Catharanthus roseus (L.) G.DON

• Index
• Plant Species
• Metabolite list (1)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Catharanthus roseus (L.) G.DON
Genus	Catharanthus
Family	Apocynaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Catharanthus roseus
Linked NCBI taxonomy ID	4058
Linked level	species

Family

Family in NCBI taxonomy	Apocynaceae
ID	4056

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (1)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00001781	Vinblastine	CHEMBL22969 CHEMBL159 CHEMBL150387 CHEMBL1315323 CHEMBL1437021 CHEMBL1518759 CHEMBL1625660 CHEMBL2311781	D014747	136 / 73 / 75	208 / 97	No. 2360	No. 4

Human Protein / Gene in interactions

136 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001781	1 / 0
P42345	Serine/threonine-protein kinase mTOR	Enzyme	C00001781	0 / 0
P33527	Multidrug resistance-associated protein 1	drugs	C00001781	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00001781	7 / 37
Q9Y6L6	Solute carrier organic anion transporter family member 1B1	Electrochemical transporter	C00001781	1 / 0
O94956	Solute carrier organic anion transporter family member 2B1	Unclassified protein	C00001781	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00001781	1 / 1
O95342	Bile salt export pump	drug	C00001781	2 / 1
P21728	D(1A) dopamine receptor	Dopamine receptor	C00001781	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00001781	0 / 3
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00001781	2 / 2
P08246	Neutrophil elastase	S1A	C00001781	2 / 1
P33765	Adenosine receptor A3	Adenosine receptor	C00001781	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00001781	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00001781	0 / 0
P29466	Caspase-1	C14	C00001781	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00001781	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00001781	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00001781	2 / 2
O15245	Solute carrier family 22 member 1	Drug uniporter	C00001781	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00001781	3 / 2
P00918	Carbonic anhydrase 2	Lyase	C00001781	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00001781	0 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00001781	1 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00001781	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00001781	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00001781	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00001781	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00001781	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00001781	0 / 0
P04183	Thymidine kinase, cytosolic	Enzyme	C00001781	0 / 1
P08183	Multidrug resistance protein 1	drug	C00001781	1 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00001781	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00001781	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00001781	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001781	0 / 1
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00001781	1 / 8
P11473	Vitamin D3 receptor	NR1I1	C00001781	2 / 3
P14416	D(2) dopamine receptor	Dopamine receptor	C00001781	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00001781	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00001781	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00001781	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00001781	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00001781	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00001781	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00001781	1 / 1
P07437	Tubulin beta chain	Structural	C00001781	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00001781	0 / 0
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00001781	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00001781	1 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00001781	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00001781	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00001781	2 / 0
O75496	Geminin	Unclassified protein	C00001781	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00001781	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00001781	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00001781	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00001781	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00001781	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00001781	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00001781	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00001781	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00001781	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00001781	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00001781	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00001781	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00001781	0 / 0
P08311	Cathepsin G	S1A	C00001781	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00001781	1 / 0
P03956	Interstitial collagenase	M10A	C00001781	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00001781	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00001781	0 / 0
Q9NPD5	Solute carrier organic anion transporter family member 1B3	Electrochemical transporter	C00001781	1 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00001781	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00001781	0 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00001781	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00001781	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00001781	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00001781	2 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00001781	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00001781	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00001781	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00001781	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00001781	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00001781	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00001781	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00001781	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00001781	2 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001781	0 / 0
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00001781	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001781	0 / 0
P21439	Multidrug resistance protein 3	Enzyme	C00001781	3 / 2
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00001781	0 / 0
P03372	Estrogen receptor	NR3A1	C00001781	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00001781	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00001781	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00001781	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00001781	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00001781	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00001781	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00001781	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00001781	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00001781	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001781	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001781	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001781	0 / 1
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00001781	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00001781	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00001781	4 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00001781	0 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00001781	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00001781	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00001781	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00001781	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00001781	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00001781	0 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00001781	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00001781	0 / 0
P40225	Thrombopoietin	Unclassified protein	C00001781	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001781	0 / 0
O00255	Menin	Unclassified protein	C00001781	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001781	1 / 2
Q13748	Tubulin alpha-3C/D chain	Structural	C00001781	0 / 0
P68366	Tubulin alpha-4A chain	Structural	C00001781	0 / 0
Q9H4B7	Tubulin beta-1 chain	Structural	C00001781	1 / 0
P04350	Tubulin beta-4A chain	Structural	C00001781	2 / 0
Q3ZCM7	Tubulin beta-8 chain	Structural	C00001781	0 / 0
Q71U36	Tubulin alpha-1A chain	Structural	C00001781	1 / 1
P68371	Tubulin beta-4B chain	Structural	C00001781	0 / 0
Q13509	Tubulin beta-3 chain	Structural	C00001781	2 / 1
P68363	Tubulin alpha-1B chain	Unclassified protein	C00001781	0 / 0
Q13885	Tubulin beta-2A chain	Structural	C00001781	0 / 0
Q6PEY2	Tubulin alpha-3E chain	Unclassified protein	C00001781	0 / 0
Q9BQE3	Tubulin alpha-1C chain	Unclassified protein	C00001781	0 / 0
Q9BUF5	Tubulin beta-6 chain	Structural	C00001781	0 / 0
Q9BVA1	Tubulin beta-2B chain	Structural	C00001781	1 / 0

208 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00001781
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00001781
1244	ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	C00001781
3983	ABLIM1, ABLIM, LIMAB1, LIMATIN, abLIM-1	actin binding LIM protein 1	C00001781
39	ACAT2	acetyl-CoA acetyltransferase 2 (EC:2.3.1.9)	C00001781
55856	ACOT13, PNAS-27, THEM2	acyl-CoA thioesterase 13	C00001781
52	ACP1, HAAP	acid phosphatase 1, soluble (EC:3.1.3.2 3.1.3.48)	C00001781
120	ADD3, ADDL	adducin 3 (gamma)	C00001781
316	AOX1, AO, AOH1	aldehyde oxidase 1 (EC:1.2.3.1)	C00001781
27350	APOBEC3C, A3C, APOBEC1L, ARDC2, ARDC4, ARP5, PBI, bK150C2.3	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C	C00001781
521	ATP5I, ATP5K	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E (EC:3.6.1.14)	C00001781
9551	ATP5J2, ATP5JL	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 (EC:3.6.1.14)	C00001781
9212	AURKB, AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5, aurkb-sv1, aurkb-sv2	aurora kinase B (EC:2.7.11.1)	C00001781
558	AXL, JTK11, UFO	AXL receptor tyrosine kinase (EC:2.7.10.1)	C00001781
329	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1	baculoviral IAP repeat containing 2	C00001781
330	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2	baculoviral IAP repeat containing 3	C00001781
79444	BIRC7, KIAP, LIVIN, ML-IAP, MLIAP, RNF50	baculoviral IAP repeat containing 7	C00001781
699	BUB1, BUB1A, BUB1L, hBUB1	BUB1 mitotic checkpoint serine/threonine kinase (EC:2.7.11.1)	C00001781
56951	C5orf15, KCT2	chromosome 5 open reading frame 15	C00001781
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00001781
847	CAT	catalase (EC:1.11.1.6)	C00001781
891	CCNB1, CCNB	cyclin B1	C00001781
9133	CCNB2, HsT17299	cyclin B2	C00001781
959	CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L	CD40 ligand	C00001781
34411			C00001781
55143	CDCA8, BOR, BOREALIN, DasraB, MESRGP	cell division cycle associated 8	C00001781
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00001781
1031	CDKN2C, INK4C, p18, p18-INK4C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	C00001781
1058	CENPA, CENP-A, CenH3	centromere protein A	C00001781
26586	CKAP2, LB1, TMAP, se20-10	cytoskeleton associated protein 2	C00001781
10063	COX17	COX17 cytochrome c oxidase copper chaperone	C00001781
9377	COX5A, COX, COX-VA, VA	cytochrome c oxidase subunit Va (EC:1.9.3.1)	C00001781
1340	COX6B1, COX6B, COXG, COXVIb1	cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) (EC:1.9.3.1)	C00001781
8804	CREG1, CREG	cellular repressor of E1A-stimulated genes 1	C00001781
9419	CRIPT	cysteine-rich PDZ-binding protein	C00001781
1490	CTGF, CCN2, HCS24, IGFBP8, NOV2	connective tissue growth factor	C00001781
6374	CXCL5, ENA-78, SCYB5	chemokine (C-X-C motif) ligand 5	C00001781
100528464			C00001781
28960	DCPS, DCS1, HINT-5, HINT5, HSL1	decapping enzyme, scavenger (EC:3.6.1.59)	C00001781
9416	DDX23, PRPF28, SNRNP100, U5-100K, U5-100KD, prp28	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 (EC:3.6.4.13)	C00001781
51071	DERA, DEOC	deoxyribose-phosphate aldolase (putative) (EC:4.1.2.4)	C00001781
1677	DFFB, CAD, CPAN, DFF-40, DFF2, DFF40	DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)	C00001781
22943	DKK1, DKK-1, SK	dickkopf WNT signaling pathway inhibitor 1	C00001781
27122	DKK3, REIC, RIG	dickkopf WNT signaling pathway inhibitor 3	C00001781
29980	DONSON, B17, C21orf60	downstream neighbor of SON	C00001781
1869	E2F1, E2F-1, RBAP1, RBBP3, RBP3	E2F transcription factor 1	C00001781
84455	EFCAB7, RP4-534K7.1	EF-hand calcium binding domain 7	C00001781
2013	EMP2, XMP	epithelial membrane protein 2	C00001781
4072	EPCAM, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1	epithelial cell adhesion molecule	C00001781
2064	ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN_19, NEU, NGL, TKR1	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1)	C00001781
2069	EREG, ER	epiregulin	C00001781
2109	ETFB, MADD	electron-transfer-flavoprotein, beta polypeptide	C00001781
5393	EXOSC9, PM/Scl-75, PMSCL1, RRP45, Rrp45p, p5, p6	exosome component 9 (EC:3.1.13.-)	C00001781
10447	FAM3C, ILEI	family with sequence similarity 3, member C	C00001781
388650	FAM69A	family with sequence similarity 69, member A	C00001781
55120	FANCL, FAAP43, PHF9, POG	Fanconi anemia, complementation group L	C00001781
356	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6	Fas ligand (TNF superfamily, member 6)	C00001781
2237	FEN1, FEN-1, MF1, RAD2	flap structure-specific endonuclease 1	C00001781
2280	FKBP1A, FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE	FK506 binding protein 1A, 12kDa (EC:5.2.1.8)	C00001781
2313	FLI1, EWSR2, SIC-1	Fli-1 proto-oncogene, ETS transcription factor	C00001781
2335	FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF	fibronectin 1	C00001781
8061	FOSL1, FRA, FRA1, fra-1	FOS-like antigen 1	C00001781
50486	G0S2, RP1-28O10.2	G0/G1switch 2	C00001781
79017	GGCT, C7orf24, CRF21, GCTG, GGC	gamma-glutamylcyclotransferase (EC:2.3.2.4)	C00001781
2677	GGCX, VKCFD1	gamma-glutamyl carboxylase (EC:4.1.1.90)	C00001781
51053	GMNN, Gem	geminin, DNA replication inhibitor	C00001781
79158	GNPTAB, GNPTA, ICD	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (EC:2.7.8.17)	C00001781
11245	GPR176, HB-954	G protein-coupled receptor 176	C00001781
29899	GPSM2, CMCS, DFNB82, LGN, PINS	G-protein signaling modulator 2	C00001781
2969	GTF2I, BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6	general transcription factor IIi	C00001781
2971	GTF3A, AP2, TFIIIA	general transcription factor IIIA	C00001781
51512	GTSE1, B99	G-2 and S-phase expressed 1	C00001781
2990	GUSB, BG, MPS7	glucuronidase, beta (EC:3.2.1.31)	C00001781
3033	HADH, HAD, HADH1, HADHSC, HCDH, HHF4, MSCHAD, SCHAD	hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)	C00001781
3059	HCLS1, CTTNL, HS1	hematopoietic cell-specific Lyn substrate 1	C00001781
3006	HIST1H1C, H1.2, H1C, H1F2, H1s-1	histone cluster 1, H1c	C00001781
3146	HMGB1, HMG1, HMG3, SBP-1	high mobility group box 1	C00001781
3148	HMGB2, HMG2	high mobility group box 2	C00001781
9324	HMGN3, PNAS-25, TRIP7	high mobility group nucleosomal binding domain 3	C00001781
3161	HMMR, CD168, IHABP, RHAMM	hyaluronan-mediated motility receptor (RHAMM)	C00001781
9456	HOMER1, HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1	homer homolog 1 (Drosophila)	C00001781
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00001781
3398	ID2, GIG8, ID2A, ID2H, bHLHb26	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	C00001781
3418	IDH2, D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH	isocitrate dehydrogenase 2 (NADP+), mitochondrial (EC:1.1.1.42)	C00001781
10643	IGF2BP3, CT98, IMP-3, IMP3, KOC1, VICKZ3	insulin-like growth factor 2 mRNA binding protein 3	C00001781
3551	IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)	C00001781
3598	IL13RA2, CD213A2, CT19, IL-13R, IL13BP	interleukin 13 receptor, alpha 2	C00001781
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00001781
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00001781
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00001781
3624	INHBA, EDF, FRP	inhibin, beta A	C00001781
3683	ITGAL, CD11A, LFA-1, LFA1A	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	C00001781
9270	ITGB1BP1, ICAP-1A, ICAP-1B, ICAP-1alpha, ICAP1, ICAP1A, ICAP1B	integrin beta 1 binding protein 1	C00001781
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00001781
23189	KANK1, ANKRD15, CPSQ2, KANK	KN motif and ankyrin repeat domains 1	C00001781
23254	KAZN, KAZ	kazrin, periplakin interacting protein	C00001781
57698		KIAA1598	C00001781
3832	KIF11, EG5, HKSP, KNSL1, MCLMR, TRIP5	kinesin family member 11	C00001781
56992	KIF15, HKLP2, KNSL7, NY-BR-62	kinesin family member 15	C00001781
23095	KIF1B, CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1	kinesin family member 1B	C00001781
10112	KIF20A, MKLP2, RAB6KIFL	kinesin family member 20A	C00001781
9493	KIF23, CHO1, KNSL5, MKLP-1, MKLP1	kinesin family member 23	C00001781
24137	KIF4A, KIF4, KIF4G1	kinesin family member 4A	C00001781
3838	KPNA2, IPOA1, QIP2, RCH1, SRP1alpha	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	C00001781
4001	LMNB1, ADLD, LMN, LMN2, LMNB	lamin B1	C00001781
1902	LPAR1, EDG2, GPR26, Gpcr26, LPA1, Mrec1.3, VZG1, edg-2, rec.1.3, vzg-1	lysophosphatidic acid receptor 1	C00001781
55227	LRRC1, LANO, dJ523E19.1	leucine rich repeat containing 1	C00001781
51690	LSM7, YNL147W	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)	C00001781
4053	LTBP2, C14orf141, GLC3D, LTBP3, MSPKA, MSTP031, WMS3	latent transforming growth factor beta binding protein 2	C00001781
4085	MAD2L1, HSMAD2, MAD2	MAD2 mitotic arrest deficient-like 1 (yeast)	C00001781
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00001781
5601	MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK	mitogen-activated protein kinase 9 (EC:2.7.11.24)	C00001781
8550	MAPKAPK5, MAPKAP-K5, MK-5, MK5, PRAK	mitogen-activated protein kinase-activated protein kinase 5 (EC:2.7.11.1)	C00001781
9833	MELK, HPK38	maternal embryonic leucine zipper kinase (EC:2.7.11.1 2.7.10.2)	C00001781
4311	MME, CALLA, CD10, NEP, SFE	membrane metallo-endopeptidase (EC:3.4.24.11)	C00001781
4312	MMP1, CLG, CLGN	matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)	C00001781
5891	MOK, RAGE, RAGE-1, RAGE1	MOK protein kinase (EC:2.7.11.22)	C00001781
78988	MRP63, bMRP63	mitochondrial ribosomal protein 63	C00001781
51765	MST4, MASK	serine/threonine protein kinase MST4 (EC:2.7.11.1)	C00001781
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00001781
26292	MYCBP, AMY-1	MYC binding protein	C00001781
64151	NCAPG, CAPG, CHCG, NY-MEL-3	non-SMC condensin I complex, subunit G	C00001781
23397	NCAPH, BRRN1, CAP-H	non-SMC condensin I complex, subunit H	C00001781
10403	NDC80, HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80	NDC80 kinetochore complex component	C00001781
4694	NDUFA1, CI-MWFE, MWFE, ZNF183	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa (EC:1.6.99.3)	C00001781
51079	NDUFA13, B16.6, CDA016, GRIM-19, GRIM19	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13	C00001781
4696	NDUFA3, B9, CI-B9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa	C00001781
4701	NDUFA7, B14.5a	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa	C00001781
4708	NDUFB2, AGGG, CI-AGGG	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa (EC:1.6.5.3 1.6.99.3)	C00001781
4717	NDUFC1, KFYI	NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa	C00001781
4718	NDUFC2, B14.5b, CI-B14.5b, HLC-1, NADHDH2	NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa	C00001781
4726	NDUFS6, CI-13kA, CI-13kD-A, CI13KDA	NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3)	C00001781
4729	NDUFV2, CI-24k	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (EC:1.6.5.3 1.6.99.3)	C00001781
4776	NFATC4, NF-ATc4, NFAT3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	C00001781
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00001781
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00001781
8439	NSMAF, FAN	neutral sphingomyelinase (N-SMase) activation associated factor	C00001781
55270	NUDT15, MTH2, RP11-90M2.1	nudix (nucleoside diphosphate linked moiety X)-type motif 15 (EC:3.6.1.55)	C00001781
11163	NUDT4, DIPP2, DIPP2alpha, DIPP2beta	nudix (nucleoside diphosphate linked moiety X)-type motif 4 (EC:3.6.1.52)	C00001781
51203	NUSAP1, ANKT, BM037, LNP, NUSAP, PRO0310p1, Q0310, SAPL	nucleolar and spindle associated protein 1	C00001781
4946	OAZ1, AZI, OAZ	ornithine decarboxylase antizyme 1	C00001781
11339	OIP5, 5730547N13Rik, CT86, LINT-25, MIS18B, MIS18beta, hMIS18beta	Opa interacting protein 5	C00001781
401903			C00001781
126370	OR1I1, OR19-20, OR1I1P, OR1I1Q	olfactory receptor, family 1, subfamily I, member 1	C00001781
23594	ORC6, ORC6L	origin recognition complex, subunit 6	C00001781
114884	OSBPL10, ORP10, OSBP9	oxysterol binding protein-like 10	C00001781
3355109			C00001781
5162	PDHB, PDHBD, PDHE1-B, PHE1B	pyruvate dehydrogenase (lipoamide) beta (EC:1.2.4.1)	C00001781
53918	PELO, PRO1770	pelota homolog (Drosophila)	C00001781
10857	PGRMC1, HPR6.6, MPR	progesterone receptor membrane component 1	C00001781
8544	PIR	pirin (iron-binding nuclear protein) (EC:1.13.11.24)	C00001781
5328	PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA	plasminogen activator, urokinase (EC:3.4.21.73)	C00001781
9055	PRC1, ASE1	protein regulator of cytokinesis 1	C00001781
5689	PSMB1, HC5, PMSB1, PSC5	proteasome (prosome, macropain) subunit, beta type, 1 (EC:3.4.25.1)	C00001781
23198	PSME4, PA200	proteasome (prosome, macropain) activator subunit 4	C00001781
10728	PTGES3, P23, TEBP, cPGES	prostaglandin E synthase 3 (cytosolic) (EC:5.3.99.3)	C00001781
9232	PTTG1, EAP1, HPTTG, PTTG, TUTR1	pituitary tumor-transforming 1	C00001781
5806	PTX3, TNFAIP5, TSG-14	pentraxin 3, long	C00001781
54870	QRICH1	glutamine-rich 1	C00001781
80223	RAB11FIP1, NOEL1A, RCP, rab11-FIP1	RAB11 family interacting protein 1 (class I)	C00001781
29127	RACGAP1, CYK4, HsCYK-4, ID-GAP, MgcRacGAP	Rac GTPase activating protein 1	C00001781
5902	RANBP1, HTF9A	RAN binding protein 1	C00001781
5980	REV3L, POLZ, REV3	REV3-like, polymerase (DNA directed), zeta, catalytic subunit (EC:2.7.7.7)	C00001781
5985	RFC5, RFC36	replication factor C (activator 1) 5, 36.5kDa	C00001781
6119	RPA3, REPA3	replication protein A3, 14kDa	C00001781
393715			C00001781
6241	RRM2, R2, RR2, RR2M	ribonucleotide reductase M2 (EC:1.17.4.1)	C00001781
5055	SERPINB2, HsT1201, PAI, PAI-2, PAI2, PLANH2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	C00001781
5054	SERPINE1, PAI, PAI-1, PAI1, PLANH1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	C00001781
94081	SFXN1	sideroflexin 1	C00001781
6502	SKP2, FBL1, FBXL1, FLB1, p45	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	C00001781
6581	SLC22A3, EMT, EMTH, OCT3	solute carrier family 22 (organic cation transporter), member 3	C00001781
79622	SNRNP25, C16orf33	small nuclear ribonucleoprotein 25kDa (U11/U12)	C00001781
29887	SNX10, OPTB8	sorting nexin 10	C00001781
6647	SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	C00001781
6272	SORT1, Gp95, LDLCQ6, NT3	sortilin 1	C00001781
6715	SRD5A1, S5AR_1	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) (EC:1.3.1.22)	C00001781
5552	SRGN, PPG, PRG, PRG1	serglycin	C00001781
8614	STC2, STC-2, STCRP	stanniocalcin 2	C00001781
6801	STRN, SG2NA	striatin, calmodulin binding protein	C00001781
8803	SUCLA2, A-BETA, MTDPS5, SCS-betaA	succinate-CoA ligase, ADP-forming, beta subunit (EC:6.2.1.5)	C00001781
8802	SUCLG1, GALPHA, MTDPS9, SUCLA1	succinate-CoA ligase, alpha subunit (EC:6.2.1.4 6.2.1.5)	C00001781
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00001781
85360	SYDE1, 7h3	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)	C00001781
9882	TBC1D4, AS160	TBC1 domain family, member 4	C00001781
6996	TDG, hTDG	thymine-DNA glycosylase (EC:3.2.2.29)	C00001781
7980	TFPI2, PP5, REF1, TFPI-2	tissue factor pathway inhibitor 2	C00001781
80194	TMEM134	transmembrane protein 134	C00001781
28978	TMEM14A, C6orf73	transmembrane protein 14A	C00001781
80008	TMEM156	transmembrane protein 156	C00001781
27346	TMEM97, MAC30	transmembrane protein 97	C00001781
7112	TMPO, CMD1T, LAP2, LEMD4, PRO0868, TP	thymopoietin	C00001781
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00001781
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00001781
7164	TPD52L1, D53, hD53	tumor protein D52-like 1	C00001781
23321	TRIM2, CMT2R, RNF86	tripartite motif containing 2	C00001781
57570	TRMT5, KIAA1393, TRM5	tRNA methyltransferase 5 (EC:2.1.1.228)	C00001781
27075	TSPAN13, NET-6, NET6, TM4SF13	tetraspanin 13	C00001781
8458	TTF2, HuF2	transcription termination factor, RNA polymerase II	C00001781
7272	TTK, CT96, ESK, MPH1, MPS1, MPS1L1, PYT	TTK protein kinase (EC:2.7.12.1)	C00001781
659925			C00001781
7424	VEGFC, Flt4-L, VRP	vascular endothelial growth factor C	C00001781
80349	WDR61, REC14, SKI8	WD repeat domain 61	C00001781
55884	WSB2, SBA2	WD repeat and SOCS box containing 2	C00001781
10971	YWHAQ, 14-3-3, 1C5, HS1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	C00001781
79844	ZDHHC11, ZNF399	zinc finger, DHHC-type containing 11 (EC:2.3.1.225)	C00001781
678	ZFP36L2, BRF2, ERF-2, ERF2, RNF162C, TIS11D	ZFP36 ring finger protein-like 2	C00001781
11130	ZWINT, HZwint-1, KNTC2AP, ZWINT1	ZW10 interacting kinetochore protein	C00001781

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