PCIDB

KNApSAcK Metabolite C00000152

Metabolite

KNApSAcK Entry

id C00000152
Name p-Coumaric acid
CAS RN 7400-08-0
Standard InChI InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+
Standard InChI (Main Layer) InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)

Cluster

Phytochemical cluster No. 6
KCF-S cluster No. 904

Link

ChEMBL

By standard InChI CHEMBL66879
By standard InChI Main Layer CHEMBL66879 CHEMBL2336752

KEGG

By LinkDB C00811

CTD

By CAS RN C032171

Species

Summary

Plant class

class name count
rosids 21
Liliopsida 8
eudicotyledons 7
asterids 6
Spermatophyta 4
Magnoliophyta 4

Family (Top 10)

family name count
Fabaceae 5
Malvaceae 4
Poaceae 3
Rosaceae 3
Rutaceae 2
Ranunculaceae 2
Sarcolaenaceae 2
Annonaceae 2
Pinaceae 2
Orchidaceae 2

List (52)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Actaea racemosa 64040 Ranunculaceae eudicotyledons Viridiplantae
Althaea nudiflora 145744 Malvaceae rosids Viridiplantae
Althaea rosea 1219290 Malvaceae rosids Viridiplantae
Annona muricata 13337 Annonaceae Magnoliophyta Viridiplantae
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Aristolochia manshuriensis 158555 Aristolochiaceae Magnoliophyta Viridiplantae
Balanophora abbreviata B1 25674 Balanophoraceae eudicotyledons Viridiplantae
Begonia nantoensis 78253 Begoniaceae rosids Viridiplantae
Beta vulgaris L. var. saccharifera 3563 Amaranthaceae eudicotyledons Viridiplantae
Bulbophyllum vaginatum 1138424 Orchidaceae Liliopsida Viridiplantae
Calligonum leucocladum 1202986 Polygonaceae eudicotyledons Viridiplantae
Cananga latifolia 13392 Annonaceae Magnoliophyta Viridiplantae
Chamaecyparis formosensis 187461 Cupressaceae Spermatophyta Viridiplantae
Citrus limon 2708 Rutaceae rosids Viridiplantae
Colubrina faralaotra subsp.trichocarpa. 106663 Rhamnaceae rosids Viridiplantae
Cowania mexicana 3745 Rosaceae rosids Viridiplantae
Crocus sativus 82528 Iridaceae Liliopsida Viridiplantae
Cucumis sativus 3659 Cucurbitaceae rosids Viridiplantae
Cyperus rotundus L. 512623 Cyperaceae Liliopsida Viridiplantae
Epimedium sagittatum 253616 Berberidaceae eudicotyledons Viridiplantae
Equsetum arvense
Eucalyptus maculata 87660 Myrtaceae rosids Viridiplantae
Falcaria vulgaris 52469 Apiaceae asterids Viridiplantae
Gymnadenia conopsea R.BR. 59323 Orchidaceae Liliopsida Viridiplantae
Gynerium sagittatum 42053 Poaceae Liliopsida Viridiplantae
Hibiscus taiwanensis 47605 Malvaceae rosids Viridiplantae
Lens esculenta 3864 Fabaceae rosids Viridiplantae
Leptolaena diospyroidea 217266 Sarcolaenaceae rosids Viridiplantae
Leptolaena pauciflora 217266 Sarcolaenaceae rosids Viridiplantae
Maize bran 4479 Poaceae Liliopsida Viridiplantae
Malva silvestris 96479 Malvaceae rosids Viridiplantae
Melilotus messanensis 1279044 Fabaceae rosids Viridiplantae
Mentha piperitae 21819 Lamiaceae asterids Viridiplantae
Nymphaea caerulea 49506 Nymphaeaceae Magnoliophyta Viridiplantae
Phellodendron japonicum MAXIM 68553 Rutaceae rosids Viridiplantae
Phyllostachys edulis 38705 Poaceae Liliopsida Viridiplantae
Picea ajanensis 3328 Pinaceae Spermatophyta Viridiplantae
Picea obovata 331118 Pinaceae Spermatophyta Viridiplantae
Plantago media 101992 Plantaginaceae asterids Viridiplantae
Prunus avium 42229 Rosaceae rosids Viridiplantae
Ranunculus baudotii 568534 Ranunculaceae eudicotyledons Viridiplantae
Rhaponticum carthamoides 362630 Asteraceae asterids Viridiplantae
Rhodiola sachalinensis 265354 Crassulaceae eudicotyledons Viridiplantae
Sarcolaeana multiflora
Solanum tuberosum 4113 Solanaceae asterids Viridiplantae
Spiraea formosana 409510 Rosaceae rosids Viridiplantae
Stereospermum zenkeri 260324 Bignoniaceae asterids Viridiplantae
Taxus baccata 25629 Taxaceae Spermatophyta Viridiplantae
Trifolium alpestre 97007 Fabaceae rosids Viridiplantae
Trifolium medium 97028 Fabaceae rosids Viridiplantae
Trifolium pratense L. 57577 Fabaceae rosids Viridiplantae
Typha domingensis P. 4732 Typhaceae Liliopsida Viridiplantae

Human Protein / Gene in interaction

23 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P17516 Aldo-keto reductase family 1 member C4 Enzyme CHEMBL66879 CHEMBL2038591 (1)
1 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme CHEMBL66879 CHEMBL1942331 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL66879 CHEMBL1014033 (1)
0 / 3
Q13093 Platelet-activating factor acetylhydrolase Enzyme CHEMBL66879 CHEMBL1032505 (1)
3 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL66879 CHEMBL1074270 (1)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL66879 CHEMBL1074269 (1)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL66879 CHEMBL1074272 (1)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL66879 CHEMBL1074266 (1)
1 / 2
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL66879 CHEMBL674643 (1) CHEMBL675636 (1)
1 / 11
P23280 Carbonic anhydrase 6 Lyase CHEMBL66879 CHEMBL1074271 (1)
0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL66879 CHEMBL1074276 (1)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL66879 CHEMBL1074274 (1)
1 / 2
P42330 Aldo-keto reductase family 1 member C3 Enzyme CHEMBL66879 CHEMBL2038590 (1)
0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor CHEMBL66879 CHEMBL1772553 (1)
0 / 0
P15121 Aldose reductase Enzyme CHEMBL66879 CHEMBL984565 (1) CHEMBL1942330 (1)
0 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL66879 CHEMBL1074265 (1)
0 / 0
P14679 Tyrosinase Oxidoreductase CHEMBL66879 CHEMBL870666 (1)
4 / 2
Q16790 Carbonic anhydrase 9 Lyase CHEMBL66879 CHEMBL1074273 (1)
0 / 1
Q04828 Aldo-keto reductase family 1 member C1 Enzyme CHEMBL66879 CHEMBL2038588 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL66879 CHEMBL1941568 (1) CHEMBL1941569 (1)
1 / 1
P52895 Aldo-keto reductase family 1 member C2 Enzyme CHEMBL66879 CHEMBL2038589 (1)
1 / 0
P07451 Carbonic anhydrase 3 Lyase CHEMBL66879 CHEMBL1074267 (1)
0 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL66879 CHEMBL1074268 (1)
1 / 1

CTD interaction (7)

compound gene gene name gene description interaction interaction type form reference
pmid
C032171 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) 4-coumaric acid results in decreased activity of CYP1A1 protein decreases activity
protein 15841493
C032171 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) 4-coumaric acid results in decreased activity of CYP1A2 protein decreases activity
protein 15841493
C032171 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) 4-coumaric acid results in increased expression of NOS3 mRNA increases expression
mRNA 15740983
C032171 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) 4-coumaric acid results in decreased expression of PTGS2 protein decreases expression
protein 15841493
C032171 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) 4-coumaric acid results in increased activity of SULT1A1 protein increases activity
protein 16308312
C032171 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) TYR protein results in increased oxidation of 4-coumaric acid increases oxidation
protein 20685355
C032171 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) [TYR protein results in increased oxidation of 4-coumaric acid] which results in decreased abundance of Glutathione decreases abundance
/ increases oxidation
protein 20685355

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (13)

OMIM preferred title UniProt
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#600807 Asthma, susceptibility to Q13093
#615363 Estrogen resistance; estrr P03372
#143860 Hyperchlorhidrosis, isolated O43570
#147050 Ige responsiveness, atopic; iger Q13093
#211980 Lung cancer P00533
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#600852 Retinitis pigmentosa 17; rp17 P22748
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679

KEGG DISEASE (18)

KEGG disease name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D008545 C032171 Melanoma therapeutic
20685355