0006289
Organism
Loa loa (eye worm) [GN:loa]
Gene
LOAG_03239  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
LOAG_04763  hypothetical protein [KO:K10609]
LOAG_18703  CPSF A subunit region family protein [KO:K10610]
LOAG_01614  DNA repair protein Rad4 containing protein [KO:K10838]
LOAG_18596  DNA repair protein Rad4 containing protein [KO:K10838]
LOAG_12911  UV excision repair protein Rad23 [KO:K10839]
LOAG_08405  hypothetical protein [KO:K10570]
LOAG_03215  hypothetical protein [KO:K10841]
LOAG_00660  hypothetical protein [KO:K23720]
LOAG_05313  DNA-directed RNA polymerase II largest subunit [KO:K03006] [EC:2.7.7.6]
LOAG_06607  DNA-directed RNA polymerase II subunit RPB2 [KO:K03010] [EC:2.7.7.6]
LOAG_08410  RNA polymerase Rpb3/Rpb11 dimerization domain-containing protein [KO:K03011]
LOAG_07020  DNA-directed RNA polymerase II polypeptide [KO:K03012]
LOAG_12762  DNA-directed RNA polymerase I [KO:K03013]
LOAG_16668  hypothetical protein [KO:K03014]
LOAG_03448  DNA-directed RNA polymerase II subunit RPB7 [KO:K03015]
LOAG_00799  DNA-directed RNA polymerase I [KO:K03016]
LOAG_16581  DNA-directed RNA polymerase II subunit RPB9 [KO:K03017]
LOAG_00477  hypothetical protein [KO:K03007]
LOAG_10524  hypothetical protein [KO:K03009]
LOAG_11251  DNA-directed RNA polymerase II subunit RPB11-a [KO:K03008]
LOAG_00613  CMGC/CDK/CDK7 protein kinase [KO:K02202] [EC:2.7.11.22 2.7.11.23]
LOAG_04607  CDK-activating kinase assembly factor MAT1 [KO:K10842]
LOAG_03272  cyclin domain-containing protein [KO:K06634]
LOAG_00638  helicase [KO:K10843] [EC:5.6.2.4]
LOAG_16970  Ercc2 protein [KO:K10844] [EC:5.6.2.3]
LOAG_00967  hypothetical protein [KO:K10845]
LOAG_06008  BSD domain-containing protein [KO:K03141]
LOAG_06368  basic transcription factor 2 [KO:K03143]
LOAG_02354  transcription factor Tfb2 family protein [KO:K03144]
LOAG_00986  hypothetical protein [KO:K10846]
LOAG_09881  xeroderma pigmentosum group A [KO:K10847]
LOAG_09949  replication factor A 73 kDa subunit [KO:K07466]
LOAG_08766  hypothetical protein [KO:K10739]
LOAG_00528  ERCC4 domain-containing protein [KO:K10848] [EC:3.1.-.-]
LOAG_05710  helix-hairpin-helix domain-containing protein family protein [KO:K10849]
LOAG_07617  DNA-directed DNA polymerase III [KO:K02327] [EC:2.7.7.7]
LOAG_16701  hypothetical protein [KO:K02328]
LOAG_16711  DNA polymerase [KO:K02324] [EC:2.7.7.7]
LOAG_18179  DNA polymerase epsilon subunit 2 [KO:K02325] [EC:2.7.7.7]
LOAG_09571  DNA polymerase epsilon p17 subunit [KO:K02326] [EC:2.7.7.7]
LOAG_10202  proliferating cell nuclear antigen [KO:K04802]
LOAG_04342  ATPase [KO:K10754]
LOAG_04686  replication factor C [KO:K10755]
LOAG_05796  hypothetical protein [KO:K10755]
LOAG_02279  replication factor C subunit 3 [KO:K10756]
LOAG_00800  activator 1 38 kDa subunit [KO:K10756]
LOAG_06875  DNA ligase [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
loa03020  RNA polymerase
loa04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (48)   
   KEGG GENES (48)   
All databases (49)   

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