PCIDB

KNApSAcK Metabolite C00001774

Metabolite

KNApSAcK Entry

id C00001774
Name Tetrahydroharmine
CAS RN 17019-01-1
Standard InChI InChI=1S/C13H16N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-4,7-8,14-15H,5-6H2,1-2H3/t8-/m1/s1
Standard InChI (Main Layer) InChI=1S/C13H16N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-4,7-8,14-15H,5-6H2,1-2H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 2351

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL129208

KEGG

By LinkDB C09243

CTD

By CAS RN C035525

Human Protein / Gene in interaction

17 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL129208 CHEMBL1738312 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL129208 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL129208 CHEMBL1614076 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL129208 CHEMBL1794585 (1)
0 / 0
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor CHEMBL129208 CHEMBL618086 (1)
0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL129208 CHEMBL1794495 (1)
2 / 2
P39748 Flap endonuclease 1 Enzyme CHEMBL129208 CHEMBL1794486 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL129208 CHEMBL1794569 (1)
1 / 1
P08253 72 kDa type IV collagenase M10A CHEMBL129208 CHEMBL1964000 (1)
1 / 3
Q9UNA4 DNA polymerase iota Enzyme CHEMBL129208 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL129208 CHEMBL1737991 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL129208 CHEMBL1614421 (1) CHEMBL1614502 (1)
4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL129208 CHEMBL1613914 (1)
0 / 0
O00487 26S proteasome non-ATPase regulatory subunit 14 Enzyme CHEMBL129208 CHEMBL1963965 (1)
0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL129208 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL129208 CHEMBL1613933 (1)
1 / 6
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL129208 CHEMBL2114738 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (14)

KEGG disease name UniProt
H00025 Penile cancer P08253 (related)
H00028 Choriocarcinoma P08253 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)