KEGG   PATHWAY: tva03015
Entry
tva03015                    Pathway                                
Name
mRNA surveillance pathway - Trichomonas vaginalis
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
tva03015  mRNA surveillance pathway
tva03015

Other DBs
GO: 0071028
Organism
Trichomonas vaginalis [GN:tva]
Gene
TVAG_2v0955660  pre-mRNA 5' cap binding protein family [KO:K12882]
TVAG_2v0120600  RNA cap binding [KO:K12883]
TVAG_2v0616030  helicase protein [KO:K13025] [EC:5.6.2.7]
TVAG_2v0175780  negative regulation of mRNA splicing, via spliceosome [KO:K14324]
TVAG_2v0213440  helicase [KO:K18655] [EC:5.6.2.7]
TVAG_2v0283960  helicase [KO:K18655] [EC:5.6.2.7]
TVAG_2v0005540  NTF2-like family [KO:K14285]
TVAG_2v1002400  ATP-dependent RNA helicase DBP3 family [KO:K12812] [EC:5.6.2.7]
TVAG_2v0939950  mRNA guanylyltransferase protein [KO:K13917] [EC:2.7.7.50 3.6.1.74]
TVAG_2v0213620  mRNA (guanine-N7-)-methyltransferase protein [KO:K00565] [EC:2.1.1.56]
TVAG_2v0930760  mRNA (guanine-N7-)-methyltransferase protein [KO:K00565] [EC:2.1.1.56]
TVAG_2v0093440  positive regulation of polynucleotide adenylyltransferase protein [KO:K14396]
TVAG_2v0265930  regulation of mRNA cleavage [KO:K14397]
TVAG_2v0213930  poly(A) polymerase family [KO:K14376] [EC:2.7.7.19]
TVAG_2v0323720  polynucleotide adenylyltransferase protein [KO:K14376] [EC:2.7.7.19]
TVAG_2v0951080  mRNA 3'-end processing [KO:K14399] [EC:2.7.1.78]
TVAG_2v0551580  mRNA 3'-end processing [KO:K14399] [EC:2.7.1.78]
TVAG_2v0291320  DNA repair/RNA processing CPSF family [KO:K14401]
TVAG_2v0948710  cleavage and polyadenylation specificity factor subunit 2 family [KO:K14402]
TVAG_2v0498420  cleavage and polyadenylation specificity factor family member family [KO:K14403] [EC:3.1.27.-]
TVAG_2v0959040  pre-mRNA cleavage required for polyadenylation [KO:K14404]
TVAG_2v0380640  pre-mRNA cleavage required for polyadenylation [KO:K14404]
TVAG_2v1048870  Fip1 motif family [KO:K14405]
TVAG_2v0994430  mRNA cleavage [KO:K15542]
TVAG_2v0535050  WD repeat-containing protein 82 family [KO:K14962]
TVAG_2v0214320  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0726870  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0726920  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0334530  protein phosphatase 2A family, catalytic domain family [KO:K06269] [EC:3.1.3.16]
TVAG_2v0100060  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0400810  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0217320  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0858640  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0522010  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0077940  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0172690  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0842220  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v1055060  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0652560  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0588350  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0542180  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0542580  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0339520  serine/threonine protein phosphatase type 1 catalytic subunit [KO:K06269] [EC:3.1.3.16]
TVAG_2v0394210  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0240140  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0227880  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0445910  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v1025120  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0925330  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0673290  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0669220  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0151960  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0248990  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0220250  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0220290  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0631160  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0438380  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0438150  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0438130  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0968330  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0388290  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0849260  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0253510  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0481810  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0623430  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v1015880  protein phosphatase 2A family, catalytic domain family [KO:K06269] [EC:3.1.3.16]
TVAG_2v0155940  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0615390  serine/threonine protein phosphatase family [KO:K06269] [EC:3.1.3.16]
TVAG_2v0697070  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0971690  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0136420  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0748420  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0497880  protein phosphatase 2A family, catalytic domain family [KO:K06269] [EC:3.1.3.16]
TVAG_2v0765230  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0413620  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0837890  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0198040  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0365190  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0076300  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0362120  Serine/threonine protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
TVAG_2v0290760  protein phosphatase 2A family, catalytic domain family [KO:K06269] [EC:3.1.3.16]
TVAG_2v1035900  protein phosphatase 2A family, catalytic domain family [KO:K06269] [EC:3.1.3.16]
TVAG_2v0601170  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0271660  protein phosphatase 2A family, catalytic domain family [KO:K06269] [EC:3.1.3.16]
TVAG_2v0211040  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0031670  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0623040  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0674760  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v1008080  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0661150  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0046920  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0322990  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0287410  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0888390  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0456320  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0671490  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0986180  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0606940  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0606050  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0381680  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0381620  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0363930  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v1028120  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0528990  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0379660  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0775950  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0774410  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0676480  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0503700  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0317290  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0892460  protein phosphatase 2A family, catalytic domain family [KO:K06269] [EC:3.1.3.16]
TVAG_2v0612030  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0345180  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0284690  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0411400  phosphoprotein phosphatase protein [KO:K06269] [EC:3.1.3.16]
TVAG_2v0903890  RNA polymerase II subunit A C-terminal domain phosphatase family [KO:K15544] [EC:3.1.3.16]
TVAG_2v0378760  RNA binding [KO:K13126]
TVAG_2v0714040  RNA-binding domain, RBD family-containing protein [KO:K13126]
TVAG_2v0477640  RNA binding [KO:K13126]
TVAG_2v0640300  RNA binding [KO:K13126]
TVAG_2v0914670  RNA binding [KO:K13126]
TVAG_2v0781700  RNA binding [KO:K13126]
TVAG_2v0481290  RNA binding [KO:K13126]
TVAG_2v0429280  RNA binding [KO:K13126]
TVAG_2v0671560  RNA binding [KO:K13126]
TVAG_2v0688610  RNA binding [KO:K13126]
TVAG_2v0816410  RNA binding [KO:K13126]
TVAG_2v0441650  RNA binding [KO:K13126]
TVAG_2v0338450  peptide chain release factor subunit 1 family [KO:K03265]
TVAG_2v0905730  EF1 alpha-like protein eukaryotic release factor 3, GTPase subunit [KO:K03267]
TVAG_2v0552350  DNA2/NAM7 helicase family [KO:K14326] [EC:5.6.2.5 5.6.2.3]
TVAG_2v0948650  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [KO:K14327]
TVAG_2v0755000  phosphoprotein phosphatase protein [KO:K04382] [EC:3.1.3.16]
TVAG_2v0409490  phosphoprotein phosphatase protein [KO:K04382] [EC:3.1.3.16]
TVAG_2v0644390  phosphoprotein phosphatase protein [KO:K04382] [EC:3.1.3.16]
TVAG_2v0068900  phosphoprotein phosphatase protein [KO:K04382] [EC:3.1.3.16]
TVAG_2v0595260  serine threonine-protein phosphatase family [KO:K04382] [EC:3.1.3.16]
TVAG_2v0163670  phosphoprotein phosphatase protein [KO:K04382] [EC:3.1.3.16]
TVAG_2v0483760  phosphoprotein phosphatase protein [KO:K04382] [EC:3.1.3.16]
TVAG_2v1008070  phosphoprotein phosphatase protein [KO:K04382] [EC:3.1.3.16]
TVAG_2v0997990  phosphoprotein phosphatase protein [KO:K04382] [EC:3.1.3.16]
TVAG_2v0569020  phosphoprotein phosphatase protein [KO:K04382] [EC:3.1.3.16]
TVAG_2v0955150  phosphoprotein phosphatase protein [KO:K04382] [EC:3.1.3.16]
TVAG_2v1034180  phosphoprotein phosphatase protein [KO:K04382] [EC:3.1.3.16]
TVAG_2v0173000  meiotic spindle elongation [KO:K03456]
TVAG_2v0394650  meiotic spindle elongation [KO:K03456]
TVAG_2v0320210  meiotic spindle elongation [KO:K03456]
TVAG_2v0960510  meiotic spindle elongation [KO:K03456]
TVAG_2v0941070  meiotic spindle elongation [KO:K03456]
TVAG_2v0597730  meiotic spindle elongation [KO:K03456]
TVAG_2v0384970  meiotic spindle elongation [KO:K03456]
TVAG_2v0709470  meiotic spindle elongation [KO:K03456]
TVAG_2v1011260  meiotic spindle elongation [KO:K03456]
TVAG_2v0247070  meiotic spindle elongation [KO:K03456]
TVAG_2v0290890  meiotic spindle elongation [KO:K03456]
TVAG_2v0028560  meiotic spindle elongation [KO:K03456]
TVAG_2v0493000  peptidyl-serine dephosphorylation [KO:K04354]
TVAG_2v0116110  peptidyl-serine dephosphorylation [KO:K04354]
TVAG_2v0272270  peptidyl-serine dephosphorylation [KO:K04354]
TVAG_2v0958490  positive regulation of B cell differentiation protein family [KO:K11583]
TVAG_2v0018720  Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma family [KO:K11583]
TVAG_2v0961060  positive regulation of B cell differentiation protein family [KO:K11583]
TVAG_2v0551990  positive regulation of B cell differentiation protein family [KO:K11583]
TVAG_2v1044460  positive regulation of B cell differentiation protein family [KO:K11583]
TVAG_2v0249440  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0049100  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0933890  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0981740  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0311840  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0354270  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0992950  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0964920  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0893870  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0318330  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0281460  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0451860  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0788780  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0475000  protein phosphatase regulator protein [KO:K11584]
TVAG_2v1023640  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0864810  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0246900  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0347650  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0554400  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0561250  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0371340  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0705270  armadillo (ARM) repeat-containing protein family [KO:K11584]
TVAG_2v0576960  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0828060  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0456400  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0292070  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0612830  serine/threonine protein phosphatase 2A PP2A regulatory subunit B family [KO:K11584]
TVAG_2v1071120  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0442580  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0267970  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0486520  protein phosphatase regulator protein [KO:K11584]
TVAG_2v0669620  GTPase protein [KO:K14416]
TVAG_2v0577060  nuclear-transcribed mRNA catabolic process, no-go decay [KO:K06965]
TVAG_2v0019880  nuclear-transcribed mRNA catabolic process, no-go decay [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
tva03013  Nucleocytoplasmic transport
tva03018  RNA degradation
tva03040  Spliceosome
KO pathway
ko03015   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (198)   
   KEGG GENES (198)   
All databases (199)   

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