Species

KNApSAcK Entry

Organism name Combretum caffrum
Genus Combretum
Family Combretaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Combretum caffrum
Linked NCBI taxonomy ID 507393
Linked level species

Family

Family in NCBI taxonomy Combretaceae
ID 3954

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (15)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00015607 External link 512 6,7-Dihydroxy-2,3,4-trimethoxy-9,10-dihydrophenanthrene
No. 75 No. 28
C00015683 External link 512 7-Hydroxy-2,3,4,6-tetramethoxy-9,10-dihydrophenanthrene
CHEMBL79985
No. 75 No. 28
C00015271 External link 512 2-Hydroxy-3,4,6,7-tetramethoxy-9,10-dihydrophenanthrene
No. 75 No. 28
C00015256 External link 512 2,7-Dihydroxy-3,4,6-trimethoxy-9,10-dihydrophenanthrene
No. 75 No. 28
C00015206 External link 512 Combretastatin B2
No. 96 No. 26
C00015305 External link 512 Combretastatin B3
/ 3',4'-Dihydroxy-3,4,5-trimethoxybibenzyl
CHEMBL485822
C056668
No. 96 No. 26
C00015310 External link 512 Combretastatin B4
/ 3,4-Dihydroxy-3',5'-dimethoxybibenzyl
CHEMBL487612
C056667
No. 96 No. 26
C00015685 External link 512 7-Hydroxy-2,3,4,6-tetramethoxyphenanthrene
CHEMBL421968
No. 104 No. 27
C00015204 External link 512 Combretastatin A1
/ (Z)-3-Methoxy-6-[2-(3,4,5-trimethoxyphenyl)ethenyl]-1,2-benzenediol
CHEMBL36255
CHEMBL520204
C063690
5 / 0 / 0 No. 344 No. 13
C00015328 External link 512 Combretastatin A3
/ 3',5-Dihydroxy-3,4,4'-trimethoxystilbene
CHEMBL464382
C440905
No. 344 No. 13
C00015429 External link 512 CRC 87-09
/ Combretastatin A4
/ 3'-Hydroxy-3,4,4'5-tetramethoxystilbene
CHEMBL67
CHEMBL36455
CHEMBL2142429
17 / 7 / 2 No. 344 No. 13
C00015319 External link 512 Combretastatin A2
/ 3',4'-Dimethoxy-3'-hydroxy-4,5-methylenedioxystilbene
CHEMBL47037
CHEMBL1642222
C061751
No. 344 No. 13
C00015203 External link 512 Combretastatin B-1
/ 2,3-Dihydroxy-3',4,4',5-tetramethoxybibenzyl
CHEMBL285152
No. 673
C00015422 External link 512 Combretastatin
/ 3',7'-Dihydroxy-3,4,4'5-tetramethoxybibenzyl
CHEMBL151766
CHEMBL246600
C040105
No. 673
C00035241 External link 512 9,10-Dihydrophenanthrene
No. 6139

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9H4B7 Tubulin beta-1 chain Structural C00015429 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00015429 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00015429 0 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00015429 0 / 0
P68366 Tubulin alpha-4A chain Structural C00015429 0 / 0
P04350 Tubulin beta-4A chain Structural C00015429 2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00015429 0 / 0
P07437 Tubulin beta chain Structural C00015429 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00015429 1 / 1
P68371 Tubulin beta-4B chain Structural C00015429 0 / 0
Q13509 Tubulin beta-3 chain Structural C00015429 2 / 1
P30874 Somatostatin receptor type 2 Somatostatin receptor C00015204 0 / 0
P31391 Somatostatin receptor type 4 Somatostatin receptor C00015204 0 / 0
P32745 Somatostatin receptor type 3 Somatostatin receptor C00015204 0 / 0
P35346 Somatostatin receptor type 5 Somatostatin receptor C00015204 0 / 0
P30872 Somatostatin receptor type 1 Somatostatin receptor C00015204 0 / 0
P68363 Tubulin alpha-1B chain Unclassified protein C00015429 0 / 0
Q13885 Tubulin beta-2A chain Structural C00015429 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00015429 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00015429 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00015429 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00015429 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1

KEGG DISEASE (2)

KEGG name UniProt
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)