KEGG ORTHOLOGY: K10569

ORTHOLOGY: K10569

Entry

K10569                      KO

Symbol

NEIL3

Name

endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]

Pathway

map03410

Base excision repair

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    K10569  NEIL3; endonuclease VIII-like 3
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K10569  NEIL3; endonuclease VIII-like 3
Enzymes [BR:ko01000]
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.99  Other carbon-oxygen lyases
    4.2.99.18  DNA-(apurinic or apyrimidinic site) lyase
     K10569  NEIL3; endonuclease VIII-like 3
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    DNA glycosylases
     K10569  NEIL3; endonuclease VIII-like 3

Other DBs

GO:	0019104 0140078

Genes

HSA:	55247(NEIL3)

PTR:	471359(NEIL3)

PPS:	100995915(NEIL3)

GGO:	101141621(NEIL3)

PON:	100454526(NEIL3)

PPYG:

129035494(NEIL3)

NLE:	100592038(NEIL3)

HMH:	116466047(NEIL3)

SSYN:

129481276(NEIL3)

MCC:	699618(NEIL3)

MCF:	102118607(NEIL3)

MTHB:

126954497

MNI:	105466630(NEIL3)

CSAB:

103236567(NEIL3)

CATY:

105597770(NEIL3)

PANU:

101010354(NEIL3)

MLEU:

105543585(NEIL3)

RRO:	104678732(NEIL3)

RBB:	108534050(NEIL3)

TFN:	117086162(NEIL3)

PTEH:

111552583(NEIL3)

CANG:

105524368(NEIL3)

CJC:	100394929(NEIL3)

SBQ:	101036229(NEIL3)

CIMI:

108313700(NEIL3)

ANAN:

105728275(NEIL3)

CSYR:

103275893(NEIL3)

MMUR:

105874670(NEIL3)

LCAT:

123638669(NEIL3)

ERUF:

138398998(NEIL3)

PCOQ:

105816265(NEIL3)

OGA:	100966787(NEIL3)

MMU:	234258(Neil3)

MCAL:

110300682(Neil3)

MPAH:

110336758(Neil3)

RNO:	290729(Neil3)

MCOC:

116069278(Neil3)

ANU:	117721860(Neil3)

ASYL:

127668713(Neil3)

MMIU:

308429568(NEIL3)

MUN:	110566315(Neil3)

CGE:	100753722(Neil3)

MAUA:

101828347(Neil3)

PROB:

127220556(Neil3)

PLEU:

114699823(Neil3)

PMAV:

102915933(Neil3)

MORG:

121462367(Neil3)

MFOT:

126504795

AAMP:

119812718(Neil3)

CNL:	130862892(Neil3)

NGI:	103745234(Neil3)

HGL:	101721261(Neil3)

CPOC:

100723918(Neil3)

CCAN:

109676955(Neil3)

DORD:

105992064(Neil3)

DSP:	122126703(Neil3)

DMER:

138823045(Neil3)

PLOP:

125339344(Neil3)

NCAR:

124983570

SVUL:

306661809(NEIL3)

MMMA:

107142699(Neil3)

ITI:	101955673(Neil3)

SCIL:

308635199(NEIL3)

MAVE:

308272778(NEIL3)

OCU:

100338717

OPI:	101534927(NEIL3)

OCZ:	121146669(NEIL3)

TUP:	102497136(NEIL3)

GVR:	103604847(NEIL3)

CFA:	475639(NEIL3)

CLUD:

112651115(NEIL3)

VVP:	112932862(NEIL3)

VLG:	121489489(NEIL3)

NPO:	129515069(NEIL3)

AML:	100472788(NEIL3)

UMR:	103679361(NEIL3)

UAH:	113262020(NEIL3)

UAR:	123802604(NEIL3)

ELK:

111144508

LLV:

125090956

MPUF:

101670123(NEIL3)

MNP:	132006464(NEIL3)

MLK:	131820422(NEIL3)

NVS:	122890018(NEIL3)

MMAQ:

308337343(NEIL3)

ORO:	101374325(NEIL3)

EJU:	114206114(NEIL3)

ZCA:	113925029(NEIL3)

MLX:	118010092(NEIL3)

MANO:

123847363(NEIL3)

NSU:	110584219(NEIL3)

LWW:	102749213(NEIL3)

FCA:	101085881(NEIL3)

PYU:	121039642(NEIL3)

PCOO:

112870032(NEIL3)

PBG:	122470394(NEIL3)

PVIV:

125164679(NEIL3)

LRUF:

124521248

LGF:	123584673(NEIL3)

AJU:

106981493

PTG:	102951659(NEIL3)

PPAD:

109257862(NEIL3)

PLEZ:

122217347(NEIL3)

HHV:	120222107(NEIL3)

CCRU:

144243926(NEIL3)

BTA:	515343(NEIL3)

BOM:	102286612(NEIL3)

BIU:	109553582(NEIL3)

BJV:	133239841(NEIL3)

BBUB:

102398926(NEIL3)

BKE:	129643214(NEIL3)

BBIS:

104981041(NEIL3)

CHX:	102173065(NEIL3)

OAS:	101106140(NEIL3)

OCAN:

138430965(NEIL3)

BTAX:

128068373(NEIL3)

CSUM:

138079231(NEIL3)

ODA:	120860536 120865841(NEIL3)

CCAD:

122432552(NEIL3)

MREE:

136176298(NEIL3)

OVR:	110133064(NEIL3)

MBEZ:

129549288(NEIL3)

SSC:	100156631(NEIL3)

CFR:	102509882(NEIL3)

CBAI:

105067703(NEIL3)

CDK:	105084418(NEIL3)

VPC:	102539132(NEIL3)

BACU:

103009943(NEIL3)

BMUS:

118887749(NEIL3)

LVE:	103090691(NEIL3)

OOR:	101286571(NEIL3)

LALB:

132512662(NEIL3)

GMF:	115838747(NEIL3)

DDP:	132417507(NEIL3)

SCOO:

307179620(NEIL3)

PCRS:

137215910(NEIL3)

DLE:	111173341(NEIL3)

PCAD:

102988885(NEIL3)

PSIU:

116746867(NEIL3)

PPHC:

136141833(NEIL3)

NASI:

112399670(NEIL3)

HAMP:

307068690(NEIL3)

ECB:	100060702(NEIL3)

EPZ:	103540338(NEIL3)

EAI:	106843563(NEIL3)

MYB:	102252719(NEIL3)

MYD:	102770894(NEIL3)

MMYO:

118651918(NEIL3)

MLF:	102436089(NEIL3)

MDT:	132228768(NEIL3)

MYUM:

139004824(NEIL3)

PKL:	118729391(NEIL3)

EFUS:

103295458(NEIL3)

MNA:	107541938(NEIL3)

DRO:	112306653(NEIL3)

SHON:

118993054(NEIL3)

AJM:	119050310(NEIL3)

PDIC:

114508862(NEIL3)

PHAS:

123807650(NEIL3)

MMF:	118622997(NEIL3)

PPAM:

129064734(NEIL3)

HAI:	109387650(NEIL3)

RFQ:	117021550(NEIL3)

RHII:

308496860(NEIL3)

PALE:

102894583(NEIL3)

PGIG:

120618405(NEIL3)

PVP:	105299626(NEIL3)

RAY:	107504304(NEIL3)

MJV:	108390776(NEIL3)

TOD:	119257998(NEIL3)

SARA:

101553363(NEIL3)

SFUM:

130023771(NEIL3)

SETR:

126005967(NEIL3)

LAV:	100658133(NEIL3)

ETF:	101650266(NEIL3)

DNM:	101423639(NEIL3)

MDO:	100017570(NEIL3)

GAS:	123252288(NEIL3)

SHR:	100930463(NEIL3)

AFZ:

127539862

PCW:	110215994(NEIL3)

TVP:	118854265(NEIL3)

PBRV:

138167659(NEIL3)

MLAO:

141517660(NEIL3)

GGA:	428750(NEIL3)

PCOC:

116237981(NEIL3)

MGP:	100548485(NEIL3)

CJO:	107313323(NEIL3)

TPAI:

128080271(NEIL3)

LMUT:

125692022(NEIL3)

APLA:

101796632(NEIL3)

AACU:

137856198(NEIL3)

OJA:	118166402(NEIL3)

BCLA:

308442678(NEIL3)

ACYG:

106041778(NEIL3)

ABRC:

308194470(NEIL3)

CATA:

118253481(NEIL3)

AFUL:

116489021(NEIL3)

TGU:	100219386(NEIL3)

LSR:	110480924(NEIL3)

VMC:	128806836(NEIL3)

VCHA:

128786835(NEIL3)

AIB:	137472184(NEIL3)

SCAN:

103825788(NEIL3)

PMOA:

120498044(NEIL3)

OTC:	121348438(NEIL3)

PRUF:

121360377(NEIL3)

ATRC:

139592372(NEIL3)

MATE:

118686464(NEIL3)

MAEN:

136556013(NEIL3)

GFR:	102033031(NEIL3)

FAB:	101816896(NEIL3)

OMA:	130252740(NEIL3)

PHI:	102101755(NEIL3)

PMAJ:

107203516(NEIL3)

CCAE:

111927938(NEIL3)

CCW:	104690851(NEIL3)

CBRC:

103622582(NEIL3)

ACOE:

138109767(NEIL3)

ETL:	114066048(NEIL3)

ZAB:	102073802(NEIL3)

ZLE:	135447294(NEIL3)

ACHL:

103807505(NEIL3)

SVG:	106863233(NEIL3)

MMEA:

130584900(NEIL3)

LCAI:

146438266(NEIL3)

HRT:	120752852(NEIL3)

SATI:

136360369(NEIL3)

CFAI:

136291158(NEIL3)

CCIC:

134044387(NEIL3)

NNT:	104411680(NEIL3)

SHAB:

115610709(NEIL3)

POCC:

134166547(NEIL3)

PECH:

308232818(NEIL3)

FPG:	101916334(NEIL3)

FCH:	102048722(NEIL3)

FRS:	119153211(NEIL3)

ACUN:

113479243(NEIL3)

ANOC:

141959802(NEIL3)

SURA:

141941997(NEIL3)

TALA:

104366585(NEIL3)

ACHC:

115342552(NEIL3)

HALD:

104316568(NEIL3)

HLE:	104833367(NEIL3)

AGEN:

126052218

HHAR:

128138170(NEIL3)

BBUT:

142037375(NEIL3)

GCL:

127015836

CSTI:

104555195(NEIL3)

LDI:	104339942(NEIL3)

MNB:

103769371

DPUB:

104296540(NEIL3)

PPUS:

135178221(NEIL3)

IIN:	128968606(NEIL3)

AVIT:

104268207(NEIL3)

BRHI:

104496472(NEIL3)

EGZ:	104129421(NEIL3)

NNI:	104021376(NEIL3)

PLEC:

309591963(NEIL3)

PCRI:

104024284(NEIL3)

PCAO:

104042289(NEIL3)

PARX:

142056435(NEIL3)

PADL:

103922573(NEIL3)

AFOR:

103893308(NEIL3)

FGA:	104069451(NEIL3)

CBOR:

142081923(NEIL3)

GSTE:

104253241(NEIL3)

CBOY:

140652297(NEIL3)

MAME:

142409126(NEIL3)

CLV:	102090822(NEIL3)

CNIC:

135988564(NEIL3)

NMAY:

308039870(NEIL3)

PGUU:

104458743(NEIL3)

PLET:

104614525(NEIL3)

EHS:	104513600(NEIL3)

CMAC:

104473209(NEIL3)

CUCA:

104063512(NEIL3)

PCUR:

138720372(NEIL3)

TEO:	104376182(NEIL3)

BREG:

104641675

GAME:

129206017(NEIL3)

OHA:	104333472(NEIL3)

ACAR:

104518543(NEIL3)

CEUR:

306718135(NEIL3)

CPEA:

104387287(NEIL3)

HEK:	139795930(NEIL3)

CVF:	104283799(NEIL3)

RTD:	128909972(NEIL3)

CRID:

134516686(NEIL3)

LMIC:

141743655(NEIL3)

NARQ:

141469128(NEIL3)

AAM:	106484054(NEIL3)

AROW:

112966788(NEIL3)

NPD:	112948545(NEIL3)

TGT:	104579870(NEIL3)

DNE:	112986093(NEIL3)

SCAM:

104145211(NEIL3)

ASN:	102379940(NEIL3)

AMJ:	102565574(NEIL3)

CPOO:

109309773(NEIL3)

GGN:	109301012(NEIL3)

PSS:	102450651(NEIL3)

CIZ:	142012058(NEIL3)

CMY:	102943219(NEIL3)

CCAY:

125635749(NEIL3)

LKP:	140909985(NEIL3)

NDS:	141985888(NEIL3)

DCC:	119854674(NEIL3)

CPIC:

101937016(NEIL3)

TST:	117878346(NEIL3)

EOB:	135879527(NEIL3)

CABI:

116826661(NEIL3)

MRV:	120406418(NEIL3)

EMQ:	137155577(NEIL3)

ACS:	100566810(neil3)

ASAO:

132776718(NEIL3)

PVT:	110084088(NEIL3)

SUND:

121932077(NEIL3)

PBI:	103056400(NEIL3)

PMUR:

107285705(NEIL3)

CTIG:

120297705(NEIL3)

TSR:	106541249(NEIL3)

PGUT:

117680138(NEIL3)

PCAE:

139320499(NEIL3)

APRI:

131202974(NEIL3)

PTEX:

113435704(NEIL3)

NSS:	113411899(NEIL3)

VKO:	123023814(NEIL3)

PMUA:

114604355(NEIL3)

PRAF:

128420832(NEIL3)

ZVI:	118083608(NEIL3)

HCG:	128328306(NEIL3)

GJA:	107117471(NEIL3)

STOW:

125439899(NEIL3)

EMC:	129336967(NEIL3)

XLA:	100380996(neil3.L)

XTR:	549955(neil3)

NPR:	108792717(NEIL3)

RTEM:

120921095(NEIL3)

ACAT:

141113559(NEIL3)

PADS:

140326991(NEIL3)

BBUF:

120991756(NEIL3)

BGAR:

122933110(NEIL3)

DTC:	141091972(NEIL3)

PWL:	138304544(NEIL3)

DRE:	492463(neil3)

DAES:

130240626(neil3)

SRX:	107740121(neil3)

SANH:

107669105(neil3)

SGH:	107602597(neil3)

CCAR:

109076943(neil3)

CAUA:

113114141(neil3)

CGIB:

127971928

PTET:

122357172(neil3)

LROH:

127176346(neil3)

GRF:	141288339(neil3)

OMC:	131552906(neil3)

PPRM:

120474318(neil3) 120474324

RKG:	130095163(neil3)

SCEP:

307170593(neil3)

PPHX:

307008715(neil3)

MAMB:

125258738(neil3)

CIDE:

127494524

CERY:

137021441(neil3)

MASI:

127412913 127417811

TROS:

130564225(neil3)

TDW:	130438424(neil3)

MANU:

129422010(neil3)

PDAB:

135757958(neil3)

IPU:	108268715(neil3)

IFU:	128612093(neil3)

PHYP:

113524439(neil3)

SMEO:

124386428(neil3)

TFD:	113655024(neil3)

TVC:	132856190(neil3)

CGAR:

128532289(neil3)

NGRA:

132898182(neil3)

AMEX:

103035931(neil3)

CMAO:

118807298(neil3)

EEE:	113579935(neil3)

CHAR:

105906170(neil3)

SPIL:

134095529(neil3)

ASAD:

121682012(neil3)

TRU:	101065987(neil3)

TFS:	130531368(neil3)

TNG:	GSTEN00024419G001

NCC:	104966476(neil3)

TBEN:

117490935(neil3)

CGOB:

115014304(neil3)

PGEO:

117444679(neil3)

GACU:

117553611(neil3)

EMAC:

134860224(neil3)

ELY:	117261371(neil3)

EFO:	125894031(neil3)

PLEP:

121948254(neil3)

SLUC:

116052908(neil3)

SVIT:

144524112(neil3)

ECRA:

117951976(neil3)

ESP:	116696515(neil3)

PFLV:

114562974(neil3)

PFLT:

120567092(neil3)

GAT:	120817941(neil3)

PPUG:

119211253(neil3)

AFB:	129090007(neil3)

CLUM:

117737389(neil3)

PSWI:

130209328(neil3)

CANA:

137798690(neil3)

TBU:	306745629(neil3)

CVE:	137875723(neil3)

AMIR:

142962594(neil3)

MSAM:

119888874(neil3)

SCHU:

122880620(neil3)

EARM:

139291561(neil3)

CUD:	121516187(neil3)

SPUL:

138598655(neil3)

LMIX:

132981639(neil3)

HTC:	141793677(neil3)

ALAT:

119007488(neil3)

ASTR:

137602965(neil3)

PKLU:

139207381(neil3)

LCO:	104917917(neil3)

MZE:	101465661(neil3)

ONL:	100707610(neil3)

OAU:	116335221(neil3)

OLA:	101159899(neil3)

OML:	112139734(neil3)

CSAI:

133447491(neil3)

XMA:	102218098(neil3)

XCO:	114139532(neil3)

XHE:	116714796(neil3)

PRET:

103471838(neil3)

PFOR:

103137337(neil3)

PLAI:

106947130(neil3)

PMEI:

106914868(neil3)

GAF:	122837016(neil3)

PPRL:

129360688 129360694

CVG:	107091723(neil3)

CTUL:

119772626(neil3)

GMU:	124860760(neil3)

NFU:	107379824(neil3)

KMR:	108236679(neil3)

ALIM:

106513251(neil3)

NWH:	119408624(neil3)

LTU:	140317741(neil3)

TBT:	306763148(neil3)

MCEP:

125008635(neil3)

AOCE:

111581512(neil3)

EJA:	138211070(neil3)

BFRE:

138622737(neil3)

LCF:

108885183

CSEM:

103390674(neil3)

POV:	109628325(neil3)

SSEN:

122778357(neil3)

SSOE:

131472964(neil3)

HHIP:

117769496(neil3)

HSP:	118112531(neil3)

PPLT:

128446451(neil3)

SMAU:

118319482(neil3)

SDU:	111232489(neil3)

SLAL:

111648198(neil3)

XGL:	120785501(neil3)

HCQ:	109524434(neil3)

SSCV:

125991131(neil3)

SBIA:

133509181(neil3)

PEE:	133407524(neil3)

PTAO:

133484833(neil3)

BPEC:

110153707

ENY:	140348454(neil3)

MALB:

109964313(neil3)

BSPL:

114864480(neil3)

SJO:	128363152(neil3)

SSCO:

133986188(neil3)

TTY:	137189818(neil3)

GMH:	115552539(neil3)

SASA:

106604520(neil3)

STRU:

115170776(neil3)

OTW:	112221048(neil3)

OMY:	110488926(neil3)

OGO:	123993500(neil3)

ONE:	115130805(neil3)

OKI:	109864840(neil3)

OKE:	118379525(neil3)

OMM:	135526494(neil3)

OCLA:

139366355

SALP:

111965830(neil3)

SNH:	120048035(neil3)

SFON:

129858263(neil3)

CCLU:

121541508(neil3)

ELS:	105027604(neil3)

OEP:	134032268(neil3)

SFM:	108925953(neil3)

PKI:	111845367(neil3)

AANG:

118231380(neil3)

AROT:

135260042(neil3)

CCOG:

133135506(neil3)

LOC:	102689381(neil3)

PSPA:

121320684(neil3)

ARUT:

117420415(neil3)

LCM:	102349592(NEIL3)

CMK:	103180213(neil3)

RTP:	109920269(neil3)

CPLA:

122557301(neil3)

CPUN:

140495463(neil3)

HOC:	132826867(neil3)

SCAU:

119970701(neil3)

LERI:

129716208

HAKA:

140728935(neil3)

PMRN:

116942953(NEIL3)

LRJ:	133342974(NEIL3)

BFO:

BBEL:

PFLL:

FOC:

TPAL:

EAF:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PTRU:

SPRM:

ESN:

MRJ:

PORN:

OOT:

LGI:	LOTGIDRAFT_174963

PVUL:

PCAN:

LSAX:

BARL:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

DPOL:

127854528 127872003 127877185

MAEA:

128226081 128229319 128229320 128229340

LJP:

LAK:

LLON:

ATH:

ALY:

CRB:

CSAT:

104705655 104735405 104769618

EUS:	EUTSA_v10013728mg

BRP:

103856039

BNA:	106431170 111214308

BOE:	106331551 106331650

RSZ:

108846377

FCY:	FRACYDRAFT_225447

TPS:	THAPSDRAFT_262318(Fpg)

» show all

Reference

PMID:19170771

Authors

Takao M, Oohata Y, Kitadokoro K, Kobayashi K, Iwai S, Yasui A, Yonei S, Zhang QM

Title

Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant.

Journal

Genes Cells 14:261-70 (2009)
DOI:10.1111/j.1365-2443.2008.01271.x

Sequence

[hsa:55247]

Reference

PMID:12200441

Authors

Takao M, Kanno S, Kobayashi K, Zhang QM, Yonei S, van der Horst GT, Yasui A

Title

A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue.

Journal

J Biol Chem 277:42205-13 (2002)
DOI:10.1074/jbc.M206884200

Sequence

[hsa:55247]

All links

Ontology (2)   
   GO (2)   
Gene (851)   
   MGENES (80)   
   RefGene (767)   
   OC (4)   
All databases (853)   

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