PCIDB

KNApSAcK Metabolite C00015429

Metabolite

KNApSAcK Entry

id C00015429
Name CRC 87-09 / Combretastatin A4 / 3'-Hydroxy-3,4,4'5-tetramethoxystilbene
CAS RN 117048-59-6
Standard InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
Standard InChI (Main Layer) InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3

Cluster

Phytochemical cluster No. 13
KCF-S cluster No. 344

Link

ChEMBL

By standard InChI CHEMBL67
By standard InChI Main Layer CHEMBL67 CHEMBL36455 CHEMBL2142429

KEGG

By LinkDB

CTD

By CAS RN

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Combretaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Combretum caffrum 507393 Combretaceae rosids Viridiplantae

Human Protein / Gene in interaction

17 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9H4B7 Tubulin beta-1 chain Structural CHEMBL67 CHEMBL36455 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL876479 (1) CHEMBL832762 (2)
CHEMBL832453 (2) CHEMBL863352 (1)
CHEMBL867154 (1) CHEMBL867157 (1)
CHEMBL861004 (1) CHEMBL861005 (1)
CHEMBL869355 (1) CHEMBL860083 (1)
CHEMBL866616 (1) CHEMBL865513 (1)
CHEMBL864359 (1) CHEMBL907127 (1)
CHEMBL907128 (1) CHEMBL907129 (1)
CHEMBL911786 (1) CHEMBL911787 (1)
CHEMBL912967 (1) CHEMBL912968 (1)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL67 CHEMBL2092313 (1)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL67 CHEMBL2092313 (1)
0 / 0
Q13748 Tubulin alpha-3C/D chain Structural CHEMBL67 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL863352 (1) CHEMBL867154 (1)
CHEMBL867157 (1) CHEMBL861004 (1)
CHEMBL861005 (1) CHEMBL869355 (1)
CHEMBL860083 (1) CHEMBL866616 (1)
CHEMBL865513 (1) CHEMBL864359 (1)
CHEMBL907127 (1) CHEMBL907128 (1)
CHEMBL907129 (1) CHEMBL911786 (1)
CHEMBL911787 (1) CHEMBL912967 (1)
CHEMBL912968 (1)
0 / 0
P68366 Tubulin alpha-4A chain Structural CHEMBL67 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL863352 (1) CHEMBL867154 (1)
CHEMBL867157 (1) CHEMBL861004 (1)
CHEMBL861005 (1) CHEMBL869355 (1)
CHEMBL860083 (1) CHEMBL866616 (1)
CHEMBL865513 (1) CHEMBL864359 (1)
CHEMBL907127 (1) CHEMBL907128 (1)
CHEMBL907129 (1) CHEMBL911786 (1)
CHEMBL911787 (1) CHEMBL912967 (1)
CHEMBL912968 (1)
0 / 0
P04350 Tubulin beta-4A chain Structural CHEMBL67 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL863352 (1) CHEMBL867154 (1)
CHEMBL867157 (1) CHEMBL861004 (1)
CHEMBL861005 (1) CHEMBL869355 (1)
CHEMBL860083 (1) CHEMBL866616 (1)
CHEMBL865513 (1) CHEMBL864359 (1)
CHEMBL907127 (1) CHEMBL907128 (1)
CHEMBL907129 (1) CHEMBL911786 (1)
CHEMBL911787 (1) CHEMBL912967 (1)
CHEMBL912968 (1)
2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural CHEMBL67 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL863352 (1) CHEMBL867154 (1)
CHEMBL867157 (1) CHEMBL861004 (1)
CHEMBL861005 (1) CHEMBL869355 (1)
CHEMBL860083 (1) CHEMBL866616 (1)
CHEMBL865513 (1) CHEMBL864359 (1)
CHEMBL907127 (1) CHEMBL907128 (1)
CHEMBL907129 (1) CHEMBL911786 (1)
CHEMBL911787 (1) CHEMBL912967 (1)
CHEMBL912968 (1)
0 / 0
P07437 Tubulin beta chain Structural CHEMBL67 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL863352 (1) CHEMBL867154 (1)
CHEMBL867157 (1) CHEMBL861004 (1)
CHEMBL861005 (1) CHEMBL869355 (1)
CHEMBL860083 (1) CHEMBL866616 (1)
CHEMBL865513 (1) CHEMBL864359 (1)
CHEMBL907127 (1) CHEMBL907128 (1)
CHEMBL907129 (1) CHEMBL911786 (1)
CHEMBL911787 (1) CHEMBL912967 (1)
CHEMBL912968 (1)
0 / 0
Q71U36 Tubulin alpha-1A chain Structural CHEMBL67 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL863352 (1) CHEMBL867154 (1)
CHEMBL867157 (1) CHEMBL861004 (1)
CHEMBL861005 (1) CHEMBL869355 (1)
CHEMBL860083 (1) CHEMBL866616 (1)
CHEMBL865513 (1) CHEMBL864359 (1)
CHEMBL907127 (1) CHEMBL907128 (1)
CHEMBL907129 (1) CHEMBL911786 (1)
CHEMBL911787 (1) CHEMBL912967 (1)
CHEMBL912968 (1)
1 / 1
P68371 Tubulin beta-4B chain Structural CHEMBL67 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL863352 (1) CHEMBL867154 (1)
CHEMBL867157 (1) CHEMBL861004 (1)
CHEMBL861005 (1) CHEMBL869355 (1)
CHEMBL860083 (1) CHEMBL866616 (1)
CHEMBL865513 (1) CHEMBL864359 (1)
CHEMBL907127 (1) CHEMBL907128 (1)
CHEMBL907129 (1) CHEMBL911786 (1)
CHEMBL911787 (1) CHEMBL912967 (1)
CHEMBL912968 (1)
0 / 0
Q13509 Tubulin beta-3 chain Structural CHEMBL67 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL863352 (1) CHEMBL867154 (1)
CHEMBL867157 (1) CHEMBL861004 (1)
CHEMBL861005 (1) CHEMBL869355 (1)
CHEMBL860083 (1) CHEMBL866616 (1)
CHEMBL865513 (1) CHEMBL864359 (1)
CHEMBL907127 (1) CHEMBL907128 (1)
CHEMBL907129 (1) CHEMBL911786 (1)
CHEMBL911787 (1) CHEMBL912967 (1)
CHEMBL912968 (1)
2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein CHEMBL67 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL863352 (1) CHEMBL867154 (1)
CHEMBL867157 (1) CHEMBL861004 (1)
CHEMBL861005 (1) CHEMBL869355 (1)
CHEMBL860083 (1) CHEMBL866616 (1)
CHEMBL865513 (1) CHEMBL864359 (1)
CHEMBL907127 (1) CHEMBL907128 (1)
CHEMBL907129 (1) CHEMBL911786 (1)
CHEMBL911787 (1) CHEMBL912967 (1)
CHEMBL912968 (1)
0 / 0
Q13885 Tubulin beta-2A chain Structural CHEMBL67 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL863352 (1) CHEMBL867154 (1)
CHEMBL867157 (1) CHEMBL861004 (1)
CHEMBL861005 (1) CHEMBL869355 (1)
CHEMBL860083 (1) CHEMBL866616 (1)
CHEMBL865513 (1) CHEMBL864359 (1)
CHEMBL907127 (1) CHEMBL907128 (1)
CHEMBL907129 (1) CHEMBL911786 (1)
CHEMBL911787 (1) CHEMBL912967 (1)
CHEMBL912968 (1)
0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein CHEMBL67 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL863352 (1) CHEMBL867154 (1)
CHEMBL867157 (1) CHEMBL861004 (1)
CHEMBL861005 (1) CHEMBL869355 (1)
CHEMBL860083 (1) CHEMBL866616 (1)
CHEMBL865513 (1) CHEMBL864359 (1)
CHEMBL907127 (1) CHEMBL907128 (1)
CHEMBL907129 (1) CHEMBL911786 (1)
CHEMBL911787 (1) CHEMBL912967 (1)
CHEMBL912968 (1)
0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein CHEMBL67 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL863352 (1) CHEMBL867154 (1)
CHEMBL867157 (1) CHEMBL861004 (1)
CHEMBL861005 (1) CHEMBL869355 (1)
CHEMBL860083 (1) CHEMBL866616 (1)
CHEMBL865513 (1) CHEMBL864359 (1)
CHEMBL907127 (1) CHEMBL907128 (1)
CHEMBL907129 (1) CHEMBL911786 (1)
CHEMBL911787 (1) CHEMBL912967 (1)
CHEMBL912968 (1)
0 / 0
Q9BUF5 Tubulin beta-6 chain Structural CHEMBL67 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL863352 (1) CHEMBL867154 (1)
CHEMBL867157 (1) CHEMBL861004 (1)
CHEMBL861005 (1) CHEMBL869355 (1)
CHEMBL860083 (1) CHEMBL866616 (1)
CHEMBL865513 (1) CHEMBL864359 (1)
CHEMBL907127 (1) CHEMBL907128 (1)
CHEMBL907129 (1) CHEMBL911786 (1)
CHEMBL911787 (1) CHEMBL912967 (1)
CHEMBL912968 (1)
0 / 0
Q9BVA1 Tubulin beta-2B chain Structural CHEMBL67 CHEMBL816885 (1) CHEMBL845253 (1)
CHEMBL863352 (1) CHEMBL867154 (1)
CHEMBL867157 (1) CHEMBL861004 (1)
CHEMBL861005 (1) CHEMBL869355 (1)
CHEMBL860083 (1) CHEMBL866616 (1)
CHEMBL865513 (1) CHEMBL864359 (1)
CHEMBL907127 (1) CHEMBL907128 (1)
CHEMBL907129 (1) CHEMBL911786 (1)
CHEMBL911787 (1) CHEMBL912967 (1)
CHEMBL912968 (1)
1 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1

KEGG DISEASE (2)

KEGG disease name UniProt
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)