PCIDB

KNApSAcK Metabolite C00001769

Metabolite

KNApSAcK Entry

id C00001769
Name Serpentine
CAS RN 18786-24-8
Standard InChI InChI=1S/C21H20N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-8,11-12,15-16H,9-10H2,1-2H3/p+1/t12-,15-,16+/m0/s1
Standard InChI (Main Layer) InChI=1S/C21H20N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-8,11-12,15-16H,9-10H2,1-2H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 4006

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL14755 CHEMBL1187439 CHEMBL1994588

KEGG

By LinkDB C09241

CTD

By CAS RN C009244

Human Protein / Gene in interaction

1 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL14755 CHEMBL729206 (1)
1 / 0

CTD interaction (2)

compound gene gene name gene description interaction interaction type form reference
pmid
C009244 1565 CYP2D6
CPD6
CYP2D
CYP2D7AP
CYP2D7BP
CYP2D7P2
CYP2D8P2
CYP2DL1
CYPIID6
P450-DB1
P450C2D
P450DB1
cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan] affects metabolic processing
/ decreases reaction
protein 15930738
C009244 1565 CYP2D6
CPD6
CYP2D
CYP2D7AP
CYP2D7BP
CYP2D7P2
CYP2D8P2
CYP2DL1
CYPIID6
P450-DB1
P450C2D
P450DB1
cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) serpentine (alkaloid) results in decreased activity of CYP2D6 protein decreases activity
protein 15930738

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (1)

OMIM preferred title UniProt
#608902 Drug metabolism, poor, cyp2d6-related P10635

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D002375 C009244 Catalepsy therapeutic
9610935
10412490