KEGG   PATHWAY: hsa00051
Entry
hsa00051                    Pathway                                
Name
Fructose and mannose metabolism - Homo sapiens (human)
Class
Metabolism; Carbohydrate metabolism
Pathway map
hsa00051  Fructose and mannose metabolism
hsa00051

Module
hsa_M01000  GDP-Man biosynthesis, Fru-6P => GDP-Man [PATH:hsa00051]
hsa_M01015  GDP-Man biosynthesis, Man => GDP-Man [PATH:hsa00051]
hsa_M01016  GDP-L-Fuc biosynthesis, GDP-Man => GDP-L-Fuc [PATH:hsa00051]
Drug
D01688  Epalrestat (JP18/INN)
D01715  Risarestat (INN)
D01842  Fidarestat (JAN/INN)
D02323  Tolrestat (USAN/INN)
D02328  Zopolrestat (USAN/INN)
D02835  Alrestatin sodium (USAN)
D03803  Lidorestat (USAN)
D03805  Minalrestat (USAN/INN)
D03806  Ponalrestat (USAN/INN)
D03807  Zenarestat (USAN/INN)
D05893  Sorbinil (USAN/INN)
D06403  Ranirestat (JAN/INN)
D12384  Govorestat (USAN/INN)
D12390  Caficrestat (USAN/INN)
Other DBs
GO: 0006000 0006013
Organism
Homo sapiens (human) [GN:hsa]
Gene
197258  FCSK; L-fucose kinase [KO:K05305] [EC:2.7.1.52]
2203  FBP1; fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
226  ALDOA; fructose-bisphosphate aldolase A isoform 1 [KO:K01623] [EC:4.1.2.13]
229  ALDOB; fructose-bisphosphate aldolase B [KO:K01623] [EC:4.1.2.13]
230  ALDOC; fructose-bisphosphate aldolase C [KO:K01623] [EC:4.1.2.13]
231  AKR1B1; aldo-keto reductase family 1 member B1 isoform 1 [KO:K00011] [EC:1.1.1.21]
26007  TKFC; triokinase/FMN cyclase isoform b [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
2762  GMDS; GDP-mannose 4,6 dehydratase isoform 1 [KO:K01711] [EC:4.2.1.47]
29925  GMPPB; mannose-1-phosphate guanylyltransferase catalytic subunit beta isoform 2 [KO:K00966] [EC:2.7.7.13]
29926  GMPPA; mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 1 [KO:K00966] [EC:2.7.7.13]
3098  HK1; hexokinase-1 isoform HKI [KO:K00844] [EC:2.7.1.1]
3099  HK2; hexokinase-2 isoform 1 [KO:K00844] [EC:2.7.1.1]
3101  HK3; hexokinase-3 [KO:K00844] [EC:2.7.1.1]
3795  KHK; ketohexokinase isoform b [KO:K00846] [EC:2.7.1.3]
4351  MPI; mannose-6-phosphate isomerase isoform 1 [KO:K01809] [EC:5.3.1.8]
441282  AKR1B15; aldo-keto reductase family 1 member B15 isoform b [KO:K00011] [EC:1.1.1.21]
51171  HSD17B14; L-fucose dehydrogenase [KO:K28472]
5207  PFKFB1; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
5208  PFKFB2; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform a [KO:K19029] [EC:2.7.1.105 3.1.3.46]
5209  PFKFB3; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 1 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
5210  PFKFB4; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform b [KO:K19030] [EC:2.7.1.105 3.1.3.46]
5211  PFKL; ATP-dependent 6-phosphofructokinase, liver type isoform b [KO:K00850] [EC:2.7.1.11]
5213  PFKM; ATP-dependent 6-phosphofructokinase, muscle type isoform 2 [KO:K00850] [EC:2.7.1.11]
5214  PFKP; ATP-dependent 6-phosphofructokinase, platelet type isoform 1 [KO:K00850] [EC:2.7.1.11]
5372  PMM1; phosphomannomutase 1 [KO:K17497] [EC:5.4.2.8]
5373  PMM2; phosphomannomutase 2 [KO:K17497] [EC:5.4.2.8]
55556  ENOSF1; mitochondrial enolase superfamily member 1 isoform rTSbeta [KO:K18334] [EC:4.2.1.68]
57016  AKR1B10; aldo-keto reductase family 1 member B10 [KO:K00011] [EC:1.1.1.21]
57103  TIGAR; fructose-2,6-bisphosphatase TIGAR [KO:K14634] [EC:3.1.3.46]
6652  SORD; sorbitol dehydrogenase [KO:K00008] [EC:1.1.1.14]
7167  TPI1; triosephosphate isomerase isoform 1 [KO:K01803] [EC:5.3.1.1]
7264  GFUS; GDP-L-fucose synthase isoform 2 [KO:K02377] [EC:1.1.1.271]
80201  HKDC1; hexokinase HKDC1 [KO:K00844] [EC:2.7.1.1]
8789  FBP2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
8790  FPGT; fucose-1-phosphate guanylyltransferase isoform 1 [KO:K00976] [EC:2.7.7.30]
Compound
C00085  D-Fructose 6-phosphate
C00095  D-Fructose
C00096  GDP-mannose
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00159  D-Mannose
C00186  (S)-Lactate
C00247  L-Sorbose
C00267  alpha-D-Glucose
C00275  D-Mannose 6-phosphate
C00325  GDP-L-fucose
C00354  D-Fructose 1,6-bisphosphate
C00392  Mannitol
C00424  (S)-Lactaldehyde
C00464  Mannan
C00507  L-Rhamnose
C00577  D-Glyceraldehyde
C00636  D-Mannose 1-phosphate
C00644  D-Mannitol 1-phosphate
C00665  beta-D-Fructose 2,6-bisphosphate
C00794  D-Sorbitol
C00861  L-Rhamnulose
C00976  GDP-D-mannuronate
C01019  L-Fucose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01099  L-Fuculose 1-phosphate
C01131  L-Rhamnulose 1-phosphate
C01222  GDP-4-dehydro-6-deoxy-D-mannose
C01355  Fructan
C01487  D-Allose
C01720  L-Fuconate
C01721  L-Fuculose
C01768  (Alginate)n
C01934  L-Rhamnonate
C02431  L-Rhamnofuranose
C02492  1,4-beta-D-Mannan
C02888  Sorbose 1-phosphate
C02962  D-Allose 6-phosphate
C02977  GDP-6-deoxy-D-talose
C02985  L-Fucose 1-phosphate
C02991  L-Rhamnono-1,4-lactone
C03117  GDP-6-deoxy-D-mannose
C03267  beta-D-Fructose 2-phosphate
C03827  2-Dehydro-3-deoxy-L-fuconate
C03979  2-Dehydro-3-deoxy-L-rhamnonate
C05144  (beta-D-Mannuronate)n
C05392  Oligouronide with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl group
C06192  ADP-mannose
C11516  2-(alpha-D-Mannosyl)-3-phosphoglycerate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C18028  L-Fucono-1,5-lactone
C18096  D-Allulose 6-phosphate
C20781  2,4-Diketo-3-deoxy-L-fuconate
C20836  beta-L-Fucopyranose
Related
pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00052  Galactose metabolism
hsa00053  Ascorbate and aldarate metabolism
hsa00510  N-Glycan biosynthesis
hsa00520  Amino sugar and nucleotide sugar metabolism
hsa00620  Pyruvate metabolism
KO pathway
ko00051   

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