KNApSAcK Metabolite C00018736
Metabolite
KNApSAcK Entry
| id | C00018736 |
|---|---|
| Name | EN 141 / Jomybel / Josamina / Iosalide / Josacine / Vilprafen / Josamycin / Wilprafen / Turimycin A5 / Kitasamycin A3 / Antibiotic YL 704A3 |
| CAS RN | 16846-24-5 |
| Standard InChI | InChI=1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26?,27?,29+,30+,31-,34+,35-,36?,37-,38+,39+,40+,41+,42-/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 180 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL329011 CHEMBL224436 CHEMBL1326015 CHEMBL1671903 CHEMBL1995525 CHEMBL2361089 |
KEGG
| By LinkDB | C12662 |
|---|
CTD
| By CAS RN | D015570 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Streptomycetaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Streptomyces narbonenensis var. josamyceticus nov. var. A 204-P2 | 1883 | Streptomycetaceae | Bacteria |
Human Protein / Gene in interaction
9 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL1326015 |
CHEMBL1741321
(1)
|
1 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | CHEMBL1671903 |
CHEMBL1676103
(1)
|
2 / 2 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | CHEMBL1326015 |
CHEMBL1614331
(1)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL1326015 |
CHEMBL1741325
(1)
|
0 / 1 |
| P55085 | Proteinase-activated receptor 2 | Protease-activated receptor | CHEMBL224436 |
CHEMBL1262320
(1)
|
0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | CHEMBL1326015 |
CHEMBL1794467
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL1326015 |
CHEMBL1741322
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL1326015 |
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL1326015 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
CHEMBL1741324 (1) |
0 / 1 |
CTD interaction (4)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D015570 | 1378 |
CR1
C3BR C4BR CD35 KN |
complement component (3b/4b) receptor 1 (Knops blood group) | Josamycin results in decreased expression of CR1 protein |
decreases expression
|
protein |
8096833
|
| D015570 | 1378 |
CR1
C3BR C4BR CD35 KN |
complement component (3b/4b) receptor 1 (Knops blood group) | Ribomunyl inhibits the reaction [Josamycin results in decreased expression of CR1 protein] |
decreases expression
/ decreases reaction |
protein |
8096833
|
| D015570 | 3689 |
ITGB2
CD18 LAD LCAMB LFA-1 MAC-1 MF17 MFI7 |
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | Josamycin results in decreased expression of ITGB2 protein |
decreases expression
|
protein |
8096833
|
| D015570 | 3689 |
ITGB2
CD18 LAD LCAMB LFA-1 MAC-1 MF17 MFI7 |
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | Ribomunyl inhibits the reaction [Josamycin results in decreased expression of ITGB2 protein] |
decreases expression
/ decreases reaction |
protein |
8096833
|