Calcium signaling |
N00953 |
|
| | Glutamate | → | GRM1 | → | GNAQ | → | PLCB | → | IP3 | → | ITPR | → | Ca2+ | → | PKC | ⊣ | TRPC3 | → | Ca2+ |
N00960 |
SCA |
| | SPTBN2* | ⊣ | GRM1 | → | GNAQ | → | PLCB | → | IP3 | → | ITPR | → | Ca2+ |
N00954 |
SCA |
| | Glutamate | → | GRM1* | → | GNAQ | → | PLCB | → | IP3 | → | ITPR | → | Ca2+ |
N00958 |
SCA |
| | Glutamate | → | GRM1 | → | GNAQ | → | PLCB | → | IP3 | → | ITPR1* | → | Ca2+ |
N00959 |
SCA |
| | Glutamate | → | GRM1 | → | GNAQ | → | PLCB | → | IP3 | → | ITPR1* | ⌿ | Ca2+ |
N00955 |
SCA |
| | Glutamate | → | GRM1 | → | GNAQ | → | PLCB | → | IP3 | → | ITPR | → | Ca2+ | → | PRKCG* | ⌿ | TRPC3 |
N00956 |
SCA |
| | Glutamate | → | GRM1 | → | GNAQ | → | PLCB | → | IP3 | → | ITPR | → | Ca2+ | → | PRKCG* | ⊣ | TRPC3 |
N00961 |
SCA |
| | | | | | | | | | | | TRPC3* | → | Ca2+ |
N01032 |
PD |
| | | | | | PRKN* | → | PLCG1 | → | IP3 | → | ITPR | → | Ca2+ |
N00984 |
|
| | Glutamate | → | GRM5 | → | GNAQ | → | PLCB | → | IP3 | → | ITPR | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
N01002 |
AD |
APP* | → | Abeta | → | GRM5 | → | GNAQ | → | PLCB | → | IP3 | → | ITPR | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS | = | APAF1 | → | CASP9 | → | CASP3 |
N01151 |
ALS |
| | | | | | | | | | SIGMAR1* | → | ITPR | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS |
N01008 |
AD |
| | | | | | | | | | PSEN1* | → | ITPR | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS |
N01007 |
AD |
| | | | | | | | | | (PSEN1*,PSEN2*) | → | RYR3 | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
N01199 |
PrD |
| | | | | | | | | | PRNP* | → | (RYR,ITPR) | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS | = | APAF1 | → | CASP9 | → | CASP3 |
N00985 |
HD |
| | Glutamate | → | GRM5 | → | GNAQ | → | PLCB | → | IP3 | → | (ITPR+HTT*) | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
N00957 |
SCA |
| | Glutamate | → | GRM1 | → | GNAQ | → | PLCB | → | IP3 | → | (ITPR1+(ATXN2*,ATX.. | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS |
N01000 |
|
| | ACh | → | mAChR | → | GNAQ | → | PLCB | → | IP3 | → | ITPR | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS |
N01001 |
AD |
APP* | → | Abeta | → | mAChR | → | GNAQ | → | PLCB | → | IP3 | → | ITPR | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS |
N00967 |
|
| | | | | | | | | | Ca2+(extracellular.. | − | VGCC | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
N00986 |
HD |
| | | | | | | | HTT* | ⊣ | STX1A | ⊣ | VGCC(N-type) | → | Ca2+ |
N01004 |
AD |
| | | | | | | | APP* | → | Abeta | → | VGCC(L-type) | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS |
N01201 |
PrD |
| | | | | | | | | | PRNP* | ⊣ | VGCC(N,L-type) | → | Ca2+ |
N01006 |
AD |
| | | | | | | | | | | | | | APP* | → | Abeta | → | PPID | → | MPTP | → | CYCS |
N01031 |
PD |
| | | | | | | | | | Ca2+(extracellular.. | − | SNCA* | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS | = | APAF1 | → | CASP9 | → | CASP3 |
N00968 |
SCA |
| | | | | | | | | | Ca2+(extracellular.. | − | CACNA1A* | → | Ca2+ |
N00969 |
SCA |
| | | | | | | | | | Ca2+(extracellular.. | ⌿ | CACNA1A* | ⌿ | Ca2+ |
N00970 |
|
| | | | | | | | | | Glutamate | → | NMDAR | → | Ca2+ |
N00987 |
HD |
| | | | | | | | HTT* | ⌿ | DLG4 | → | NMDAR | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS | = | APAF1 | → | CASP9 | → | CASP3 |
N01200 |
PrD |
| | | | | | | | | | PRNP* | → | NMDAR | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS | = | APAF1 | → | CASP9 | → | CASP3 |
N00971 |
SCA |
| | | | | | | | | | PDYN* | → | NMDAR | → | Ca2+ |
N01003 |
AD |
| | | | | | | | APP* | → | Abeta | → | NMDAR | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS |
Ubiquitin-proteasome system |
N01019 |
|
UBCH7/8 | = | PRKN | ⊣ | alphaSp22 |
N01020 |
PD |
UBCH7/8 | ⌿ | PRKN* | ⌿ | alphaSp22 |
N01021 |
|
UBCH7/8 | = | PRKN | ⊣ | PAELR |
N01022 |
PD |
UBCH7/8 | ⌿ | PRKN* | ⌿ | PAELR |
N01023 |
|
UBCH7/8 | = | PRKN | ⊣ | CDCREL1 |
N01024 |
PD |
UBCH7/8 | ⌿ | PRKN* | ⌿ | CDCREL1 |
N01025 |
|
UBCH7/8 | = | PRKN | ⊣ | SYPH1 |
N01026 |
PD |
UBCH7/8 | ⌿ | PRKN* | ⌿ | SYPH1 |
N01029 |
|
| | | | (Protein+UB) | − | 26S | → | Peptide |
N01144 |
ALS |
SOD1* | ⊣ | DERL1 | → | (Protein+UB) | − | 26S | → | Peptide |
N01145 |
ALS |
| | VCP* | ⊣ | (Protein+UB) | − | 26S | → | Peptide |
N01146 |
ALS |
| | UBQLN2* | ⊣ | (Protein+UB) | − | 26S | → | Peptide |
N01060 |
AD |
| | APP* | → | Abeta | ⊣ | 26S |
N01030 |
PD |
| | | | SNCA* | ⊣ | 26S |
N01061 |
HD |
| | | | HTT* | ⊣ | 26S |
N01197 |
PrD |
| | | | PRNP* | ⊣ | 26S |
N01027 |
|
UB(chain) | − | UCHL1 | → | UB(free) |
N01028 |
PD |
UB(chain) | ⌿ | UCHL1* | ⌿ | UB(free) |
Unfolded protein response (UPR) signaling |
N01009 |
|
| | | | EIF2AK3 | → | EIF2S1 | → | ATF4 | ⇒ | DDIT3 |
N01010 |
AD |
| | PSEN1* | ⊣ | EIF2AK3 | → | EIF2S1 | → | ATF4 | ⇒ | DDIT3 |
N01035 |
PD |
SNCA* | ⊣ | BIP | ⊣ | EIF2AK3 | → | EIF2S1 | → | ATF4 | ⇒ | DDIT3 |
N01149 |
ALS |
SOD1* | ⊣ | BIP | ⊣ | EIF2AK3 | → | EIF2S1 | → | ATF4 | ⇒ | DDIT3 |
N01198 |
PrD |
PRNP* | ⊣ | BIP | ⊣ | EIF2AK3 | → | EIF2S1 | → | ATF4 | ⇒ | DDIT3 |
N01011 |
|
| | | | ERN1 | → | XBP1 | ⇒ | DDIT3 |
N01012 |
AD |
| | PSEN1* | ⊣ | ERN1 | → | XBP1 |
N01034 |
PD |
SNCA* | ⊣ | BIP | ⊣ | ERN1 | → | XBP1 |
N01148 |
ALS |
SOD1* | ⊣ | BIP | ⊣ | ERN1 | → | XBP1 |
N01013 |
|
ERN1 | → | TRAF2 | → | MAP3K5 | → | MAP2K7 | → | JNK |
N01014 |
AD |
APP* | → | Abeta | → | MAP3K5 | → | MAP2K7 | → | JNK |
N01015 |
|
| | | | ATF6 | ⇒ | (DDIT3,XBP1,HSPA5) |
N01016 |
AD |
| | PSEN1* | ⊣ | ATF6 | ⇒ | (DDIT3,XBP1) |
N01150 |
ALS |
| | VAPB* | ⊣ | ATF6 |
N01033 |
PD |
SNCA* | ⊣ | BIP | ⊣ | ATF6 | ⇒ | DDIT3 |
N01147 |
ALS |
SOD1* | ⊣ | BIP | ⊣ | ATF6 | ⇒ | DDIT3 |
Autophagy |
N01142 |
|
RAB1A | → | (C9orf72+WDR41+SMC.. | → | ULK1_complex |
N01143 |
ALS |
RAB1A | ⌿ | (C9orf72*+WDR41+SM.. | ⌿ | (ULK1+RB1CC1+ATG10.. |
N00155 |
|
mTORC1 | → | ULK1_complex | → | PI3KC3-C1 |
N00962 |
SCA |
| | ATXN3* | ⌿ | (BECN1+PIK3C3+ATG1.. |
N00993 |
HD |
| | HTT* | ⊣ | (BECN1+PIK3C3+ATG1.. |
Mitophagy |
N01052 |
|
PINK1 | → | PRKN | ⊣ | MFN1/2 |
N01053 |
PD |
PINK1* | ⌿ | PRKN | ⌿ | MFN1/2 |
N01054 |
PD |
| | PRKN* | ⌿ | MFN1/2 |
N01137 |
|
PINK1 | → | PRKN | → | (CISD1,CISD2,FAF2,.. | = | (SQSTM1,OPTN,NDP52.. | = | LC3 |
N01138 |
ALS |
PINK1 | → | PRKN | → | (CISD1,CISD2,FAF2,.. | ⌿ | OPTN* |
N01139 |
ALS |
PINK1 | → | PRKN | → | (CISD1,CISD2,FAF2,.. | ⌿ | SQSTM1* | ⌿ | LC3 |
N01140 |
|
TBK1 | → | (SQSTM1,OPTN,NDP52.. | = | LC3-II |
N01141 |
ALS |
TBK1* | ⌿ | (SQSTM1,OPTN,NDP52.. | = | LC3-II |
Apoptosis |
N00146 |
|
| | (FASLG,TNFSF10) | → | (FAS,TNFRSF10B) | → | FADD | → | (CASP8,CASP10) | → | BID | → | (BAX,BAK1) | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
N01005 |
AD |
APP* | → | Abeta | → | FAS | → | FADD | → | CASP8 | → | BID | → | (BAX,BAK1) | → | CYCS | = | APAF1 | → | CASP9 | → | CASP3 |
N00098 |
|
| | | | | | | | (PMAIP1,BBC3,BAD,B.. | ⊣ | (BCL2,BCL2L1) | ⊣ | (BAX,BAK1) | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
N01135 |
ALS |
| | | | | | | | SOD1* | ⊣ | BCL2 | ⊣ | (BAX,BAK1) | → | CYCS | = | APAF1 | → | CASP9 | → | CASP3 |
N01051 |
PD |
| | | | | | | | DJ1* | ⌿ | BCL2L1 | ⌿ | BAX |
N01050 |
PD |
| | | | | | | | PINK1* | ⌿ | PRKN | ⌿ | BAX | → | CYCS | = | APAF1 | → | CASP9 | → | CASP3 |
N01049 |
PD |
| | | | | | | | | | PRKN* | ⌿ | BAX | → | CYCS | = | APAF1 | → | CASP9 | → | CASP3 |
N01048 |
PD |
| | | | | | | | | | PINK1* | ⌿ | (HTRA2,TRAP1) | ⌿ | CYCS | = | APAF1 | → | CASP9 | → | CASP3 |
N01047 |
PD |
| | | | | | | | | | | | LRRK2* | → | CYCS | = | APAF1 | → | CASP9 | → | CASP3 |
AGE-RAGE signaling |
N00994 |
|
| | AGE | → | AGER | → | RAS | → | RAF | → | MEK | → | ERK | → | NFKB | ⇒ | (TNF,IL6,NOS2) |
N00996 |
AD |
APP* | → | Abeta | → | AGER | → | RAS | → | RAF | → | MEK | → | ERK | → | NFKB | ⇒ | (TNF,IL6,NOS2) |
Oxidative phosphorylation |
N00995 |
|
| | | | | | | | | | | | | | NADH | − | CxI | → | Q |
N00997 |
AD |
APP* | → | Abeta | → | CHRNA7 | → | Ca2+ | → | CAPN | → | CDK5R1 | = | CDK5 | → | MAPT | ⊣ | CxI | → | Q |
N01136 |
ALS |
| | | | | | | | | | | | | | TARDBP* | ⊣ | CxI | → | Q |
N01042 |
PD |
| | | | | | | | | | | | | | SNCA* | ⊣ | CxI | → | Q |
N01043 |
PD |
| | | | | | | | | | | | | | PINK1* | ⊣ | CxI | → | Q |
N01044 |
PD |
| | | | | | | | | | | | | | MPP+ | ⊣ | CxI | → | Q |
N01045 |
PD |
| | | | | | | | | | | | | | Rotenone | ⊣ | CxI | → | Q |
N00988 |
|
Succinate | − | CxII | → | QH2 |
N00989 |
HD |
HTT* | ⊣ | CxII | → | QH2 |
N01402 |
AD,PD |
Mn2+ | ⊣ | CxII | → | QH2 |
N00990 |
|
QH2 | − | CxIII | → | CytC |
N00991 |
HD |
HTT* | ⊣ | CxIII | → | CytC |
N01046 |
PD |
Maneb | ⊣ | CxIII | → | CytC |
N00998 |
|
| | CytC | − | CxIV | → | H2O |
N00999 |
AD |
APP* | → | Abeta | ⊣ | CxIV | → | H2O |
Microtubule-based transport |
N00976 |
|
| | | | | | | | | | | | | | (DCTN+DNAH+DNAI+DN.. | = | (TUBA+TUBB) |
N00977 |
HD |
| | | | | | | | | | | | (HTT*+HAP1) | ⊣ | (DCTN+DNAH+DNAI+DN.. | = | (TUBA+TUBB) |
N01160 |
ALS |
| | | | | | | | | | | | SOD1* | ⊣ | (DCTN+DNAH+DNAI+DN.. |
N01158 |
ALS |
| | | | | | | | | | | | | | DCTN1* | ⌿ | (TUBA+TUBB) |
N01159 |
ALS |
| | | | | | | | | | | | | | (DCTN+DNAH+DNAI+DN.. | ⌿ | TUBA4A* |
N00978 |
|
| | | | | | | | | | | | | | (KIF5+KLC) | = | (TUBA+TUBB) |
N01055 |
PD |
| | | | | | | | | | | | SNCA* | ⊣ | (KIF5+KLC) | ⌿ | (TUBA+TUBB) |
N00979 |
HD |
| | | | | | | | | | HTT* | → | JNK3 | ⊣ | (KIF5+KLC) | = | (TUBA+TUBB) |
N01017 |
AD |
| | | | | | | | | | PSEN1* | → | GSK3B | ⊣ | (KIF5+KLC) |
N01202 |
PrD |
| | | | | | | | | | PRNP* | → | (GSK3B,CK2) | ⊣ | (KIF5+KLC) |
N01018 |
AD |
APP* | → | Abeta | → | CHRNA7 | → | Ca2+ | → | CAPN | → | CDK5R1 | = | CDK5 | → | MAPT | ⊣ | (TUBA+TUBB) |
N01403 |
AD |
| | | | | | | | | | Zn2+ | → | GSK3B | → | MAPT | ⊣ | (TUBA+TUBB) |
N01414 |
AD |
| | | | | | | | | | Fe2+ | → | CDK5 | → | MAPT | ⊣ | (TUBA+TUBB) |
|