KCF-S cluster No. 4250 (3 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (3)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
eudicotyledons	3
rosids	3
Liliopsida	1
asterids	1

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Cumulative family count

class name	count
Brassicaceae	2
Amaranthaceae	1
Nepenthaceae	1
Sarraceniaceae	1
Musaceae	1
Urticaceae	1
Enterobacteriaceae	1
Droseraceae	1

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (3)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001414	Histamine	CHEMBL90	D006632	30 / 21 / 20	63 / 40
C00007479	L-Histidinol	CHEMBL278081 CHEMBL19588 CHEMBL2007999		1 / 0 / 0
C00007495	L-Histidinal	CHEMBL307302

Human Protein / Gene in interactions

31 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001414	1 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00001414	0 / 0
O15244	Solute carrier family 22 member 2	Drug uniporter	C00001414	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00001414	2 / 0
Q9Y5N1	Histamine H3 receptor	Histamine receptor	C00001414	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00001414	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00001414	0 / 0
P43166	Carbonic anhydrase 7	Lyase	C00001414	0 / 0
O15245	Solute carrier family 22 member 1	Drug uniporter	C00001414	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00001414	11 / 10
P16473	Thyrotropin receptor	Glycohormone receptor	C00001414	3 / 2
P00918	Carbonic anhydrase 2	Lyase	C00001414	1 / 2
P25021	Histamine H2 receptor	Histamine receptor	C00001414	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00001414	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001414	0 / 1
P23280	Carbonic anhydrase 6	Lyase	C00001414	0 / 0
Q9ULX7	Carbonic anhydrase 14	Lyase	C00001414	0 / 0
O43570	Carbonic anhydrase 12	Lyase	C00001414	1 / 2
P00915	Carbonic anhydrase 1	Lyase	C00001414	0 / 0
Q9H3N8	Histamine H4 receptor	Histamine receptor	C00001414	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00001414	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001414	0 / 0
Q16790	Carbonic anhydrase 9	Lyase	C00001414	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001414	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001414	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00001414	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00007479	0 / 0
P07451	Carbonic anhydrase 3	Lyase	C00001414	0 / 0
P22748	Carbonic anhydrase 4	Lyase	C00001414	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001414	0 / 0
O75751	Solute carrier family 22 member 3	Unclassified protein	C00001414	0 / 0

63 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
25	ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl	c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2)	C00001414
154	ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR	adrenoceptor beta 2, surface	C00001414
240	ALOX5, 5-LO, 5-LOX, 5LPG, LOG5	arachidonate 5-lipoxygenase (EC:1.13.11.34)	C00001414
241	ALOX5AP, FLAP	arachidonate 5-lipoxygenase-activating protein	C00001414
26	AOC1, ABP, ABP1, DAO, DAO1, KAO	amine oxidase, copper containing 1 (EC:1.4.3.22)	C00001414
362	AQP5, AQP-5, PPKB	aquaporin 5	C00001414
613	BCR, ALL, BCR1, CML, D22S11, D22S662, PHL	breakpoint cluster region (EC:2.7.11.1)	C00001414
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00001414
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00001414
929	CD14	CD14 molecule	C00001414
958	CD40, Bp50, CDW40, TNFRSF5, p50	CD40 molecule, TNF receptor superfamily member 5	C00001414
941	CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7	CD80 molecule	C00001414
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00001414
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00001414
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00001414
1179	CLCA1, CACC, CACC1, CLCRG1, CaCC-1, GOB5, hCLCA1, hCaCC-1	chloride channel accessory 1	C00001414
1437	CSF2, GMCSF	colony stimulating factor 2 (granulocyte-macrophage)	C00001414
1906	EDN1, ET1, HDLCQ7, PPET1	endothelin 1	C00001414
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00001414
2152	F3, CD142, TF, TFA	coagulation factor III (thromboplastin, tissue factor)	C00001414
2205	FCER1A, FCE1A, FcERI	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	C00001414
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00001414
2990	GUSB, BG, MPS7	glucuronidase, beta (EC:3.2.1.31)	C00001414
3067	HDC	histidine decarboxylase (EC:4.1.1.22)	C00001414
3176	HNMT, HMT, HNMT-S1, HNMT-S2	histamine N-methyltransferase (EC:2.1.1.8)	C00001414
3269	HRH1, H1-R, hisH1	histamine receptor H1	C00001414
3274	HRH2, H2R	histamine receptor H2	C00001414
11255	HRH3, GPCR97, HH3R	histamine receptor H3	C00001414
59340	HRH4, AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R	histamine receptor H4	C00001414
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00001414
3458	IFNG, IFG, IFI	interferon, gamma	C00001414
3586	IL10, CSIF, GVHDS, IL-10, IL10A, TGIF	interleukin 10	C00001414
3592	IL12A, CLMF, IL-12A, NFSK, NKSF1, P35	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	C00001414
3593	IL12B, CLMF, CLMF2, IL-12B, NKSF, NKSF2	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	C00001414
3603	IL16, LCF, NIL16, PRIL16, prIL-16	interleukin 16	C00001414
3606	IL18, IGIF, IL-18, IL-1g, IL1F4	interleukin 18 (interferon-gamma-inducing factor)	C00001414
3567	IL5, EDF, IL-5, TRF	interleukin 5 (colony-stimulating factor, eosinophil)	C00001414
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00001414
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00001414
3785	KCNQ2, BFNC, BFNS1, EBN, EBN1, EIEE7, ENB1, HNSPC, KCNA11, KV7.2, KVEBN1	potassium voltage-gated channel, KQT-like subfamily, member 2	C00001414
3786	KCNQ3, BFNC2, EBN2, KV7.3	potassium voltage-gated channel, KQT-like subfamily, member 3	C00001414
4056	LTC4S	leukotriene C4 synthase (EC:4.4.1.20)	C00001414
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00001414
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00001414
4312	MMP1, CLG, CLGN	matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)	C00001414
4586	MUC5AC, MUC5, TBM, leB	mucin 5AC, oligomeric mucus/gel-forming	C00001414
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00001414
4843	NOS2, HEP-NOS, INOS, NOS, NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	C00001414
5142	PDE4B, DPDE4, PDE4B5, PDEIVB	phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17)	C00001414
5321	PLA2G4A, PLA2G4, cPLA2-alpha	phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)	C00001414
5562	PRKAA1, AMPK, AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	C00001414
5563	PRKAA2, AMPK, AMPK2, AMPKa2, PRKAA	protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31)	C00001414
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00001414
5788	PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200	protein tyrosine phosphatase, receptor type, C (EC:3.1.3.48)	C00001414
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00001414
6570	SLC18A1, CGAT, VAT1, VMAT1	solute carrier family 18 (vesicular monoamine transporter), member 1	C00001414
6571	SLC18A2, SVAT, SVMT, VAT2, VMAT2	solute carrier family 18 (vesicular monoamine transporter), member 2	C00001414
6581	SLC22A3, EMT, EMTH, OCT3	solute carrier family 22 (organic cation transporter), member 3	C00001414
6794	STK11, LKB1, PJS, hLKB1	serine/threonine kinase 11 (EC:2.7.11.1)	C00001414
6863	TAC1, Hs.2563, NK2, NKNA, NPK, TAC2	tachykinin, precursor 1	C00001414
7097	TLR2, CD282, TIL4	toll-like receptor 2	C00001414
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00001414
7351	UCP2, BMIQ4, SLC25A8, UCPH	uncoupling protein 2 (mitochondrial, proton carrier)	C00001414

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions