KCF-S cluster No. 344 (20 metabolites)

Corresponding Phytochemical cluster No. 13

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (20)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	19
Embryophyta	4
Liliopsida	4
Magnoliophyta	2
Spermatophyta	1

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Cumulative family count

class name	count
Fabaceae	12
Combretaceae	4
Orchidaceae	4
Vitaceae	2
Corsiniaceae	2
Myristicaceae	2
Frullaniaceae	2
Betulaceae	1
Gnetaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Stilbenes	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Stilbenes	C10287	C00002902

Metabolite list (20)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002902	Pterostilbene / 3,5-Dimethoxy-4'-hydroxystilbene	CHEMBL87712 CHEMBL83527	C107773	19 / 19 / 20	54 / 15
C00015204	Combretastatin A1 / (Z)-3-Methoxy-6-[2-(3,4,5-trimethoxyphenyl)ethenyl]-1,2-benzenediol	CHEMBL36255 CHEMBL520204	C063690	5 / 0 / 0
C00015303	3,4',6-Trimethoxystilbene	CHEMBL2043271
C00015311	3',4-Dihydroxy-3,5'-dimethoxystilbene
C00015319	Combretastatin A2 / 3',4'-Dimethoxy-3'-hydroxy-4,5-methylenedioxystilbene	CHEMBL47037 CHEMBL1642222	C061751
C00015320	3,4'-Dimethoxy-5-hydroxystilbene	CHEMBL315853 CHEMBL465542
C00015322	3,4-Methylenedioxy-4'-methoxystilbene
C00015328	Combretastatin A3 / 3',5-Dihydroxy-3,4,4'-trimethoxystilbene	CHEMBL464382	C440905
C00015400	3,5-Dimethoxystilbene / Pinosylvin dimethyl ether	CHEMBL188181 CHEMBL2165238		6 / 7 / 3
C00015429	CRC 87-09 / Combretastatin A4 / 3'-Hydroxy-3,4,4'5-tetramethoxystilbene	CHEMBL67 CHEMBL36455 CHEMBL2142429		17 / 7 / 2
C00015430	3'-Hydroxy-3,4,5'-trimethoxystilbene	CHEMBL109860		2 / 0 / 0
C00018988	Resveratrol trimethyl ether / 3,5,4'-Trimethoxy-trans-stilbene	CHEMBL296411 CHEMBL311636		25 / 16 / 22
C00019230	(E)-3,4'-Dimethoxystilbene / (E)-1-Methoxy-3-[2-(4-methoxyphenyl)ethenyl]-benzene	CHEMBL215583 CHEMBL244727
C00019231	(Z)-3,4'-Dimethoxystilbene / (Z)-1-Methoxy-3-[2-(4-methoxyphenyl)ethenyl]-benzene	CHEMBL215583 CHEMBL244727
C00031008	Phoyunbene A	CHEMBL2012416
C00031009	Phoyunbene B	CHEMBL2012417
C00031010	Phoyunbene C	CHEMBL2012418
C00031011	Phoyunbene D	CHEMBL2012419
C00036552	3-Methoxy-3',4'-methylenedioxy-cis-stilbene
C00036553	3-Methoxy-3',4'-methylenedioxy-trans-stilbene

Human Protein / Gene in interactions

54 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q9BVA1	Tubulin beta-2B chain	Structural	C00015429 C00018988	1 / 0
Q9BUF5	Tubulin beta-6 chain	Structural	C00015429 C00018988	0 / 0
Q9BQE3	Tubulin alpha-1C chain	Unclassified protein	C00015429 C00018988	0 / 0
Q9H4B7	Tubulin beta-1 chain	Structural	C00015429 C00018988	1 / 0
Q6PEY2	Tubulin alpha-3E chain	Unclassified protein	C00015429 C00018988	0 / 0
Q13885	Tubulin beta-2A chain	Structural	C00015429 C00018988	0 / 0
P08183	Multidrug resistance protein 1	drug	C00002902 C00018988	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00002902 C00015429	0 / 0
P68363	Tubulin alpha-1B chain	Unclassified protein	C00015429 C00018988	0 / 0
Q13509	Tubulin beta-3 chain	Structural	C00015429 C00018988	2 / 1
P68371	Tubulin beta-4B chain	Structural	C00015429 C00018988	0 / 0
O75496	Geminin	Unclassified protein	C00002902 C00015400	0 / 0
Q71U36	Tubulin alpha-1A chain	Structural	C00015429 C00018988	1 / 1
P07437	Tubulin beta chain	Structural	C00015429 C00018988	0 / 0
Q3ZCM7	Tubulin beta-8 chain	Structural	C00015429 C00018988	0 / 0
P04350	Tubulin beta-4A chain	Structural	C00015429 C00018988	2 / 0
P68366	Tubulin alpha-4A chain	Structural	C00015429 C00018988	0 / 0
Q13748	Tubulin alpha-3C/D chain	Structural	C00015429 C00018988	0 / 0
P11274	Breakpoint cluster region protein	Bcr	C00002902 C00018988	1 / 2
P00519	Tyrosine-protein kinase ABL1	Abl	C00002902 C00018988	1 / 2
P10636	Microtubule-associated protein tau	Unclassified protein	C00002902	4 / 3
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00018988	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00002902	1 / 1
P03372	Estrogen receptor	NR3A1	C00018988	1 / 1
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00015430	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00015400	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00015400	0 / 0
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00018988	4 / 4
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00015400	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002902	0 / 0
O00255	Menin	Unclassified protein	C00002902	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002902	1 / 2
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00002902	2 / 2
P01106	Myc proto-oncogene protein	Unclassified protein	C00018988	1 / 13
P83916	Chromobox protein homolog 1	Unclassified protein	C00015400	0 / 0
Q04206	Transcription factor p65	Transcription Factor	C00015430	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00015400	7 / 3
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002902	0 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00002902	4 / 2
P51151	Ras-related protein Rab-9A	Unclassified protein	C00002902	0 / 0
Q12778	Forkhead box protein O1	Unclassified protein	C00018988	1 / 1
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00002902	0 / 0
P30874	Somatostatin receptor type 2	Somatostatin receptor	C00015204	0 / 0
P31391	Somatostatin receptor type 4	Somatostatin receptor	C00015204	0 / 0
P32745	Somatostatin receptor type 3	Somatostatin receptor	C00015204	0 / 0
P35346	Somatostatin receptor type 5	Somatostatin receptor	C00015204	0 / 0
P30872	Somatostatin receptor type 1	Somatostatin receptor	C00015204	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00002902	1 / 1
P27361	Mitogen-activated protein kinase 3	Erk	C00015429	0 / 0
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00018988	0 / 0
P55789	FAD-linked sulfhydryl oxidase ALR	Enzyme	C00002902	1 / 0
P17252	Protein kinase C alpha type	Alpha	C00018988	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00002902	1 / 1
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00002902	0 / 3

54 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00002902
23600	AMACR, AMACRD, CBAS4, RACE, RM	alpha-methylacyl-CoA racemase (EC:5.1.99.4)	C00002902
1386	ATF2, CRE-BP1, CREB2, HB16, TREB7	activating transcription factor 2 (EC:2.3.1.48)	C00002902
578	BAK1, BAK, BAK-LIKE, BCL2L7, CDN1	BCL2-antagonist/killer 1	C00002902
581	BAX, BCL2L4	BCL2-associated X protein	C00002902
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00002902
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00002902
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00002902
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00002902
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00002902
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00002902
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00002902
2921	CXCL3, CINC-2b, GRO3, GROg, MIP-2b, MIP2B, SCYB3	chemokine (C-X-C motif) ligand 3	C00002902
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00002902
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002902
1649	DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153	DNA-damage-inducible transcript 3	C00002902
56616	DIABLO, DFNA64, SMAC	diablo, IAP-binding mitochondrial protein	C00002902
1950	EGF, HOMG4, URG	epidermal growth factor	C00002902
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00002902
2002	ELK1	ELK1, member of ETS oncogene family	C00002902
2523	FUT1, H, HH, HSC	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) (EC:2.4.1.69)	C00002902
9518	GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB	growth differentiation factor 15	C00002902
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00002902
4670	HNRNPM, CEAR, HNRNPM4, HNRPM, HNRPM4, HTGR1, NAGR1, hnRNP_M	heterogeneous nuclear ribonucleoprotein M	C00002902
3313	HSPA9, CSA, GRP-75, GRP75, HSPA9B, MOT, MOT2, MTHSP75, PBP74	heat shock 70kDa protein 9 (mortalin)	C00002902
3458	IFNG, IFG, IFI	interferon, gamma	C00002902
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00002902
3696	ITGB8	integrin, beta 8	C00002902
3717	JAK2, JTK10, THCYT3	Janus kinase 2 (EC:2.7.10.2)	C00002902
3949	LDLR, FH, FHC, LDLCQ2	low density lipoprotein receptor	C00002902
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00002902
1432	MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	C00002902
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00002902
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00002902
5601	MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK	mitogen-activated protein kinase 9 (EC:2.7.11.24)	C00002902
4170	MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT	myeloid cell leukemia sequence 1 (BCL2-related)	C00002902
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00002902
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00002902
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00002902
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00002902
4843	NOS2, HEP-NOS, INOS, NOS, NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	C00002902
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00002902
9970	NR1I3, CAR, CAR1, MB67	nuclear receptor subfamily 1, group I, member 3	C00002902
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00002902
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002902
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002902
6301	SARS, SERRS, SERS	seryl-tRNA synthetase (EC:6.1.1.11)	C00002902
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00002902
6667	SP1	Sp1 transcription factor	C00002902
6774	STAT3, APRF, HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	C00002902
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002902
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00002902
9189	ZBED1, ALTE, DREF, TRAMP, hDREF	zinc finger, BED-type containing 1	C00002902
118738	ZNF488	zinc finger protein 488	C00002902

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions