KCF-S cluster No. 180 (34 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (34)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count

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Cumulative family count

class name	count
Streptomycetaceae	31
Nocardiaceae	3

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (34)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00017662	Cirramycin F1 / Antibiotic A 6888C		C059003
C00017663	Cirramycin F2		C059004
C00018001	18-Dihydromaridomycin III
C00018002	18-Dihydro-9-propionylmaridomycin III
C00018003	18-Dihydrojosamycin / Dihydroleucomycin A3 / 18-Dihydroleucomycin A3 / 18-Dihydroleukomycin A3
C00018165	Turimycin EP2 / Maridomycin V / Antibiotic B 5050E
C00018176	Deltamycin A1
C00018177	Deltamycin A2
C00018178	Deltamycin A3
C00018179	M 4209 / NSC 51001 / NSC 55924 / Magnamycin / Carbomycin / Magnamycin A / Deltamycin A4	CHEMBL1231649 CHEMBL1882991 CHEMBL1979878 CHEMBL2104385 CHEMBL2355445	C059423	3 / 2 / 0
C00018233	Aboren / SF 837 / Myoxam / Midecin / Momicine / Macropen / SF 837A1 / YL 704B1 / Normicina / Medemycin / Rubimycin / NSC 154011 / Midecamycin / Mydecamycin / Medemycin A1 / Turimycin P3 / Espinomycin A / Mydecamycin A1 / Medecamycin A1 / Midecamycin A1 / Platenomycin B1 / Antibiotic SF 837 / Antibiotic YL 704B1 / Antibiotic SF 837A1	CHEMBL444963 CHEMBL1305053 CHEMBL1436846	C026483	8 / 2 / 3	2 / 0
C00018234	Mydecamycin A3 / Medecamycin A3 / Midecamycin A3 / Antibiotic SF 837A3
C00018256	Staphcoccomycin		C023522
C00018311	3-O-Acetyltylosin
C00018435	Antibiotic YT 3927 / 23-Deoxydemycinosyltylosin	CHEMBL296632
C00018436	Demycinosyltylosin / Antibiotic YO 9010 / 23-Demycinosyltylosin / 23-O-Demycinosyltylosin	CHEMBL296337
C00018437	DOMM / Demethylmacrocin / Antibiotic YO 7625 / 2'''-O-Demethylmacrocin
C00018513	Chimeramycin A		C039124
C00018514	Chimeramycin B		C039125
C00018566	Deltamycin X / 4''-Deacyl-deltamycin / Deisovaleryl magnamycin A / 4''-Deisopentanoylcarbomycin A
C00018567	Carbomycin A-P 1
C00018568	Carbomycin A-P 2
C00018569	Carbomycin A-P 3
C00018710	Turimycin H5 / Leucomycin A1 / Kitasamycin A1 / 3-Deacetyljosamycin / 3-O-Deacetyljosamycin / Leucomycin V 4-isovalerate	CHEMBL2106399		89 / 36 / 31
C00018716	Macrocin / Tylosin C / 3C-O-demethyl-tylosin	CHEMBL263259	C041661
C00018736	EN 141 / Jomybel / Josamina / Iosalide / Josacine / Vilprafen / Josamycin / Wilprafen / Turimycin A5 / Kitasamycin A3 / Antibiotic YL 704A3	CHEMBL329011 CHEMBL224436 CHEMBL1326015 CHEMBL1671903 CHEMBL1995525 CHEMBL2361089	D015570	9 / 4 / 5	2 / 2
C00018742	Leucomycin A4 / Oxacyclohexadecane,Leukomycin A4
C00018743	Turimycin H4 / Leukomycin A5 / Kitasamycin A5	CHEMBL317991
C00018744	Turimycin A3 / Leukomycin A6 / Antibiotic YL 704B3		C071430
C00018745	Turimycin H3 / Leucomycin A7
C00018746	Turimycin A2 / Leukomycin A8
C00018747	Turimycin H2 / Leucomycin A9
C00018827	Dehydroantibiotic YL-704 C1
C00018828	YL 704W1 / Antibiotic YL 704W1 / Antibiotic YL-704 W1

Human Protein / Gene in interactions

96 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00018233 C00018710 C00018736	1 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00018233 C00018710 C00018736	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00018233 C00018710 C00018736	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00018233 C00018710 C00018736	0 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00018233 C00018710 C00018736	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00018233 C00018736	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00018710 C00018736	2 / 2
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00018233 C00018736	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00018710	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00018710	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00018710	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00018710	2 / 2
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00018710	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00018710	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00018710	0 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00018710	1 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00018710	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00018710	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00018710	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00018710	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00018710	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00018710	0 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00018710	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00018710	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00018710	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00018710	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00018710	1 / 8
P14416	D(2) dopamine receptor	Dopamine receptor	C00018710	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00018710	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00018710	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00018710	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00018710	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00018710	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00018710	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00018710	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00018710	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00018710	1 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00018710	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00018179	2 / 0
O75496	Geminin	Unclassified protein	C00018179	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00018710	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00018710	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00018710	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00018710	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00018710	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00018710	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00018710	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00018710	0 / 0
P29466	Caspase-1	C14	C00018710	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00018710	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00018710	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00018710	0 / 0
P08311	Cathepsin G	S1A	C00018710	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00018710	1 / 0
P03956	Interstitial collagenase	M10A	C00018710	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00018710	0 / 0
P55085	Proteinase-activated receptor 2	Protease-activated receptor	C00018736	0 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00018710	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00018710	0 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00018710	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00018710	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00018710	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00018710	2 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00018710	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00018710	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00018710	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00018710	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00018710	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00018710	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00018710	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00018710	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00018710	2 / 1
P08246	Neutrophil elastase	S1A	C00018710	2 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00018233	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00018710	0 / 0
P03372	Estrogen receptor	NR3A1	C00018710	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00018710	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00018710	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00018710	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00018710	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00018710	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00018710	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00018710	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00018710	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00018710	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00018710	0 / 3
P21728	D(1A) dopamine receptor	Dopamine receptor	C00018710	0 / 0
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00018710	0 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00018710	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00018710	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00018710	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00018710	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00018710	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00018710	0 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00018710	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00018179	0 / 0

4 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
8647	ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP	ATP-binding cassette, sub-family B (MDR/TAP), member 11	C00018233
1244	ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	C00018233
1378	CR1, C3BR, C4BR, CD35, KN	complement component (3b/4b) receptor 1 (Knops blood group)	C00018736
3689	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	C00018736

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions