PCIDB

KNApSAcK Metabolite C00001414

Metabolite

KNApSAcK Entry

id C00001414
Name Histamine
CAS RN 51-45-6
Standard InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
Standard InChI (Main Layer) InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)

Cluster

Phytochemical cluster
KCF-S cluster No. 4250

Link

ChEMBL

By standard InChI CHEMBL90
By standard InChI Main Layer CHEMBL90

KEGG

By LinkDB C00388

CTD

By CAS RN D006632

Human Protein / Gene in interaction

30 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL90 CHEMBL1741321 (1)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL90 CHEMBL1738312 (1)
0 / 0
O15244 Solute carrier family 22 member 2 Drug uniporter CHEMBL90 CHEMBL2076309 (1) CHEMBL2077797 (1)
CHEMBL2077798 (1)
0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL90 CHEMBL1794499 (1)
2 / 0
Q9Y5N1 Histamine H3 receptor Histamine receptor CHEMBL90 CHEMBL695765 (1) CHEMBL695767 (1)
CHEMBL695770 (1) CHEMBL694891 (1)
CHEMBL694892 (1) CHEMBL692575 (1)
CHEMBL692580 (1) CHEMBL692581 (1)
CHEMBL854650 (1) CHEMBL937681 (1)
CHEMBL1015353 (1) CHEMBL1104102 (1)
CHEMBL1121261 (1) CHEMBL1121262 (1)
CHEMBL1112036 (1) CHEMBL1112037 (1)
CHEMBL1112038 (1) CHEMBL1638845 (1)
CHEMBL1638849 (1) CHEMBL1638850 (1)
CHEMBL1694495 (1) CHEMBL1694499 (1)
CHEMBL1925206 (1)
0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL90 CHEMBL885804 (1) CHEMBL1051887 (1)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL90 CHEMBL891288 (1) CHEMBL891294 (1)
CHEMBL885803 (1) CHEMBL1051886 (1)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL90 CHEMBL889439 (1) CHEMBL891289 (1)
CHEMBL891295 (1) CHEMBL1051889 (1)
0 / 0
O15245 Solute carrier family 22 member 1 Drug uniporter CHEMBL90 CHEMBL993349 (1) CHEMBL2076204 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL90 CHEMBL1614544 (1)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL90 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL90 CHEMBL656565 (1) CHEMBL657922 (1)
CHEMBL657923 (1) CHEMBL658038 (1)
CHEMBL658048 (1) CHEMBL869780 (1)
CHEMBL889437 (1) CHEMBL891286 (1)
CHEMBL891292 (1) CHEMBL932482 (1)
CHEMBL970751 (1) CHEMBL953312 (1)
CHEMBL1017969 (1) CHEMBL1017972 (1)
CHEMBL1051883 (1) CHEMBL1067709 (1)
CHEMBL1106963 (1) CHEMBL1106967 (1)
CHEMBL1810618 (1) CHEMBL2156561 (1)
CHEMBL2318049 (1)
1 / 2
P25021 Histamine H2 receptor Histamine receptor CHEMBL90 CHEMBL697132 (1) CHEMBL702006 (1)
CHEMBL852020 (1) CHEMBL852509 (1)
CHEMBL854649 (1) CHEMBL953176 (1)
CHEMBL1015352 (1) CHEMBL1104101 (1)
CHEMBL1121102 (1) CHEMBL1121103 (1)
CHEMBL1638842 (1)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL90 CHEMBL691446 (1) CHEMBL691450 (1)
CHEMBL691452 (1) CHEMBL692983 (1)
CHEMBL692992 (1) CHEMBL699237 (1)
CHEMBL699238 (1) CHEMBL854648 (1)
CHEMBL953174 (1) CHEMBL1015351 (1)
CHEMBL1104100 (1) CHEMBL1121259 (1)
CHEMBL1121260 (1) CHEMBL1224920 (1)
CHEMBL1638837 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL90 CHEMBL1741325 (1)
0 / 1
P23280 Carbonic anhydrase 6 Lyase CHEMBL90 CHEMBL1051888 (1) CHEMBL1067710 (1)
0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL90 CHEMBL889441 (1) CHEMBL891290 (1)
CHEMBL891296 (1) CHEMBL1051893 (1)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL90 CHEMBL932484 (1) CHEMBL1051891 (1)
1 / 2
P00915 Carbonic anhydrase 1 Lyase CHEMBL90 CHEMBL662714 (1) CHEMBL662715 (1)
CHEMBL662717 (1) CHEMBL662718 (1)
CHEMBL662719 (1) CHEMBL874534 (1)
CHEMBL869779 (1) CHEMBL889435 (1)
CHEMBL891285 (1) CHEMBL891291 (1)
CHEMBL932481 (1) CHEMBL970750 (1)
CHEMBL965608 (1) CHEMBL1051882 (1)
CHEMBL1067708 (1) CHEMBL1810617 (1)
CHEMBL2156560 (1) CHEMBL2318048 (1)
0 / 0
Q9H3N8 Histamine H4 receptor Histamine receptor CHEMBL90 CHEMBL700763 (1) CHEMBL700767 (1)
CHEMBL696445 (1) CHEMBL696446 (1)
CHEMBL696450 (1) CHEMBL852182 (1)
CHEMBL854651 (1) CHEMBL934603 (1)
CHEMBL937683 (1) CHEMBL1005955 (1)
CHEMBL960690 (1) CHEMBL1015354 (1)
CHEMBL1046845 (1) CHEMBL1046847 (1)
CHEMBL1072277 (1) CHEMBL1072279 (1)
CHEMBL1104103 (1) CHEMBL1121263 (1)
CHEMBL1121264 (1) CHEMBL1117989 (1)
CHEMBL1638839 (1) CHEMBL1638840 (1)
CHEMBL1638851 (1) CHEMBL1638852 (1)
CHEMBL1638863 (1) CHEMBL1638864 (1)
CHEMBL1638865 (1) CHEMBL1694496 (1)
CHEMBL1694498 (1) CHEMBL1925207 (1)
CHEMBL1936672 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL90 CHEMBL1794467 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL90 CHEMBL1741322 (1)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL90 CHEMBL932483 (1) CHEMBL1051890 (1)
0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL90 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL90 CHEMBL1741324 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL90 CHEMBL1794483 (1)
0 / 0
P07451 Carbonic anhydrase 3 Lyase CHEMBL90 CHEMBL970752 (1) CHEMBL953319 (1)
CHEMBL1051884 (1)
0 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL90 CHEMBL863243 (1) CHEMBL891287 (1)
CHEMBL891293 (1) CHEMBL970753 (1)
CHEMBL1008327 (1) CHEMBL1051885 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL90 CHEMBL1738442 (1)
0 / 0
O75751 Solute carrier family 22 member 3 Unclassified protein CHEMBL90 CHEMBL2075863 (1) CHEMBL2078182 (1)
0 / 0

CTD interaction (325)

compound gene gene name gene description interaction interaction type form reference
pmid
D006632 25 ABL1
ABL
JTK7
bcr/abl
c-ABL
p150
v-abl
c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine] affects binding
/ decreases reaction
/ increases chemical synthesis
protein 16849647
D006632 25 ABL1
ABL
JTK7
bcr/abl
c-ABL
p150
v-abl
c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine] affects binding
/ decreases reaction
/ increases chemical synthesis
protein 16849647
D006632 25 ABL1
ABL
JTK7
bcr/abl
c-ABL
p150
v-abl
c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) [BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine affects binding
/ increases chemical synthesis
protein 16849647
D006632 25 ABL1
ABL
JTK7
bcr/abl
c-ABL
p150
v-abl
c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) imatinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine] affects binding
/ decreases reaction
/ increases chemical synthesis
protein 16849647
D006632 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Histamine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein] increases activity
/ increases reaction
protein 17196553
D006632 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Histamine results in increased activity of ADRB2 protein increases activity
protein 17196553
D006632 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4] increases abundance
/ increases response to substance
protein 9609743
D006632 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] decreases reaction
/ increases abundance
/ increases response to substance
protein 9609743
D006632 241 ALOX5AP
FLAP
arachidonate 5-lipoxygenase-activating protein ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4] increases abundance
/ increases response to substance
protein 9609743
D006632 241 ALOX5AP
FLAP
arachidonate 5-lipoxygenase-activating protein L 655238 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] decreases reaction
/ increases abundance
/ increases response to substance
protein 9609743
D006632 241 ALOX5AP
FLAP
arachidonate 5-lipoxygenase-activating protein L 663536 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] decreases reaction
/ increases abundance
/ increases response to substance
protein 9609743
D006632 26 AOC1
ABP
ABP1
DAO
DAO1
KAO
amine oxidase, copper containing 1 (EC:1.4.3.22) AOC1 protein results in increased metabolism of Histamine increases metabolic processing
protein 12072962
D006632 362 AQP5
AQP-5
PPKB
aquaporin 5 Histamine affects the localization of AQP5 protein affects localization
protein 19443731
D006632 613 BCR
ALL
BCR1
CML
D22S11
D22S662
PHL
breakpoint cluster region (EC:2.7.11.1) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine] affects binding
/ decreases reaction
/ increases chemical synthesis
protein 16849647
D006632 613 BCR
ALL
BCR1
CML
D22S11
D22S662
PHL
breakpoint cluster region (EC:2.7.11.1) 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine] affects binding
/ decreases reaction
/ increases chemical synthesis
protein 16849647
D006632 613 BCR
ALL
BCR1
CML
D22S11
D22S662
PHL
breakpoint cluster region (EC:2.7.11.1) [BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine affects binding
/ increases chemical synthesis
protein 16849647
D006632 613 BCR
ALL
BCR1
CML
D22S11
D22S662
PHL
breakpoint cluster region (EC:2.7.11.1) imatinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine] affects binding
/ decreases reaction
/ increases chemical synthesis
protein 16849647
D006632 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Lipopolysaccharides promotes the reaction [Histamine results in increased expression of CCL2 protein] increases expression
/ increases reaction
protein 11336536
D006632 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 TNF protein promotes the reaction [Histamine results in increased expression of CCL2 protein] increases expression
/ increases reaction
protein 11336536
D006632 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 [HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CCND1 protein decreases expression
/ increases response to substance
protein 22363581
D006632 929 CD14
CD14 molecule Histamine affects the expression of CD14 protein affects expression
protein 14499251
D006632 929 CD14
CD14 molecule HRH2 protein affects the reaction [Histamine affects the expression of CD14 protein] affects expression
/ affects reaction
protein 14499251
D006632 958 CD40
Bp50
CDW40
TNFRSF5
p50
CD40 molecule, TNF receptor superfamily member 5 [alpha-fluoromethylhistamine results in decreased chemical synthesis of Histamine] which results in decreased expression of CD40 protein decreases chemical synthesis
/ decreases expression
protein 11306145
D006632 958 CD40
Bp50
CDW40
TNFRSF5
p50
CD40 molecule, TNF receptor superfamily member 5 [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of CD40 protein affects binding
/ decreases expression
/ decreases reaction
/ increases activity
protein 11306145
D006632 958 CD40
Bp50
CDW40
TNFRSF5
p50
CD40 molecule, TNF receptor superfamily member 5 [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein affects binding
/ decreases expression
/ decreases reaction
/ increases activity
protein 11306145
D006632 941 CD80
B7
B7-1
B7.1
BB1
CD28LG
CD28LG1
LAB7
CD80 molecule Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]] decreases reaction
/ increases expression
protein 12538815
D006632 941 CD80
B7
B7-1
B7.1
BB1
CD28LG
CD28LG1
LAB7
CD80 molecule Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein] decreases reaction
/ increases expression
protein 12538815
D006632 941 CD80
B7
B7-1
B7.1
BB1
CD28LG
CD28LG1
LAB7
CD80 molecule Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]] decreases reaction
/ increases expression
protein 12538815
D006632 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) [HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CDK2 protein decreases expression
/ increases response to substance
protein 22363581
D006632 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) [HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1A protein increases expression
/ increases response to substance
protein 22363581
D006632 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) [HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1B protein increases expression
/ increases response to substance
protein 22363581
D006632 1179 CLCA1
CACC
CACC1
CLCRG1
CaCC-1
GOB5
hCLCA1
hCaCC-1
chloride channel accessory 1 Histamine results in increased expression of CLCA1 mRNA increases expression
mRNA 17622767
D006632 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) Histamine results in increased expression of CSF2 protein increases expression
protein 9856766
D006632 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) Histamine results in increased secretion of CSF2 protein increases secretion
protein 9606035
D006632 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] affects cotreatment
/ decreases activity
protein 12906840
D006632 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) EGFR protein affects the reaction [Histamine results in increased secretion of MMP1 protein] affects reaction
/ increases secretion
protein 17656145
D006632 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased expression of F3] decreases reaction
/ increases expression
16009787
D006632 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Histamine results in increased expression of F3] increases expression
/ increases reaction
16009787
D006632 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Histamine results in increased expression of F3] decreases reaction
/ increases expression
16009787
D006632 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) Chlorpheniramine inhibits the reaction [Histamine results in increased expression of F3] decreases reaction
/ increases expression
16009787
D006632 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3] decreases reaction
/ increases expression
16009787
D006632 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) [Histamine co-treated with splitomicin] results in increased expression of F3 protein affects cotreatment
/ increases expression
protein 20978007
D006632 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) Histamine results in increased activity of F3 protein increases activity
protein 16009787
D006632 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) Histamine results in increased expression of F3 mRNA increases expression
mRNA 16009787
D006632 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) Histamine results in increased expression of F3 protein increases expression
protein 16009787
D006632 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) Pyrilamine inhibits the reaction [Histamine results in increased activity of F3 protein] decreases reaction
/ increases activity
protein 16009787
D006632 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) Pyrilamine inhibits the reaction [Histamine results in increased expression of F3] decreases reaction
/ increases expression
16009787
D006632 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) SB 203580 inhibits the reaction [Histamine results in increased expression of F3] decreases reaction
/ increases expression
16009787
D006632 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) wortmannin promotes the reaction [Histamine results in increased expression of F3] increases expression
/ increases reaction
16009787
D006632 2205 FCER1A
FCE1A
FcERI
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide FCER1A polymorphism affects the secretion of Histamine affects secretion
polymorphism 17125826
D006632 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA] affects binding
/ decreases reaction
/ increases activity
/ increases expression
mRNA 9187264
D006632 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog [Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA affects binding
/ increases activity
/ increases expression
mRNA 9187264
D006632 2990 GUSB
BG
MPS7
glucuronidase, beta (EC:3.2.1.31) fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein] affects binding
/ decreases reaction
/ increases activity
/ increases expression
protein 11238657
D006632 2990 GUSB
BG
MPS7
glucuronidase, beta (EC:3.2.1.31) fexofenadine inhibits the reaction [Histamine results in increased expression of GUSB protein] decreases reaction
/ increases expression
protein 11238657
D006632 2990 GUSB
BG
MPS7
glucuronidase, beta (EC:3.2.1.31) Histamine results in increased expression of GUSB protein increases expression
protein 11238657
D006632 2990 GUSB
BG
MPS7
glucuronidase, beta (EC:3.2.1.31) HRH1 protein promotes the reaction [Histamine results in increased expression of GUSB protein] increases expression
/ increases reaction
protein 11238657
D006632 3067 HDC
histidine decarboxylase (EC:4.1.1.22) [troglitazone results in decreased expression of HDC mRNA] which results in decreased secretion of Histamine decreases expression
/ decreases secretion
mRNA 11834241
D006632 3176 HNMT
HMT
HNMT-S1
HNMT-S2
histamine N-methyltransferase (EC:2.1.1.8) HNMT protein results in increased methylation of Histamine increases methylation
protein 7943261
D006632 3176 HNMT
HMT
HNMT-S1
HNMT-S2
histamine N-methyltransferase (EC:2.1.1.8) SK&F 91488 inhibits the reaction [HNMT protein results in increased methylation of Histamine] decreases reaction
/ increases methylation
protein 7943261
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 1-Methyl-3-isobutylxanthine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]] decreases abundance
/ decreases reaction
/ increases reaction
protein 2419744
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]] affects cotreatment
/ decreases activity
/ decreases reaction
protein 12147327
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium] affects binding
/ decreases reaction
/ increases abundance
/ increases activity
protein 11238657
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein] affects binding
/ decreases reaction
/ increases activity
/ increases expression
protein 11238657
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]] affects binding
/ affects reaction
/ decreases reaction
protein 2419744
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein] affects binding
/ decreases reaction
protein 2419744
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein] affects cotreatment
/ decreases activity
protein 12147327
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 Histamine results in increased activity of HRH1 protein increases activity
protein 11238657
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 [Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium increases abundance
/ increases activity
protein 11238657
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 HRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]] affects reaction
/ increases expression
/ increases reaction
20040740
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP] decreases abundance
/ increases reaction
protein 2419744
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 HRH1 protein promotes the reaction [Histamine results in increased export of Calcium] increases export
/ increases reaction
protein 2419744
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 HRH1 protein promotes the reaction [Histamine results in increased expression of GUSB protein] increases expression
/ increases reaction
protein 11238657
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 HRH1 protein promotes the reaction [Histamine results in increased expression of IL6 protein] increases expression
/ increases reaction
protein 11238657
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols] increases metabolic processing
/ increases reaction
protein 2419744
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein] affects binding
/ decreases reaction
/ increases activity
protein 11306145
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein affects binding
/ decreases expression
/ decreases reaction
/ increases activity
protein 11306145
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein affects binding
/ decreases expression
/ decreases reaction
/ increases activity
protein 11306145
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 Triprolidine inhibits the reaction [[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium] decreases reaction
/ increases abundance
/ increases activity
protein 11527950
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]] decreases abundance
/ decreases reaction
/ increases reaction
protein 2419744
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]] decreases reaction
/ increases export
/ increases reaction
protein 2419744
D006632 3269 HRH1
H1-R
hisH1
histamine receptor H1 Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]] decreases reaction
/ increases metabolic processing
/ increases reaction
protein 2419744
D006632 3274 HRH2
H2R
histamine receptor H2 Burimamide inhibits the reaction [[Cyclic AMP binds to and results in increased activity of HRH2 protein] which results in increased abundance of Histamine] affects binding
/ decreases reaction
/ increases abundance
/ increases activity
protein 9681472
D006632 3274 HRH2
H2R
histamine receptor H2 Burimamide inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein] affects binding
/ decreases reaction
/ increases activity
protein 9681472
D006632 3274 HRH2
H2R
histamine receptor H2 [Cimetidine binds to and results in decreased activity of HRH2 protein] results in decreased susceptibility to [Histamine co-treated with [Oxygen deficiency co-treated with Oxygen]] affects binding
/ affects cotreatment
/ decreases activity
/ decreases response to substance
protein 22926047
D006632 3274 HRH2
H2R
histamine receptor H2 Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 12235264
D006632 3274 HRH2
H2R
histamine receptor H2 Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein] decreases expression
/ increases activity
/ increases reaction
protein 15843518
D006632 3274 HRH2
H2R
histamine receptor H2 Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein] decreases expression
/ increases activity
/ increases reaction
protein 15843518
D006632 3274 HRH2
H2R
histamine receptor H2 Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA] affects binding
/ decreases reaction
/ increases activity
/ increases expression
protein 9187264
D006632 3274 HRH2
H2R
histamine receptor H2 Histamine affects the expression of HRH2 protein affects expression
protein 9681472
D006632 3274 HRH2
H2R
histamine receptor H2 Histamine affects the localization of HRH2 protein affects localization
protein 15961859
D006632 3274 HRH2
H2R
histamine receptor H2 [Histamine affects the localization of HRH2 protein] which affects the degradation of HRH2 protein affects degradation
/ affects localization
protein 15961859
D006632 3274 HRH2
H2R
histamine receptor H2 Histamine binds to and results in increased activity of HRH2 protein affects binding
/ increases activity
protein 9681472
D006632 3274 HRH2
H2R
histamine receptor H2 [Histamine binds to and results in increased activity of HRH2 protein] which results in decreased expression of IFNG mRNA affects binding
/ decreases expression
/ increases activity
protein 10569698
D006632 3274 HRH2
H2R
histamine receptor H2 [Histamine binds to and results in increased activity of HRH2 protein] which results in increased abundance of Cyclic AMP affects binding
/ increases abundance
/ increases activity
protein 9187264
9681472
D006632 3274 HRH2
H2R
histamine receptor H2 [Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA affects binding
/ increases activity
/ increases expression
protein 9187264
D006632 3274 HRH2
H2R
histamine receptor H2 Histamine results in increased activity of HRH2 protein increases activity
protein 15843518
D006632 3274 HRH2
H2R
histamine receptor H2 [Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein decreases expression
/ increases activity
protein 15843518
D006632 3274 HRH2
H2R
histamine receptor H2 [Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein decreases expression
/ increases activity
protein 15843518
D006632 3274 HRH2
H2R
histamine receptor H2 HRH2 protein affects the reaction [Histamine affects the expression of CD14 protein] affects expression
/ affects reaction
protein 14499251
D006632 3274 HRH2
H2R
histamine receptor H2 HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]] affects reaction
/ decreases expression
/ decreases reaction
protein 11752121
D006632 3274 HRH2
H2R
histamine receptor H2 HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]] affects reaction
/ decreases reaction
/ increases expression
protein 11752121
D006632 3274 HRH2
H2R
histamine receptor H2 HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]] affects reaction
/ decreases reaction
/ increases expression
protein 11752121
D006632 3274 HRH2
H2R
histamine receptor H2 HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] affects binding
/ affects reaction
/ decreases reaction
/ increases expression
protein 11752121
D006632 3274 HRH2
H2R
histamine receptor H2 HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]] affects reaction
/ decreases reaction
/ increases expression
protein 11752121
D006632 3274 HRH2
H2R
histamine receptor H2 HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]] decreases reaction
/ increases expression
/ increases reaction
protein 10569698
D006632 3274 HRH2
H2R
histamine receptor H2 HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]] decreases reaction
/ increases expression
/ increases reaction
protein 10569698
D006632 3274 HRH2
H2R
histamine receptor H2 HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12A protein] decreases expression
/ increases reaction
protein 9819373
D006632 3274 HRH2
H2R
histamine receptor H2 HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12B protein] decreases expression
/ increases reaction
protein 9819373
D006632 3274 HRH2
H2R
histamine receptor H2 HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein] increases expression
/ increases reaction
protein 12235264
D006632 3274 HRH2
H2R
histamine receptor H2 tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein] affects binding
/ decreases reaction
/ increases activity
protein 11306145
D006632 3274 HRH2
H2R
histamine receptor H2 [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of CD40 protein affects binding
/ decreases expression
/ decreases reaction
/ increases activity
protein 11306145
D006632 3274 HRH2
H2R
histamine receptor H2 [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of PTPRC protein affects binding
/ decreases expression
/ decreases reaction
/ increases activity
protein 11306145
D006632 11255 HRH3
GPCR97
HH3R
histamine receptor H3 Histamine binds to and results in increased activity of HRH3 protein affects binding
/ increases activity
protein 12706455
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [HRH4 protein results in increased susceptibility to Histamine] decreases reaction
/ increases response to substance
protein 22363581
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 Histamine binds to and results in increased activity of HRH4 protein affects binding
/ increases activity
protein 11181941
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 [Histamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium affects binding
/ increases abundance
/ increases activity
protein 11181941
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 [Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK1 protein affects binding
/ increases activity
/ increases phosphorylation
protein 11181941
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 [Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK3 protein affects binding
/ increases activity
/ increases phosphorylation
protein 11181941
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 Histamine promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to HRH4 protein] affects binding
/ increases reaction
protein 11181941
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 Histamine results in increased activity of HRH4 protein increases activity
protein 15843518
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein decreases expression
/ increases activity
protein 15843518
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein decreases expression
/ increases activity
protein 15843518
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 HRH4 protein results in increased susceptibility to Histamine increases response to substance
protein 22363581
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 [HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CCND1 protein decreases expression
/ increases response to substance
protein 22363581
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 [HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CDK2 protein decreases expression
/ increases response to substance
protein 22363581
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 [HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1A protein increases expression
/ increases response to substance
protein 22363581
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 [HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1B protein increases expression
/ increases response to substance
protein 22363581
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein] decreases expression
/ decreases reaction
/ increases activity
protein 15843518
D006632 59340 HRH4
AXOR35
BG26
GPCR105
GPRv53
H4
H4R
HH4R
histamine receptor H4 U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein] decreases expression
/ decreases reaction
/ increases activity
protein 15843518
D006632 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
protein 11752121
12364868
D006632 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
protein 12538815
D006632 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 11752121
12364868
D006632 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 12538815
D006632 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]] affects reaction
/ decreases reaction
/ increases expression
protein 11752121
D006632 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
protein 11752121
D006632 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
protein 12538815
D006632 3458 IFNG
IFG
IFI
interferon, gamma Cimetidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]] decreases reaction
/ increases expression
protein 10569698
D006632 3458 IFNG
IFG
IFI
interferon, gamma Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]] decreases reaction
/ increases expression
protein 11752121
12364868
D006632 3458 IFNG
IFG
IFI
interferon, gamma Histamine affects the expression of IFNG protein affects expression
protein 17346280
D006632 3458 IFNG
IFG
IFI
interferon, gamma [Histamine binds to and results in increased activity of HRH2 protein] which results in decreased expression of IFNG mRNA affects binding
/ decreases expression
/ increases activity
mRNA 10569698
D006632 3458 IFNG
IFG
IFI
interferon, gamma Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein] decreases reaction
/ increases expression
protein 11752121
12364868
D006632 3458 IFNG
IFG
IFI
interferon, gamma Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA] decreases reaction
/ increases expression
mRNA 10569698
D006632 3458 IFNG
IFG
IFI
interferon, gamma Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein] decreases reaction
/ increases expression
protein 10569698
D006632 3458 IFNG
IFG
IFI
interferon, gamma HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]] affects reaction
/ decreases reaction
/ increases expression
protein 11752121
D006632 3458 IFNG
IFG
IFI
interferon, gamma HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]] decreases reaction
/ increases expression
/ increases reaction
mRNA 10569698
D006632 3458 IFNG
IFG
IFI
interferon, gamma HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]] decreases reaction
/ increases expression
/ increases reaction
protein 10569698
D006632 3458 IFNG
IFG
IFI
interferon, gamma [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]] affects binding
/ decreases reaction
/ increases expression
protein 11752121
D006632 3458 IFNG
IFG
IFI
interferon, gamma Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]] decreases reaction
/ increases expression
protein 11752121
D006632 3458 IFNG
IFG
IFI
interferon, gamma Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]] decreases reaction
/ increases expression
protein 10569698
D006632 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]] decreases expression
/ decreases reaction
protein 11752121
D006632 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein] decreases expression
/ decreases reaction
protein 11752121
D006632 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]] affects reaction
/ decreases expression
/ decreases reaction
protein 11752121
D006632 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]] affects binding
/ decreases expression
/ decreases reaction
protein 11752121
D006632 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]] decreases expression
/ decreases reaction
protein 11752121
D006632 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 Terfenadine inhibits the reaction [Histamine results in increased expression of IL10 protein] decreases reaction
/ increases expression
protein 12925206
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein] decreases expression
/ increases activity
/ increases reaction
protein 15843518
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] affects binding
/ decreases reaction
/ increases expression
protein 11752121
12364868
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]] affects binding
/ decreases reaction
/ increases expression
protein 11752121
12364868
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) Histamine results in decreased expression of IL12A mRNA decreases expression
mRNA 9819373
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) Histamine results in decreased expression of IL12A protein decreases expression
protein 9819373
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein decreases expression
/ increases activity
protein 15843518
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein decreases expression
/ increases activity
protein 15843518
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) Histamine results in increased expression of IL12A protein increases expression
protein 15843518
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] affects binding
/ affects reaction
/ decreases reaction
/ increases expression
protein 11752121
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12A protein] decreases expression
/ increases reaction
protein 9819373
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]] affects binding
/ decreases expression
/ decreases reaction
protein 11752121
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]] affects binding
/ decreases reaction
/ increases expression
protein 11752121
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] affects binding
/ decreases reaction
/ increases expression
protein 11752121
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12A protein] decreases expression
/ decreases reaction
protein 9819373
D006632 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein] decreases expression
/ decreases reaction
/ increases activity
protein 15843518
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein] decreases expression
/ increases activity
/ increases reaction
protein 15843518
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] affects binding
/ decreases reaction
/ increases expression
protein 11752121
12364868
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]] affects binding
/ decreases reaction
/ increases expression
protein 11752121
12364868
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Histamine results in decreased expression of IL12B mRNA decreases expression
mRNA 9819373
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Histamine results in decreased expression of IL12B protein decreases expression
protein 9819373
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein decreases expression
/ increases activity
protein 15843518
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein decreases expression
/ increases activity
protein 15843518
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Histamine results in increased expression of IL12B protein increases expression
protein 15843518
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] affects binding
/ affects reaction
/ decreases reaction
/ increases expression
protein 11752121
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12B protein] decreases expression
/ increases reaction
protein 9819373
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]] affects binding
/ decreases expression
/ decreases reaction
protein 11752121
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]] affects binding
/ decreases reaction
/ increases expression
protein 11752121
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] affects binding
/ decreases reaction
/ increases expression
protein 11752121
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12B protein] decreases expression
/ decreases reaction
protein 9819373
D006632 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein] decreases expression
/ decreases reaction
/ increases activity
protein 15843518
D006632 3603 IL16
LCF
NIL16
PRIL16
prIL-16
interleukin 16 Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 12235264
D006632 3603 IL16
LCF
NIL16
PRIL16
prIL-16
interleukin 16 Histamine results in increased expression of IL16 protein increases expression
protein 12235264
D006632 3603 IL16
LCF
NIL16
PRIL16
prIL-16
interleukin 16 HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein] increases expression
/ increases reaction
protein 12235264
D006632 3603 IL16
LCF
NIL16
PRIL16
prIL-16
interleukin 16 thioperamide inhibits the reaction [Histamine results in increased expression of IL16 protein] decreases reaction
/ increases expression
protein 12235264
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]] decreases expression
/ decreases reaction
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
protein 11752121
12364868
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]] decreases reaction
/ increases expression
protein 11752121
12364868
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] affects binding
/ decreases reaction
/ increases expression
protein 11752121
12364868
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]] decreases reaction
/ increases expression
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein] decreases expression
/ decreases reaction
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 11752121
12364868
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein] decreases reaction
/ increases expression
protein 11752121
12364868
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]] affects binding
/ decreases reaction
/ increases expression
protein 11752121
12364868
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein] decreases reaction
/ increases expression
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Histamine results in increased expression of IL18 protein increases expression
protein 16723495
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]] affects reaction
/ decreases expression
/ decreases reaction
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]] affects reaction
/ decreases reaction
/ increases expression
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]] affects reaction
/ decreases reaction
/ increases expression
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] affects binding
/ affects reaction
/ decreases reaction
/ increases expression
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]] affects reaction
/ decreases reaction
/ increases expression
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]] affects binding
/ decreases expression
/ decreases reaction
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]] affects binding
/ decreases reaction
/ increases expression
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Histamine results in increased expression of IL18 protein] decreases reaction
/ increases expression
protein 16723495
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]] decreases expression
/ decreases reaction
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]] decreases reaction
/ increases expression
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] affects binding
/ decreases reaction
/ increases expression
protein 11752121
D006632 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]] decreases reaction
/ increases expression
protein 11752121
D006632 3567 IL5
EDF
IL-5
TRF
interleukin 5 (colony-stimulating factor, eosinophil) Terfenadine inhibits the reaction [Histamine results in increased expression of IL5 protein] decreases reaction
/ increases expression
protein 12925206
D006632 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Calcimycin inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 11238657
D006632 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Calcium promotes the reaction [Histamine results in increased expression of IL6 protein] increases expression
/ increases reaction
protein 11238657
D006632 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL6 protein] decreases reaction
/ increases expression
protein 11336536
D006632 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Edetic Acid inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 11238657
D006632 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) fexofenadine inhibits the reaction [Histamine results in increased expression of IL6 protein] decreases reaction
/ increases expression
protein 11238657
D006632 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Histamine results in increased expression of IL6 protein increases expression
protein 9856766
11238657
11336536
D006632 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) HRH1 protein promotes the reaction [Histamine results in increased expression of IL6 protein] increases expression
/ increases reaction
protein 11238657
D006632 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Lipopolysaccharides promotes the reaction [Histamine results in increased expression of IL6 protein] increases expression
/ increases reaction
protein 11336536
D006632 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) TNF protein promotes the reaction [Histamine results in increased expression of IL6 protein] increases expression
/ increases reaction
protein 11336536
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Cyclosporine inhibits the reaction [Histamine results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 9609743
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Dexamethasone inhibits the reaction [Histamine results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 9609743
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Dexamethasone inhibits the reaction [Histamine results in increased expression of IL8 protein] decreases reaction
/ increases expression
protein 9609743
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 9609743
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL8 protein] decreases reaction
/ increases expression
protein 9609743
11336536
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Histamine results in increased activity of [IL8 protein binds to RELA protein] affects binding
/ increases activity
protein 9609743
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Histamine results in increased expression of IL8 mRNA increases expression
mRNA 9609743
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Histamine results in increased expression of IL8 protein increases expression
protein 9609743
11336536
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 L 655238 inhibits the reaction [Histamine results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 9609743
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 L 663536 inhibits the reaction [Histamine results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 9609743
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 L 663536 inhibits the reaction [Histamine results in increased expression of IL8 protein] decreases reaction
/ increases expression
protein 9609743
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Leukotriene B4 inhibits the reaction [zileuton inhibits the reaction [Histamine results in increased expression of IL8 protein]] decreases reaction
/ increases expression
protein 9609743
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Lipopolysaccharides promotes the reaction [Histamine results in increased expression of IL8 protein] increases expression
/ increases reaction
protein 11336536
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 TNF protein promotes the reaction [Histamine results in increased expression of IL8 protein] increases expression
/ increases reaction
protein 11336536
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 zileuton inhibits the reaction [Histamine results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 9609743
D006632 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 zileuton inhibits the reaction [Histamine results in increased expression of IL8 protein] decreases reaction
/ increases expression
protein 9609743
D006632 3785 KCNQ2
BFNC
BFNS1
EBN
EBN1
EIEE7
ENB1
HNSPC
KCNA11
KV7.2
KVEBN1
potassium voltage-gated channel, KQT-like subfamily, member 2 Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]] affects cotreatment
/ decreases activity
/ decreases reaction
protein 12147327
D006632 3785 KCNQ2
BFNC
BFNS1
EBN
EBN1
EIEE7
ENB1
HNSPC
KCNA11
KV7.2
KVEBN1
potassium voltage-gated channel, KQT-like subfamily, member 2 Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein] affects cotreatment
/ decreases activity
protein 12147327
D006632 3786 KCNQ3
BFNC2
EBN2
KV7.3
potassium voltage-gated channel, KQT-like subfamily, member 3 Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]] affects cotreatment
/ decreases activity
/ decreases reaction
protein 12147327
D006632 3786 KCNQ3
BFNC2
EBN2
KV7.3
potassium voltage-gated channel, KQT-like subfamily, member 3 Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein] affects cotreatment
/ decreases activity
protein 12147327
D006632 4056 LTC4S
leukotriene C4 synthase (EC:4.4.1.20) LTC4S polymorphism results in decreased susceptibility to Histamine decreases response to substance
polymorphism 19862937
D006632 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 17656145
D006632 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK1 protein affects binding
/ increases activity
/ increases phosphorylation
protein 11181941
D006632 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Histamine results in increased phosphorylation of and results in increased activity of MAPK1 protein increases activity
/ increases phosphorylation
protein 16009787
D006632 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Histamine results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 17656145
21179406
D006632 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Hydrogen Peroxide promotes the reaction [Histamine results in increased phosphorylation of MAPK1 protein] increases phosphorylation
/ increases reaction
protein 21179406
D006632 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 16009787
D006632 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) tyrphostin AG 1478 inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 17656145
D006632 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 17656145
D006632 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK3 protein affects binding
/ increases activity
/ increases phosphorylation
protein 11181941
D006632 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Histamine results in increased phosphorylation of and results in increased activity of MAPK3 protein increases activity
/ increases phosphorylation
protein 16009787
D006632 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Histamine results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 17656145
21179406
D006632 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Hydrogen Peroxide promotes the reaction [Histamine results in increased phosphorylation of MAPK3 protein] increases phosphorylation
/ increases reaction
protein 21179406
D006632 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 16009787
D006632 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) tyrphostin AG 1478 inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 17656145
D006632 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased expression of MMP1 mRNA] decreases reaction
/ increases expression
mRNA 17656145
D006632 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased secretion of MMP1 protein] decreases reaction
/ increases secretion
protein 17656145
D006632 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) EGFR protein affects the reaction [Histamine results in increased secretion of MMP1 protein] affects reaction
/ increases secretion
protein 17656145
D006632 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Famotidine inhibits the reaction [Histamine results in increased expression of MMP1 mRNA] decreases reaction
/ increases expression
mRNA 17656145
D006632 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Famotidine inhibits the reaction [Histamine results in increased secretion of MMP1 protein] decreases reaction
/ increases secretion
protein 17656145
D006632 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Histamine results in increased expression of MMP1 mRNA increases expression
mRNA 9856766
17656145
D006632 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Histamine results in increased secretion of MMP1 protein increases secretion
protein 17656145
D006632 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) tyrphostin AG 1478 inhibits the reaction [Histamine results in increased expression of MMP1 mRNA] decreases reaction
/ increases expression
mRNA 17656145
D006632 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) tyrphostin AG 1478 inhibits the reaction [Histamine results in increased secretion of MMP1 protein] decreases reaction
/ increases secretion
protein 17656145
D006632 4586 MUC5AC
MUC5
TBM
leB
mucin 5AC, oligomeric mucus/gel-forming Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA] decreases reaction
/ increases expression
mRNA 17622767
D006632 4586 MUC5AC
MUC5
TBM
leB
mucin 5AC, oligomeric mucus/gel-forming Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC protein] decreases reaction
/ increases expression
protein 17622767
D006632 4586 MUC5AC
MUC5
TBM
leB
mucin 5AC, oligomeric mucus/gel-forming Histamine results in increased expression of MUC5AC mRNA increases expression
mRNA 17622767
D006632 4586 MUC5AC
MUC5
TBM
leB
mucin 5AC, oligomeric mucus/gel-forming Histamine results in increased expression of MUC5AC protein increases expression
protein 17622767
D006632 4586 MUC5AC
MUC5
TBM
leB
mucin 5AC, oligomeric mucus/gel-forming Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA] decreases reaction
/ increases expression
mRNA 17622767
D006632 4586 MUC5AC
MUC5
TBM
leB
mucin 5AC, oligomeric mucus/gel-forming Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC protein] decreases reaction
/ increases expression
protein 17622767
D006632 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Histamine affects the localization of NFKB1 protein affects localization
protein 11336536
D006632 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Histamine promotes the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] affects localization
/ increases reaction
protein 11336536
D006632 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Histamine promotes the reaction [TNF protein affects the localization of NFKB1 protein] affects localization
/ increases reaction
protein 11336536
D006632 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) Deoxyglucose promotes the reaction [STO 609 inhibits the reaction [Histamine results in increased phosphorylation of NOS2 protein]] decreases reaction
/ increases phosphorylation
/ increases reaction
protein 21145922
D006632 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) Histamine results in increased phosphorylation of NOS2 protein increases phosphorylation
protein 21145922
D006632 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) [PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein] affects cotreatment
/ affects reaction
/ increases phosphorylation
protein 21145922
D006632 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) STK11 protein promotes the reaction [Histamine results in increased phosphorylation of NOS2 protein] increases phosphorylation
/ increases reaction
protein 21145922
D006632 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) STO 609 inhibits the reaction [Histamine results in increased phosphorylation of NOS2 protein] decreases reaction
/ increases phosphorylation
protein 21145922
D006632 5142 PDE4B
DPDE4
PDE4B5
PDEIVB
phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17) Cimetidine inhibits the reaction [Histamine results in increased expression of PDE4B mRNA] decreases reaction
/ increases expression
mRNA 11131300
D006632 5142 PDE4B
DPDE4
PDE4B5
PDEIVB
phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17) Histamine results in increased expression of PDE4B mRNA increases expression
mRNA 11131300
D006632 5321 PLA2G4A
PLA2G4
cPLA2-alpha
phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) Dexamethasone inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA] decreases reaction
/ increases expression
mRNA 9609743
D006632 5321 PLA2G4A
PLA2G4
cPLA2-alpha
phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA] decreases reaction
/ increases expression
mRNA 9609743
D006632 5321 PLA2G4A
PLA2G4
cPLA2-alpha
phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) Histamine results in increased expression of PLA2G4A mRNA increases expression
mRNA 9609743
D006632 5321 PLA2G4A
PLA2G4
cPLA2-alpha
phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) L 663536 inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA] decreases reaction
/ increases expression
mRNA 9609743
D006632 5562 PRKAA1
AMPK
AMPKa1
protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31) [PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein] affects cotreatment
/ affects reaction
/ increases phosphorylation
protein 21145922
D006632 5563 PRKAA2
AMPK
AMPK2
AMPKa2
PRKAA
protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31) [PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein] affects cotreatment
/ affects reaction
/ increases phosphorylation
protein 21145922
D006632 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Histamine promotes the reaction [TLR2 results in increased expression of PTGS2] increases expression
/ increases reaction
20040740
D006632 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone] increases chemical synthesis
/ increases expression
/ increases reaction
20040740
D006632 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) HRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]] affects reaction
/ increases expression
/ increases reaction
20040740
D006632 5788 PTPRC
B220
CD45
CD45R
GP180
L-CA
LCA
LY5
T200
protein tyrosine phosphatase, receptor type, C (EC:3.1.3.48) [alpha-fluoromethylhistamine results in decreased chemical synthesis of Histamine] which results in decreased expression of PTPRC protein decreases chemical synthesis
/ decreases expression
protein 11306145
D006632 5788 PTPRC
B220
CD45
CD45R
GP180
L-CA
LCA
LY5
T200
protein tyrosine phosphatase, receptor type, C (EC:3.1.3.48) [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of PTPRC protein affects binding
/ decreases expression
/ decreases reaction
/ increases activity
protein 11306145
D006632 5788 PTPRC
B220
CD45
CD45R
GP180
L-CA
LCA
LY5
T200
protein tyrosine phosphatase, receptor type, C (EC:3.1.3.48) [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein affects binding
/ decreases expression
/ decreases reaction
/ increases activity
protein 11306145
D006632 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Histamine affects the localization of RELA protein affects localization
protein 11336536
D006632 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Histamine promotes the reaction [Lipopolysaccharides affects the localization of RELA protein] affects localization
/ increases reaction
protein 11336536
D006632 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Histamine promotes the reaction [TNF protein affects the localization of RELA protein] affects localization
/ increases reaction
protein 11336536
D006632 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Histamine results in increased activity of [IL8 protein binds to RELA protein] affects binding
/ increases activity
protein 9609743
D006632 6570 SLC18A1
CGAT
VAT1
VMAT1
solute carrier family 18 (vesicular monoamine transporter), member 1 Histamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] decreases reaction
/ increases uptake
protein 8245983
D006632 6571 SLC18A2
SVAT
SVMT
VAT2
VMAT2
solute carrier family 18 (vesicular monoamine transporter), member 2 Histamine binds to SLC18A2 protein affects binding
protein 7912402
D006632 6581 SLC22A3
EMT
EMTH
OCT3
solute carrier family 22 (organic cation transporter), member 3 Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] decreases reaction
/ increases uptake
protein 12411423
D006632 6581 SLC22A3
EMT
EMTH
OCT3
solute carrier family 22 (organic cation transporter), member 3 SLC22A3 protein polymorphism affects the uptake of Histamine affects uptake
protein 20562519
D006632 6794 STK11
LKB1
PJS
hLKB1
serine/threonine kinase 11 (EC:2.7.11.1) Histamine results in increased phosphorylation of STK11 protein increases phosphorylation
protein 21145922
D006632 6794 STK11
LKB1
PJS
hLKB1
serine/threonine kinase 11 (EC:2.7.11.1) STK11 protein promotes the reaction [Histamine results in increased abundance of Cyclic GMP] increases abundance
/ increases reaction
protein 21145922
D006632 6794 STK11
LKB1
PJS
hLKB1
serine/threonine kinase 11 (EC:2.7.11.1) STK11 protein promotes the reaction [Histamine results in increased phosphorylation of NOS2 protein] increases phosphorylation
/ increases reaction
protein 21145922
D006632 6863 TAC1
Hs.2563
NK2
NKNA
NPK
TAC2
tachykinin, precursor 1 Nedocromil inhibits the reaction [TAC1 protein results in increased secretion of Histamine] decreases reaction
/ increases secretion
protein 1707400
D006632 6863 TAC1
Hs.2563
NK2
NKNA
NPK
TAC2
tachykinin, precursor 1 TAC1 protein results in increased secretion of Histamine increases secretion
protein 1707400
9291295
D006632 6863 TAC1
Hs.2563
NK2
NKNA
NPK
TAC2
tachykinin, precursor 1 Theophylline inhibits the reaction [TAC1 protein results in increased secretion of Histamine] decreases reaction
/ increases secretion
protein 1707400
D006632 7097 TLR2
CD282
TIL4
toll-like receptor 2 Histamine promotes the reaction [TLR2 results in increased expression of PTGS2] increases expression
/ increases reaction
20040740
D006632 7097 TLR2
CD282
TIL4
toll-like receptor 2 Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone] increases chemical synthesis
/ increases expression
/ increases reaction
20040740
D006632 7097 TLR2
CD282
TIL4
toll-like receptor 2 HRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]] affects reaction
/ increases expression
/ increases reaction
20040740
D006632 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]] decreases reaction
/ increases expression
protein 11752121
D006632 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] decreases reaction
/ increases expression
protein 12538815
D006632 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein] decreases reaction
/ increases expression
protein 11752121
D006632 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] decreases reaction
/ increases expression
protein 12538815
14499251
D006632 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Histamine promotes the reaction [TNF protein affects the localization of NFKB1 protein] affects localization
/ increases reaction
protein 11336536
D006632 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Histamine promotes the reaction [TNF protein affects the localization of RELA protein] affects localization
/ increases reaction
protein 11336536
D006632 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]] affects reaction
/ decreases reaction
/ increases expression
protein 11752121
D006632 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]] decreases reaction
/ increases expression
protein 11752121
D006632 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] decreases reaction
/ increases expression
protein 12538815
D006632 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor TNF protein promotes the reaction [Histamine results in increased expression of CCL2 protein] increases expression
/ increases reaction
protein 11336536
D006632 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor TNF protein promotes the reaction [Histamine results in increased expression of IL6 protein] increases expression
/ increases reaction
protein 11336536
D006632 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor TNF protein promotes the reaction [Histamine results in increased expression of IL8 protein] increases expression
/ increases reaction
protein 11336536
D006632 7351 UCP2
BMIQ4
SLC25A8
UCPH
uncoupling protein 2 (mitochondrial, proton carrier) UCP2 protein results in decreased secretion of Histamine decreases secretion
protein 19846869

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (21)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798

KEGG DISEASE (20)

KEGG disease name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)

Diseases related to CTD interactions

40 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000799 D006632 Angioedema marker/mechanism
2443044
D001145 D006632 Arrhythmias, Cardiac therapeutic
7359351
D001249 D006632 Asthma marker/mechanism
16344897
16387687
D055963 D006632 Asthma, Aspirin-Induced marker/mechanism
2443044
D001862 D006632 Bone Resorption marker/mechanism
14751566
D001986 D006632 Bronchial Spasm marker/mechanism
3230472
18298128
D002389 D006632 Catatonia marker/mechanism
4477392
D003233 D006632 Conjunctivitis, Allergic marker/mechanism
8951675
D003329 D006632 Coronary Vasospasm marker/mechanism
16009787
D004342 D006632 Drug Hypersensitivity marker/mechanism
2443044
D056486 D006632 Drug-Induced Liver Injury marker/mechanism
22926047
D004417 D006632 Dyspnea marker/mechanism
3230472
D004802 D006632 Eosinophilia marker/mechanism
12689652
D004890 D006632 Erythema marker/mechanism
74166
D006261 D006632 Headache marker/mechanism
8866624
D006930 D006632 Hyperalgesia marker/mechanism
18234883
21521205
D006967 D006632 Hypersensitivity therapeutic
11160071
D006968 D006632 Hypersensitivity, Delayed marker/mechanism
7686799
D006969 D006632 Hypersensitivity, Immediate marker/mechanism
7686799
D006975 D006632 Hypertension, Portal marker/mechanism
1971191
D007022 D006632 Hypotension marker/mechanism
1033105
1899682
2439840
14051999
D007410 D006632 Intestinal Diseases therapeutic
17729160
D034701 D006632 Mastocytosis, Cutaneous marker/mechanism
20559008
D008545 D006632 Melanoma therapeutic
17709802
D008569 D006632 Memory Disorders therapeutic
19215234
D008881 D006632 Migraine Disorders marker/mechanism
8866624
D009135 D006632 Muscular Diseases marker/mechanism
8123399
D009203 D006632 Myocardial Infarction marker/mechanism
16009787
D010146 D006632 Pain marker/mechanism
therapeutic
18155693
19552055
D010149 D006632 Pain, Postoperative marker/mechanism
8123399
D011537 D006632 Pruritus marker/mechanism
74166
8707580
18789837
19652466
D011833 D006632 Radiation Injuries, Experimental therapeutic
17729160
D012130 D006632 Respiratory Hypersensitivity marker/mechanism
12095164
D012220 D006632 Rhinitis marker/mechanism
12689652
D012640 D006632 Seizures therapeutic
16914292
D012771 D006632 Shock, Hemorrhagic marker/mechanism
1285366
D012772 D006632 Shock, Septic marker/mechanism
2414028
D013276 D006632 Stomach Ulcer marker/mechanism
12832840
D014456 D006632 Ulcer marker/mechanism
2062949
D014581 D006632 Urticaria marker/mechanism
18298128