ID A0A8C8IMT2_ONCTS Unreviewed; 1226 AA.
AC A0A8C8IMT2;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2025, sequence version 2.
DT 28-JAN-2026, entry version 19.
DE RecName: Full=Thrombospondin-like N-terminal domain-containing protein {ECO:0000259|SMART:SM00210};
GN Name=LOC112227571 {ECO:0000313|Ensembl:ENSOTSP00005078578.2};
OS Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=74940 {ECO:0000313|Ensembl:ENSOTSP00005078578.2, ECO:0000313|Proteomes:UP000694402};
RN [1] {ECO:0000313|Ensembl:ENSOTSP00005078578.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSOTSP00005078578.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
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DR RefSeq; XP_042164850.1; XM_042308916.1.
DR AlphaFoldDB; A0A8C8IMT2; -.
DR Ensembl; ENSOTST00005085142.2; ENSOTSP00005078578.2; ENSOTSG00005037000.2.
DR GeneID; 112227571; -.
DR KEGG; otw:112227571; -.
DR GeneTree; ENSGT00940000164061; -.
DR Proteomes; UP000694402; Unassembled WGS sequence.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IEA:TreeGrafter.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:TreeGrafter.
DR FunFam; 2.60.120.200:FF:000039; Collagen XV alpha 1 chain; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023:SF1112; COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR Pfam; PF01391; Collagen; 3.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SMART; SM00210; TSPN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000694402};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1226
FT /note="Thrombospondin-like N-terminal domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5044323192"
FT DOMAIN 37..225
FT /note="Thrombospondin-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00210"
FT REGION 223..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..349
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..383
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..476
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..488
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..567
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..640
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..676
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..900
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..958
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..980
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1226 AA; 124596 MW; 7C3184E4681CD5A7 CRC64;
MTSRSLSLWS FGIHLALCYC QLSTAYQLLD ERGSQGQIDL TELIGIPLPP SVSFITGFEG
YPAYSFGPDA NVGRLTKSFI PDPFYRDFAM TVTAKPTTQR GGVLFAITDA YQRVVHLGVA
LSPVEDGSQR VLLYYTDPGD GSTKEAASFK LGDLTGRWAR FTLTVQGAEV RLYMDCEEYH
RVAFQRSPEP LTFEASSGIF VGNAGGTGLD RFVGSIQQLV LKGDPTAPDD QCEEDDPYAS
GYGSGDDSFD DTETLDEVKK VVEEREYIMP EEPMITPVRA PPTEASPSDD EEDAGETSGQ
EVELTAERGP SQTADAAYRL GSAMPSQKGE RGDPGPAGPP GSPGPPGPQS PLGDGSSGEG
EPGPRGPQGP QGPAGTPGAP GNDGQPGSGG KDGDPGENGV QGFPGLPGDP GPKGDKGDPG
VGKPGSPGPP GPPGRPNSSR SLNVVDGSGF EDFDSDTEIM TGPPGPPGSP GLPGPPGSSE
GLSASPGAPG TPGKDGEMGK PGQPGVDGHD GDPGPAGERG EKGEPGLSGP PGPKGEPSAA
GFPGLPGSEG PEGTPGLRGP PGPPGPPGRG FSLDLEDIEG SGTLGGFGAV MPRGPQGPIG
KPGPPGPKGK DGQDGLPGVA VKGEPGAPGA AGSSGLDGLP GHTGVKGDSG VMGPKGERGQ
DGLSFPGPPG PPGPPGPVIN LQDLLLNDTE GVFNFSGGLE SQGPRGPRGP KGDLGMTGFM
GPPGLKGEKG EPGVMVAADG SMMSGLTGPQ GPKGIKGDCG VPGPAGVMGP IGPEGPKGEY
GYPGHPGRPG ISGHKGDRGD AVVVSGPPGP PGPPGRPGMF NCPKGTVFPI PPRPHCKKAI
NGSKSSTNGG ANCLPTGTKG DRGERGFPGM PAPSLTMLPK GTTGNKGDHG FRGDKGEKGE
AGLPGSPGMP GRSGLVGPKG ETVMGPRGYP GVPGSPGTPG YGRPGPQGPQ GPPGPPGEPS
RFGSAVTIHG PPGPTGPAGP PGTSAMTFPS SEVMMQQTKY SSEGTLSFTT GTGKLYIRVQ
QGWKEVLLGD LIPLPMNLLL NDEAQPGSGR KYGLKLVALN QPHTGNFGGV YIADKMCYEQ
AKAMGLSAYY RAFLSSPKPR AINKDLVPQK FRESYPVTNL RGDILFSNYK SIFTGGGGKF
PPNIPIYSFD GRDVLADPFW PKKSIWHGSN TFGNMAVDRS CESWRVNDIS IVGQSSSLSS
GSLIGQQTSS CSNELIILCI ETIEHV
//
