KEGG   PATHWAY: sma00360
Entry
sma00360                    Pathway                                
Name
Phenylalanine metabolism - Streptomyces avermitilis
Class
Metabolism; Amino acid metabolism
Pathway map
sma00360  Phenylalanine metabolism
sma00360

Other DBs
GO: 0006558
Organism
Streptomyces avermitilis [GN:sma]
Gene
SAVERM_2149  putative copper amine oxidase, secreted [KO:K00276] [EC:1.4.3.21]
SAVERM_1257  paaK; putative phenylacetate:CoA ligase [KO:K01912] [EC:6.2.1.30]
SAVERM_4354  paaA; putative phenylacetic acid degradation protein [KO:K02609] [EC:1.14.13.149]
SAVERM_4353  paaB; putative phenylacetic acid degradation protein [KO:K02610]
SAVERM_4352  paaC; putative phenylacetic acid degradation protein [KO:K02611] [EC:1.14.13.149]
SAVERM_4351  paaD; putative phenylacetic acid degradation protein [KO:K02612]
SAVERM_4350  paaE; putative phenylacetic acid degradation NADH oxidoreductase [KO:K02613]
SAVERM_3829  echA11; putative enoyl-CoA hydratase [KO:K15866] [EC:5.3.3.18]
SAVERM_3120  putative enoyl-CoA hydratase/isomerase [KO:K15866] [EC:5.3.3.18]
SAVERM_2786  echA8; putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SAVERM_2870  fadC3; putative 3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
SAVERM_4359  paaH; putative 3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
SAVERM_6748  fadC5; putative 3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
SAVERM_2045  fadC2; putative 3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
SAVERM_4907  aspC1; putative aspartate aminotransferase [KO:K00812] [EC:2.6.1.1]
SAVERM_1375  hisC3; putative histidinol-phosphate aminotransferase [KO:K00817] [EC:2.6.1.9]
SAVERM_4261  hisC2; putative histidinol-phosphate aminotransferase [KO:K00817] [EC:2.6.1.9]
SAVERM_6154  hisC1; putative histidinol-phosphate aminotransferase [KO:K00817] [EC:2.6.1.9]
SAVERM_6404  cobC; putative aminotransferase [KO:K00817] [EC:2.6.1.9]
SAVERM_5149  hpd; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
SAVERM_7269  amdA1; putative amidase [KO:K01426] [EC:3.5.1.4]
SAVERM_7345  amdA2; putative amidase [KO:K01426] [EC:3.5.1.4]
SAVERM_6955  hcaC2; putative ferredoxin subunit of phenylpropionate dioxygenase [KO:K05710]
SAVERM_6327  hcaC1; putative ferredoxin subunit of phenylpropionate dioxygenase [KO:K05710]
SAVERM_5675  fprD; putative NAD(P)H-ferredoxin reductase [KO:K00529] [EC:1.18.1.3]
SAVERM_6097  fprE; putative NAD(P)H-ferredoxin reductase [KO:K00529] [EC:1.18.1.3]
SAVERM_563  mhpA; putative 3-(3-hydroxy-phenyl)propionate hydroxylase [KO:K05712] [EC:1.14.13.127]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00042  Succinate
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00084  Acetaldehyde
C00091  Succinyl-CoA
C00122  Fumarate
C00166  Phenylpyruvate
C00423  trans-Cinnamate
C00512  Benzoyl-CoA
C00582  Phenylacetyl-CoA
C00596  2-Hydroxy-2,4-pentadienoate
C00601  Phenylacetaldehyde
C00642  4-Hydroxyphenylacetate
C01198  3-(2-Hydroxyphenyl)propanoate
C01772  trans-2-Hydroxycinnamate
C02137  alpha-Oxo-benzeneacetic acid
C02232  3-Oxoadipyl-CoA
C02265  D-Phenylalanine
C02505  2-Phenylacetamide
C02763  2-Hydroxy-3-phenylpropenoate
C03519  N-Acetyl-L-phenylalanine
C03589  4-Hydroxy-2-oxopentanoate
C04044  3-(2,3-Dihydroxyphenyl)propanoate
C04148  Phenylacetylglutamine
C04479  2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
C05332  Phenethylamine
C05593  3-Hydroxyphenylacetate
C05598  Phenylacetylglycine
C05607  Phenyllactate
C05629  Phenylpropanoate
C05852  2-Hydroxyphenylacetate
C05853  Phenylethyl alcohol
C06207  2,6-Dihydroxyphenylacetate
C07086  Phenylacetic acid
C11457  3-(3-Hydroxyphenyl)propanoic acid
C11588  cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol
C12621  trans-3-Hydroxycinnamate
C12622  cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
C12623  trans-2,3-Dihydroxycinnamate
C12624  2-Hydroxy-6-ketononatrienedioate
C14144  5-Carboxy-2-pentenoyl-CoA
C14145  (3S)-3-Hydroxyadipyl-CoA
C15524  Phenylglyoxylyl-CoA
C19945  3-Oxo-5,6-dehydrosuberyl-CoA
C19946  3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde
C19975  2-Oxepin-2(3H)-ylideneacetyl-CoA
C20062  2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-CoA
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:10537203
  Authors
Arai H, Yamamoto T, Ohishi T, Shimizu T, Nakata T, Kudo T.
  Title
Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441.
  Journal
Microbiology 145 ( Pt 10):2813-20 (1999)
DOI:10.1099/00221287-145-10-2813
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
DOI:10.1128/JB.180.11.2915-2923.1998
Reference
PMID:9098055
  Authors
Ferrandez A, Garcia JL, Diaz E.
  Title
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
  Journal
J Bacteriol 179:2573-81 (1997)
DOI:10.1128/JB.179.8.2573-2581.1997
Reference
PMID:19016485
  Authors
Hwang JY, Park J, Seo JH, Cha M, Cho BK, Kim J, Kim BG
  Title
Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway.
  Journal
Biotechnol Bioeng 102:1323-9 (2009)
DOI:10.1002/bit.22178
Reference
PMID:20660314
  Authors
Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G
  Title
Bacterial phenylalanine and phenylacetate catabolic pathway revealed.
  Journal
Proc Natl Acad Sci U S A 107:14390-5 (2010)
DOI:10.1073/pnas.1005399107
Related
pathway
sma00010  Glycolysis / Gluconeogenesis
sma00020  Citrate cycle (TCA cycle)
sma00350  Tyrosine metabolism
sma00362  Benzoate degradation
sma00400  Phenylalanine, tyrosine and tryptophan biosynthesis
sma00643  Styrene degradation
KO pathway
ko00360   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG GENES (27)   
All databases (28)   

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