KEGG   REACTION: R02726
Entry
R02726                      Reaction                               
Name
steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating)
Definition
2 Reduced adrenal ferredoxin + Steroid + Oxygen + 2 H+ <=> 11beta-Hydroxysteroid + 2 Oxidized adrenal ferredoxin + H2O
Equation
2 C00662 + C00377 + C00007 + 2 C00080 <=> C01058 + 2 C00667 + C00001
Comment
general reaction (see R02218, R02725, R02843, R03329, R03851 and R04850)
Enzyme
1.14.15.4
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R02726  2 Reduced adrenal ferredoxin + Steroid + Oxygen + 2 H+ <=> 11beta-Hydroxysteroid + 2 Oxidized adrenal ferredoxin + H2O
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.15.4
   R02726  Steroid <=> 11beta-Hydroxysteroid
Other DBs
RHEA: 15632

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KEGG   REACTION: R02725
Entry
R02725                      Reaction                               
Name
androstenedione,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating)
Definition
2 Reduced adrenal ferredoxin + Androstenedione + Oxygen + 2 H+ <=> 11beta-Hydroxyandrost-4-ene-3,17-dione + 2 Oxidized adrenal ferredoxin + H2O
Equation
2 C00662 + C00280 + C00007 + 2 C00080 <=> C05284 + 2 C00667 + C00001
Reaction class
RC00661  C00280_C05284
Enzyme
1.14.15.4
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R02725  2 Reduced adrenal ferredoxin + Androstenedione + Oxygen + 2 H+ <=> 11beta-Hydroxyandrost-4-ene-3,17-dione + 2 Oxidized adrenal ferredoxin + H2O
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.15.4
   R02726  Steroid <=> 11beta-Hydroxysteroid
    R02725  Androstenedione <=> 11beta-Hydroxyandrost-4-ene-3,17-dione
Orthology
K00497  steroid 11beta-monooxygenase [EC:1.14.15.4]
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]

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KEGG   REACTION: R02218
Entry
R02218                      Reaction                               
Name
progesterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)
Definition
Progesterone + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> 11beta-Hydroxyprogesterone + 2 Oxidized ferredoxin + H2O
Equation
C00410 + 2 C00138 + C00007 + 2 C00080 <=> C05498 + 2 C00139 + C00001
Reaction class
RC00661  C00410_C05498
Enzyme
1.14.15.4
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R02218  Progesterone + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> 11beta-Hydroxyprogesterone + 2 Oxidized ferredoxin + H2O
Orthology
K00497  steroid 11beta-monooxygenase [EC:1.14.15.4]
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]

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KEGG   REACTION: R02843
Entry
R02843                      Reaction                               
Name
steroid,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)
Definition
11-Deoxycortisol + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> Cortisol + 2 Oxidized ferredoxin + H2O
Equation
C05488 + 2 C00138 + C00007 + 2 C00080 <=> C00735 + 2 C00139 + C00001
Reaction class
RC00661  C00735_C05488
Enzyme
1.14.15.4
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R02843  11-Deoxycortisol + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> Cortisol + 2 Oxidized ferredoxin + H2O
Orthology
K00497  steroid 11beta-monooxygenase [EC:1.14.15.4]
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]

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KEGG   REACTION: R03262
Entry
R03262                      Reaction                               
Name
corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)
Definition
Corticosterone + 2 Reduced adrenal ferredoxin + Oxygen + 2 H+ <=> 18-Hydroxycorticosterone + 2 Oxidized adrenal ferredoxin + H2O
Equation
C02140 + 2 C00662 + C00007 + 2 C00080 <=> C01124 + 2 C00667 + C00001
Reaction class
RC00257  C01124_C02140
Enzyme
1.14.15.4       1.14.15.5
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R03262  Corticosterone + 2 Reduced adrenal ferredoxin + Oxygen + 2 H+ <=> 18-Hydroxycorticosterone + 2 Oxidized adrenal ferredoxin + H2O
    1.14.15.5
     R03262  Corticosterone + 2 Reduced adrenal ferredoxin + Oxygen + 2 H+ <=> 18-Hydroxycorticosterone + 2 Oxidized adrenal ferredoxin + H2O
Orthology
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]
Other DBs
RHEA: 11875

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KEGG   REACTION: R03263
Entry
R03263                      Reaction                               
Definition
18-Hydroxycorticosterone + Reduced adrenal ferredoxin + Oxygen <=> Aldosterone + Oxidized adrenal ferredoxin + 2 H2O
Equation
C01124 + C00662 + C00007 <=> C01780 + C00667 + 2 C00001
Reaction class
RC00893  C01124_C01780
Enzyme
1.14.15.4       1.14.15.5
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R03263  18-Hydroxycorticosterone + Reduced adrenal ferredoxin + Oxygen <=> Aldosterone + Oxidized adrenal ferredoxin + 2 H2O
    1.14.15.5
     R03263  18-Hydroxycorticosterone + Reduced adrenal ferredoxin + Oxygen <=> Aldosterone + Oxidized adrenal ferredoxin + 2 H2O
Orthology
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]
Reference
1  [PMID:21598279]
  Authors
Roumen L, Van Hoof B, Pieterse K, Hilbers PA, Custers EM, Plate R, De Gooyer M, Beugels IP, Emmen JM, Leysen D, Smits JF, Ottenheijm HC, Hermans JJ.
  Title
Application of a ligand-based theoretical approach to derive conversion paths and ligand conformations in CYP11B2-mediated aldosterone formation.
  Journal
J Comput Chem 32:2441-8 (2011)
DOI:10.1002/jcc.21827
Other DBs
RHEA: 50795

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KEGG   REACTION: R03329
Entry
R03329                      Reaction                               
Name
steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating)
Definition
17alpha-Hydroxyprogesterone + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> 21-Deoxycortisol + 2 Oxidized ferredoxin + H2O
Equation
C01176 + 2 C00138 + C00007 + 2 C00080 <=> C05497 + 2 C00139 + C00001
Comment
Oxidized ferredoxin is reduced by NADPH (see R01195)
Reaction class
RC00661  C01176_C05497
Enzyme
1.14.15.4
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R03329  17alpha-Hydroxyprogesterone + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> 21-Deoxycortisol + 2 Oxidized ferredoxin + H2O
Orthology
K00497  steroid 11beta-monooxygenase [EC:1.14.15.4]
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]

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KEGG   REACTION: R03851
Entry
R03851                      Reaction                               
Name
11-deoxycorticosterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)
Definition
11-Deoxycorticosterone + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> Corticosterone + 2 Oxidized ferredoxin + H2O
Equation
C03205 + 2 C00138 + C00007 + 2 C00080 <=> C02140 + 2 C00139 + C00001
Reaction class
RC00661  C02140_C03205
Enzyme
1.14.15.4
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R03851  11-Deoxycorticosterone + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> Corticosterone + 2 Oxidized ferredoxin + H2O
Orthology
K00497  steroid 11beta-monooxygenase [EC:1.14.15.4]
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]

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KEGG   REACTION: R04850
Entry
R04850                      Reaction                               
Name
17alpha,21-dihydroxypregnenolone:oxygen oxidoreductase (11-hydroxylating)
Definition
17alpha,21-Dihydroxypregnenolone + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> 11beta,17alpha,21-Trihydroxypregnenolone + 2 Oxidized ferredoxin + H2O
Equation
C05487 + 2 C00138 + C00007 + 2 C00080 <=> C05489 + 2 C00139 + C00001
Comment
Oxidized ferredoxin is reduced by NADPH (see R01195)
Reaction class
RC00661  C05487_C05489
Enzyme
1.14.15.4
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R04850  17alpha,21-Dihydroxypregnenolone + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> 11beta,17alpha,21-Trihydroxypregnenolone + 2 Oxidized ferredoxin + H2O
Orthology
K00497  steroid 11beta-monooxygenase [EC:1.14.15.4]
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]

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KEGG   REACTION: R08949
Entry
R08949                      Reaction                               
Name
11-deoxycorticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta,18-hydroxylating)
Definition
11-Deoxycorticosterone + 3 Reduced adrenal ferredoxin + 3 Oxygen <=> Aldosterone + 3 Oxidized adrenal ferredoxin + 4 H2O
Equation
C03205 + 3 C00662 + 3 C00007 <=> C01780 + 3 C00667 + 4 C00001
Comment
three-step reaction (see R03851+R03262+R03263)
Reaction class
RC02388  C01780_C03205
Enzyme
1.14.15.4
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R08949  11-Deoxycorticosterone + 3 Reduced adrenal ferredoxin + 3 Oxygen <=> Aldosterone + 3 Oxidized adrenal ferredoxin + 4 H2O
Orthology
K00497  steroid 11beta-monooxygenase [EC:1.14.15.4]

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