PCIDB

Rauwolfia serpentina Benth ex Kurz.

Species

KNApSAcK Entry

Organism name Rauwolfia serpentina Benth ex Kurz.
Genus Rauwolfia
Family Apocynaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Rauvolfia
Linked NCBI taxonomy ID 4059
Linked level genus

Family

Family in NCBI taxonomy Apocynaceae
ID 4056

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00025207 External link 512 Reserpilin
/ Elliptamine
/ Reserpiline
/ (-)-Reserpiline
CHEMBL1622689
No. 246 No. 4
C00024294 External link 512 Ritmos
/ Ignazin
/ Takycor
/ Ajmalin
/ Siddiqui
/ Rytmalin
/ Merabitol
/ Rhytmaton
/ Tachmalin
/ Rauwolfin
/ Rauwolfine
/ Raugalline
/ Gilurytmal
/ (+)-Ajmaline
/ Cardiorythmine
CHEMBL1434779
CHEMBL1452040
CHEMBL1460192
CHEMBL1515845
CHEMBL1525248
CHEMBL2105617
CHEMBL2356868
CHEMBL2357792
D000404
96 / 49 / 43 2 / 32 No. 407 No. 4
C00001767 External link 512 Sarpagine
CHEMBL498733
No. 490 No. 4
C00024288 External link 512 Ajmalimine
/ 17-O-(3',4'5'-Trimethoxybenzoyl)ajmaline
/ Ajmaline 17-O-(3',4',5'-trimethoxybenzoate)
No. 1568
C00001763 External link 512 Reserpine
CHEMBL772
CHEMBL357497
CHEMBL388848
CHEMBL1315313
CHEMBL1396912
CHEMBL1433658
CHEMBL1452716
D012110
156 / 107 / 86 18 / 67 No. 2040 No. 4
C00001769 External link 512 Serpentine
CHEMBL14755
CHEMBL1187439
CHEMBL1994588
C009244
1 / 1 / 0 1 / 1 No. 4006 No. 4

Human Protein / Gene in interactions

158 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001763 C00001769 C00024294 1 / 0
O00255 Menin Unclassified protein C00001763 C00024294 2 / 5
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00001763 C00024294 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00001763 C00024294 0 / 1
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00001763 C00024294 1 / 1
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00001763 C00024294 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00001763 C00024294 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001763 C00024294 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00001763 C00024294 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001763 C00024294 2 / 2
P08246 Neutrophil elastase S1A C00001763 C00024294 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00001763 C00024294 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00001763 C00024294 0 / 0
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00001763 C00024294 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00001763 C00024294 0 / 0
P29466 Caspase-1 C14 C00001763 C00024294 0 / 0
P17252 Protein kinase C alpha type Alpha C00001763 C00024294 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00001763 C00024294 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00001763 C00024294 1 / 1
P14780 Matrix metalloproteinase-9 M10A C00001763 C00024294 2 / 2
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001763 C00024294 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00001763 C00024294 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001763 C00024294 0 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00001763 C00024294 3 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001763 C00024294 1 / 1
P33032 Melanocortin receptor 5 Melanocortin receptor C00001763 C00024294 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00001763 C00024294 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00001763 C00024294 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00001763 C00024294 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00001763 C00024294 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00001763 C00024294 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00001763 C00024294 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00001763 C00024294 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00001763 C00024294 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00001763 C00024294 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00001763 C00024294 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00001763 C00024294 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00001763 C00024294 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00001763 C00024294 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001763 C00024294 0 / 1
P25103 Substance-P receptor Neurokinin receptor C00001763 C00024294 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00001763 C00024294 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00001763 C00024294 1 / 8
P35372 Mu-type opioid receptor Opioid receptor C00001763 C00024294 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00001763 C00024294 2 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00001763 C00024294 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001763 C00024294 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00001763 C00024294 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00001763 C00024294 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00001763 C00024294 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00001763 C00024294 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00001763 C00024294 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00001763 C00024294 1 / 1
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001763 C00024294 0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00001763 C00024294 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00001763 C00024294 1 / 0
P22303 Acetylcholinesterase Hydrolase C00001763 C00024294 1 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00001763 C00024294 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00001763 C00024294 0 / 0
P03372 Estrogen receptor NR3A1 C00001763 C00024294 1 / 1
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00001763 C00024294 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001763 C00024294 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001763 C00024294 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00001763 C00024294 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00001763 C00024294 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00001763 C00024294 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00001763 C00024294 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00001763 C00024294 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00001763 C00024294 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00001763 C00024294 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00001763 C00024294 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00001763 C00024294 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00001763 C00024294 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00001763 C00024294 2 / 1
P32245 Melanocortin receptor 4 Melanocortin receptor C00001763 C00024294 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00001763 C00024294 0 / 0
P08311 Cathepsin G S1A C00001763 C00024294 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00001763 C00024294 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001763 C00024294 0 / 0
P03956 Interstitial collagenase M10A C00001763 C00024294 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00001763 C00024294 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00001763 C00024294 1 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00001763 C00024294 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00001763 C00024294 3 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001763 C00024294 1 / 2
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00001763 C00024294 0 / 0
P21452 Substance-K receptor Neurokinin receptor C00001763 C00024294 0 / 0
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00001763 C00024294 1 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00001763 C00024294 5 / 9
P04150 Glucocorticoid receptor NR3C1 C00001763 C00024294 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00001763 C00024294 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00001763 C00024294 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00001763 C00024294 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001763 C00024294 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001763 5 / 3
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001763 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00001763 1 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00001763 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001763 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001763 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00001763 1 / 1
Q96RI1 Bile acid receptor NR1H4 C00001763 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00024294 7 / 3
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001763 0 / 0
P10145 Interleukin-8 Secreted protein C00001763 0 / 0
O75496 Geminin Unclassified protein C00001763 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001763 3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00001763 2 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00001763 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001763 2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein C00001763 5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00001763 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001763 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001763 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001763 0 / 0
P68871 Hemoglobin subunit beta Secreted protein C00001763 4 / 4
P00352 Retinal dehydrogenase 1 Enzyme C00001763 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001763 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00001763 2 / 3
P11387 DNA topoisomerase 1 Isomerase C00001763 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001763 1 / 0
P54132 Bloom syndrome protein Enzyme C00001763 1 / 2
P08183 Multidrug resistance protein 1 drug C00001763 1 / 0
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00001763 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00001763 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001763 0 / 0
P55210 Caspase-7 C14 C00001763 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00001763 3 / 1
P02545 Prelamin-A/C Unclassified protein C00001763 11 / 10
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00001763 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001763 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00001763 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001763 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001763 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001763 4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein C00001763 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001763 0 / 0
P10275 Androgen receptor NR3C4 C00001763 3 / 4
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00001763 0 / 0
P06746 DNA polymerase beta Enzyme C00001763 0 / 0
O95342 Bile salt export pump drug C00001763 2 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001763 2 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00001763 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001763 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00001763 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001763 0 / 0
P40225 Thrombopoietin Unclassified protein C00001763 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001763 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001763 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001763 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00001763 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00001763 4 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00001763 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001763 1 / 4
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x C00001763 0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x C00001763 2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x C00001763 3 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00024294 0 / 0

20 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3757 KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 potassium voltage-gated channel, subfamily H (eag-related), member 2 C00001763 C00024294
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00001763
6331 SCN5A, CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1 sodium channel, voltage-gated, type V, alpha subunit C00024294
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00001763
8647 ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP ATP-binding cassette, sub-family B (MDR/TAP), member 11 C00001763
9429 ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 ATP-binding cassette, sub-family G (WHITE), member 2 C00001763
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00001763
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00001763
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001763
1555 CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) C00001763
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00001769
1577 CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) C00001763
3586 IL10, CSIF, GVHDS, IL-10, IL10A, TGIF interleukin 10 C00001763
3738 KCNA3, HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3 potassium voltage-gated channel, shaker-related subfamily, member 3 C00001763
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00001763
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00001763
9970 NR1I3, CAR, CAR1, MB67 nuclear receptor subfamily 1, group I, member 3 C00001763
6477 SIAH1, SIAH1A siah E3 ubiquitin protein ligase 1 (EC:6.3.2.-) C00001763
6570 SLC18A1, CGAT, VAT1, VMAT1 solute carrier family 18 (vesicular monoamine transporter), member 1 C00001763
6571 SLC18A2, SVAT, SVMT, VAT2, VMAT2 solute carrier family 18 (vesicular monoamine transporter), member 2 C00001763

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (114)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#605479 Cholestasis, benign recurrent intrahepatic, 2; bric2 O95342
#601847 Cholestasis, progressive familial intrahepatic, 2; pfic2 O95342
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#607208 Dravet syndrome P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#140700 Heinz body anemias P68871
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#603903 Sickle cell anemia P68871
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (89)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00624 Familial cholestasis O95342 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P68871 (marker)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H00020 Colorectal cancer P68871 (marker)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

95 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002375 Catalepsy C00001769
C00001763
D005334 Fever C00024294
C00001763
D064420 Drug-Related Side Effects and Adverse Reactions C00024294
C00001763
D056486 Drug-Induced Liver Injury C00024294
C00001763
D001145 Arrhythmias, Cardiac C00024294
C00001763
D008569 Memory Disorders C00001763
D001281 Atrial Fibrillation C00024294
D054537 Atrioventricular Block C00024294
C535438 Bidirectional tachycardia C00024294
D053840 Brugada Syndrome C00024294
D002037 Bundle-Branch Block C00024294
D023341 Chills C00024294
D002779 Cholestasis C00024294
D002780 Cholestasis, Intrahepatic C00024294
D004342 Drug Hypersensitivity C00024294
D000743 Anemia, Hemolytic C00024294
D056487 Drug-Induced Liver Injury, Chronic C00024294
D058186 Acute Kidney Injury C00024294
D004802 Eosinophilia C00024294
D015746 Abdominal Pain C00024294
D006461 Hemolysis C00024294
D006505 Hepatitis C00024294
D007565 Jaundice C00024294
D009461 Neurologic Manifestations C00024294
D011537 Pruritus C00024294
D013611 Tachycardia, Atrioventricular Nodal Reentry C00024294
D013617 Tachycardia, Supraventricular C00024294
D017180 Tachycardia, Ventricular C00024294
D013921 Thrombocytopenia C00024294
D016171 Torsades de Pointes C00024294
D014693 Ventricular Fibrillation C00024294
D018879 Ventricular Premature Complexes C00024294
D014973 Xanthomatosis C00024294
D000544 Alzheimer Disease C00001763
D000855 Anorexia C00001763
D001161 Arteriosclerosis C00001763
D001714 Bipolar Disorder C00001763
D001763 Blepharoptosis C00001763
D001919 Bradycardia C00001763
D001943 Breast Neoplasms C00001763
D009202 Cardiomyopathies C00001763
D002389 Catatonia C00001763
D002493 Central Nervous System Diseases C00001763
D002819 Chorea C00001763
D019970 Cocaine-Related Disorders C00001763
D003866 Depressive Disorder C00001763
D004195 Disease Models, Animal C00001763
D004409 Dyskinesia, Drug-Induced C00001763
D020820 Dyskinesias C00001763
D005183 Failure to Thrive C00001763
D005221 Fatigue C00001763
D005313 Fetal Death C00001763
D005767 Gastrointestinal Diseases C00001763
D005921 Glomerulonephritis C00001763
D005923 Glomerulosclerosis, Focal Segmental C00001763
D006323 Heart Arrest C00001763
D006327 Heart Block C00001763
D006396 Hematemesis C00001763
D006930 Hyperalgesia C00001763
D006948 Hyperkinesis C00001763
D006965 Hyperplasia C00001763
D006966 Hyperprolactinemia C00001763
D006973 Hypertension C00001763
D006980 Hyperthyroidism C00001763
D018476 Hypokinesia C00001763
D007022 Hypotension C00001763
D007035 Hypothermia C00001763
D007154 Immune System Diseases C00001763
D007674 Kidney Diseases C00001763
D008325 Mammary Neoplasms, Experimental C00001763
D001002 Anuria C00024294
D001523 Mental Disorders C00001763
D017240 Mitochondrial Myopathies C00001763
D009069 Movement Disorders C00001763
D009127 Muscle Rigidity C00001763
D009203 Myocardial Infarction C00001763
D009207 Myoclonus C00001763
D009325 Nausea C00001763
D009374 Neoplasms, Experimental C00001763
D016584 Panic Disorder C00001763
D010243 Paralysis C00001763
D010302 Parkinson Disease, Secondary C00001763
D020734 Parkinsonian Disorders C00001763
D010468 Perceptual Disorders C00001763
D010673 Pheochromocytoma C00001763
D010488 Polyarteritis Nodosa C00001763
D011297 Prenatal Exposure Delayed Effects C00001763
D012021 Reflex, Abnormal C00001763
D012559 Schizophrenia C00001763
D012640 Seizures C00001763
D012893 Sleep Disorders C00001763
D013276 Stomach Ulcer C00001763
D013610 Tachycardia C00001763
D014202 Tremor C00001763
D014456 Ulcer C00001763