PCIDB

Vinca major

Species

KNApSAcK Entry

Organism name Vinca major
Genus Vinca
Family Apocynaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Vinca major
Linked NCBI taxonomy ID 185238
Linked level species

Family

Family in NCBI taxonomy Apocynaceae
ID 4056

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (15)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00006703 External link 512 Vincanin B
/ Delphinidin 3-(6-rhamnosylgalactoside)
No. 1 No. 15
C00006714 External link 512 Vincanin A
No. 5 No. 15
C00005225 External link 512 Kaempferol 3-robinobioside-7-glucoside
No. 5 No. 15
C00024333 External link 512 (-)-Majoridine
No. 279
C00001782 External link 512 Vincamine
CHEMBL1165342
CHEMBL1361052
CHEMBL1592905
CHEMBL1604925
CHEMBL1728279
D014749
27 / 24 / 25 0 / 1 No. 452 No. 4
C00024311 External link 512 Vincamajinine
/ Epivincamajine
/ 17-Epivincamajine
/ (-)-Vincamajinine
CHEMBL607365
2 / 2 / 2 No. 507
C00024329 External link 512 (+)-Vincarine
No. 507
C00024296 External link 512 (-)-Vincamedine
/ O-Acetylvincamajine
/ Vincamajine acetate
CHEMBL600638
2 / 2 / 2 No. 507
C00024321 External link 512 Vincamajinine
CHEMBL607365
2 / 2 / 2 No. 507
C00024335 External link 512 (-)-Vincamajine
/ N-Methylquebrachidine
CHEMBL607365
2 / 2 / 2 No. 507
C00024323 External link 512 (-)-10-Methoxyperakine
No. 523 No. 4
C00024337 External link 512 (-)-Vincawajine
No. 523 No. 4
C00024307 External link 512 10-Methoxyvomilenine
/ 21-Hydroxy-10-methoxyvinorine
No. 523 No. 4
C00024339 External link 512 (+)-10-Methoxyvinorine
No. 523 No. 4
C00001769 External link 512 Serpentine
CHEMBL14755
CHEMBL1187439
CHEMBL1994588
C009244
1 / 1 / 0 1 / 1 No. 4006 No. 4

Human Protein / Gene in interactions

29 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P31639 Sodium/glucose cotransporter 2 Glucose C00024296 C00024311 C00024321 C00024335 1 / 1
P13866 Sodium/glucose cotransporter 1 Glucose C00024296 C00024311 C00024321 C00024335 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001769 C00001782 1 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001782 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00001782 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001782 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001782 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001782 1 / 0
P11473 Vitamin D3 receptor NR1I1 C00001782 2 / 3
P17405 Sphingomyelin phosphodiesterase Enzyme C00001782 2 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001782 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001782 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001782 7 / 3
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001782 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001782 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001782 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001782 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001782 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001782 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001782 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001782 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001782 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001782 0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00001782 0 / 0
O00255 Menin Unclassified protein C00001782 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001782 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00001782 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001782 1 / 4
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001782 1 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00001769

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (26)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#606824 Glucose/galactose malabsorption; ggm P13866
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#233100 Renal glucosuria; glys1 P31639
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (27)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H01261 Congenital glucose-galactose malabsorption (GGM) P13866 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01126 Familial renal glucosuria (FRG) P31639 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002375 Catalepsy C00001769
D000647 Amnesia C00001782