PCIDB

KNApSAcK Metabolite C00002902

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00002902
Name	Pterostilbene / 3,5-Dimethoxy-4'-hydroxystilbene
CAS RN	537-42-8
Standard InChI	InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
Standard InChI (Main Layer)	InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3

Cluster

Phytochemical cluster	No. 13
KCF-S cluster	No. 344

Link

ChEMBL

By standard InChI	CHEMBL83527
By standard InChI Main Layer	CHEMBL87712 CHEMBL83527

KEGG

By LinkDB	C10287

CTD

By CAS RN	C107773

Species

Summary

Plant class

class name	count
rosids	10

Family

family name	count
Fabaceae	8
Vitaceae	2

List (10)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Dalea versicolor	248514	Fabaceae	rosids	Viridiplantae
Pterocarpus dalbergioides	1071182	Fabaceae	rosids	Viridiplantae
Pterocarpus macrocarpus	108278	Fabaceae	rosids	Viridiplantae
Pterocarpus marsupium	1071187	Fabaceae	rosids	Viridiplantae
Pterocarpus santalinus	1071199	Fabaceae	rosids	Viridiplantae
Pterocarpus soyauxii	1071200	Fabaceae	rosids	Viridiplantae
Pterocarpus tinctorius	1071202	Fabaceae	rosids	Viridiplantae
Pterolobium hexapetallum	162891	Fabaceae	rosids	Viridiplantae
Vitis riparia	96939	Vitaceae	rosids	Viridiplantae
Vitis vinifera	29760	Vitaceae	rosids	Viridiplantae

Human Protein / Gene in interaction

19 ChEMBL Protein in interactions

accession	description	class description	compound	assay ID (# of activities)	# of diseases (OMIM / KEGG)
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	CHEMBL83527	CHEMBL941537 (1)	0 / 3
P10253	Lysosomal alpha-glucosidase	Hydrolase	CHEMBL83527	CHEMBL1614076 (1)	1 / 1
P55789	FAD-linked sulfhydryl oxidase ALR	Enzyme	CHEMBL83527	CHEMBL1738573 (1)	1 / 0
P08183	Multidrug resistance protein 1	drug	CHEMBL83527	CHEMBL861699 (1) CHEMBL861700 (1)	1 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	CHEMBL83527	CHEMBL941536 (1)	0 / 0
O75496	Geminin	Unclassified protein	CHEMBL83527	CHEMBL2114780 (1)	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	CHEMBL83527	CHEMBL1613838 (1)	0 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	CHEMBL83527	CHEMBL2114807 (1)	4 / 2
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	CHEMBL83527	CHEMBL2114788 (1)	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	CHEMBL83527	CHEMBL1175840 (1) CHEMBL1175842 (1)	2 / 2
P28482	Mitogen-activated protein kinase 1	Erk	CHEMBL83527	CHEMBL1614521 (1)	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	CHEMBL83527	CHEMBL1614342 (1)	1 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	CHEMBL83527	CHEMBL1614421 (1) CHEMBL1614502 (1)	4 / 3
B2RXH2	Lysine-specific demethylase 4E	Enzyme	CHEMBL83527	CHEMBL1613914 (1)	0 / 0
O00255	Menin	Unclassified protein	CHEMBL83527	CHEMBL1614257 (1)	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	CHEMBL83527	CHEMBL1614257 (1)	1 / 3
P00519	Tyrosine-protein kinase ABL1	Abl	CHEMBL83527	CHEMBL861701 (1) CHEMBL861702 (1)	1 / 4
P11274	Breakpoint cluster region protein	Bcr	CHEMBL83527	CHEMBL861701 (1) CHEMBL861702 (1)	1 / 4
Q13148	TAR DNA-binding protein 43	Unclassified protein	CHEMBL83527	CHEMBL2354287 (1)	1 / 1

CTD interaction (96)

compound	gene	gene name	gene description	interaction	interaction type	form	reference pmid
C107773	207	AKT1 AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	pterostilbene results in decreased expression of AKT1 mRNA	decreases expression	mRNA	20152895
C107773	23600	AMACR AMACRD CBAS4 RACE RM	alpha-methylacyl-CoA racemase (EC:5.1.99.4)	pterostilbene results in decreased expression of AMACR mRNA	decreases expression	mRNA	20152895
C107773	1386	ATF2 CRE-BP1 CREB2 HB16 TREB7	activating transcription factor 2 (EC:2.3.1.48)	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of ATF2 protein modified form]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	578	BAK1 BAK BAK-LIKE BCL2L7 CDN1	BCL2-antagonist/killer 1	pterostilbene results in increased expression of BAK1 protein	increases expression	protein	23313376
C107773	581	BAX BCL2L4	BCL2-associated X protein	BAX protein affects the susceptibility to pterostilbene	affects response to substance	protein	22572619
C107773	581	BAX BCL2L4	BCL2-associated X protein	pterostilbene results in increased expression of BAX mRNA	increases expression	mRNA	20152895
C107773	581	BAX BCL2L4	BCL2-associated X protein	pterostilbene results in increased expression of BAX protein	increases expression	protein	20152895 22572619 23313376
C107773	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	[pterostilbene co-treated with Quercetin] results in decreased expression of BCL2 protein	affects cotreatment / decreases expression	protein	18852136
C107773	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	pterostilbene results in decreased expression of BCL2 mRNA	decreases expression	mRNA	20152895
C107773	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	pterostilbene results in decreased expression of BCL2 protein	decreases expression	protein	20152895
C107773	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	RELA protein affects the reaction [[pterostilbene co-treated with Quercetin] results in decreased expression of BCL2 protein]	affects cotreatment / affects reaction / decreases expression	protein	18852136
C107773	598	BCL2L1 BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS	BCL2-like 1	pterostilbene results in decreased expression of BCL2L1 protein	decreases expression	protein	23313376
C107773	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	pterostilbene results in increased activity of CASP3 protein	increases activity	protein	20152895
C107773	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	pterostilbene results in increased cleavage of CASP3 protein	increases cleavage	protein	23313376
C107773	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	pterostilbene results in increased expression of CASP3 mRNA	increases expression	mRNA	20152895
C107773	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	pterostilbene results in increased expression of CASP9 protein	increases expression	protein	20152895
C107773	595	CCND1 BCL1 D11S287E PRAD1 U21B31	cyclin D1	pterostilbene results in decreased expression of CCND1 protein	decreases expression	protein	19549798
C107773	1026	CDKN1A CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	pterostilbene results in increased expression of CDKN1A protein	increases expression	protein	23313376
C107773	1027	CDKN1B CDKN4 KIP1 MEN1B MEN4 P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	pterostilbene results in increased expression of CDKN1B protein	increases expression	protein	23313376
C107773	2921	CXCL3 CINC-2b GRO3 GROg MIP-2b MIP2B SCYB3	chemokine (C-X-C motif) ligand 3	pterostilbene results in increased expression of CXCL3 mRNA	increases expression	mRNA	22450950
C107773	54205	CYCS CYC HCS THC4	cytochrome c, somatic	pterostilbene affects the localization of CYCS protein	affects localization	protein	22572619
C107773	54205	CYCS CYC HCS THC4	cytochrome c, somatic	pterostilbene results in increased expression of CYCS protein	increases expression	protein	22450950 22572619
C107773	1543	CYP1A1 AHH AHRR CP11 CYP1 P1-450 P450-C P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	pterostilbene results in decreased expression of CYP1A1 mRNA	decreases expression	mRNA	22450950
C107773	1649	DDIT3 CEBPZ CHOP CHOP-10 CHOP10 GADD153	DNA-damage-inducible transcript 3	pterostilbene results in increased expression of DDIT3 mRNA	increases expression	mRNA	22450950
C107773	56616	DIABLO DFNA64 SMAC	diablo, IAP-binding mitochondrial protein	pterostilbene affects the localization of DIABLO protein	affects localization	protein	22572619
C107773	56616	DIABLO DFNA64 SMAC	diablo, IAP-binding mitochondrial protein	pterostilbene results in increased expression of DIABLO protein	increases expression	protein	22450950 22572619
C107773	1950	EGF HOMG4 URG	epidermal growth factor	pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGF protein]	decreases reaction / increases expression	protein	19447859
C107773	1956	EGFR ERBB ERBB1 HER1 PIG61 mENA	epidermal growth factor receptor (EC:2.7.10.1)	pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR protein]	decreases reaction / increases expression	protein	19447859
C107773	2002	ELK1	ELK1, member of ETS oncogene family	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of ELK1 protein modified form]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	2523	FUT1 H HH HSC	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) (EC:2.4.1.69)	pterostilbene results in increased expression of FUT1 mRNA	increases expression	mRNA	22450950
C107773	9518	GDF15 GDF-15 MIC-1 MIC1 NAG-1 PDF PLAB PTGFB	growth differentiation factor 15	pterostilbene results in increased expression of GDF15 mRNA	increases expression	mRNA	22450950
C107773	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	pterostilbene results in increased expression of HMOX1 mRNA	increases expression	mRNA	22450950
C107773	4670	HNRNPM CEAR HNRNPM4 HNRPM HNRPM4 HTGR1 NAGR1 hnRNP_M	heterogeneous nuclear ribonucleoprotein M	pterostilbene results in increased expression of HNRNPM mRNA	increases expression	mRNA	22450950
C107773	3313	HSPA9 CSA GRP-75 GRP75 HSPA9B MOT MOT2 MTHSP75 PBP74	heat shock 70kDa protein 9 (mortalin)	pterostilbene results in increased expression of HSPA9 mRNA	increases expression	mRNA	22450950
C107773	3458	IFNG IFG IFI	interferon, gamma	MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of NOS2 protein]]	affects cotreatment / affects reaction / decreases reaction / increases expression	protein	19549798
C107773	3458	IFNG IFG IFI	interferon, gamma	MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of PTGS2 protein]]	affects cotreatment / affects reaction / decreases reaction / increases expression	protein	19549798
C107773	3458	IFNG IFG IFI	interferon, gamma	pterostilbene inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]	affects cotreatment / decreases reaction / increases abundance	protein	22698256
C107773	3458	IFNG IFG IFI	interferon, gamma	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of ATF2 protein modified form]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	3458	IFNG IFG IFI	interferon, gamma	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of ELK1 protein modified form]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	3458	IFNG IFG IFI	interferon, gamma	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of IL1B mRNA]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	3458	IFNG IFG IFI	interferon, gamma	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of NOS2 mRNA]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	3458	IFNG IFG IFI	interferon, gamma	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of NOS2 protein]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	3458	IFNG IFG IFI	interferon, gamma	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of PTGS2 mRNA]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	3458	IFNG IFG IFI	interferon, gamma	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of PTGS2 protein]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of IL1B mRNA]	affects cotreatment / decreases reaction / increases expression	mRNA	19549798
C107773	3696	ITGB8	integrin, beta 8	pterostilbene results in decreased expression of ITGB8 mRNA	decreases expression	mRNA	22450950
C107773	3696	ITGB8	integrin, beta 8	pterostilbene results in increased expression of ITGB8 mRNA	increases expression	mRNA	22450950
C107773	3717	JAK2 JTK10 THCYT3	Janus kinase 2 (EC:2.7.10.2)	pterostilbene results in decreased phosphorylation of JAK2 protein	decreases phosphorylation	protein	23313376
C107773	3949	LDLR FH FHC LDLCQ2	low density lipoprotein receptor	pterostilbene results in decreased expression of LDLR mRNA	decreases expression	mRNA	22153697
C107773	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]	decreases reaction / increases phosphorylation	protein	19447859
C107773	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of NOS2 protein]]	affects cotreatment / affects reaction / decreases reaction / increases expression	protein	19549798
C107773	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of PTGS2 protein]]	affects cotreatment / affects reaction / decreases reaction / increases expression	protein	19549798
C107773	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]	decreases reaction / increases phosphorylation	protein	19447859
C107773	5599	MAPK8 JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK8 protein]	decreases reaction / increases phosphorylation	protein	19447859
C107773	5601	MAPK9 JNK-55 JNK2 JNK2A JNK2ALPHA JNK2B JNK2BETA PRKM9 SAPK SAPK1a p54a p54aSAPK	mitogen-activated protein kinase 9 (EC:2.7.11.24)	pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]	decreases reaction / increases phosphorylation	protein	19447859
C107773	4170	MCL1 BCL2L3 EAT MCL1-ES MCL1L MCL1S Mcl-1 TM bcl2-L-3 mcl1/EAT	myeloid cell leukemia sequence 1 (BCL2-related)	pterostilbene results in decreased expression of MCL1 protein	decreases expression	protein	23313376
C107773	4318	MMP9 CLG4B GELB MANDP2 MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]	decreases reaction / increases activity / increases expression	protein	19447859
C107773	4318	MMP9 CLG4B GELB MANDP2 MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]	decreases reaction / increases expression	mRNA	19447859
C107773	4318	MMP9 CLG4B GELB MANDP2 MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	pterostilbene results in decreased activity of MMP9 protein	decreases activity	protein	19617202
C107773	4318	MMP9 CLG4B GELB MANDP2 MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	pterostilbene results in decreased expression of MMP9 mRNA	decreases expression	mRNA	20152895
C107773	4609	MYC MRTL MYCC bHLHe39 c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	pterostilbene results in decreased expression of MYC protein	decreases expression	protein	19549798
C107773	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	[pterostilbene co-treated with Quercetin] results in decreased activity of [NFKB1 protein binds to RELA protein]	affects binding / affects cotreatment / decreases activity	protein	18852136
C107773	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	[pterostilbene co-treated with Quercetin] results in decreased degradation of NFKBIA protein	affects cotreatment / decreases degradation	protein	18852136
C107773	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	[pterostilbene co-treated with Quercetin] results in decreased phosphorylation of NFKBIA protein	affects cotreatment / decreases phosphorylation	protein	18852136
C107773	4843	NOS2 HEP-NOS INOS NOS NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of NOS2 protein]]	affects cotreatment / affects reaction / decreases reaction / increases expression	protein	19549798
C107773	4843	NOS2 HEP-NOS INOS NOS NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of NOS2 mRNA]	affects cotreatment / decreases reaction / increases expression	mRNA	19549798
C107773	4843	NOS2 HEP-NOS INOS NOS NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of NOS2 protein]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	8856	NR1I2 BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR	nuclear receptor subfamily 1, group I, member 2	pterostilbene binds to and results in increased activity of NR1I2 protein	affects binding / increases activity	protein	20869355
C107773	9970	NR1I3 CAR CAR1 MB67	nuclear receptor subfamily 1, group I, member 3	pterostilbene binds to and results in increased activity of NR1I3 protein alternative form	affects binding / increases activity	protein	20869355
C107773	142	PARP1 ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	pterostilbene results in increased expression of PARP1 protein modified form	increases expression	protein	19549798
C107773	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of PTGS2 protein]]	affects cotreatment / affects reaction / decreases reaction / increases expression	protein	19549798
C107773	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of PTGS2 mRNA]	affects cotreatment / decreases reaction / increases expression	mRNA	19549798
C107773	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of PTGS2 protein]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	[pterostilbene co-treated with Quercetin] affects the localization of RELA protein	affects cotreatment / affects localization	protein	18852136
C107773	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	[pterostilbene co-treated with Quercetin] results in decreased activity of [NFKB1 protein binds to RELA protein]	affects binding / affects cotreatment / decreases activity	protein	18852136
C107773	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	RELA protein affects the reaction [[pterostilbene co-treated with Quercetin] results in decreased expression of BCL2 protein]	affects cotreatment / affects reaction / decreases expression	protein	18852136
C107773	6301	SARS SERRS SERS	seryl-tRNA synthetase (EC:6.1.1.11)	pterostilbene results in increased expression of SARS mRNA	increases expression	mRNA	22450950
C107773	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein	affects cotreatment / increases expression	protein	18852136
C107773	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	pterostilbene results in increased activity of SOD2 protein	increases activity	protein	22450950 22572619
C107773	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	pterostilbene results in increased expression of SOD2 mRNA	increases expression	mRNA	22450950
C107773	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein]	affects cotreatment / affects reaction / increases expression	protein	18852136
C107773	6667	SP1	Sp1 transcription factor	SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein]	affects cotreatment / affects reaction / increases expression	protein	18852136
C107773	6774	STAT3 APRF HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	pterostilbene results in decreased activity of STAT3 protein	decreases activity	protein	23313376
C107773	6774	STAT3 APRF HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	pterostilbene results in decreased expression of STAT3 protein modified form	decreases expression	protein	22450950
C107773	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of NOS2 protein]]	affects cotreatment / affects reaction / decreases reaction / increases expression	protein	19549798
C107773	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of PTGS2 protein]]	affects cotreatment / affects reaction / decreases reaction / increases expression	protein	19549798
C107773	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of ATF2 protein modified form]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of ELK1 protein modified form]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of IL1B mRNA]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of NOS2 mRNA]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of NOS2 protein]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of PTGS2 mRNA]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of PTGS2 protein]	affects cotreatment / decreases reaction / increases expression	protein	19549798
C107773	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	pterostilbene results in increased expression of TP53 mRNA	increases expression	mRNA	20152895
C107773	9189	ZBED1 ALTE DREF TRAMP hDREF	zinc finger, BED-type containing 1	pterostilbene results in decreased expression of ZBED1 mRNA	decreases expression	mRNA	22450950
C107773	118738	ZNF488	zinc finger protein 488	pterostilbene results in decreased expression of ZNF488 mRNA	decreases expression	mRNA	22450950

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM	preferred title	UniProt
#612069	Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10	Q13148
#613546	Aromatase deficiency	P11511
#139300	Aromatase excess syndrome; aexs	P11511
#114480	Breast cancer	P38398
#604370	Breast-ovarian cancer, familial, susceptibility to, 1; brovca1	P38398
#600274	Frontotemporal dementia; ftd	P10636
#232300	Glycogen storage disease ii	P10253
#605130	Hairy elbows, short stature, facial dysmorphism, and developmental delay	Q03164
#145000	Hyperparathyroidism 1; hrpt1	O00255
#612244	Inflammatory bowel disease 13; ibd13	P08183
#608232	Leukemia, chronic myeloid; cml	P00519 P11274
#131100	Multiple endocrine neoplasia, type i; men1	O00255
#613076	Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay	P55789
#257220	Niemann-pick disease, type c1; npc1	O15118
#167000	Ovarian cancer	P38398
#614320	Pancreatic cancer, susceptibility to, 4; pnca4	P38398
#260540	Parkinson-dementia syndrome	P10636
#172700	Pick disease of brain	P10636
#601104	Supranuclear palsy, progressive, 1; psnp1	P10636

KEGG DISEASE (20)

KEGG	disease name	UniProt
H00033	Adrenal carcinoma	O00255 (related)
H00034	Carcinoid	O00255 (related)
H00045	Malignant islet cell carcinoma	O00255 (related)
H00246	Primary hyperparathyroidism	O00255 (related)
H01102	Pituitary adenomas	O00255 (related)
H00136	Niemann-Pick disease type C (NPC)	O15118 (related)
H00001	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	P00519 (related) P00519 (marker) P11274 (related) P11274 (marker) Q03164 (related) Q03164 (marker)
H00004	Chronic myeloid leukemia (CML)	P00519 (related) P00519 (marker) P11274 (related) P11274 (marker)
H00069	Glycogen storage diseases (GSD)	P10253 (related)
H00058	Amyotrophic lateral sclerosis (ALS)	P10636 (related) Q13148 (related)
H00077	Progressive supranuclear palsy (PSP)	P10636 (related)
H00078	Frontotemporal lobar degeneration (FTLD)	P10636 (related)
H00599	46,XX disorders of sex development (Disorders related to androgen excess)	P11511 (related)
H00794	Aromatase excess syndrome	P11511 (related)
H00017	Esophageal cancer	P35354 (related)
H00025	Penile cancer	P35354 (related)
H00046	Cholangiocarcinoma	P35354 (related)
H00027	Ovarian cancer	P38398 (related)
H00031	Breast cancer	P38398 (related)
H00002	Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)	Q03164 (related)

Diseases related to CTD interactions

15 disease from interactions of metabolites

MeSH disease	compound	disease name	evidence type	reference pmid
D058739	C107773	Aberrant Crypt Foci	therapeutic	19549798 20681671
D000236	C107773	Adenoma	therapeutic	20681671
D001943	C107773	Breast Neoplasms	therapeutic	19617202 22572619
D006528	C107773	Carcinoma, Hepatocellular	therapeutic	19447859
D002471	C107773	Cell Transformation, Neoplastic	therapeutic	19617202
D003110	C107773	Colonic Neoplasms	therapeutic	20681671 21355597
D015179	C107773	Colorectal Neoplasms	therapeutic	18852136
D007249	C107773	Inflammation	therapeutic	19549798 20681671
D015464	C107773	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	therapeutic	22293408
D009361	C107773	Neoplasm Invasiveness	therapeutic	19447859 19617202
D009362	C107773	Neoplasm Metastasis	therapeutic	19447859
D012516	C107773	Osteosarcoma	therapeutic	23313376
D010190	C107773	Pancreatic Neoplasms	therapeutic	22450950
D010212	C107773	Papilloma	therapeutic	22842666
D012878	C107773	Skin Neoplasms	therapeutic	22842666

KNApSAcK Metabolite C00002902

Index Metabolite Species Human Protein / Gene in interactions Related Diseases

Metabolite

KNApSAcK Entry

Cluster

Link

ChEMBL

KEGG

CTD

Species

Summary

Plant class

Family

List (10)

* NCBI

Human Protein / Gene in interaction

19 ChEMBL Protein in interactions

CTD interaction (96)

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (19)

KEGG DISEASE (20)

Diseases related to CTD interactions

15 disease from interactions of metabolites

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases