PCIDB

KNApSAcK Metabolite C00001033

Metabolite

KNApSAcK Entry

id C00001033
Name Cirsiliol
CAS RN 34334-69-5
Standard InChI InChI=1S/C17H14O7/c1-22-14-7-13-15(16(21)17(14)23-2)11(20)6-12(24-13)8-3-4-9(18)10(19)5-8/h3-7,18-19,21H,1-2H3
Standard InChI (Main Layer) InChI=1S/C17H14O7/c1-22-14-7-13-15(16(21)17(14)23-2)11(20)6-12(24-13)8-3-4-9(18)10(19)5-8/h3-7,18-19,21H,1-2H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 3

Link

ChEMBL

By standard InChI CHEMBL72637
By standard InChI Main Layer CHEMBL72637

KEGG

By LinkDB C10033

CTD

By CAS RN C039824

Human Protein / Gene in interaction

2 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 CHEMBL72637 CHEMBL1780345 (1) CHEMBL1780385 (1)
0 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 CHEMBL72637 CHEMBL1780346 (1)
4 / 4

CTD interaction (6)

compound gene gene name gene description interaction interaction type form reference
pmid
C039824 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) cirsiliol results in decreased activity of CYP1A1 protein decreases activity
protein 21482471
C039824 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) cirsiliol results in increased expression of CYP1A1 mRNA increases expression
mRNA 19601638
C039824 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) CYP1A1 protein results in increased metabolism of cirsiliol increases metabolic processing
protein 19601638
C039824 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) cirsiliol results in decreased activity of CYP1B1 protein decreases activity
protein 21482471
C039824 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) cirsiliol results in increased expression of CYP1B1 mRNA increases expression
mRNA 19601638
C039824 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) CYP1B1 protein results in increased metabolism of cirsiliol increases metabolic processing
protein 19601638

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#604229 Peters anomaly Q16678

KEGG DISEASE (4)

KEGG disease name UniProt
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)