PCIDB

KNApSAcK Metabolite C00001781

Metabolite

KNApSAcK Entry

id C00001781
Name Vinblastine
CAS RN 865-21-4
Standard InChI InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1
Standard InChI (Main Layer) InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 2360

Link

ChEMBL

By standard InChI CHEMBL22969
By standard InChI Main Layer CHEMBL22969 CHEMBL159 CHEMBL150387 CHEMBL1315323 CHEMBL1437021 CHEMBL1518759 CHEMBL1625660 CHEMBL2311781

KEGG

By LinkDB C07201

CTD

By CAS RN D014747

Species

Summary

Plant class

class name count
asterids 2

Family

family name count
Apocynaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Catharanthus roseus (L.) G.DON 4058 Apocynaceae asterids Viridiplantae
Vinca rosea 4058 Apocynaceae asterids Viridiplantae

Human Protein / Gene in interaction

136 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL159 CHEMBL1315323 CHEMBL1741321 (1) CHEMBL1909136 (2)
1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme CHEMBL1437021 CHEMBL1613805 (1) CHEMBL1614009 (1)
CHEMBL1614293 (1)
0 / 0
P33527 Multidrug resistance-associated protein 1 drugs CHEMBL159 CHEMBL2077586 (1) CHEMBL2076374 (1)
CHEMBL2076533 (1) CHEMBL2075738 (1)
CHEMBL2077890 (1)
0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL1315323 CHEMBL1613992 (1) CHEMBL1613995 (1)
7 / 44
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL159 CHEMBL2169429 (1)
1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL159 CHEMBL2169431 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL1437021 CHEMBL1794367 (1) CHEMBL2114784 (1)
1 / 1
O95342 Bile salt export pump drug CHEMBL159 CHEMBL2076226 (1) CHEMBL2076242 (1)
2 / 1
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL159 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL159 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL159 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL159 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL159 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL159 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL159 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL159 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL159 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL159 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL159 CHEMBL1909197 (2)
2 / 2
O15245 Solute carrier family 22 member 1 Drug uniporter CHEMBL159 CHEMBL993349 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1315323 CHEMBL1614361 (1)
3 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL159 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL159 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL159 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL159 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL159 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL159 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL159 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL159 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL159 CHEMBL1909093 (2)
0 / 0
P04183 Thymidine kinase, cytosolic Enzyme CHEMBL159 CHEMBL910877 (1)
0 / 1
P08183 Multidrug resistance protein 1 drug CHEMBL159 CHEMBL754774 (1) CHEMBL755181 (1)
CHEMBL753510 (1) CHEMBL753511 (1)
CHEMBL755826 (1) CHEMBL755827 (1)
CHEMBL754160 (1) CHEMBL754161 (1)
CHEMBL925479 (1) CHEMBL925480 (1)
CHEMBL925481 (1) CHEMBL1108200 (1)
CHEMBL1743157 (1) CHEMBL1908285 (1)
CHEMBL1908286 (1) CHEMBL1908289 (1)
CHEMBL1908291 (1) CHEMBL1908292 (1)
CHEMBL2077115 (1) CHEMBL2075099 (1)
CHEMBL2076107 (1) CHEMBL2076278 (1)
CHEMBL2076682 (1) CHEMBL2076706 (1)
CHEMBL2076714 (1) CHEMBL2077346 (1)
CHEMBL2077347 (1) CHEMBL2077674 (1)
CHEMBL2075621 (1) CHEMBL2076143 (1)
CHEMBL2076761 (1) CHEMBL2075231 (1)
CHEMBL2075368 (1) CHEMBL2075377 (1)
CHEMBL2075383 (1) CHEMBL2075690 (1)
CHEMBL2076580 (1) CHEMBL2075280 (1)
CHEMBL2076207 (1) CHEMBL2076209 (1)
CHEMBL2076213 (1) CHEMBL2076214 (1)
CHEMBL2076218 (1) CHEMBL2076241 (1)
CHEMBL2076250 (1) CHEMBL2076251 (1)
CHEMBL2076066 (1) CHEMBL2078148 (1)
CHEMBL2078150 (1) CHEMBL2078576 (1)
CHEMBL2078578 (1) CHEMBL2077896 (1)
CHEMBL2168297 (1) CHEMBL2168778 (1)
1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL159 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL159 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL159 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL159 CHEMBL1315323 CHEMBL1614027 (1) CHEMBL1741325 (1)
CHEMBL1909135 (2)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL159 CHEMBL1909203 (2)
1 / 11
P11473 Vitamin D3 receptor NR1I1 CHEMBL22969 CHEMBL1794311 (1)
2 / 3
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL159 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL159 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL159 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL159 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL159 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL159 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL159 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL159 CHEMBL1909096 (2)
1 / 1
P07437 Tubulin beta chain Structural CHEMBL159 CHEMBL815200 (1) CHEMBL1012659 (1)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL1315323 CHEMBL1613800 (1)
0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL159 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL159 CHEMBL1909166 (2)
1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL159 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1315323 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL22969 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL22969 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL1437021 CHEMBL1613838 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL159 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL159 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL159 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL159 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL159 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL159 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL159 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL159 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL159 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL159 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL159 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL159 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL159 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL159 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL159 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL159 CHEMBL1909119 (2)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1437021 CHEMBL1738610 (1)
0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL159 CHEMBL2169430 (1)
1 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL22969 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL159 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL159 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL159 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL159 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL159 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL159 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL159 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL159 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL159 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL159 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL159 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL159 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL159 CHEMBL1315323 CHEMBL1613808 (1) CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL159 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL159 CHEMBL1315323 CHEMBL1741322 (1) CHEMBL1909132 (2)
0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL159 CHEMBL1006005 (1) CHEMBL2076881 (1)
CHEMBL2077627 (1) CHEMBL2078137 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1437021 CHEMBL1738675 (1) CHEMBL1737868 (1)
0 / 0
P21439 Multidrug resistance protein 3 Enzyme CHEMBL159 CHEMBL1743163 (1)
3 / 2
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL159 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL159 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL159 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL159 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL159 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL159 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL159 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL159 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL159 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL159 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL159 CHEMBL1909168 (2)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL1315323 CHEMBL1614240 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL159 CHEMBL1315323 CHEMBL1741323 (1) CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL159 CHEMBL1315323 CHEMBL664809 (1) CHEMBL836230 (1)
CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1) CHEMBL1743273 (1)
CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL159 CHEMBL1909137 (2)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL22969 CHEMBL1794483 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1518759 CHEMBL1614250 (1) CHEMBL1614421 (1)
CHEMBL1614502 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1437021 CHEMBL1737980 (1)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL159 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL159 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL159 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL159 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL159 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL159 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL159 CHEMBL1909128 (2)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1437021 CHEMBL1794536 (1)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL1315323 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL22969 CHEMBL1437021 CHEMBL1518759 CHEMBL1738442 (3)
0 / 0
O00255 Menin Unclassified protein CHEMBL22969 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL22969 CHEMBL1614531 (1)
1 / 3
Q13748 Tubulin alpha-3C/D chain Structural CHEMBL159 CHEMBL815200 (1)
0 / 0
P68366 Tubulin alpha-4A chain Structural CHEMBL159 CHEMBL815200 (1)
0 / 0
Q9H4B7 Tubulin beta-1 chain Structural CHEMBL159 CHEMBL815200 (1)
1 / 0
P04350 Tubulin beta-4A chain Structural CHEMBL159 CHEMBL815200 (1)
2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural CHEMBL159 CHEMBL815200 (1)
0 / 0
Q71U36 Tubulin alpha-1A chain Structural CHEMBL159 CHEMBL815200 (1)
1 / 1
P68371 Tubulin beta-4B chain Structural CHEMBL159 CHEMBL815200 (1)
0 / 0
Q13509 Tubulin beta-3 chain Structural CHEMBL159 CHEMBL815200 (1)
2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein CHEMBL159 CHEMBL815200 (1)
0 / 0
Q13885 Tubulin beta-2A chain Structural CHEMBL159 CHEMBL815200 (1)
0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein CHEMBL159 CHEMBL815200 (1)
0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein CHEMBL159 CHEMBL815200 (1)
0 / 0
Q9BUF5 Tubulin beta-6 chain Structural CHEMBL159 CHEMBL815200 (1)
0 / 0
Q9BVA1 Tubulin beta-2B chain Structural CHEMBL159 CHEMBL815200 (1)
1 / 0

CTD interaction (252)

compound gene gene name gene description interaction interaction type form reference
pmid
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein affects the uptake of Vinblastine affects uptake
protein 15640379
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein results in decreased susceptibility to Vinblastine decreases response to substance
protein 8917702
9148857
11355955
15725475
17284363
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein results in increased secretion of Vinblastine increases secretion
protein 12235267
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein results in increased transport of Vinblastine increases transport
protein 12708479
16221533
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Amiodarone inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine] decreases reaction
/ increases secretion
protein 12235267
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine] decreases reaction
/ increases transport
protein 12708479
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) [carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]] which results in decreased susceptibility to Vinblastine decreases reaction
/ decreases response to substance
/ increases transport
protein 12708479
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine] decreases reaction
/ increases secretion
protein 12235267
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) cnidiadin inhibits the reaction [ABCB1 protein results in increased export of Vinblastine] decreases reaction
/ increases export
protein 15824923
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine] decreases reaction
/ increases secretion
protein 12235267
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Diazinon affects the reaction [ABCB1 protein results in increased transport of Vinblastine] affects reaction
/ increases transport
protein 16221533
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Erythromycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine] decreases reaction
/ increases secretion
protein 12235267
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine] decreases reaction
/ increases secretion
protein 12235267
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine] decreases reaction
/ increases secretion
protein 12235267
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) NR1I2 protein promotes the reaction [Vinblastine results in increased expression of ABCB1 protein] increases expression
/ increases reaction
protein 20041327
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine] decreases reaction
/ increases secretion
protein 12235267
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Sesquiterpenes analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine] decreases reaction
/ decreases response to substance
protein 15466210
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) [sodium arsenite results in increased expression of ABCB1 protein] which results in decreased susceptibility to Vinblastine decreases response to substance
/ increases expression
protein 1967174
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine] decreases reaction
/ increases secretion
protein 12235267
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Verapamil inhibits the reaction [ABCB1 protein affects the uptake of Vinblastine] affects uptake
/ decreases reaction
protein 15640379
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine] decreases reaction
/ increases transport
protein 12708479
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Vinblastine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form] decreases reaction
/ increases activity
protein 12711602
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Vinblastine results in increased activity of ABCB1 protein mutant form increases activity
protein 12711602
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) [Vinblastine results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA increases activity
/ increases expression
mRNA 20041327
D014747 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Vinblastine results in increased expression of ABCB1 protein increases expression
protein 20041327
D014747 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 ABCC1 protein affects the susceptibility to Vinblastine affects response to substance
protein 9334814
D014747 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 ABCC1 protein results in decreased susceptibility to Vinblastine decreases response to substance
protein 16156793
D014747 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ABCC2 protein affects the transport of Vinblastine affects transport
protein 9525973
15849751
D014747 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Probenecid promotes the reaction [ABCC2 protein affects the transport of Vinblastine] affects transport
/ increases reaction
protein 15849751
D014747 3983 ABLIM1
ABLIM
LIMAB1
LIMATIN
abLIM-1
actin binding LIM protein 1 ABLIM1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 39 ACAT2
acetyl-CoA acetyltransferase 2 (EC:2.3.1.9) ACAT2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 55856 ACOT13
PNAS-27
THEM2
acyl-CoA thioesterase 13 ACOT13 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 52 ACP1
HAAP
acid phosphatase 1, soluble (EC:3.1.3.2 3.1.3.48) ACP1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 120 ADD3
ADDL
adducin 3 (gamma) ADD3 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 316 AOX1
AO
AOH1
aldehyde oxidase 1 (EC:1.2.3.1) AOX1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 27350 APOBEC3C
A3C
APOBEC1L
ARDC2
ARDC4
ARP5
PBI
bK150C2.3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C APOBEC3C protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 521 ATP5I
ATP5K
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E (EC:3.6.1.14) ATP5I protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 9551 ATP5J2
ATP5JL
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 (EC:3.6.1.14) ATP5J2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 9212 AURKB
AIK2
AIM-1
AIM1
ARK2
AurB
IPL1
PPP1R48
STK12
STK5
aurkb-sv1
aurkb-sv2
aurora kinase B (EC:2.7.11.1) AURKB protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 558 AXL
JTK11
UFO
AXL receptor tyrosine kinase (EC:2.7.10.1) AXL protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 BIRC2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 BIRC3 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 79444 BIRC7
KIAP
LIVIN
ML-IAP
MLIAP
RNF50
baculoviral IAP repeat containing 7 BIRC7 protein results in decreased susceptibility to Vinblastine decreases response to substance
protein 17437058
D014747 699 BUB1
BUB1A
BUB1L
hBUB1
BUB1 mitotic checkpoint serine/threonine kinase (EC:2.7.11.1) BUB1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 56951 C5orf15
KCT2
chromosome 5 open reading frame 15 C5ORF15 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) CD40LG protein inhibits the reaction [Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP protein]] decreases reaction
/ increases cleavage
/ increases reaction
protein 16545138
D014747 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP protein] increases cleavage
/ increases reaction
protein 16545138
D014747 847 CAT
catalase (EC:1.11.1.6) CAT protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 891 CCNB1
CCNB
cyclin B1 CCNB1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 891 CCNB1
CCNB
cyclin B1 CCNB1 protein results in increased susceptibility to Vinblastine increases response to substance
protein 16849574
D014747 9133 CCNB2
HsT17299
cyclin B2 CCNB2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 959 CD40LG
CD154
CD40L
HIGM1
IGM
IMD3
T-BAM
TNFSF5
TRAP
gp39
hCD40L
CD40 ligand CD40LG protein inhibits the reaction [Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP protein]] decreases reaction
/ increases cleavage
/ increases reaction
protein 16545138
D014747 959 CD40LG
CD154
CD40L
HIGM1
IGM
IMD3
T-BAM
TNFSF5
TRAP
gp39
hCD40L
CD40 ligand CD40LG protein results in decreased susceptibility to Vinblastine decreases response to substance
protein 16545138
D014747 34411 CDC2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 55143 CDCA8
BOR
BOREALIN
DasraB
MESRGP
cell division cycle associated 8 CDCA8 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) CDK2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 1031 CDKN2C
INK4C
p18
p18-INK4C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) CDKN2C protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 1058 CENPA
CENP-A
CenH3
centromere protein A CENPA protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 26586 CKAP2
LB1
TMAP
se20-10
cytoskeleton associated protein 2 CKAP2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 10063 COX17
COX17 cytochrome c oxidase copper chaperone COX17 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 9377 COX5A
COX
COX-VA
VA
cytochrome c oxidase subunit Va (EC:1.9.3.1) COX5A protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 1340 COX6B1
COX6B
COXG
COXVIb1
cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) (EC:1.9.3.1) COX6B1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 8804 CREG1
CREG
cellular repressor of E1A-stimulated genes 1 CREG1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 9419 CRIPT
cysteine-rich PDZ-binding protein CRIPT protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 1490 CTGF
CCN2
HCS24
IGFBP8
NOV2
connective tissue growth factor CTGF protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 6374 CXCL5
ENA-78
SCYB5
chemokine (C-X-C motif) ligand 5 CXCL5 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 100528464 DCC1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 28960 DCPS
DCS1
HINT-5
HINT5
HSL1
decapping enzyme, scavenger (EC:3.6.1.59) DCPS protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 9416 DDX23
PRPF28
SNRNP100
U5-100K
U5-100KD
prp28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 (EC:3.6.4.13) DDX23 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 51071 DERA
DEOC
deoxyribose-phosphate aldolase (putative) (EC:4.1.2.4) DERA protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 1677 DFFB
CAD
CPAN
DFF-40
DFF2
DFF40
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) DFFB protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 22943 DKK1
DKK-1
SK
dickkopf WNT signaling pathway inhibitor 1 DKK1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 27122 DKK3
REIC
RIG
dickkopf WNT signaling pathway inhibitor 3 DKK3 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 29980 DONSON
B17
C21orf60
downstream neighbor of SON DONSON protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 1869 E2F1
E2F-1
RBAP1
RBBP3
RBP3
E2F transcription factor 1 E2F1 protein results in increased susceptibility to Vinblastine increases response to substance
protein 16849574
D014747 84455 EFCAB7
RP4-534K7.1
EF-hand calcium binding domain 7 EFCAB7 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 2013 EMP2
XMP
epithelial membrane protein 2 EMP2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4072 EPCAM
DIAR5
EGP-2
EGP314
EGP40
ESA
HNPCC8
KS1/4
KSA
M4S1
MIC18
MK-1
TACSTD1
TROP1
epithelial cell adhesion molecule EPCAM protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 2064 ERBB2
CD340
HER-2
HER-2/neu
HER2
MLN_19
NEU
NGL
TKR1
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) ERBB2 protein affects the susceptibility to Vinblastine affects response to substance
protein 10327070
D014747 2069 EREG
ER
epiregulin EREG protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 2109 ETFB
MADD
electron-transfer-flavoprotein, beta polypeptide ETFB protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 5393 EXOSC9
PM/Scl-75
PMSCL1
RRP45
Rrp45p
p5
p6
exosome component 9 (EC:3.1.13.-) EXOSC9 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 10447 FAM3C
ILEI
family with sequence similarity 3, member C FAM3C protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 388650 FAM69A
family with sequence similarity 69, member A FAM69A protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 55120 FANCL
FAAP43
PHF9
POG
Fanconi anemia, complementation group L FANCL protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) Vinblastine results in increased expression of FASLG protein increases expression
protein 11716366
D014747 2237 FEN1
FEN-1
MF1
RAD2
flap structure-specific endonuclease 1 FEN1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 2280 FKBP1A
FKBP-12
FKBP-1A
FKBP1
FKBP12
PKC12
PKCI2
PPIASE
FK506 binding protein 1A, 12kDa (EC:5.2.1.8) FKBP1A protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 2313 FLI1
EWSR2
SIC-1
Fli-1 proto-oncogene, ETS transcription factor FLI1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 FN1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 8061 FOSL1
FRA
FRA1
fra-1
FOS-like antigen 1 FOSL1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 50486 G0S2
RP1-28O10.2
G0/G1switch 2 G0S2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 79017 GGCT
C7orf24
CRF21
GCTG
GGC
gamma-glutamylcyclotransferase (EC:2.3.2.4) GGCT protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 2677 GGCX
VKCFD1
gamma-glutamyl carboxylase (EC:4.1.1.90) GGCX protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 51053 GMNN
Gem
geminin, DNA replication inhibitor GMNN protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 79158 GNPTAB
GNPTA
ICD
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (EC:2.7.8.17) GNPTAB protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 11245 GPR176
HB-954
G protein-coupled receptor 176 GPR176 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 29899 GPSM2
CMCS
DFNB82
LGN
PINS
G-protein signaling modulator 2 GPSM2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 2969 GTF2I
BAP135
BTKAP1
DIWS
GTFII-I
IB291
SPIN
TFII-I
WBS
WBSCR6
general transcription factor IIi GTF2I protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 2971 GTF3A
AP2
TFIIIA
general transcription factor IIIA GTF3A protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 51512 GTSE1
B99
G-2 and S-phase expressed 1 GTSE1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 2990 GUSB
BG
MPS7
glucuronidase, beta (EC:3.2.1.31) GUSB protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3033 HADH
HAD
HADH1
HADHSC
HCDH
HHF4
MSCHAD
SCHAD
hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35) HADH protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3059 HCLS1
CTTNL
HS1
hematopoietic cell-specific Lyn substrate 1 HCLS1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3006 HIST1H1C
H1.2
H1C
H1F2
H1s-1
histone cluster 1, H1c HIST1H1C protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 HMGB1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3148 HMGB2
HMG2
high mobility group box 2 HMGB2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 9324 HMGN3
PNAS-25
TRIP7
high mobility group nucleosomal binding domain 3 HMGN3 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3161 HMMR
CD168
IHABP
RHAMM
hyaluronan-mediated motility receptor (RHAMM) HMMR protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 9456 HOMER1
HOMER
HOMER1A
HOMER1B
HOMER1C
SYN47
Ves-1
homer homolog 1 (Drosophila) HOMER1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Vinblastine results in decreased expression of ICAM1 mRNA decreases expression
mRNA 12649748
D014747 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Vinblastine results in decreased expression of ICAM1 protein decreases expression
protein 12649748
D014747 3398 ID2
GIG8
ID2A
ID2H
bHLHb26
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein ID2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3418 IDH2
D2HGA2
ICD-M
IDH
IDHM
IDP
IDPM
mNADP-IDH
isocitrate dehydrogenase 2 (NADP+), mitochondrial (EC:1.1.1.42) IDH2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 10643 IGF2BP3
CT98
IMP-3
IMP3
KOC1
VICKZ3
insulin-like growth factor 2 mRNA binding protein 3 IGF2BP3 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3551 IKBKB
IKK-beta
IKK2
IKKB
NFKBIKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) Vinblastine results in decreased localization of [IKBKB protein binds to NFKBIA protein] affects binding
/ decreases localization
protein 17029595
D014747 3551 IKBKB
IKK-beta
IKK2
IKKB
NFKBIKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) Vinblastine results in increased phosphorylation of IKBKB protein increases phosphorylation
protein 17029595
D014747 3598 IL13RA2
CD213A2
CT19
IL-13R
IL13BP
interleukin 13 receptor, alpha 2 IL13RA2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta IL1B protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Vinblastine results in decreased chemical synthesis of IL6 protein decreases chemical synthesis
protein 16499908
D014747 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Vinblastine results in increased stability of IL6 mRNA increases stability
mRNA 16499908
D014747 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 IL8 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Paclitaxel inhibits the reaction [Vinblastine results in increased stability of IL8 mRNA] decreases reaction
/ increases stability
mRNA 16499908
D014747 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Vinblastine results in increased stability of IL8 mRNA increases stability
mRNA 16499908
D014747 3624 INHBA
EDF
FRP
inhibin, beta A INHBA protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3683 ITGAL
CD11A
LFA-1
LFA1A
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) Vinblastine results in decreased expression of ITGAL mRNA decreases expression
mRNA 12649748
D014747 3683 ITGAL
CD11A
LFA-1
LFA1A
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) Vinblastine results in decreased expression of ITGAL protein decreases expression
protein 12649748
D014747 9270 ITGB1BP1
ICAP-1A
ICAP-1B
ICAP-1alpha
ICAP1
ICAP1A
ICAP1B
integrin beta 1 binding protein 1 ITGB1BP1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of JUN protein] affects reaction
/ increases phosphorylation
protein 12221076
D014747 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Vinblastine results in increased phosphorylation of JUN protein increases phosphorylation
protein 12221076
D014747 23189 KANK1
ANKRD15
CPSQ2
KANK
KN motif and ankyrin repeat domains 1 KANK1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 23254 KAZN
KAZ
kazrin, periplakin interacting protein KAZN protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 57698 KIAA1598 KIAA1598 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3832 KIF11
EG5
HKSP
KNSL1
MCLMR
TRIP5
kinesin family member 11 KIF11 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 56992 KIF15
HKLP2
KNSL7
NY-BR-62
kinesin family member 15 KIF15 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 23095 KIF1B
CMT2
CMT2A
CMT2A1
HMSNII
KLP
NBLST1
kinesin family member 1B KIF1B protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 10112 KIF20A
MKLP2
RAB6KIFL
kinesin family member 20A KIF20A protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 9493 KIF23
CHO1
KNSL5
MKLP-1
MKLP1
kinesin family member 23 KIF23 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 24137 KIF4A
KIF4
KIF4G1
kinesin family member 4A KIF4A protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3838 KPNA2
IPOA1
QIP2
RCH1
SRP1alpha
karyopherin alpha 2 (RAG cohort 1, importin alpha 1) KPNA2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4001 LMNB1
ADLD
LMN
LMN2
LMNB
lamin B1 LMNB1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 1902 LPAR1
EDG2
GPR26
Gpcr26
LPA1
Mrec1.3
VZG1
edg-2
rec.1.3
vzg-1
lysophosphatidic acid receptor 1 LPAR1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 55227 LRRC1
LANO
dJ523E19.1
leucine rich repeat containing 1 LRRC1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 51690 LSM7
YNL147W
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) LSM7 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4053 LTBP2
C14orf141
GLC3D
LTBP3
MSPKA
MSTP031
WMS3
latent transforming growth factor beta binding protein 2 LTBP2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4085 MAD2L1
HSMAD2
MAD2
MAD2 mitotic arrest deficient-like 1 (yeast) MAD2L1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK8 protein] affects reaction
/ increases phosphorylation
protein 12221076
D014747 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Vinblastine results in increased phosphorylation of MAPK8 protein increases phosphorylation
protein 12221076
D014747 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK9 protein] affects reaction
/ increases phosphorylation
protein 12221076
D014747 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) Vinblastine results in increased phosphorylation of MAPK9 protein increases phosphorylation
protein 12221076
D014747 8550 MAPKAPK5
MAPKAP-K5
MK-5
MK5
PRAK
mitogen-activated protein kinase-activated protein kinase 5 (EC:2.7.11.1) MAPKAPK5 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 9833 MELK
HPK38
maternal embryonic leucine zipper kinase (EC:2.7.11.1 2.7.10.2) MELK protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4311 MME
CALLA
CD10
NEP
SFE
membrane metallo-endopeptidase (EC:3.4.24.11) MME protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) MMP1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 5891 MOK
RAGE
RAGE-1
RAGE1
MOK protein kinase (EC:2.7.11.22) MOK protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 78988 MRP63
bMRP63
mitochondrial ribosomal protein 63 MRP63 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 51765 MST4
MASK
serine/threonine protein kinase MST4 (EC:2.7.11.1) MST4 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog MYC protein affects the susceptibility to Vinblastine affects response to substance
protein 18802399
D014747 26292 MYCBP
AMY-1
MYC binding protein MYCBP protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 64151 NCAPG
CAPG
CHCG
NY-MEL-3
non-SMC condensin I complex, subunit G NCAPG protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 23397 NCAPH
BRRN1
CAP-H
non-SMC condensin I complex, subunit H NCAPH protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 10403 NDC80
HEC
HEC1
HsHec1
KNTC2
TID3
hsNDC80
NDC80 kinetochore complex component NDC80 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4694 NDUFA1
CI-MWFE
MWFE
ZNF183
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa (EC:1.6.99.3) NDUFA1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 51079 NDUFA13
B16.6
CDA016
GRIM-19
GRIM19
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 NDUFA13 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4696 NDUFA3
B9
CI-B9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa NDUFA3 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4701 NDUFA7
B14.5a
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa NDUFA7 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4708 NDUFB2
AGGG
CI-AGGG
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa (EC:1.6.5.3 1.6.99.3) NDUFB2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4717 NDUFC1
KFYI
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa NDUFC1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4718 NDUFC2
B14.5b
CI-B14.5b
HLC-1
NADHDH2
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa NDUFC2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4726 NDUFS6
CI-13kA
CI-13kD-A
CI13KDA
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3) NDUFS6 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4729 NDUFV2
CI-24k
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (EC:1.6.5.3 1.6.99.3) NDUFV2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4776 NFATC4
NF-ATc4
NFAT3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 Vinblastine results in decreased localization of NFATC4 protein decreases localization
protein 17044076
D014747 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Vinblastine results in decreased localization of [IKBKB protein binds to NFKBIA protein] affects binding
/ decreases localization
protein 17029595
D014747 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Vinblastine results in increased phosphorylation of NFKBIA protein increases phosphorylation
protein 17029595
D014747 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 NR1I2 protein promotes the reaction [Vinblastine results in increased expression of ABCB1 protein] increases expression
/ increases reaction
protein 20041327
D014747 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 Vinblastine results in increased activity of NR1I2 protein increases activity
protein 20041327
D014747 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 [Vinblastine results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA increases activity
/ increases expression
protein 20041327
D014747 8439 NSMAF
FAN
neutral sphingomyelinase (N-SMase) activation associated factor NSMAF protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 55270 NUDT15
MTH2
RP11-90M2.1
nudix (nucleoside diphosphate linked moiety X)-type motif 15 (EC:3.6.1.55) NUDT15 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 11163 NUDT4
DIPP2
DIPP2alpha
DIPP2beta
nudix (nucleoside diphosphate linked moiety X)-type motif 4 (EC:3.6.1.52) NUDT4 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 51203 NUSAP1
ANKT
BM037
LNP
NUSAP
PRO0310p1
Q0310
SAPL
nucleolar and spindle associated protein 1 NUSAP1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 4946 OAZ1
AZI
OAZ
ornithine decarboxylase antizyme 1 OAZ1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 11339 OIP5
5730547N13Rik
CT86
LINT-25
MIS18B
MIS18beta
hMIS18beta
Opa interacting protein 5 OIP5 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 401903 OR10B1P protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 126370 OR1I1
OR19-20
OR1I1P
OR1I1Q
olfactory receptor, family 1, subfamily I, member 1 OR1I1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 23594 ORC6
ORC6L
origin recognition complex, subunit 6 ORC6 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 114884 OSBPL10
ORP10
OSBP9
oxysterol binding protein-like 10 OSBPL10 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 3355109 CD40LG protein inhibits the reaction [Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP protein]] decreases reaction
/ increases cleavage
/ increases reaction
protein 16545138
D014747 3355109 Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP protein] increases cleavage
/ increases reaction
protein 16545138
D014747 5162 PDHB
PDHBD
PDHE1-B
PHE1B
pyruvate dehydrogenase (lipoamide) beta (EC:1.2.4.1) PDHB protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 53918 PELO
PRO1770
pelota homolog (Drosophila) PELO protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 10857 PGRMC1
HPR6.6
MPR
progesterone receptor membrane component 1 PGRMC1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 8544 PIR
pirin (iron-binding nuclear protein) (EC:1.13.11.24) PIR protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 5328 PLAU
ATF
BDPLT5
QPD
UPA
URK
u-PA
plasminogen activator, urokinase (EC:3.4.21.73) PLAU protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 9055 PRC1
ASE1
protein regulator of cytokinesis 1 PRC1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 5689 PSMB1
HC5
PMSB1
PSC5
proteasome (prosome, macropain) subunit, beta type, 1 (EC:3.4.25.1) PSMB1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 23198 PSME4
PA200
proteasome (prosome, macropain) activator subunit 4 PSME4 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 10728 PTGES3
P23
TEBP
cPGES
prostaglandin E synthase 3 (cytosolic) (EC:5.3.99.3) PTGES3 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 9232 PTTG1
EAP1
HPTTG
PTTG
TUTR1
pituitary tumor-transforming 1 PTTG1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 5806 PTX3
TNFAIP5
TSG-14
pentraxin 3, long PTX3 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 54870 QRICH1
glutamine-rich 1 Vinblastine results in increased phosphorylation of QRICH1 protein increases phosphorylation
protein 17510977
D014747 80223 RAB11FIP1
NOEL1A
RCP
rab11-FIP1
RAB11 family interacting protein 1 (class I) RAB11FIP1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 29127 RACGAP1
CYK4
HsCYK-4
ID-GAP
MgcRacGAP
Rac GTPase activating protein 1 RACGAP1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 5902 RANBP1
HTF9A
RAN binding protein 1 RANBP1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 5980 REV3L
POLZ
REV3
REV3-like, polymerase (DNA directed), zeta, catalytic subunit (EC:2.7.7.7) REV3L protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 5985 RFC5
RFC36
replication factor C (activator 1) 5, 36.5kDa RFC5 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 6119 RPA3
REPA3
replication protein A3, 14kDa RPA3 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 393715 RPS26L protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 6241 RRM2
R2
RR2
RR2M
ribonucleotide reductase M2 (EC:1.17.4.1) RRM2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 5055 SERPINB2
HsT1201
PAI
PAI-2
PAI2
PLANH2
serpin peptidase inhibitor, clade B (ovalbumin), member 2 SERPINB2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 SERPINE1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 94081 SFXN1
sideroflexin 1 SFXN1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 6502 SKP2
FBL1
FBXL1
FLB1
p45
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase SKP2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 6581 SLC22A3
EMT
EMTH
OCT3
solute carrier family 22 (organic cation transporter), member 3 SLC22A3 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 79622 SNRNP25
C16orf33
small nuclear ribonucleoprotein 25kDa (U11/U12) SNRNP25 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 29887 SNX10
OPTB8
sorting nexin 10 SNX10 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) SOD1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 6272 SORT1
Gp95
LDLCQ6
NT3
sortilin 1 SORT1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 6715 SRD5A1
S5AR_1
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) (EC:1.3.1.22) SRD5A1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 5552 SRGN
PPG
PRG
PRG1
serglycin SRGN protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 8614 STC2
STC-2
STCRP
stanniocalcin 2 STC2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 6801 STRN
SG2NA
striatin, calmodulin binding protein STRN protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 8803 SUCLA2
A-BETA
MTDPS5
SCS-betaA
succinate-CoA ligase, ADP-forming, beta subunit (EC:6.2.1.5) SUCLA2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 8802 SUCLG1
GALPHA
MTDPS9
SUCLA1
succinate-CoA ligase, alpha subunit (EC:6.2.1.4 6.2.1.5) SUCLG1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) SULT1A1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 85360 SYDE1
7h3
synapse defective 1, Rho GTPase, homolog 1 (C. elegans) SYDE1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 9882 TBC1D4
AS160
TBC1 domain family, member 4 TBC1D4 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 6996 TDG
hTDG
thymine-DNA glycosylase (EC:3.2.2.29) TDG protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 7980 TFPI2
PP5
REF1
TFPI-2
tissue factor pathway inhibitor 2 TFPI2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 80194 TMEM134
transmembrane protein 134 TMEM134 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 28978 TMEM14A
C6orf73
transmembrane protein 14A TMEM14A protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 80008 TMEM156
transmembrane protein 156 TMEM156 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 27346 TMEM97
MAC30
transmembrane protein 97 TMEM97 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 7112 TMPO
CMD1T
LAP2
LEMD4
PRO0868
TP
thymopoietin TMPO protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 7153 TOP2A
TOP2
TP2A
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) TOP2A protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of JUN protein] affects reaction
/ increases phosphorylation
protein 12221076
D014747 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK8 protein] affects reaction
/ increases phosphorylation
protein 12221076
D014747 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK9 protein] affects reaction
/ increases phosphorylation
protein 12221076
D014747 7164 TPD52L1
D53
hD53
tumor protein D52-like 1 TPD52L1 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 23321 TRIM2
CMT2R
RNF86
tripartite motif containing 2 TRIM2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 57570 TRMT5
KIAA1393
TRM5
tRNA methyltransferase 5 (EC:2.1.1.228) TRMT5 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 27075 TSPAN13
NET-6
NET6
TM4SF13
tetraspanin 13 TSPAN13 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 8458 TTF2
HuF2
transcription termination factor, RNA polymerase II TTF2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 7272 TTK
CT96
ESK
MPH1
MPS1
MPS1L1
PYT
TTK protein kinase (EC:2.7.12.1) TTK protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 659925 UCRC protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 7424 VEGFC
Flt4-L
VRP
vascular endothelial growth factor C VEGFC protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 80349 WDR61
REC14
SKI8
WD repeat domain 61 WDR61 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 55884 WSB2
SBA2
WD repeat and SOCS box containing 2 WSB2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 10971 YWHAQ
14-3-3
1C5
HS1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide YWHAQ protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 79844 ZDHHC11
ZNF399
zinc finger, DHHC-type containing 11 (EC:2.3.1.225) ZDHHC11 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 678 ZFP36L2
BRF2
ERF-2
ERF2
RNF162C
TIS11D
ZFP36 ring finger protein-like 2 ZFP36L2 protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747
D014747 11130 ZWINT
HZwint-1
KNTC2AP
ZWINT1
ZW10 interacting kinetochore protein ZWINT protein affects the susceptibility to Vinblastine affects response to substance
protein 16217747

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (73)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#605479 Cholestasis, benign recurrent intrahepatic, 2; bric2 O95342
#614972 Cholestasis, intrahepatic, of pregnancy 3; icp3 P21439
#601847 Cholestasis, progressive familial intrahepatic, 2; pfic2 O95342
#602347 Cholestasis, progressive familial intrahepatic, 3; pfic3 P21439
#114500 Colorectal cancer; crc P84022
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#600274 Frontotemporal dementia; ftd P10636
#600803 Gallbladder disease 1; gbd1 P21439
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (75)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00624 Familial cholestasis O95342 (related)
P21439 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04183 (marker)
P04637 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01213 Gallbladder disease P21439 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

97 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D015746 D014747 Abdominal Pain marker/mechanism
4163141
C538231 D014747 Adenocarcinoma of lung therapeutic
15384034
D000380 D014747 Agranulocytosis marker/mechanism
3978656
7105387
D000505 D014747 Alopecia marker/mechanism
5768441
11104554
D000787 D014747 Angina Pectoris marker/mechanism
2456930
D018771 D014747 Arthralgia marker/mechanism
5768441
D001342 D014747 Autonomic Nervous System Diseases marker/mechanism
1329697
1690581
D019575 D014747 Blindness, Cortical marker/mechanism
6085288
7683015
C536572 D014747 Bone Marrow failure syndromes marker/mechanism
5768441
D001919 D014747 Bradycardia marker/mechanism
7636536
D001943 D014747 Breast Neoplasms therapeutic
3677109
8123940
8483557
9004059
D006502 D014747 Budd-Chiari Syndrome marker/mechanism
509400
D002277 D014747 Carcinoma therapeutic
3686684
7105387
D018236 D014747 Carcinoma, Embryonal therapeutic
7420580
D002289 D014747 Carcinoma, Non-Small-Cell Lung therapeutic
8635092
9256128
D002292 D014747 Carcinoma, Renal Cell therapeutic
1485588
7636536
D002295 D014747 Carcinoma, Transitional Cell marker/mechanism
therapeutic
1949449
11104554
D002637 D014747 Chest Pain marker/mechanism
2467791
D023341 D014747 Chills marker/mechanism
3091246
D015179 D014747 Colorectal Neoplasms therapeutic
18802399
D003248 D014747 Constipation marker/mechanism
4163141
11104554
D003324 D014747 Coronary Artery Disease marker/mechanism
87274
6161700
6166992
D003967 D014747 Diarrhea marker/mechanism
11104554
D004342 D014747 Drug Hypersensitivity marker/mechanism
6163385
D062787 D014747 Drug Overdose marker/mechanism
7105387
D064420 D014747 Drug-Related Side Effects and Adverse Reactions marker/mechanism
7805175
D004407 D014747 Dysgerminoma therapeutic
7683015
D007172 D014747 Erectile Dysfunction marker/mechanism
1690581
D005157 D014747 Facial Pain marker/mechanism
4163141
D005334 D014747 Fever marker/mechanism
3091246
D005734 D014747 Gangrene marker/mechanism
9415644
D006258 D014747 Head and Neck Neoplasms therapeutic
6173125
D006314 D014747 Hearing Loss, Conductive marker/mechanism
2476531
D006333 D014747 Heart Failure marker/mechanism
3091246
7636536
D006463 D014747 Hemolytic-Uremic Syndrome marker/mechanism
7679450
8483557
D006504 D014747 Hepatic Veno-Occlusive Disease marker/mechanism
15591910
D006505 D014747 Hepatitis marker/mechanism
3091246
D006646 D014747 Histiocytosis, Langerhans-Cell therapeutic
12571475
D006689 D014747 Hodgkin Disease therapeutic
509400
1329697
4163141
4301062
4336128
4688040
4821134
5013538
5768441
15922437
18180244
18501091
D006932 D014747 Hyperbilirubinemia marker/mechanism
54212
D006973 D014747 Hypertension marker/mechanism
54212
2447295
D006978 D014747 Hypertension, Renovascular marker/mechanism
6181679
D006987 D014747 Hypesthesia marker/mechanism
1329697
D007008 D014747 Hypokalemia marker/mechanism
3686684
D007010 D014747 Hyponatremia marker/mechanism
3091246
7105387
D007022 D014747 Hypotension marker/mechanism
3091246
7636536
D045823 D014747 Ileus marker/mechanism
5768441
D007177 D014747 Inappropriate ADH Syndrome marker/mechanism
3686684
7105387
7420580
D007511 D014747 Ischemia marker/mechanism
2456930
6168223
D007674 D014747 Kidney Diseases marker/mechanism
2413982
6181679
D007970 D014747 Leukopenia marker/mechanism
54212
3686684
5768441
D008113 D014747 Liver Neoplasms therapeutic
3686684
D008545 D014747 Melanoma therapeutic
12374674
15577320
15577323
16248763
16432458
16809738
17761969
18176117
18332650
18505091
19459849
D008881 D014747 Migraine Disorders marker/mechanism
2456930
D009120 D014747 Muscle Cramp marker/mechanism
5768441
D018908 D014747 Muscle Weakness marker/mechanism
1329697
4301062
D009135 D014747 Muscular Diseases marker/mechanism
11104554
D009188 D014747 Myelitis, Transverse marker/mechanism
4688040
D009203 D014747 Myocardial Infarction marker/mechanism
6106802
D017202 D014747 Myocardial Ischemia marker/mechanism
3708625
D009325 D014747 Nausea marker/mechanism
3091246
D009362 D014747 Neoplasm Metastasis therapeutic
3686684
D009374 D014747 Neoplasms, Experimental therapeutic
2188316
D009373 D014747 Neoplasms, Germ Cell and Embryonal therapeutic
1690581
2413982
2447295
2472472
2476531
6168223
12078977
D009443 D014747 Neuritis marker/mechanism
5768441
D020258 D014747 Neurotoxicity Syndromes marker/mechanism
3978656
D009503 D014747 Neutropenia marker/mechanism
9256128
11104554
17378895
D010051 D014747 Ovarian Neoplasms therapeutic
7683015
12078977
D010146 D014747 Pain marker/mechanism
1329697
11104554
D010291 D014747 Paresis marker/mechanism
1329697
D010292 D014747 Paresthesia marker/mechanism
1329697
2476531
4301062
5768441
11104554
D016506 D014747 Pemphigus, Benign Familial therapeutic
11450592
D010523 D014747 Peripheral Nervous System Diseases marker/mechanism
2476531
4301062
5768441
11104554
D010538 D014747 Peritonitis marker/mechanism
4688040
D011014 D014747 Pneumonia marker/mechanism
54212
D054038 D014747 Posterior Leukoencephalopathy Syndrome marker/mechanism
12078977
D011471 D014747 Prostatic Neoplasms therapeutic
4016795
D011507 D014747 Proteinuria marker/mechanism
3091246
D011552 D014747 Pseudomonas Infections marker/mechanism
4688040
D011658 D014747 Pulmonary Fibrosis marker/mechanism
4688040
D011928 D014747 Raynaud Disease marker/mechanism
70274
77726
81878
1702313
2413982
2423995
2456930
2472472
6162955
6163385
6168223
6173125
6174061
6183087
6846998
9415644
D012021 D014747 Reflex, Abnormal marker/mechanism
1329697
4301062
D012078 D014747 Renal Artery Obstruction marker/mechanism
6181679
D051437 D014747 Renal Insufficiency marker/mechanism
3091246
11104554
D012208 D014747 Rhabdomyosarcoma therapeutic
15591910
D012514 D014747 Sarcoma, Kaposi therapeutic
9415644
D012640 D014747 Seizures marker/mechanism
6209833
7683015
12078977
D018805 D014747 Sepsis marker/mechanism
4688040
D018243 D014747 Teratocarcinoma therapeutic
7420580
D013736 D014747 Testicular Neoplasms marker/mechanism
therapeutic
54212
70274
2447295
2456930
6174061
7105387
7420580
D013921 D014747 Thrombocytopenia marker/mechanism
54212
7105387
D013927 D014747 Thrombosis marker/mechanism
7742194
D014523 D014747 Urethral Neoplasms therapeutic
7742194
D001749 D014747 Urinary Bladder Neoplasms marker/mechanism
therapeutic
1384952
1949449
D014625 D014747 Vaginal Neoplasms therapeutic
15577323
D014652 D014747 Vascular Diseases marker/mechanism
6173125
D014839 D014747 Vomiting marker/mechanism
3091246
8635092