PCIDB

KNApSAcK Metabolite C00001763

Metabolite

KNApSAcK Entry

id C00001763
Name Reserpine
CAS RN 50-55-5
Standard InChI InChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
Standard InChI (Main Layer) InChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 2040

Link

ChEMBL

By standard InChI CHEMBL772
By standard InChI Main Layer CHEMBL772 CHEMBL357497 CHEMBL388848 CHEMBL1315313 CHEMBL1396912 CHEMBL1433658 CHEMBL1452716

KEGG

By LinkDB C06539

CTD

By CAS RN D012110

Human Protein / Gene in interaction

156 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL772 CHEMBL1315313 CHEMBL1396912 CHEMBL1614110 (2) CHEMBL1741321 (1)
CHEMBL1909136 (2)
1 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL1396912 CHEMBL1613842 (1)
4 / 2
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL772 CHEMBL2169429 (1)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL772 CHEMBL1738312 (1)
0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL772 CHEMBL2169431 (1)
0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL772 CHEMBL1794499 (1)
2 / 0
O95342 Bile salt export pump drug CHEMBL772 CHEMBL2076226 (1) CHEMBL2076242 (1)
2 / 1
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL772 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL772 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL772 CHEMBL1794573 (2) CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL772 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL772 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL772 CHEMBL1909201 (2)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL772 CHEMBL1614079 (1)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL772 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL772 CHEMBL1433658 CHEMBL1452716 CHEMBL1614158 (3) CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL772 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL772 CHEMBL1909199 (2)
0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL772 CHEMBL1794524 (2) CHEMBL1794552 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL772 CHEMBL1909197 (2)
2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL772 CHEMBL1738600 (1) CHEMBL1794585 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL1396912 CHEMBL1433658 CHEMBL1614331 (2)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL772 CHEMBL1614544 (1)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL772 CHEMBL1315313 CHEMBL1396912 CHEMBL1614281 (3) CHEMBL1614361 (4)
3 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL772 CHEMBL1452716 CHEMBL1613776 (1) CHEMBL1794399 (2)
3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL772 CHEMBL1794371 (2) CHEMBL1794471 (1)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL772 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL772 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL772 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL772 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL772 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL772 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL772 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL772 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL772 CHEMBL1909093 (2)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL772 CHEMBL754774 (1) CHEMBL925479 (1)
CHEMBL925480 (1) CHEMBL925481 (1)
CHEMBL1908285 (1) CHEMBL1908286 (1)
CHEMBL1908289 (1) CHEMBL1908291 (1)
CHEMBL1908292 (1) CHEMBL2075698 (1)
CHEMBL2076213 (1) CHEMBL2076214 (1)
CHEMBL2076217 (1) CHEMBL2076218 (1)
CHEMBL2076229 (1) CHEMBL2076230 (1)
CHEMBL2076253 (1) CHEMBL2076254 (1)
CHEMBL2076066 (1) CHEMBL2078544 (1)
CHEMBL2078545 (1) CHEMBL2078546 (1)
CHEMBL2078547 (1) CHEMBL2078576 (1)
1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL772 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL772 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL772 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL772 CHEMBL1315313 CHEMBL1396912 CHEMBL1614027 (1) CHEMBL1741325 (1)
CHEMBL1909135 (2)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL772 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL772 CHEMBL1614166 (1)
1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL772 CHEMBL1909203 (2)
1 / 11
P11387 DNA topoisomerase 1 Isomerase CHEMBL772 CHEMBL1003401 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL772 CHEMBL1433658 CHEMBL1794311 (3) CHEMBL1794376 (1)
CHEMBL1794339 (1)
2 / 3
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL772 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL772 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL772 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL772 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL772 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL772 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL772 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL772 CHEMBL1909096 (2)
1 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL357497 CHEMBL1433658 CHEMBL1613800 (2)
0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL772 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL772 CHEMBL1909166 (2)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL772 CHEMBL1396912 CHEMBL1452716 CHEMBL1614458 (4)
0 / 0
P68871 Hemoglobin subunit beta Secreted protein CHEMBL772 CHEMBL1315313 CHEMBL1396912 CHEMBL1433658 CHEMBL1452716 CHEMBL1614204 (2) CHEMBL1613976 (1)
CHEMBL1614225 (3)
4 / 4
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL772 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1396912 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL772 CHEMBL1794486 (2)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL772 CHEMBL1452716 CHEMBL1738606 (2)
0 / 0
O75496 Geminin Unclassified protein CHEMBL772 CHEMBL1613941 (1) CHEMBL1738636 (1)
CHEMBL2114843 (1) CHEMBL2114780 (2)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL772 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL772 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL772 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL772 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL772 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL772 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL772 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL772 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL772 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL772 CHEMBL1909100 (2)
0 / 0
P10145 Interleukin-8 Secreted protein CHEMBL772 CHEMBL2114835 (1)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL772 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL772 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL772 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL772 CHEMBL1909110 (2)
1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL772 CHEMBL2114788 (1)
0 / 0
P03956 Interstitial collagenase M10A CHEMBL772 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL772 CHEMBL1909119 (2)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL772 CHEMBL1794569 (1)
1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL772 CHEMBL1614280 (1)
0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL772 CHEMBL357497 CHEMBL1396912 CHEMBL1433658 CHEMBL1452716 CHEMBL1614410 (1) CHEMBL1614531 (6)
1 / 3
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL772 CHEMBL1738610 (1) CHEMBL1794401 (1)
0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL357497 CHEMBL1794342 (1)
0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL772 CHEMBL2169430 (1)
1 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL772 CHEMBL1396912 CHEMBL1433658 CHEMBL1452716 CHEMBL1794467 (5)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL772 CHEMBL1794456 (1) CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL772 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL772 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL772 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL772 CHEMBL1909109 (2)
2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL772 CHEMBL1794293 (2) CHEMBL1794510 (1)
5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL772 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL772 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL772 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL772 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL772 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL772 CHEMBL1909108 (2)
0 / 0
Q96RI1 Bile acid receptor NR1H4 CHEMBL772 CHEMBL1794415 (1) CHEMBL1794437 (1)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL772 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL772 CHEMBL1613808 (1) CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL772 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL772 CHEMBL1396912 CHEMBL1741322 (1) CHEMBL1909132 (2)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL772 CHEMBL1452716 CHEMBL1613910 (2)
3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL772 CHEMBL974473 (1)
2 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL772 CHEMBL1006005 (1) CHEMBL2078561 (1)
1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL1452716 CHEMBL1614038 (1)
2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL772 CHEMBL1614171 (1)
5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL772 CHEMBL2114842 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL772 CHEMBL1738588 (1) CHEMBL1738675 (1)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL772 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL772 CHEMBL1794364 (1) CHEMBL1794542 (2)
CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL772 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL772 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL772 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL772 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL772 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL772 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL772 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL772 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL772 CHEMBL1909168 (2)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL772 CHEMBL2114853 (2)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL772 CHEMBL1433658 CHEMBL1452716 CHEMBL1614240 (3)
0 / 0
P55210 Caspase-7 C14 CHEMBL772 CHEMBL1452716 CHEMBL1613779 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL772 CHEMBL1396912 CHEMBL1741323 (1) CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL772 CHEMBL357497 CHEMBL1396912 CHEMBL1433658 CHEMBL1452716 CHEMBL1614108 (5) CHEMBL1613886 (5)
CHEMBL1741324 (1) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL772 CHEMBL1909137 (2)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL772 CHEMBL1794483 (1)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL772 CHEMBL1614052 (1)
1 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL772 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL357497 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL772 CHEMBL357497 CHEMBL1433658 CHEMBL1452716 CHEMBL1614250 (1) CHEMBL1614421 (4)
CHEMBL1614502 (4)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL772 CHEMBL1738402 (2)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL772 CHEMBL1738184 (1) CHEMBL2114890 (2)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL772 CHEMBL1794560 (2)
3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL772 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL772 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL772 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL772 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL772 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL772 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL772 CHEMBL1909128 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL772 CHEMBL357497 CHEMBL1396912 CHEMBL1433658 CHEMBL1452716 CHEMBL1613914 (5)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL772 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL772 CHEMBL1396912 CHEMBL1738442 (4)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL772 CHEMBL357497 CHEMBL1396912 CHEMBL1433658 CHEMBL1452716 CHEMBL1614364 (8)
1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL772 CHEMBL2354311 (1)
1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme CHEMBL772 CHEMBL1963966 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL772 CHEMBL357497 CHEMBL1396912 CHEMBL1433658 CHEMBL1452716 CHEMBL1614531 (6)
2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL772 CHEMBL357497 CHEMBL1433658 CHEMBL1613933 (3)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL772 CHEMBL357497 CHEMBL1433658 CHEMBL1613933 (3)
1 / 6
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x CHEMBL772 CHEMBL806152 (1) CHEMBL806153 (1)
0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x CHEMBL772 CHEMBL806152 (1) CHEMBL806153 (1)
2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x CHEMBL772 CHEMBL806152 (1) CHEMBL806153 (1)
3 / 2

CTD interaction (37)

compound gene gene name gene description interaction interaction type form reference
pmid
D012110 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Cycloheximide promotes the reaction [Reserpine results in increased expression of ABCB1 mRNA] increases expression
/ increases reaction
mRNA 7476894
D012110 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Reserpine inhibits the reaction [ABCB1 protein affects the export of calcein AM] affects export
/ decreases reaction
protein 10617675
D012110 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon] decreases reaction
/ increases secretion
protein 12235267
D012110 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine] decreases reaction
/ increases secretion
protein 12235267
D012110 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Reserpine results in decreased activity of ABCB1 protein decreases activity
protein 19528478
D012110 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Reserpine results in increased expression of ABCB1 mRNA increases expression
mRNA 7476894
D012110 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Reserpine results in increased expression of ABCB1 protein increases expression
protein 8632764
D012110 8647 ABCB11
ABC16
BRIC2
BSEP
PFIC-2
PFIC2
PGY4
SPGP
ATP-binding cassette, sub-family B (MDR/TAP), member 11 Reserpine results in decreased activity of ABCB11 protein decreases activity
protein 20829430
D012110 9429 ABCG2
ABC15
ABCP
BCRP
BCRP1
BMDP
CD338
CDw338
EST157481
GOUT1
MRX
MXR
MXR1
UAQTL1
ATP-binding cassette, sub-family G (WHITE), member 2 Reserpine inhibits the reaction [ABCG2 protein results in increased transport of HOE 33342] decreases reaction
/ increases transport
protein 12869632
D012110 9429 ABCG2
ABC15
ABCP
BCRP
BCRP1
BMDP
CD338
CDw338
EST157481
GOUT1
MRX
MXR
MXR1
UAQTL1
ATP-binding cassette, sub-family G (WHITE), member 2 Reserpine inhibits the reaction [ABCG2 protein results in increased transport of irinotecan] decreases reaction
/ increases transport
protein 12869632
D012110 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 Reserpine binds to BIRC5 promoter affects binding
promoter 17968851
D012110 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Reserpine results in decreased expression of CCND1 mRNA decreases expression
mRNA 19607803
D012110 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Reserpine results in decreased expression of CCND1 protein decreases expression
protein 19607803
D012110 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Reserpine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] decreases reaction
/ increases activity
protein 18493746
D012110 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein] increases activity
/ increases expression
/ increases reaction
protein 15627480
D012110 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] increases expression
/ increases reaction
mRNA 15627480
D012110 1555 CYP2B6
CPB6
CYP2B
CYP2B7
CYP2B7P
CYPIIB6
EFVM
IIB1
P450
cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) [Reserpine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA increases activity
/ increases expression
mRNA 17041008
D012110 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) [Reserpine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA increases activity
/ increases expression
mRNA 17041008
D012110 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Reserpine results in increased expression of CYP3A4 mRNA increases expression
mRNA 16837568
D012110 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Reserpine results in increased expression of CYP3A4 protein increases expression
protein 8632764
D012110 1577 CYP3A5
CP35
CYPIIIA5
P450PCN3
PCN3
cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) Reserpine results in increased expression of CYP3A5 protein increases expression
protein 8632764
D012110 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 Reserpine results in decreased expression of IL10 mRNA decreases expression
mRNA 16985181
D012110 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 Reserpine results in decreased expression of IL10 protein decreases expression
protein 16985181
D012110 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 SCH 23390 inhibits the reaction [Reserpine results in decreased expression of IL10 mRNA] decreases expression
/ decreases reaction
mRNA 16985181
D012110 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 SCH 23390 inhibits the reaction [Reserpine results in decreased expression of IL10 protein] decreases expression
/ decreases reaction
protein 16985181
D012110 3738 KCNA3
HGK5
HLK3
HPCN3
HUKIII
KV1.3
MK3
PCN3
potassium voltage-gated channel, shaker-related subfamily, member 3 Reserpine results in decreased activity of KCNA3 protein decreases activity
protein 21362439
D012110 3738 KCNA3
HGK5
HLK3
HPCN3
HUKIII
KV1.3
MK3
PCN3
potassium voltage-gated channel, shaker-related subfamily, member 3 [Reserpine results in decreased activity of KCNA3 protein] which results in decreased import of Thallium decreases activity
/ decreases import
protein 21362439
D012110 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 Reserpine results in decreased activity of KCNH2 protein decreases activity
protein 21362439
D012110 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 [Reserpine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium decreases activity
/ decreases import
protein 21362439
D012110 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog Reserpine results in decreased expression of MYC protein decreases expression
protein 19607803
D012110 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 [Reserpine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA increases activity
/ increases expression
protein 17041008
D012110 9970 NR1I3
CAR
CAR1
MB67
nuclear receptor subfamily 1, group I, member 3 [Reserpine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA increases activity
/ increases expression
protein 17041008
D012110 6477 SIAH1
SIAH1A
siah E3 ubiquitin protein ligase 1 (EC:6.3.2.-) Reserpine results in increased expression of SIAH1 mRNA increases expression
mRNA 19607803
D012110 6570 SLC18A1
CGAT
VAT1
VMAT1
solute carrier family 18 (vesicular monoamine transporter), member 1 Reserpine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] decreases reaction
/ increases uptake
protein 8245983
D012110 6571 SLC18A2
SVAT
SVMT
VAT2
VMAT2
solute carrier family 18 (vesicular monoamine transporter), member 2 Reserpine binds to SLC18A2 protein affects binding
protein 7912402
D012110 6571 SLC18A2
SVAT
SVMT
VAT2
VMAT2
solute carrier family 18 (vesicular monoamine transporter), member 2 Reserpine results in decreased activity of SLC18A2 protein decreases activity
protein 15475732
D012110 6571 SLC18A2
SVAT
SVMT
VAT2
VMAT2
solute carrier family 18 (vesicular monoamine transporter), member 2 SLC18A2 gene SNP results in decreased susceptibility to Reserpine decreases response to substance
gene 15475732

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (107)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#605479 Cholestasis, benign recurrent intrahepatic, 2; bric2 O95342
#601847 Cholestasis, progressive familial intrahepatic, 2; pfic2 O95342
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#607208 Dravet syndrome P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#140700 Heinz body anemias P68871
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#603903 Sickle cell anemia P68871
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (86)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00624 Familial cholestasis O95342 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P68871 (marker)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H00020 Colorectal cancer P68871 (marker)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

67 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000544 D012110 Alzheimer Disease therapeutic
19264117
D000855 D012110 Anorexia marker/mechanism
4942478
D001145 D012110 Arrhythmias, Cardiac therapeutic
4990592
D001161 D012110 Arteriosclerosis therapeutic
10729376
D001714 D012110 Bipolar Disorder therapeutic
4402472
D001763 D012110 Blepharoptosis marker/mechanism
4022276
6890359
7193623
7454609
9364413
10030729
D001919 D012110 Bradycardia marker/mechanism
1179459
6614959
D001943 D012110 Breast Neoplasms marker/mechanism
11921183
D009202 D012110 Cardiomyopathies marker/mechanism
17737440
D002375 D012110 Catalepsy marker/mechanism
therapeutic
945050
1033567
1168927
1172422
8045270
10030729
10591873
10651103
10683491
11999899
12711835
15111244
15332494
16430090
17486685
17719177
19309549
20964730
21161603
D002389 D012110 Catatonia marker/mechanism
4397415
11980384
D002493 D012110 Central Nervous System Diseases marker/mechanism
937377
D002819 D012110 Chorea therapeutic
3949727
D019970 D012110 Cocaine-Related Disorders therapeutic
15730350
15730354
15773068
D003866 D012110 Depressive Disorder marker/mechanism
4431808
6143649
6781010
16956388
18363858
D004195 D012110 Disease Models, Animal marker/mechanism
6781010
8527005
9398468
10683491
11980384
12774329
15561468
16956388
D056486 D012110 Drug-Induced Liver Injury marker/mechanism
19182437
D064420 D012110 Drug-Related Side Effects and Adverse Reactions therapeutic
5071802
D004409 D012110 Dyskinesia, Drug-Induced marker/mechanism
therapeutic
1742751
6143649
11999899
14685008
15561468
15649445
16124929
16444668
19109989
19761039
20628966
20973483
21161603
D020820 D012110 Dyskinesias marker/mechanism
therapeutic
4383787
6858776
7845612
8811507
D005183 D012110 Failure to Thrive marker/mechanism
6519379
D005221 D012110 Fatigue marker/mechanism
4942478
D005313 D012110 Fetal Death marker/mechanism
6519379
D005334 D012110 Fever therapeutic
12860512
D005767 D012110 Gastrointestinal Diseases marker/mechanism
937377
D005921 D012110 Glomerulonephritis therapeutic
11318962
D005923 D012110 Glomerulosclerosis, Focal Segmental therapeutic
2996345
D006323 D012110 Heart Arrest marker/mechanism
39448
D006327 D012110 Heart Block marker/mechanism
6036652
D006396 D012110 Hematemesis marker/mechanism
5053741
D006930 D012110 Hyperalgesia therapeutic
7908645
D006948 D012110 Hyperkinesis marker/mechanism
therapeutic
44745
129788
413140
2880302
3809523
6504948
12539206
16814282
D006965 D012110 Hyperplasia therapeutic
10354516
D006966 D012110 Hyperprolactinemia marker/mechanism
6492995
8613910
9819799
D006973 D012110 Hypertension marker/mechanism
therapeutic
677215
937377
1722376
2996345
3011863
4942478
7418711
7731138
9596073
11518857
14871401
15308481
15888567
15894892
17082731
17278980
17318787
22318512
D006980 D012110 Hyperthyroidism therapeutic
4589407
D018476 D012110 Hypokinesia marker/mechanism
44745
945166
989390
2055429
3670563
7927523
8998404
9137910
9398468
10591873
10711353
14597605
20950413
D007022 D012110 Hypotension marker/mechanism
937377
2233698
5053741
6614959
6858776
15605399
D007035 D012110 Hypothermia marker/mechanism
402662
577864
945166
1171662
1240830
1718290
1977408
2045013
2530142
2561889
2896509
3196380
3691630
4022276
4041037
6890359
7193623
7454609
9142555
9660111
9798262
18088364
20223878
D007154 D012110 Immune System Diseases marker/mechanism
16956388
D007674 D012110 Kidney Diseases marker/mechanism
19952499
D008325 D012110 Mammary Neoplasms, Experimental marker/mechanism
11921183
D008569 D012110 Memory Disorders marker/mechanism
14685008
16444668
18579275
20628966
D001523 D012110 Mental Disorders therapeutic
2409454
D017240 D012110 Mitochondrial Myopathies marker/mechanism
17737440
D009069 D012110 Movement Disorders marker/mechanism
4854165
15728856
16806299
20072119
D009127 D012110 Muscle Rigidity marker/mechanism
3670563
6894183
7201824
8527005
8834096
8873138
9871435
10594343
11400182
14172950
17719177
19309549
D009203 D012110 Myocardial Infarction marker/mechanism
5712346
D009207 D012110 Myoclonus therapeutic
12860512
D009325 D012110 Nausea marker/mechanism
4942478
D009374 D012110 Neoplasms, Experimental therapeutic
12127238
D016584 D012110 Panic Disorder marker/mechanism
8784656
D010243 D012110 Paralysis therapeutic
19264117
D010302 D012110 Parkinson Disease, Secondary marker/mechanism
2192787
6858776
20542064
D020734 D012110 Parkinsonian Disorders marker/mechanism
8527005
9398468
10602339
11358453
11980384
12539206
12774329
15306204
D010468 D012110 Perceptual Disorders marker/mechanism
8784656
D010673 D012110 Pheochromocytoma marker/mechanism
15837122
D010488 D012110 Polyarteritis Nodosa therapeutic
1971779
D011297 D012110 Prenatal Exposure Delayed Effects marker/mechanism
3988167
6519379
D012021 D012110 Reflex, Abnormal marker/mechanism
3540391
D012559 D012110 Schizophrenia therapeutic
6143649
D012640 D012110 Seizures marker/mechanism
123503
2364984
8103921
8645877
D012893 D012110 Sleep Disorders marker/mechanism
2293170
D013276 D012110 Stomach Ulcer marker/mechanism
8050460
8405073
9286623
9845272
14612188
16081063
19783516
D013610 D012110 Tachycardia marker/mechanism
2541852
D014202 D012110 Tremor marker/mechanism
3670563
4651776
11999899
14172950
18508458
D014456 D012110 Ulcer marker/mechanism
2345457